SIMILAR PATTERNS OF AMINO ACIDS FOR 3UJ6_A_SAMA300
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cj2 | PROTEIN(P-HYDROXYBENZOATEHYDROXYLASE) (Pseudomonasfluorescens) |
PF01494(FAD_binding_3) | 5 | LEU A 309ILE A 26ILE A 8ASP A 153LEU A 281 | NoneNoneFAD A 395 (-4.8A)NoneNone | 0.91A | 3uj6A-1cj2A:undetectable | 3uj6A-1cj2A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm3 | BIOSYNTHETICTHIOLASE ACETYLATEDAT CYS89 (Zoogloearamigera) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 258ILE A 269GLY A 273ILE A 275LEU A 358 | None | 1.04A | 3uj6A-1dm3A:undetectable | 3uj6A-1dm3A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3j | NADP(H)-DEPENDENTKETOSE REDUCTASE (Bemisiaargentifolii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 325GLY A 65ILE A 347ASP A 122LEU A 16 | None | 0.99A | 3uj6A-1e3jA:5.9 | 3uj6A-1e3jA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ff9 | SACCHAROPINEREDUCTASE (Magnaporthegrisea) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | TYR A 440GLY A 400ILE A 442ARG A 16ASP A 20 | None | 0.99A | 3uj6A-1ff9A:4.4 | 3uj6A-1ff9A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hh4 | RHO GDP-DISSOCIATIONINHIBITOR 1 (Homo sapiens) |
PF02115(Rho_GDI) | 5 | TYR D 428ILE D 412GLY D 374ILE D 414LEU D 394 | NoneGER D1502 ( 4.3A)NoneNoneNone | 1.02A | 3uj6A-1hh4D:undetectable | 3uj6A-1hh4D:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ksi | COPPER AMINE OXIDASE (Pisum sativum) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | LEU A 282ILE A 102GLY A 254ILE A 279ILE A 255 | None | 1.04A | 3uj6A-1ksiA:undetectable | 3uj6A-1ksiA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m68 | HYPOTHETICAL PROTEINYCDX (Escherichiacoli) |
PF02811(PHP) | 5 | LEU A 95ILE A 97ILE A 72ILE A 129HIS A 127 | None | 0.95A | 3uj6A-1m68A:undetectable | 3uj6A-1m68A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mf1 | ADENYLOSUCCINATESYNTHETASE (Mus musculus) |
PF00709(Adenylsucc_synt) | 5 | LEU A 128ILE A 59GLY A 99ILE A 130LEU A 84 | None | 0.91A | 3uj6A-1mf1A:undetectable | 3uj6A-1mf1A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogq | POLYGALACTURONASEINHIBITING PROTEIN (Phaseolusvulgaris) |
PF08263(LRRNT_2) | 5 | ILE A 154ILE A 124ILE A 145ILE A 97ASP A 131 | None | 0.96A | 3uj6A-1ogqA:undetectable | 3uj6A-1ogqA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgo | ANAEROBIC COBALAMINBIOSYNTHETIC COBALTCHELATASE (Salmonellaenterica) |
PF06180(CbiK) | 5 | LEU A 114GLY A 144ILE A 84ASP A 159LEU A 127 | None | 0.99A | 3uj6A-1qgoA:undetectable | 3uj6A-1qgoA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 5 | ILE A 177GLY A 184CYH A 243ILE A 229ILE A 78 | None | 1.05A | 3uj6A-1susA:13.3 | 3uj6A-1susA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydm | HYPOTHETICAL PROTEINYQGN (Bacillussubtilis) |
PF01812(5-FTHF_cyc-lig) | 5 | LEU A 35ILE A 120ILE A 182ILE A 183ARG A 132 | NoneNoneNoneNoneSO4 A 301 (-2.6A) | 1.04A | 3uj6A-1ydmA:undetectable | 3uj6A-1ydmA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zca | G ALPHA I/12 (Mus musculus) |
PF00503(G-alpha) | 5 | LEU A 181ILE A 95ILE A 187ASP A 97LEU A 129 | None | 0.95A | 3uj6A-1zcaA:2.5 | 3uj6A-1zcaA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2csu | 457AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF13380(CoA_binding_2)PF13607(Succ_CoA_lig) | 5 | ILE A 11GLY A 91ILE A 125ILE A 69LEU A 2 | None | 0.85A | 3uj6A-2csuA:4.7 | 3uj6A-2csuA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9i | ACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITBETA (Staphylococcusaureus) |
PF01039(Carboxyl_trans) | 5 | LEU B 221TYR B 200ILE B 70ILE B 160ILE B 279 | None | 1.01A | 3uj6A-2f9iB:undetectable | 3uj6A-2f9iB:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggq | 401AA LONGHYPOTHETICALGLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00132(Hexapep)PF00483(NTP_transferase) | 5 | LEU A 163ILE A 144GLY A 159ILE A 95ILE A 96 | None | 1.00A | 3uj6A-2ggqA:undetectable | 3uj6A-2ggqA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6e | D-ARABINOSE1-DEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 290ILE A 107GLY A 157ILE A 266ILE A 159 | None | 1.02A | 3uj6A-2h6eA:5.3 | 3uj6A-2h6eA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2myi | EXODEOXYRIBONUCLEASEIII (Pseudomonas sp.Lz4W) |
PF03372(Exo_endo_phos) | 5 | CYH A 146ILE A 144ARG A 233ASP A 252LEU A 237 | None | 1.00A | 3uj6A-2myiA:undetectable | 3uj6A-2myiA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nq5 | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Streptococcusmutans) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ILE A 511ILE A 570ILE A 547ILE A 616ASP A 514 | None | 1.00A | 3uj6A-2nq5A:undetectable | 3uj6A-2nq5A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq0 | HYPOTHETICALCONSERVED PROTEINGK1056 (Geobacilluskaustophilus) |
PF08282(Hydrolase_3) | 5 | ILE A 192GLY A 219ILE A 188ASP A 201LEU A 254 | None | 1.03A | 3uj6A-2pq0A:undetectable | 3uj6A-2pq0A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgm | SUCCINOGLYCANBIOSYNTHESIS PROTEIN (Bacillus cereus) |
PF05139(Erythro_esteras) | 5 | LEU A 319TYR A 320GLY A 411ILE A 308ILE A 414 | None | 1.03A | 3uj6A-2qgmA:undetectable | 3uj6A-2qgmA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5g | CHLORIDEINTRACELLULARCHANNEL PROTEIN 2 (Homo sapiens) |
PF13409(GST_N_2)PF13410(GST_C_2) | 5 | LEU A 139TYR A 123ILE A 193ILE A 124ASP A 202 | None | 0.99A | 3uj6A-2r5gA:undetectable | 3uj6A-2r5gA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rcy | PYRROLINECARBOXYLATEREDUCTASE (Plasmodiumfalciparum) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 5 | ILE A 29GLY A 8ILE A 23ASP A 60LEU A 87 | None | 1.05A | 3uj6A-2rcyA:4.6 | 3uj6A-2rcyA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfg | DIHYDRODIPICOLINATESYNTHASE (Hahellachejuensis) |
PF00701(DHDPS) | 6 | ILE A 202GLY A 158ILE A 129ILE A 73ASP A 161LEU A 150 | None | 1.21A | 3uj6A-2rfgA:undetectable | 3uj6A-2rfgA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v40 | ADENYLOSUCCINATESYNTHETASE ISOZYME 2 (Homo sapiens) |
PF00709(Adenylsucc_synt) | 5 | LEU A 127ILE A 56GLY A 96ILE A 129LEU A 81 | None | 0.86A | 3uj6A-2v40A:undetectable | 3uj6A-2v40A:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsq | SURFACTIN SYNTHETASESUBUNIT 3 (Bacillussubtilis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 6 | GLY A 533ILE A 531ILE A 529ARG A 504ASP A 599LEU A 495 | None | 1.34A | 3uj6A-2vsqA:undetectable | 3uj6A-2vsqA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zns | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 1 (Homo sapiens) |
PF10613(Lig_chan-Glu_bd) | 5 | LEU A 721GLY A 742ILE A 523ILE A 727ASP A 654 | None | 0.91A | 3uj6A-2znsA:undetectable | 3uj6A-2znsA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zvs | UNCHARACTERIZEDFERREDOXIN-LIKEPROTEIN YFHL (Escherichiacoli) |
PF00037(Fer4) | 5 | TYR A 30ILE A 23ILE A 9CYH A 8ILE A 4 | SF4 A 101 (-4.2A)NoneSF4 A 101 (-4.6A)SF4 A 101 (-2.3A)SF4 A 101 (-3.8A) | 1.04A | 3uj6A-2zvsA:undetectable | 3uj6A-2zvsA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b0h | NITRITE REDUCTASE (Nicotianatabacum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | LEU A 417GLY A 368ILE A 406ILE A 404ASP A 430 | None | 1.04A | 3uj6A-3b0hA:undetectable | 3uj6A-3b0hA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf0 | PROTEASE 4 (Escherichiacoli) |
PF01343(Peptidase_S49) | 5 | LEU A 138ILE A 63ILE A 100ILE A 113ASP A 119 | None | 1.00A | 3uj6A-3bf0A:undetectable | 3uj6A-3bf0A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkx | SAM-DEPENDENTMETHYLTRANSFERASE (Lactobacillusparacasei) |
PF13649(Methyltransf_25) | 5 | ILE A 34ILE A 73ARG A 124ASP A 155LEU A 143 | None | 1.04A | 3uj6A-3bkxA:13.6 | 3uj6A-3bkxA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc8 | PUTATIVEMETHYLTRANSFERASE (Bacillus cereus) |
PF13489(Methyltransf_23) | 5 | GLY A 39ILE A 81ASP A 100HIS A 104LEU A 105 | NoneNoneNone NI A 231 (-3.2A)None | 0.86A | 3uj6A-3cc8A:14.5 | 3uj6A-3cc8A:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjp | PREDICTEDAMIDOHYDROLASE,DIHYDROOROTASEFAMILY (Clostridiumacetobutylicum) |
PF04909(Amidohydro_2) | 5 | TYR A 106ILE A 74GLY A 120ILE A 135ILE A 111 | None | 0.91A | 3uj6A-3cjpA:undetectable | 3uj6A-3cjpA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6n | DIHYDROOROTASE (Aquifexaeolicus) |
PF01979(Amidohydro_1) | 5 | LEU A 25ILE A 375GLY A 29ILE A 31LEU A 2 | None | 0.96A | 3uj6A-3d6nA:undetectable | 3uj6A-3d6nA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dra | PROTEINFARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNITALPHAGERANYLGERANYLTRANSFERASE TYPE I BETASUBUNIT (Candidaalbicans;Candidaalbicans) |
PF01239(PPTA)PF00432(Prenyltrans) | 6 | LEU B 17ILE A 23CYH A 24ILE B 34ILE B 62LEU B 107 | None | 1.28A | 3uj6A-3draB:undetectable | 3uj6A-3draB:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeh | PUTATIVE LIGHT ANDREDOX SENSINGHISTIDINE KINASE (Haloarculamarismortui) |
PF08447(PAS_3) | 5 | ILE A 37GLY A 119ILE A 102ILE A 23LEU A 78 | NoneNonePG5 A 126 ( 4.4A)NoneNone | 0.91A | 3uj6A-3eehA:undetectable | 3uj6A-3eehA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hx6 | TYPE 4 FIMBRIALBIOGENESIS PROTEINPILY1 (Pseudomonasaeruginosa) |
PF05567(Neisseria_PilC) | 5 | LEU A 759ILE A 821ILE A 749ILE A 820ARG A 848 | None | 1.04A | 3uj6A-3hx6A:undetectable | 3uj6A-3hx6A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igh | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcushorikoshii) |
PF07969(Amidohydro_3) | 5 | LEU X 374ILE X 332ARG X 395ASP X 334LEU X 364 | None | 0.70A | 3uj6A-3ighX:undetectable | 3uj6A-3ighX:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1n | HTH-TYPETRANSCRIPTIONALREGULATOR BENM (Acinetobactersp. ADP1) |
PF00126(HTH_1)PF03466(LysR_substrate) | 5 | TYR A 112ILE A 121ILE A 289ILE A 109ASP A 141 | None | 0.98A | 3uj6A-3k1nA:undetectable | 3uj6A-3k1nA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd9 | COENZYME A DISULFIDEREDUCTASE (Pyrococcushorikoshii) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 156ILE A 153ILE A 177ILE A 161ARG A 186 | None | 0.98A | 3uj6A-3kd9A:3.3 | 3uj6A-3kd9A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgg | METHYLTRANSFERASE (Methanosarcinamazei) |
PF13847(Methyltransf_31) | 5 | ILE A 46GLY A 43ILE A 67ILE A 94LEU A 116 | None | 0.89A | 3uj6A-3mggA:16.7 | 3uj6A-3mggA:26.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 5 | LEU A 250ILE A 18GLY A 663ILE A 660ARG A 46 | None | 0.91A | 3uj6A-3nz4A:undetectable | 3uj6A-3nz4A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q41 | GLUTAMATE [NMDA]RECEPTOR SUBUNITZETA-1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | ILE A 83GLY A 30ILE A 116ASP A 81LEU A 33 | None | 0.99A | 3uj6A-3q41A:undetectable | 3uj6A-3q41A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk7 | TRANSCRIPTIONALREGULATORS (Yersinia pestis) |
PF00532(Peripla_BP_1) | 5 | ILE A 9GLY A 33ILE A 29ILE A 70ASP A 42 | None | 1.05A | 3uj6A-3qk7A:undetectable | 3uj6A-3qk7A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qw4 | UMP SYNTHASE (Leishmaniadonovani) |
PF00156(Pribosyltran)PF00215(OMPdecase) | 5 | ILE B 370ILE B 333ILE B 299ASP B 372LEU B 265 | None | 1.00A | 3uj6A-3qw4B:3.6 | 3uj6A-3qw4B:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0q | PROBABLE PROTEINARGININEN-METHYLTRANSFERASE4.2 (Arabidopsisthaliana) |
no annotation | 5 | LEU C 42GLY C 80ILE C 83HIS C 107LEU C 111 | NoneSAH C 1 ( 3.7A)SAH C 1 (-4.7A)NoneNone | 1.04A | 3uj6A-3r0qC:9.1 | 3uj6A-3r0qC:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5r | TRANSCRIPTIONALREGULATOR TETRFAMILY (Syntrophusaciditrophicus) |
PF00440(TetR_N) | 5 | ILE A 65ILE A 162ILE A 158ASP A 70LEU A 90 | NonePEG A 302 (-4.6A)NoneNoneNone | 0.97A | 3uj6A-3s5rA:undetectable | 3uj6A-3s5rA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tka | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE H (Escherichiacoli) |
PF01795(Methyltransf_5) | 5 | LEU A 51GLY A 35ILE A 67ASP A 55LEU A 99 | NoneSAM A 400 (-4.3A)NoneSAM A 400 (-2.8A)None | 1.03A | 3uj6A-3tkaA:13.6 | 3uj6A-3tkaA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 5 | ILE A 586GLY A 535ILE A 541ARG A 779LEU A 659 | None | 0.86A | 3uj6A-3ut2A:undetectable | 3uj6A-3ut2A:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wtc | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF00106(adh_short) | 5 | LEU A 165GLY A 120ILE A 137ILE A 63ARG A 70 | None | 1.02A | 3uj6A-3wtcA:6.5 | 3uj6A-3wtcA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 5 | ILE A 525GLY A 481ILE A 487ARG A 716LEU A 598 | None | 0.88A | 3uj6A-3wxoA:undetectable | 3uj6A-3wxoA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2l | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | LEU A 179ILE A 217ILE A 186ILE A 220ASP A 193 | None | 1.02A | 3uj6A-4a2lA:undetectable | 3uj6A-4a2lA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4blu | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Escherichiacoli) |
PF04378(RsmJ) | 5 | LEU A 220ILE A 208GLY A 239ILE A 241LEU A 257 | None | 1.05A | 3uj6A-4bluA:10.3 | 3uj6A-4bluA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 5 | LEU A 132ILE A 575GLY A 57ILE A 61HIS A 148 | None | 1.02A | 3uj6A-4btgA:undetectable | 3uj6A-4btgA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fvv | NEUROTOXIN (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | ILE A1008ILE A 968ILE A 966ILE A 969ASP A1026 | None | 0.95A | 3uj6A-4fvvA:undetectable | 3uj6A-4fvvA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i7u | DIHYDRODIPICOLINATESYNTHASE (Agrobacteriumsp. H13-3) |
PF00701(DHDPS) | 5 | ILE A 204GLY A 160ILE A 130ILE A 74ASP A 163 | None | 0.96A | 3uj6A-4i7uA:undetectable | 3uj6A-4i7uA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 7 | LEU A 182TYR A 187ILE A 204GLY A 232ARG A 298ASP A 299HIS A 303 | SAH A 501 (-4.0A)SAH A 501 ( 4.1A)SAH A 501 (-4.5A)SAH A 501 (-3.6A)NoneNoneSAH A 501 (-4.0A) | 0.87A | 3uj6A-4ineA:38.6 | 3uj6A-4ineA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 7 | LEU A 182TYR A 187ILE A 204GLY A 232ILE A 253ARG A 298ASP A 299 | SAH A 501 (-4.0A)SAH A 501 ( 4.1A)SAH A 501 (-4.5A)SAH A 501 (-3.6A)NoneNoneNone | 1.20A | 3uj6A-4ineA:38.6 | 3uj6A-4ineA:23.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iv8 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumknowlesi) |
PF08241(Methyltransf_11) | 5 | GLY A 61CYH A 85ILE A 109ARG A 125ASP A 126 | SAM A 301 (-3.5A)BME A 302 (-1.9A)SAM A 301 (-4.1A)NoneNone | 0.83A | 3uj6A-4iv8A:35.4 | 3uj6A-4iv8A:59.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iv8 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumknowlesi) |
PF08241(Methyltransf_11) | 7 | GLY A 61ILE A 84ILE A 109ARG A 125ASP A 126HIS A 130LEU A 131 | SAM A 301 (-3.5A)SAM A 301 (-3.8A)SAM A 301 (-4.1A)NoneNoneSAM A 301 (-3.9A)None | 0.36A | 3uj6A-4iv8A:35.4 | 3uj6A-4iv8A:59.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 6 | LEU A 178GLY A 230ILE A 188ARG A 294ASP A 295HIS A 299 | SAH A 701 ( 4.2A)SAH A 701 (-3.5A)NoneNoneNoneSAH A 701 (-4.2A) | 1.28A | 3uj6A-4kriA:38.6 | 3uj6A-4kriA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 7 | LEU A 178TYR A 183ILE A 200GLY A 228ARG A 294ASP A 295HIS A 299 | SAH A 701 ( 4.2A)SAH A 701 ( 4.2A)SAH A 701 ( 4.5A)SAH A 701 (-3.5A)NoneNoneSAH A 701 (-4.2A) | 0.81A | 3uj6A-4kriA:38.6 | 3uj6A-4kriA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kt6 | NICOTINE ADENINEDINUCLEOTIDEGLYCOHYDROLASE (Streptococcuspyogenes) |
PF07461(NADase_NGA) | 5 | LEU A 402ILE A 411ILE A 419ILE A 440ILE A 420 | None | 0.98A | 3uj6A-4kt6A:undetectable | 3uj6A-4kt6A:22.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mwz | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumvivax) |
PF13649(Methyltransf_25) | 7 | TYR A 16ILE A 33GLY A 60CYH A 84ILE A 108ARG A 124ASP A 125 | SAM A 301 ( 4.3A)SAM A 301 (-4.3A)SAM A 301 (-3.7A)BME A 303 (-1.9A)SAM A 301 (-4.0A)NoneNone | 0.74A | 3uj6A-4mwzA:41.6 | 3uj6A-4mwzA:63.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mwz | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumvivax) |
PF13649(Methyltransf_25) | 9 | TYR A 16ILE A 33GLY A 60ILE A 83ILE A 108ARG A 124ASP A 125HIS A 129LEU A 130 | SAM A 301 ( 4.3A)SAM A 301 (-4.3A)SAM A 301 (-3.7A)SAM A 301 (-3.7A)SAM A 301 (-4.0A)NoneNoneSAM A 301 (-3.9A)None | 0.19A | 3uj6A-4mwzA:41.6 | 3uj6A-4mwzA:63.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n58 | PECTOCIN M2 (Pectobacteriumcarotovorum) |
PF00111(Fer2)PF14859(Colicin_M) | 5 | TYR A 195ILE A 122ILE A 199ILE A 257ASP A 150 | None | 0.95A | 3uj6A-4n58A:undetectable | 3uj6A-4n58A:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nes | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Methanocaldococcusjannaschii) |
PF02350(Epimerase_2) | 5 | ILE A 231GLY A 224ILE A 331ILE A 221LEU A 204 | None | 0.93A | 3uj6A-4nesA:undetectable | 3uj6A-4nesA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhy | 2-OXOGLUTARATE ANDIRON-DEPENDENTOXYGENASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF10637(Ofd1_CTDD)PF13661(2OG-FeII_Oxy_4) | 6 | LEU A 115ILE A 139GLY A 235ILE A 233ILE A 167LEU A 207 | NoneNoneNoneNonePD2 A 603 ( 4.2A)None | 1.16A | 3uj6A-4nhyA:undetectable | 3uj6A-4nhyA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4per | RIBONUCLEASEINHIBITOR (Gallus gallus) |
PF13516(LRR_6) | 5 | LEU A 263ILE A 287GLY A 230ILE A 206LEU A 242 | None | 0.97A | 3uj6A-4perA:undetectable | 3uj6A-4perA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phb | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF14262(Cthe_2159) | 5 | LEU A 129ILE A 149CYH A 148ILE A 111LEU A 94 | None | 0.73A | 3uj6A-4phbA:undetectable | 3uj6A-4phbA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pys | BETA-N-ACETYLHEXOSAMINIDASE (Bacteroidesfragilis) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b) | 5 | ILE A 23ILE A 136ILE A 79ARG A 119LEU A 39 | FMT A 609 (-4.5A)NoneNoneNoneNone | 0.98A | 3uj6A-4pysA:undetectable | 3uj6A-4pysA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0m | MCYG PROTEIN (Microcystisaeruginosa) |
no annotation | 6 | LEU B 51TYR B 48GLY B 234ILE B 84ILE B 230ASP B 239 | None | 1.32A | 3uj6A-4r0mB:undetectable | 3uj6A-4r0mB:19.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r6w | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE (Plasmodiumfalciparum) |
PF13649(Methyltransf_25) | 7 | LEU A 14TYR A 19CYH A 87ILE A 90ILE A 62HIS A 132LEU A 133 | NoneSAH A 302 ( 4.1A)SAH A 302 (-3.4A)NoneNoneSAH A 302 (-4.3A)None | 1.16A | 3uj6A-4r6wA:46.3 | 3uj6A-4r6wA:99.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r6w | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE (Plasmodiumfalciparum) |
PF13649(Methyltransf_25) | 7 | LEU A 14TYR A 19GLY A 63ILE A 86CYH A 87ILE A 84ARG A 127 | NoneSAH A 302 ( 4.1A)SAH A 302 (-3.7A)SAH A 302 (-3.7A)SAH A 302 (-3.4A)NoneNone | 1.31A | 3uj6A-4r6wA:46.3 | 3uj6A-4r6wA:99.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r6w | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE (Plasmodiumfalciparum) |
PF13649(Methyltransf_25) | 11 | LEU A 14TYR A 19ILE A 36GLY A 63ILE A 86CYH A 87ILE A 90ILE A 111ARG A 127HIS A 132LEU A 133 | NoneSAH A 302 ( 4.1A)SAH A 302 ( 3.9A)SAH A 302 (-3.7A)SAH A 302 (-3.7A)SAH A 302 (-3.4A)NoneSAH A 302 (-4.1A)NoneSAH A 302 (-4.3A)None | 0.47A | 3uj6A-4r6wA:46.3 | 3uj6A-4r6wA:99.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u08 | LIC11098 (Leptospirainterrogans) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | LEU A 317GLY A 345ILE A 367ARG A 348LEU A 353 | None | 0.91A | 3uj6A-4u08A:undetectable | 3uj6A-4u08A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xae | FERULOYL COAORTHO-HYDROXYLASE 1 (Arabidopsisthaliana) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | ILE A 213ILE A 274ILE A 308ILE A 276LEU A 192 | None | 1.00A | 3uj6A-4xaeA:undetectable | 3uj6A-4xaeA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awf | PROBABLEATP-DEPENDENTTRANSPORTER SUFC (Escherichiacoli) |
PF00005(ABC_tran) | 5 | LEU C 22ILE C 199ILE C 200ASP C 229HIS C 217 | None | 0.96A | 3uj6A-5awfC:2.6 | 3uj6A-5awfC:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czz | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Staphylococcusaureus) |
PF13395(HNH_4)PF16592(Cas9_REC) | 5 | ILE A 676GLY A 8ILE A 21ILE A 20ASP A 10 | None | 1.04A | 3uj6A-5czzA:undetectable | 3uj6A-5czzA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7a | TRAF2 ANDNCK-INTERACTINGPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 154ILE A 130ILE A 137ARG A 277LEU A 253 | ILE A 154 ( 0.7A)ILE A 130 ( 0.7A)ILE A 137 ( 0.7A)ARG A 277 ( 0.6A)LEU A 253 ( 0.6A) | 1.03A | 3uj6A-5d7aA:undetectable | 3uj6A-5d7aA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqn | CYTOCHROME P450CYP125 (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 6 | LEU A 236GLY A 117ILE A 114ARG A 125ASP A 221LEU A 248 | NoneNoneNoneNoneNoneHEM A 501 (-4.5A) | 1.35A | 3uj6A-5dqnA:undetectable | 3uj6A-5dqnA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fkr | ENDO-1,4-BETA-GLUCANASE/XYLOGLUCANASE,PUTATIVE, GLY74A (Cellvibriojaponicus) |
no annotation | 5 | LEU A 395ILE A 46GLY A 50ILE A 484ARG A 757 | None | 1.04A | 3uj6A-5fkrA:undetectable | 3uj6A-5fkrA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwz | CELLULOSE-BINDINGFAMILY II (Streptomycessp. SirexAA-E) |
PF02012(BNR) | 5 | LEU A 364ILE A 17GLY A 21ILE A 452ARG A 724 | None | 1.03A | 3uj6A-5jwzA:undetectable | 3uj6A-5jwzA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kin | TRYPTOPHAN SYNTHASEBETA CHAIN (Streptococcuspneumoniae) |
PF00291(PALP) | 5 | LEU B 79TYR B 63ILE B 77ILE B 72LEU B 343 | None | 0.98A | 3uj6A-5kinB:undetectable | 3uj6A-5kinB:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqi | CATALASE-PEROXIDASE (Burkholderiapseudomallei) |
PF00141(peroxidase) | 5 | ILE A 551GLY A 499ILE A 505ARG A 744LEU A 624 | None | 0.90A | 3uj6A-5kqiA:undetectable | 3uj6A-5kqiA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lh9 | OMEGA TRANSAMINASE (Pseudomonas sp.) |
PF00202(Aminotran_3) | 5 | LEU A 241TYR A 237ILE A 208ASP A 179LEU A 142 | None | 1.00A | 3uj6A-5lh9A:undetectable | 3uj6A-5lh9A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m95 | DIVALENT METALCATION TRANSPORTERMNTH (Staphylococcuscapitis) |
PF01566(Nramp) | 5 | LEU A 346ILE A 358GLY A 338ILE A 350ILE A 340 | None | 1.03A | 3uj6A-5m95A:undetectable | 3uj6A-5m95A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5or4 | CATECHOL OXIDASE (Aspergillusoryzae) |
no annotation | 5 | LEU A 180GLY A 292ILE A 178ILE A 245LEU A 216 | None | 0.96A | 3uj6A-5or4A:undetectable | 3uj6A-5or4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tey | N6-ADENOSINE-METHYLTRANSFERASE 70 KDASUBUNIT (Homo sapiens) |
PF05063(MT-A70) | 5 | TYR A 518ILE A 517ILE A 521ASP A 395LEU A 547 | NoneNoneNoneSAH A 601 (-3.8A)None | 0.95A | 3uj6A-5teyA:undetectable | 3uj6A-5teyA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2p | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Treponemapallidum) |
PF01547(SBP_bac_1) | 5 | LEU A 352GLY A 310CYH A 143ILE A 127LEU A 279 | NoneEDO A 504 ( 3.9A)NoneNoneNone | 1.03A | 3uj6A-5u2pA:undetectable | 3uj6A-5u2pA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5whs | CATALASE-PEROXIDASE (Neurosporacrassa) |
no annotation | 5 | ILE A 550GLY A 499ILE A 505ARG A 738LEU A 618 | None | 0.87A | 3uj6A-5whsA:undetectable | 3uj6A-5whsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 6 | LEU A 241TYR A 246GLY A 290ARG A 355ASP A 356HIS A 360 | SAH A 703 (-4.0A)SAH A 703 ( 4.0A)SAH A 703 (-4.0A)None PC A 702 ( 4.6A)SAH A 703 (-4.0A) | 0.43A | 3uj6A-5wp4A:40.4 | 3uj6A-5wp4A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 6 | LEU A 241TYR A 246GLY A 290ILE A 311ARG A 355ASP A 356 | SAH A 703 (-4.0A)SAH A 703 ( 4.0A)SAH A 703 (-4.0A)NoneNone PC A 702 ( 4.6A) | 1.08A | 3uj6A-5wp4A:40.4 | 3uj6A-5wp4A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 6 | LEU A 241TYR A 246GLY A 292ILE A 251ARG A 355ASP A 356 | SAH A 703 (-4.0A)SAH A 703 ( 4.0A)SAH A 703 ( 3.7A)NoneNone PC A 702 ( 4.6A) | 1.28A | 3uj6A-5wp4A:40.4 | 3uj6A-5wp4A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 6 | LEU A 241TYR A 246ILE A 251ARG A 355ASP A 356HIS A 360 | SAH A 703 (-4.0A)SAH A 703 ( 4.0A)NoneNone PC A 702 ( 4.6A)SAH A 703 (-4.0A) | 1.24A | 3uj6A-5wp4A:40.4 | 3uj6A-5wp4A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4o | GLUTATHIONEREDUCTASE (Enterococcusfaecalis) |
no annotation | 5 | LEU A 94TYR A 98ILE A 16GLY A 39ILE A 37 | NoneNoneNoneFAD A 501 (-3.3A)None | 1.03A | 3uj6A-6b4oA:3.0 | 3uj6A-6b4oA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6coy | CHLORIDE CHANNELPROTEIN 1 (Homo sapiens) |
no annotation | 5 | LEU A 207ILE A 238GLY A 270ILE A 266LEU A 198 | None | 1.02A | 3uj6A-6coyA:undetectable | 3uj6A-6coyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 5 | LEU A 309ILE A 26ILE A 8ASP A 153LEU A 281 | None | 1.00A | 3uj6A-6dllA:undetectable | 3uj6A-6dllA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoq | DIPEPTIDYL PEPTIDASE9 (Homo sapiens) |
no annotation | 5 | LEU A 855TYR A 851ILE A 842GLY A 753ILE A 751 | None | 1.01A | 3uj6A-6eoqA:undetectable | 3uj6A-6eoqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 5 | LEU A1516GLY A1479ILE A1477ILE A1538ILE A1476 | None | 0.99A | 3uj6A-6fb3A:undetectable | 3uj6A-6fb3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1at3 | HERPES SIMPLEX VIRUSTYPE II PROTEASE (Humanalphaherpesvirus2) |
PF00716(Peptidase_S21) | 4 | SER A 129ASP A 34ASP A 31ALA A 28 | DFP A 300 ( 1.5A)NoneNoneNone | 1.36A | 3uj6A-1at3A:undetectable | 3uj6A-1at3A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cli | PROTEIN(PHOSPHORIBOSYL-AMINOIMIDAZOLESYNTHETASE) (Escherichiacoli) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | SER A 186ASP A 86ASP A 81ALA A 224 | None | 1.28A | 3uj6A-1cliA:undetectable | 3uj6A-1cliA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjv | CHITINASE-3 LIKEPROTEIN 1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 4 | SER A 333ASP A 357ASP A 47ALA A 375 | None | 1.27A | 3uj6A-1hjvA:undetectable | 3uj6A-1hjvA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kr5 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Homo sapiens) |
PF01135(PCMT) | 4 | SER A 59ASP A 109ASP A 141ALA A 159 | SAH A 300 (-3.7A)SAH A 300 (-2.9A)SAH A 300 (-3.7A)SAH A 300 ( 3.8A) | 1.04A | 3uj6A-1kr5A:9.4 | 3uj6A-1kr5A:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwy | PEPTIDOGLYCANHYDROLASE (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 4 | SER A 146ASP A 116ASP A 214ALA A 209 | NoneNone ZN A 400 (-2.2A)None | 1.22A | 3uj6A-1qwyA:undetectable | 3uj6A-1qwyA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vec | ATP-DEPENDENT RNAHELICASE P54 (Homo sapiens) |
PF00270(DEAD) | 4 | SER A 170ASP A 197ASP A 217ALA A 210 | None | 1.45A | 3uj6A-1vecA:3.5 | 3uj6A-1vecA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w99 | PESTICIDIAL CRYSTALPROTEIN CRY4BA (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | SER A 266ASP A 626ASP A 507ALA A 262 | None | 1.42A | 3uj6A-1w99A:undetectable | 3uj6A-1w99A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wd3 | ALPHA-L-ARABINOFURANOSIDASE B (Aspergilluskawachii) |
PF05270(AbfB)PF09206(ArabFuran-catal) | 4 | SER A 351ASP A 408ASP A 368ALA A 365 | None | 1.22A | 3uj6A-1wd3A:undetectable | 3uj6A-1wd3A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0u | INITIATION FACTOR 2B (Leishmaniamajor) |
PF01008(IF-2B) | 4 | SER A 100ASP A 50ASP A 44ALA A 77 | NoneNoneNoneSO4 A 403 ( 4.3A) | 1.49A | 3uj6A-2a0uA:3.4 | 3uj6A-2a0uA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nrh | TRANSCRIPTIONALACTIVATOR, PUTATIVE,BAF FAMILY (Campylobacterjejuni) |
PF03309(Pan_kinase) | 4 | SER A 9ASP A 89ASP A 97ALA A 93 | SO4 A 218 (-4.5A)NoneNoneNone | 1.31A | 3uj6A-2nrhA:undetectable | 3uj6A-2nrhA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pia | PHTHALATEDIOXYGENASEREDUCTASE (Burkholderiacepacia) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | SER A 224ASP A 293ASP A 290ALA A 227 | None | 1.29A | 3uj6A-2piaA:3.1 | 3uj6A-2piaA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk2 | CHITINASE A (Serratiamarcescens) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 4 | SER A 555ASP A 517ASP A 496ALA A 523 | None | 1.33A | 3uj6A-2wk2A:undetectable | 3uj6A-2wk2A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4d | PHOSPHOLYSINEPHOSPHOHISTIDINEINORGANICPYROPHOSPHATEPHOSPHATASE (Homo sapiens) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | SER A 25ASP A 214ASP A 242ALA A 160 | None MG A 501 (-2.8A)NoneGOL A 503 ( 4.9A) | 1.37A | 3uj6A-2x4dA:undetectable | 3uj6A-2x4dA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 4 | SER A 150ASP A 202ASP A 204ALA A 171 | ACA A 601 ( 2.7A)ACA A 601 ( 4.7A)NoneACA A 602 ( 3.3A) | 1.31A | 3uj6A-3a2qA:undetectable | 3uj6A-3a2qA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 4 | SER A 652ASP A 530ASP A 527ALA A 577 | None | 1.34A | 3uj6A-3aibA:undetectable | 3uj6A-3aibA:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc8 | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Mus musculus) |
PF05889(SepSecS) | 4 | SER A 174ASP A 283ASP A 321ALA A 143 | LLP A 284 ( 2.7A)LLP A 284 ( 3.2A)NoneLLP A 284 ( 3.3A) | 1.33A | 3uj6A-3bc8A:3.2 | 3uj6A-3bc8A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dad | FH1/FH2DOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
no annotation | 4 | SER A 129ASP A 27ASP A 25ALA A 122 | None | 1.24A | 3uj6A-3dadA:undetectable | 3uj6A-3dadA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dtn | PUTATIVEMETHYLTRANSFERASEMM_2633 (Methanosarcinamazei) |
PF13649(Methyltransf_25) | 4 | SER A 33ASP A 48ASP A 73ALA A 114 | None | 1.22A | 3uj6A-3dtnA:18.8 | 3uj6A-3dtnA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8h | PUTATIVE POLYKETIDECYCLASE (Ruegeria sp.TM1040) |
PF12680(SnoaL_2) | 4 | SER A 104ASP A 107ASP A 69ALA A 73 | MPD A 133 (-3.6A)NoneNoneNone | 1.43A | 3uj6A-3f8hA:undetectable | 3uj6A-3f8hA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gp0 | MITOGEN-ACTIVATEDPROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 4 | SER A 293ASP A 205ASP A 150ALA A 190 | None | 1.44A | 3uj6A-3gp0A:undetectable | 3uj6A-3gp0A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | SER A 347ASP A 86ASP A 93ALA A 308 | None | 1.30A | 3uj6A-3hrdA:undetectable | 3uj6A-3hrdA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i09 | PERIPLASMICBRANCHED-CHAIN AMINOACID-BINDING PROTEIN (Burkholderiamallei) |
PF13458(Peripla_BP_6) | 4 | SER A 275ASP A 339ASP A 58ALA A 304 | None | 1.27A | 3uj6A-3i09A:undetectable | 3uj6A-3i09A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 3NADH-QUINONEOXIDOREDUCTASESUBUNIT 9 (Thermusthermophilus;Thermusthermophilus) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4)PF12838(Fer4_7) | 4 | SER 9 57ASP 3 123ASP 3 237ALA 3 244 | None | 1.30A | 3uj6A-3i9v9:undetectable | 3uj6A-3i9v9:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF10 (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF16004(EFTUD2) | 4 | SER B 464ASP B 235ASP B 139ALA B 457 | None | 1.42A | 3uj6A-3jb9B:undetectable | 3uj6A-3jb9B:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfu | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Thermusthermophilus) |
PF01425(Amidase) | 4 | SER E 303ASP E 198ASP E 161ALA E 298 | None | 1.32A | 3uj6A-3kfuE:undetectable | 3uj6A-3kfuE:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lij | CALCIUM/CALMODULINDEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | SER A 303ASP A 242ASP A 184ALA A 229 | None | 1.50A | 3uj6A-3lijA:undetectable | 3uj6A-3lijA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0w | ABC BRANCHED CHAINAMINO ACID FAMILYTRANSPORTER,PERIPLASMIC LIGANDBINDING PROTEIN (Paraburkholderiaxenovorans) |
PF13458(Peripla_BP_6) | 4 | SER A 275ASP A 339ASP A 57ALA A 304 | None | 1.32A | 3uj6A-3n0wA:undetectable | 3uj6A-3n0wA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naf | CALCIUM-ACTIVATEDPOTASSIUM CHANNELSUBUNITALPHA-1,CALCIUM-ACTIVATED POTASSIUMCHANNEL SUBUNITALPHA-1,CALCIUM-ACTIVATED POTASSIUMCHANNEL SUBUNITALPHA-1 (Homo sapiens) |
PF03493(BK_channel_a) | 4 | SER A 728ASP A 432ASP A 437ALA A 730 | None | 1.15A | 3uj6A-3nafA:5.0 | 3uj6A-3nafA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o81 | BETA-2-MICROGLOBULIN (Gallus gallus) |
PF07654(C1-set) | 4 | SER A 55ASP A 59ASP A 2ALA A 28 | None | 1.33A | 3uj6A-3o81A:undetectable | 3uj6A-3o81A:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4e | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Vibrio cholerae) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | SER A 187ASP A 87ASP A 82ALA A 224 | None | 1.36A | 3uj6A-3p4eA:undetectable | 3uj6A-3p4eA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | SER B 258ASP B 272ASP B 349ALA B 354 | None | 1.42A | 3uj6A-3v0aB:undetectable | 3uj6A-3v0aB:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | SER A 519ASP A 527ASP A 507ALA A 513 | NoneNone MG A1768 (-2.5A)None | 1.19A | 3uj6A-4a01A:undetectable | 3uj6A-4a01A:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euk | HISTIDINE KINASE 5HISTIDINE-CONTAININGPHOSPHOTRANSFERPROTEIN 1 (Arabidopsisthaliana;Arabidopsisthaliana) |
PF00072(Response_reg)PF01627(Hpt) | 4 | SER B 86ASP A 828ASP A 835ALA A 885 | None MG A1001 (-2.5A)NoneNone | 1.21A | 3uj6A-4eukB:undetectable | 3uj6A-4eukB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kvo | N-TERMINALACETYLTRANSFERASE ACOMPLEX SUBUNIT NAT1 (Schizosaccharomycespombe) |
PF12569(NARP1) | 4 | SER A 517ASP A 499ASP A 462ALA A 512 | None | 1.33A | 3uj6A-4kvoA:undetectable | 3uj6A-4kvoA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nl4 | PRIMOSOME ASSEMBLYPROTEIN PRIA (Klebsiellapneumoniae) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | SER H 227ASP H 319ASP H 323ALA H 356 | ADP H 801 ( 3.7A)NoneNoneNone | 1.32A | 3uj6A-4nl4H:2.2 | 3uj6A-4nl4H:15.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r6w | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE (Plasmodiumfalciparum) |
PF13649(Methyltransf_25) | 4 | SER A 37ASP A 85ASP A 110ALA A 129 | SAH A 302 (-2.5A)SAH A 302 (-2.6A)SAH A 302 (-3.6A)SAH A 302 (-3.3A) | 0.21A | 3uj6A-4r6wA:46.3 | 3uj6A-4r6wA:99.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tyh | MITOGEN-ACTIVATEDPROTEIN KINASE 14 (Mus musculus) |
PF00069(Pkinase) | 4 | SER B 56ASP B 168ASP B 112ALA B 34 | None39G B 401 (-3.5A)NoneNone | 1.37A | 3uj6A-4tyhB:undetectable | 3uj6A-4tyhB:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 4 | SER A 279ASP A 151ASP A 545ALA A 537 | None | 1.30A | 3uj6A-4xqkA:undetectable | 3uj6A-4xqkA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdl | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Homo sapiens) |
PF05889(SepSecS) | 4 | SER A 174ASP A 283ASP A 321ALA A 143 | PLR A1001 (-2.7A)NoneNonePLR A1001 (-3.0A) | 1.32A | 3uj6A-4zdlA:3.4 | 3uj6A-4zdlA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2k | TRANSFORMING PROTEINRHOA,RACGTPASE-ACTIVATINGPROTEIN 1 (Homo sapiens) |
PF00071(Ras)PF00620(RhoGAP) | 4 | SER A 85ASP A 249ASP A 65ALA A 15 | NoneNoneNoneGDP A 503 ( 4.2A) | 1.48A | 3uj6A-5c2kA:undetectable | 3uj6A-5c2kA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huq | LACTATE RACEMIZATIONOPERON PROTEIN LARA (Lactobacillusplantarum) |
PF09861(DUF2088) | 4 | SER A 282ASP A 290ASP A 321ALA A 296 | NoneNoneSO4 A 505 ( 4.7A)None | 1.43A | 3uj6A-5huqA:2.1 | 3uj6A-5huqA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1p | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 4 | SER A 255ASP A 90ASP A 67ALA A 170 | NoneNoneGPE A 402 ( 4.5A)GPE A 402 (-3.6A) | 1.40A | 3uj6A-5t1pA:undetectable | 3uj6A-5t1pA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vk4 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Neisseriagonorrhoeae) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | SER A 184ASP A 84ASP A 79ALA A 222 | None | 1.39A | 3uj6A-5vk4A:undetectable | 3uj6A-5vk4A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xdy | HEAT SHOCK PROTEINHTRA (Mycobacteriumtuberculosis) |
no annotation | 4 | SER A 450ASP A 491ASP A 374ALA A 488 | None | 1.36A | 3uj6A-5xdyA:undetectable | 3uj6A-5xdyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z6o | PROTEASE (Penicilliumcyclopium) |
no annotation | 4 | SER A 10ASP A 51ASP A 46ALA A 214 | None | 1.43A | 3uj6A-5z6oA:2.4 | 3uj6A-5z6oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zl9 | CHITINASE AB (Serratiamarcescens) |
no annotation | 4 | SER A 557ASP A 519ASP A 498ALA A 525 | NoneGOL A 701 (-4.3A)NoneNone | 1.21A | 3uj6A-5zl9A:undetectable | 3uj6A-5zl9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bma | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Campylobacterjejuni) |
no annotation | 4 | SER A 105ASP A 136ASP A 24ALA A 31 | NoneNonePO4 A 306 (-3.2A)None | 1.41A | 3uj6A-6bmaA:undetectable | 3uj6A-6bmaA:22.67 |