SIMILAR PATTERNS OF AMINO ACIDS FOR 3UJ6_A_SAMA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
5 LEU A 309
ILE A  26
ILE A   8
ASP A 153
LEU A 281
None
None
FAD  A 395 (-4.8A)
None
None
0.91A 3uj6A-1cj2A:
undetectable
3uj6A-1cj2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89


(Zoogloea
ramigera)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 258
ILE A 269
GLY A 273
ILE A 275
LEU A 358
None
1.04A 3uj6A-1dm3A:
undetectable
3uj6A-1dm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE


(Bemisia
argentifolii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 325
GLY A  65
ILE A 347
ASP A 122
LEU A  16
None
0.99A 3uj6A-1e3jA:
5.9
3uj6A-1e3jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE


(Magnaporthe
grisea)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 TYR A 440
GLY A 400
ILE A 442
ARG A  16
ASP A  20
None
0.99A 3uj6A-1ff9A:
4.4
3uj6A-1ff9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1


(Homo sapiens)
PF02115
(Rho_GDI)
5 TYR D 428
ILE D 412
GLY D 374
ILE D 414
LEU D 394
None
GER  D1502 ( 4.3A)
None
None
None
1.02A 3uj6A-1hh4D:
undetectable
3uj6A-1hh4D:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
5 LEU A 282
ILE A 102
GLY A 254
ILE A 279
ILE A 255
None
1.04A 3uj6A-1ksiA:
undetectable
3uj6A-1ksiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX


(Escherichia
coli)
PF02811
(PHP)
5 LEU A  95
ILE A  97
ILE A  72
ILE A 129
HIS A 127
None
0.95A 3uj6A-1m68A:
undetectable
3uj6A-1m68A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE


(Mus musculus)
PF00709
(Adenylsucc_synt)
5 LEU A 128
ILE A  59
GLY A  99
ILE A 130
LEU A  84
None
0.91A 3uj6A-1mf1A:
undetectable
3uj6A-1mf1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN


(Phaseolus
vulgaris)
PF08263
(LRRNT_2)
5 ILE A 154
ILE A 124
ILE A 145
ILE A  97
ASP A 131
None
0.96A 3uj6A-1ogqA:
undetectable
3uj6A-1ogqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE


(Salmonella
enterica)
PF06180
(CbiK)
5 LEU A 114
GLY A 144
ILE A  84
ASP A 159
LEU A 127
None
0.99A 3uj6A-1qgoA:
undetectable
3uj6A-1qgoA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE


(Medicago sativa)
PF01596
(Methyltransf_3)
5 ILE A 177
GLY A 184
CYH A 243
ILE A 229
ILE A  78
None
1.05A 3uj6A-1susA:
13.3
3uj6A-1susA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN


(Bacillus
subtilis)
PF01812
(5-FTHF_cyc-lig)
5 LEU A  35
ILE A 120
ILE A 182
ILE A 183
ARG A 132
None
None
None
None
SO4  A 301 (-2.6A)
1.04A 3uj6A-1ydmA:
undetectable
3uj6A-1ydmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus)
PF00503
(G-alpha)
5 LEU A 181
ILE A  95
ILE A 187
ASP A  97
LEU A 129
None
0.95A 3uj6A-1zcaA:
2.5
3uj6A-1zcaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig)
5 ILE A  11
GLY A  91
ILE A 125
ILE A  69
LEU A   2
None
0.85A 3uj6A-2csuA:
4.7
3uj6A-2csuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA


(Staphylococcus
aureus)
PF01039
(Carboxyl_trans)
5 LEU B 221
TYR B 200
ILE B  70
ILE B 160
ILE B 279
None
1.01A 3uj6A-2f9iB:
undetectable
3uj6A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 LEU A 163
ILE A 144
GLY A 159
ILE A  95
ILE A  96
None
1.00A 3uj6A-2ggqA:
undetectable
3uj6A-2ggqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 290
ILE A 107
GLY A 157
ILE A 266
ILE A 159
None
1.02A 3uj6A-2h6eA:
5.3
3uj6A-2h6eA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III


(Pseudomonas sp.
Lz4W)
PF03372
(Exo_endo_phos)
5 CYH A 146
ILE A 144
ARG A 233
ASP A 252
LEU A 237
None
1.00A 3uj6A-2myiA:
undetectable
3uj6A-2myiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Streptococcus
mutans)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 ILE A 511
ILE A 570
ILE A 547
ILE A 616
ASP A 514
None
1.00A 3uj6A-2nq5A:
undetectable
3uj6A-2nq5A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056


(Geobacillus
kaustophilus)
PF08282
(Hydrolase_3)
5 ILE A 192
GLY A 219
ILE A 188
ASP A 201
LEU A 254
None
1.03A 3uj6A-2pq0A:
undetectable
3uj6A-2pq0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN


(Bacillus cereus)
PF05139
(Erythro_esteras)
5 LEU A 319
TYR A 320
GLY A 411
ILE A 308
ILE A 414
None
1.03A 3uj6A-2qgmA:
undetectable
3uj6A-2qgmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2


(Homo sapiens)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
5 LEU A 139
TYR A 123
ILE A 193
ILE A 124
ASP A 202
None
0.99A 3uj6A-2r5gA:
undetectable
3uj6A-2r5gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcy PYRROLINE
CARBOXYLATE
REDUCTASE


(Plasmodium
falciparum)
PF03807
(F420_oxidored)
PF14748
(P5CR_dimer)
5 ILE A  29
GLY A   8
ILE A  23
ASP A  60
LEU A  87
None
1.05A 3uj6A-2rcyA:
4.6
3uj6A-2rcyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE


(Hahella
chejuensis)
PF00701
(DHDPS)
6 ILE A 202
GLY A 158
ILE A 129
ILE A  73
ASP A 161
LEU A 150
None
1.21A 3uj6A-2rfgA:
undetectable
3uj6A-2rfgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2


(Homo sapiens)
PF00709
(Adenylsucc_synt)
5 LEU A 127
ILE A  56
GLY A  96
ILE A 129
LEU A  81
None
0.86A 3uj6A-2v40A:
undetectable
3uj6A-2v40A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
6 GLY A 533
ILE A 531
ILE A 529
ARG A 504
ASP A 599
LEU A 495
None
1.34A 3uj6A-2vsqA:
undetectable
3uj6A-2vsqA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1


(Homo sapiens)
PF10613
(Lig_chan-Glu_bd)
5 LEU A 721
GLY A 742
ILE A 523
ILE A 727
ASP A 654
None
0.91A 3uj6A-2znsA:
undetectable
3uj6A-2znsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvs UNCHARACTERIZED
FERREDOXIN-LIKE
PROTEIN YFHL


(Escherichia
coli)
PF00037
(Fer4)
5 TYR A  30
ILE A  23
ILE A   9
CYH A   8
ILE A   4
SF4  A 101 (-4.2A)
None
SF4  A 101 (-4.6A)
SF4  A 101 (-2.3A)
SF4  A 101 (-3.8A)
1.04A 3uj6A-2zvsA:
undetectable
3uj6A-2zvsA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 LEU A 417
GLY A 368
ILE A 406
ILE A 404
ASP A 430
None
1.04A 3uj6A-3b0hA:
undetectable
3uj6A-3b0hA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli)
PF01343
(Peptidase_S49)
5 LEU A 138
ILE A  63
ILE A 100
ILE A 113
ASP A 119
None
1.00A 3uj6A-3bf0A:
undetectable
3uj6A-3bf0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE


(Lactobacillus
paracasei)
PF13649
(Methyltransf_25)
5 ILE A  34
ILE A  73
ARG A 124
ASP A 155
LEU A 143
None
1.04A 3uj6A-3bkxA:
13.6
3uj6A-3bkxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE


(Bacillus cereus)
PF13489
(Methyltransf_23)
5 GLY A  39
ILE A  81
ASP A 100
HIS A 104
LEU A 105
None
None
None
NI  A 231 (-3.2A)
None
0.86A 3uj6A-3cc8A:
14.5
3uj6A-3cc8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY


(Clostridium
acetobutylicum)
PF04909
(Amidohydro_2)
5 TYR A 106
ILE A  74
GLY A 120
ILE A 135
ILE A 111
None
0.91A 3uj6A-3cjpA:
undetectable
3uj6A-3cjpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus)
PF01979
(Amidohydro_1)
5 LEU A  25
ILE A 375
GLY A  29
ILE A  31
LEU A   2
None
0.96A 3uj6A-3d6nA:
undetectable
3uj6A-3d6nA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT


(Candida
albicans;
Candida
albicans)
PF01239
(PPTA)
PF00432
(Prenyltrans)
6 LEU B  17
ILE A  23
CYH A  24
ILE B  34
ILE B  62
LEU B 107
None
1.28A 3uj6A-3draB:
undetectable
3uj6A-3draB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeh PUTATIVE LIGHT AND
REDOX SENSING
HISTIDINE KINASE


(Haloarcula
marismortui)
PF08447
(PAS_3)
5 ILE A  37
GLY A 119
ILE A 102
ILE A  23
LEU A  78
None
None
PG5  A 126 ( 4.4A)
None
None
0.91A 3uj6A-3eehA:
undetectable
3uj6A-3eehA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1


(Pseudomonas
aeruginosa)
PF05567
(Neisseria_PilC)
5 LEU A 759
ILE A 821
ILE A 749
ILE A 820
ARG A 848
None
1.04A 3uj6A-3hx6A:
undetectable
3uj6A-3hx6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Pyrococcus
horikoshii)
PF07969
(Amidohydro_3)
5 LEU X 374
ILE X 332
ARG X 395
ASP X 334
LEU X 364
None
0.70A 3uj6A-3ighX:
undetectable
3uj6A-3ighX:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM


(Acinetobacter
sp. ADP1)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
5 TYR A 112
ILE A 121
ILE A 289
ILE A 109
ASP A 141
None
0.98A 3uj6A-3k1nA:
undetectable
3uj6A-3k1nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE


(Pyrococcus
horikoshii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 156
ILE A 153
ILE A 177
ILE A 161
ARG A 186
None
0.98A 3uj6A-3kd9A:
3.3
3uj6A-3kd9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
5 ILE A  46
GLY A  43
ILE A  67
ILE A  94
LEU A 116
None
0.89A 3uj6A-3mggA:
16.7
3uj6A-3mggA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
5 LEU A 250
ILE A  18
GLY A 663
ILE A 660
ARG A  46
None
0.91A 3uj6A-3nz4A:
undetectable
3uj6A-3nz4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1


(Rattus
norvegicus)
PF01094
(ANF_receptor)
5 ILE A  83
GLY A  30
ILE A 116
ASP A  81
LEU A  33
None
0.99A 3uj6A-3q41A:
undetectable
3uj6A-3q41A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS


(Yersinia pestis)
PF00532
(Peripla_BP_1)
5 ILE A   9
GLY A  33
ILE A  29
ILE A  70
ASP A  42
None
1.05A 3uj6A-3qk7A:
undetectable
3uj6A-3qk7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani)
PF00156
(Pribosyltran)
PF00215
(OMPdecase)
5 ILE B 370
ILE B 333
ILE B 299
ASP B 372
LEU B 265
None
1.00A 3uj6A-3qw4B:
3.6
3uj6A-3qw4B:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2


(Arabidopsis
thaliana)
no annotation 5 LEU C  42
GLY C  80
ILE C  83
HIS C 107
LEU C 111
None
SAH  C   1 ( 3.7A)
SAH  C   1 (-4.7A)
None
None
1.04A 3uj6A-3r0qC:
9.1
3uj6A-3r0qC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY


(Syntrophus
aciditrophicus)
PF00440
(TetR_N)
5 ILE A  65
ILE A 162
ILE A 158
ASP A  70
LEU A  90
None
PEG  A 302 (-4.6A)
None
None
None
0.97A 3uj6A-3s5rA:
undetectable
3uj6A-3s5rA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H


(Escherichia
coli)
PF01795
(Methyltransf_5)
5 LEU A  51
GLY A  35
ILE A  67
ASP A  55
LEU A  99
None
SAM  A 400 (-4.3A)
None
SAM  A 400 (-2.8A)
None
1.03A 3uj6A-3tkaA:
13.6
3uj6A-3tkaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2


(Magnaporthe
oryzae)
PF00141
(peroxidase)
5 ILE A 586
GLY A 535
ILE A 541
ARG A 779
LEU A 659
None
0.86A 3uj6A-3ut2A:
undetectable
3uj6A-3ut2A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE


(Gluconobacter
oxydans)
PF00106
(adh_short)
5 LEU A 165
GLY A 120
ILE A 137
ILE A  63
ARG A  70
None
1.02A 3uj6A-3wtcA:
6.5
3uj6A-3wtcA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
5 ILE A 525
GLY A 481
ILE A 487
ARG A 716
LEU A 598
None
0.88A 3uj6A-3wxoA:
undetectable
3uj6A-3wxoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
5 LEU A 179
ILE A 217
ILE A 186
ILE A 220
ASP A 193
None
1.02A 3uj6A-4a2lA:
undetectable
3uj6A-4a2lA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J


(Escherichia
coli)
PF04378
(RsmJ)
5 LEU A 220
ILE A 208
GLY A 239
ILE A 241
LEU A 257
None
1.05A 3uj6A-4bluA:
10.3
3uj6A-4bluA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1


(Pseudomonas
virus phi6)
no annotation 5 LEU A 132
ILE A 575
GLY A  57
ILE A  61
HIS A 148
None
1.02A 3uj6A-4btgA:
undetectable
3uj6A-4btgA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
5 ILE A1008
ILE A 968
ILE A 966
ILE A 969
ASP A1026
None
0.95A 3uj6A-4fvvA:
undetectable
3uj6A-4fvvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE


(Agrobacterium
sp. H13-3)
PF00701
(DHDPS)
5 ILE A 204
GLY A 160
ILE A 130
ILE A  74
ASP A 163
None
0.96A 3uj6A-4i7uA:
undetectable
3uj6A-4i7uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
7 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ARG A 298
ASP A 299
HIS A 303
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
None
SAH  A 501 (-4.0A)
0.87A 3uj6A-4ineA:
38.6
3uj6A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
7 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ILE A 253
ARG A 298
ASP A 299
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
None
None
1.20A 3uj6A-4ineA:
38.6
3uj6A-4ineA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
knowlesi)
PF08241
(Methyltransf_11)
5 GLY A  61
CYH A  85
ILE A 109
ARG A 125
ASP A 126
SAM  A 301 (-3.5A)
BME  A 302 (-1.9A)
SAM  A 301 (-4.1A)
None
None
0.83A 3uj6A-4iv8A:
35.4
3uj6A-4iv8A:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
knowlesi)
PF08241
(Methyltransf_11)
7 GLY A  61
ILE A  84
ILE A 109
ARG A 125
ASP A 126
HIS A 130
LEU A 131
SAM  A 301 (-3.5A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.1A)
None
None
SAM  A 301 (-3.9A)
None
0.36A 3uj6A-4iv8A:
35.4
3uj6A-4iv8A:
59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
6 LEU A 178
GLY A 230
ILE A 188
ARG A 294
ASP A 295
HIS A 299
SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
None
None
None
SAH  A 701 (-4.2A)
1.28A 3uj6A-4kriA:
38.6
3uj6A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
7 LEU A 178
TYR A 183
ILE A 200
GLY A 228
ARG A 294
ASP A 295
HIS A 299
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
None
None
SAH  A 701 (-4.2A)
0.81A 3uj6A-4kriA:
38.6
3uj6A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE


(Streptococcus
pyogenes)
PF07461
(NADase_NGA)
5 LEU A 402
ILE A 411
ILE A 419
ILE A 440
ILE A 420
None
0.98A 3uj6A-4kt6A:
undetectable
3uj6A-4kt6A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
7 TYR A  16
ILE A  33
GLY A  60
CYH A  84
ILE A 108
ARG A 124
ASP A 125
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
None
0.74A 3uj6A-4mwzA:
41.6
3uj6A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
9 TYR A  16
ILE A  33
GLY A  60
ILE A  83
ILE A 108
ARG A 124
ASP A 125
HIS A 129
LEU A 130
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.0A)
None
None
SAM  A 301 (-3.9A)
None
0.19A 3uj6A-4mwzA:
41.6
3uj6A-4mwzA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n58 PECTOCIN M2

(Pectobacterium
carotovorum)
PF00111
(Fer2)
PF14859
(Colicin_M)
5 TYR A 195
ILE A 122
ILE A 199
ILE A 257
ASP A 150
None
0.95A 3uj6A-4n58A:
undetectable
3uj6A-4n58A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Methanocaldococcus
jannaschii)
PF02350
(Epimerase_2)
5 ILE A 231
GLY A 224
ILE A 331
ILE A 221
LEU A 204
None
0.93A 3uj6A-4nesA:
undetectable
3uj6A-4nesA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4)
6 LEU A 115
ILE A 139
GLY A 235
ILE A 233
ILE A 167
LEU A 207
None
None
None
None
PD2  A 603 ( 4.2A)
None
1.16A 3uj6A-4nhyA:
undetectable
3uj6A-4nhyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR


(Gallus gallus)
PF13516
(LRR_6)
5 LEU A 263
ILE A 287
GLY A 230
ILE A 206
LEU A 242
None
0.97A 3uj6A-4perA:
undetectable
3uj6A-4perA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF14262
(Cthe_2159)
5 LEU A 129
ILE A 149
CYH A 148
ILE A 111
LEU A  94
None
0.73A 3uj6A-4phbA:
undetectable
3uj6A-4phbA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE


(Bacteroides
fragilis)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
5 ILE A  23
ILE A 136
ILE A  79
ARG A 119
LEU A  39
FMT  A 609 (-4.5A)
None
None
None
None
0.98A 3uj6A-4pysA:
undetectable
3uj6A-4pysA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa)
no annotation 6 LEU B  51
TYR B  48
GLY B 234
ILE B  84
ILE B 230
ASP B 239
None
1.32A 3uj6A-4r0mB:
undetectable
3uj6A-4r0mB:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
7 LEU A  14
TYR A  19
CYH A  87
ILE A  90
ILE A  62
HIS A 132
LEU A 133
None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.4A)
None
None
SAH  A 302 (-4.3A)
None
1.16A 3uj6A-4r6wA:
46.3
3uj6A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
7 LEU A  14
TYR A  19
GLY A  63
ILE A  86
CYH A  87
ILE A  84
ARG A 127
None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
None
1.31A 3uj6A-4r6wA:
46.3
3uj6A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
11 LEU A  14
TYR A  19
ILE A  36
GLY A  63
ILE A  86
CYH A  87
ILE A  90
ILE A 111
ARG A 127
HIS A 132
LEU A 133
None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
None
0.47A 3uj6A-4r6wA:
46.3
3uj6A-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 LEU A 317
GLY A 345
ILE A 367
ARG A 348
LEU A 353
None
0.91A 3uj6A-4u08A:
undetectable
3uj6A-4u08A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1


(Arabidopsis
thaliana)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 ILE A 213
ILE A 274
ILE A 308
ILE A 276
LEU A 192
None
1.00A 3uj6A-4xaeA:
undetectable
3uj6A-4xaeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC


(Escherichia
coli)
PF00005
(ABC_tran)
5 LEU C  22
ILE C 199
ILE C 200
ASP C 229
HIS C 217
None
0.96A 3uj6A-5awfC:
2.6
3uj6A-5awfC:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Staphylococcus
aureus)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
5 ILE A 676
GLY A   8
ILE A  21
ILE A  20
ASP A  10
None
1.04A 3uj6A-5czzA:
undetectable
3uj6A-5czzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 154
ILE A 130
ILE A 137
ARG A 277
LEU A 253
ILE  A 154 ( 0.7A)
ILE  A 130 ( 0.7A)
ILE  A 137 ( 0.7A)
ARG  A 277 ( 0.6A)
LEU  A 253 ( 0.6A)
1.03A 3uj6A-5d7aA:
undetectable
3uj6A-5d7aA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqn CYTOCHROME P450
CYP125


(Mycolicibacterium
smegmatis)
PF00067
(p450)
6 LEU A 236
GLY A 117
ILE A 114
ARG A 125
ASP A 221
LEU A 248
None
None
None
None
None
HEM  A 501 (-4.5A)
1.35A 3uj6A-5dqnA:
undetectable
3uj6A-5dqnA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A


(Cellvibrio
japonicus)
no annotation 5 LEU A 395
ILE A  46
GLY A  50
ILE A 484
ARG A 757
None
1.04A 3uj6A-5fkrA:
undetectable
3uj6A-5fkrA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II


(Streptomyces
sp. SirexAA-E)
PF02012
(BNR)
5 LEU A 364
ILE A  17
GLY A  21
ILE A 452
ARG A 724
None
1.03A 3uj6A-5jwzA:
undetectable
3uj6A-5jwzA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN


(Streptococcus
pneumoniae)
PF00291
(PALP)
5 LEU B  79
TYR B  63
ILE B  77
ILE B  72
LEU B 343
None
0.98A 3uj6A-5kinB:
undetectable
3uj6A-5kinB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
5 ILE A 551
GLY A 499
ILE A 505
ARG A 744
LEU A 624
None
0.90A 3uj6A-5kqiA:
undetectable
3uj6A-5kqiA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.)
PF00202
(Aminotran_3)
5 LEU A 241
TYR A 237
ILE A 208
ASP A 179
LEU A 142
None
1.00A 3uj6A-5lh9A:
undetectable
3uj6A-5lh9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH


(Staphylococcus
capitis)
PF01566
(Nramp)
5 LEU A 346
ILE A 358
GLY A 338
ILE A 350
ILE A 340
None
1.03A 3uj6A-5m95A:
undetectable
3uj6A-5m95A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae)
no annotation 5 LEU A 180
GLY A 292
ILE A 178
ILE A 245
LEU A 216
None
0.96A 3uj6A-5or4A:
undetectable
3uj6A-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT


(Homo sapiens)
PF05063
(MT-A70)
5 TYR A 518
ILE A 517
ILE A 521
ASP A 395
LEU A 547
None
None
None
SAH  A 601 (-3.8A)
None
0.95A 3uj6A-5teyA:
undetectable
3uj6A-5teyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Treponema
pallidum)
PF01547
(SBP_bac_1)
5 LEU A 352
GLY A 310
CYH A 143
ILE A 127
LEU A 279
None
EDO  A 504 ( 3.9A)
None
None
None
1.03A 3uj6A-5u2pA:
undetectable
3uj6A-5u2pA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa)
no annotation 5 ILE A 550
GLY A 499
ILE A 505
ARG A 738
LEU A 618
None
0.87A 3uj6A-5whsA:
undetectable
3uj6A-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 6 LEU A 241
TYR A 246
GLY A 290
ARG A 355
ASP A 356
HIS A 360
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
0.43A 3uj6A-5wp4A:
40.4
3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 6 LEU A 241
TYR A 246
GLY A 290
ILE A 311
ARG A 355
ASP A 356
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
None
PC  A 702 ( 4.6A)
1.08A 3uj6A-5wp4A:
40.4
3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 6 LEU A 241
TYR A 246
GLY A 292
ILE A 251
ARG A 355
ASP A 356
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
None
None
PC  A 702 ( 4.6A)
1.28A 3uj6A-5wp4A:
40.4
3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 6 LEU A 241
TYR A 246
ILE A 251
ARG A 355
ASP A 356
HIS A 360
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
None
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
1.24A 3uj6A-5wp4A:
40.4
3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE


(Enterococcus
faecalis)
no annotation 5 LEU A  94
TYR A  98
ILE A  16
GLY A  39
ILE A  37
None
None
None
FAD  A 501 (-3.3A)
None
1.03A 3uj6A-6b4oA:
3.0
3uj6A-6b4oA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1


(Homo sapiens)
no annotation 5 LEU A 207
ILE A 238
GLY A 270
ILE A 266
LEU A 198
None
1.02A 3uj6A-6coyA:
undetectable
3uj6A-6coyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE


(Pseudomonas
putida)
no annotation 5 LEU A 309
ILE A  26
ILE A   8
ASP A 153
LEU A 281
None
1.00A 3uj6A-6dllA:
undetectable
3uj6A-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9


(Homo sapiens)
no annotation 5 LEU A 855
TYR A 851
ILE A 842
GLY A 753
ILE A 751
None
1.01A 3uj6A-6eoqA:
undetectable
3uj6A-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 5 LEU A1516
GLY A1479
ILE A1477
ILE A1538
ILE A1476
None
0.99A 3uj6A-6fb3A:
undetectable
3uj6A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE


(Human
alphaherpesvirus
2)
PF00716
(Peptidase_S21)
4 SER A 129
ASP A  34
ASP A  31
ALA A  28
DFP  A 300 ( 1.5A)
None
None
None
1.36A 3uj6A-1at3A:
undetectable
3uj6A-1at3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)


(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 SER A 186
ASP A  86
ASP A  81
ALA A 224
None
1.28A 3uj6A-1cliA:
undetectable
3uj6A-1cliA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1


(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 SER A 333
ASP A 357
ASP A  47
ALA A 375
None
1.27A 3uj6A-1hjvA:
undetectable
3uj6A-1hjvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Homo sapiens)
PF01135
(PCMT)
4 SER A  59
ASP A 109
ASP A 141
ALA A 159
SAH  A 300 (-3.7A)
SAH  A 300 (-2.9A)
SAH  A 300 (-3.7A)
SAH  A 300 ( 3.8A)
1.04A 3uj6A-1kr5A:
9.4
3uj6A-1kr5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE


(Staphylococcus
aureus)
PF01551
(Peptidase_M23)
4 SER A 146
ASP A 116
ASP A 214
ALA A 209
None
None
ZN  A 400 (-2.2A)
None
1.22A 3uj6A-1qwyA:
undetectable
3uj6A-1qwyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54


(Homo sapiens)
PF00270
(DEAD)
4 SER A 170
ASP A 197
ASP A 217
ALA A 210
None
1.45A 3uj6A-1vecA:
3.5
3uj6A-1vecA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 SER A 266
ASP A 626
ASP A 507
ALA A 262
None
1.42A 3uj6A-1w99A:
undetectable
3uj6A-1w99A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B


(Aspergillus
kawachii)
PF05270
(AbfB)
PF09206
(ArabFuran-catal)
4 SER A 351
ASP A 408
ASP A 368
ALA A 365
None
1.22A 3uj6A-1wd3A:
undetectable
3uj6A-1wd3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major)
PF01008
(IF-2B)
4 SER A 100
ASP A  50
ASP A  44
ALA A  77
None
None
None
SO4  A 403 ( 4.3A)
1.49A 3uj6A-2a0uA:
3.4
3uj6A-2a0uA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrh TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE,
BAF FAMILY


(Campylobacter
jejuni)
PF03309
(Pan_kinase)
4 SER A   9
ASP A  89
ASP A  97
ALA A  93
SO4  A 218 (-4.5A)
None
None
None
1.31A 3uj6A-2nrhA:
undetectable
3uj6A-2nrhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE


(Burkholderia
cepacia)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 SER A 224
ASP A 293
ASP A 290
ALA A 227
None
1.29A 3uj6A-2piaA:
3.1
3uj6A-2piaA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
4 SER A 555
ASP A 517
ASP A 496
ALA A 523
None
1.33A 3uj6A-2wk2A:
undetectable
3uj6A-2wk2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE


(Homo sapiens)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 SER A  25
ASP A 214
ASP A 242
ALA A 160
None
MG  A 501 (-2.8A)
None
GOL  A 503 ( 4.9A)
1.37A 3uj6A-2x4dA:
undetectable
3uj6A-2x4dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE


(Arthrobacter
sp. KI72)
PF01425
(Amidase)
4 SER A 150
ASP A 202
ASP A 204
ALA A 171
ACA  A 601 ( 2.7A)
ACA  A 601 ( 4.7A)
None
ACA  A 602 ( 3.3A)
1.31A 3uj6A-3a2qA:
undetectable
3uj6A-3a2qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI


(Streptococcus
mutans)
PF02324
(Glyco_hydro_70)
4 SER A 652
ASP A 530
ASP A 527
ALA A 577
None
1.34A 3uj6A-3aibA:
undetectable
3uj6A-3aibA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE


(Mus musculus)
PF05889
(SepSecS)
4 SER A 174
ASP A 283
ASP A 321
ALA A 143
LLP  A 284 ( 2.7A)
LLP  A 284 ( 3.2A)
None
LLP  A 284 ( 3.3A)
1.33A 3uj6A-3bc8A:
3.2
3uj6A-3bc8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
no annotation 4 SER A 129
ASP A  27
ASP A  25
ALA A 122
None
1.24A 3uj6A-3dadA:
undetectable
3uj6A-3dadA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633


(Methanosarcina
mazei)
PF13649
(Methyltransf_25)
4 SER A  33
ASP A  48
ASP A  73
ALA A 114
None
1.22A 3uj6A-3dtnA:
18.8
3uj6A-3dtnA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8h PUTATIVE POLYKETIDE
CYCLASE


(Ruegeria sp.
TM1040)
PF12680
(SnoaL_2)
4 SER A 104
ASP A 107
ASP A  69
ALA A  73
MPD  A 133 (-3.6A)
None
None
None
1.43A 3uj6A-3f8hA:
undetectable
3uj6A-3f8hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
4 SER A 293
ASP A 205
ASP A 150
ALA A 190
None
1.44A 3uj6A-3gp0A:
undetectable
3uj6A-3gp0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT


(Eubacterium
barkeri)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 SER A 347
ASP A  86
ASP A  93
ALA A 308
None
1.30A 3uj6A-3hrdA:
undetectable
3uj6A-3hrdA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN


(Burkholderia
mallei)
PF13458
(Peripla_BP_6)
4 SER A 275
ASP A 339
ASP A  58
ALA A 304
None
1.27A 3uj6A-3i09A:
undetectable
3uj6A-3i09A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9


(Thermus
thermophilus;
Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF12838
(Fer4_7)
4 SER 9  57
ASP 3 123
ASP 3 237
ALA 3 244
None
1.30A 3uj6A-3i9v9:
undetectable
3uj6A-3i9v9:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2)
4 SER B 464
ASP B 235
ASP B 139
ALA B 457
None
1.42A 3uj6A-3jb9B:
undetectable
3uj6A-3jb9B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Thermus
thermophilus)
PF01425
(Amidase)
4 SER E 303
ASP E 198
ASP E 161
ALA E 298
None
1.32A 3uj6A-3kfuE:
undetectable
3uj6A-3kfuE:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 SER A 303
ASP A 242
ASP A 184
ALA A 229
None
1.50A 3uj6A-3lijA:
undetectable
3uj6A-3lijA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN


(Paraburkholderia
xenovorans)
PF13458
(Peripla_BP_6)
4 SER A 275
ASP A 339
ASP A  57
ALA A 304
None
1.32A 3uj6A-3n0wA:
undetectable
3uj6A-3n0wA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1


(Homo sapiens)
PF03493
(BK_channel_a)
4 SER A 728
ASP A 432
ASP A 437
ALA A 730
None
1.15A 3uj6A-3nafA:
5.0
3uj6A-3nafA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o81 BETA-2-MICROGLOBULIN

(Gallus gallus)
PF07654
(C1-set)
4 SER A  55
ASP A  59
ASP A   2
ALA A  28
None
1.33A 3uj6A-3o81A:
undetectable
3uj6A-3o81A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Vibrio cholerae)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 SER A 187
ASP A  87
ASP A  82
ALA A 224
None
1.36A 3uj6A-3p4eA:
undetectable
3uj6A-3p4eA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
4 SER B 258
ASP B 272
ASP B 349
ALA B 354
None
1.42A 3uj6A-3v0aB:
undetectable
3uj6A-3v0aB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
4 SER A 519
ASP A 527
ASP A 507
ALA A 513
None
None
MG  A1768 (-2.5A)
None
1.19A 3uj6A-4a01A:
undetectable
3uj6A-4a01A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euk HISTIDINE KINASE 5
HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1


(Arabidopsis
thaliana;
Arabidopsis
thaliana)
PF00072
(Response_reg)
PF01627
(Hpt)
4 SER B  86
ASP A 828
ASP A 835
ALA A 885
None
MG  A1001 (-2.5A)
None
None
1.21A 3uj6A-4eukB:
undetectable
3uj6A-4eukB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1


(Schizosaccharomyces
pombe)
PF12569
(NARP1)
4 SER A 517
ASP A 499
ASP A 462
ALA A 512
None
1.33A 3uj6A-4kvoA:
undetectable
3uj6A-4kvoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA


(Klebsiella
pneumoniae)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 SER H 227
ASP H 319
ASP H 323
ALA H 356
ADP  H 801 ( 3.7A)
None
None
None
1.32A 3uj6A-4nl4H:
2.2
3uj6A-4nl4H:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
4 SER A  37
ASP A  85
ASP A 110
ALA A 129
SAH  A 302 (-2.5A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.3A)
0.21A 3uj6A-4r6wA:
46.3
3uj6A-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14


(Mus musculus)
PF00069
(Pkinase)
4 SER B  56
ASP B 168
ASP B 112
ALA B  34
None
39G  B 401 (-3.5A)
None
None
1.37A 3uj6A-4tyhB:
undetectable
3uj6A-4tyhB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2)
4 SER A 279
ASP A 151
ASP A 545
ALA A 537
None
1.30A 3uj6A-4xqkA:
undetectable
3uj6A-4xqkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE


(Homo sapiens)
PF05889
(SepSecS)
4 SER A 174
ASP A 283
ASP A 321
ALA A 143
PLR  A1001 (-2.7A)
None
None
PLR  A1001 (-3.0A)
1.32A 3uj6A-4zdlA:
3.4
3uj6A-4zdlA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF00071
(Ras)
PF00620
(RhoGAP)
4 SER A  85
ASP A 249
ASP A  65
ALA A  15
None
None
None
GDP  A 503 ( 4.2A)
1.48A 3uj6A-5c2kA:
undetectable
3uj6A-5c2kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA


(Lactobacillus
plantarum)
PF09861
(DUF2088)
4 SER A 282
ASP A 290
ASP A 321
ALA A 296
None
None
SO4  A 505 ( 4.7A)
None
1.43A 3uj6A-5huqA:
2.1
3uj6A-5huqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Campylobacter
jejuni)
PF13343
(SBP_bac_6)
4 SER A 255
ASP A  90
ASP A  67
ALA A 170
None
None
GPE  A 402 ( 4.5A)
GPE  A 402 (-3.6A)
1.40A 3uj6A-5t1pA:
undetectable
3uj6A-5t1pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Neisseria
gonorrhoeae)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 SER A 184
ASP A  84
ASP A  79
ALA A 222
None
1.39A 3uj6A-5vk4A:
undetectable
3uj6A-5vk4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdy HEAT SHOCK PROTEIN
HTRA


(Mycobacterium
tuberculosis)
no annotation 4 SER A 450
ASP A 491
ASP A 374
ALA A 488
None
1.36A 3uj6A-5xdyA:
undetectable
3uj6A-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium)
no annotation 4 SER A  10
ASP A  51
ASP A  46
ALA A 214
None
1.43A 3uj6A-5z6oA:
2.4
3uj6A-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens)
no annotation 4 SER A 557
ASP A 519
ASP A 498
ALA A 525
None
GOL  A 701 (-4.3A)
None
None
1.21A 3uj6A-5zl9A:
undetectable
3uj6A-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Campylobacter
jejuni)
no annotation 4 SER A 105
ASP A 136
ASP A  24
ALA A  31
None
None
PO4  A 306 (-3.2A)
None
1.41A 3uj6A-6bmaA:
undetectable
3uj6A-6bmaA:
22.67