SIMILAR PATTERNS OF AMINO ACIDS FOR 3UG2_A_IREA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
LYS A 608
LEU A 652
MET A 657
GLY A 660
LEU A 731
 None
 0.84A 3ug2A-1lufA:
24.8		 3ug2A-1lufA:
31.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 337
GLY A 340
ASP A 344
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
 0.81A 3ug2A-1opkA:
31.8		 3ug2A-1opkA:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 377
ALA A 389
LYS A 391
LEU A 433
MET A 438
GLY A 441
ASP A 445
LEU A 489
 None
 0.72A 3ug2A-1snxA:
24.1		 3ug2A-1snxA:
32.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  98
ALA A 111
LYS A 113
LEU A 157
MET A 162
GLY A 165
LEU A 212
 None
 0.94A 3ug2A-2ac5A:
19.2		 3ug2A-2ac5A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LYS A  49
LEU A  96
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.60A 3ug2A-2bujA:
24.5		 3ug2A-2bujA:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
VAL X  25
ALA X  37
LYS X  39
MET X  85
GLY X  88
ASP X  92
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
None
STU  X 902 (-4.4A)
 0.71A 3ug2A-2dq7X:
33.1		 3ug2A-2dq7X:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.69A 3ug2A-2h8hA:
29.2		 3ug2A-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.71A 3ug2A-2h8hA:
29.2		 3ug2A-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.82A 3ug2A-2hckA:
27.9		 3ug2A-2hckA:
25.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 319
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.76A 3ug2A-2hk5A:
27.5		 3ug2A-2hk5A:
33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
VAL A  63
ALA A  76
LYS A  78
LEU A 122
GLY A 130
LEU A 177
 None
 0.75A 3ug2A-2hw6A:
19.9		 3ug2A-2hw6A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
LYS A 271
MET A 318
GLY A 321
ASP A 325
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
None
None
GIN  A 600 (-4.7A)
 0.83A 3ug2A-2hz0A:
30.3		 3ug2A-2hz0A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 501
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.89A 3ug2A-2j0jA:
31.8		 3ug2A-2j0jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  29
VAL A  37
ALA A  50
LYS A  52
LEU A  96
MET A  98
LEU A 100
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
None
EDO  A1304 (-4.6A)
J60  A1305 (-4.4A)
 0.67A 3ug2A-2jamA:
16.6		 3ug2A-2jamA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLY A 322
ASP A 326
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
 0.77A 3ug2A-2og8A:
29.4		 3ug2A-2og8A:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
ASP A 326
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
 0.66A 3ug2A-2og8A:
29.4		 3ug2A-2og8A:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		10 LEU A  25
VAL A  33
ALA A  46
LYS A  48
LEU A 101
LEU A 105
MET A 106
GLY A 109
ASP A 113
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
None
ATP  A 381 ( 4.8A)
 0.86A 3ug2A-2phkA:
23.8		 3ug2A-2phkA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
LEU A 263
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.87A 3ug2A-2qluA:
26.0		 3ug2A-2qluA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 724
VAL A 732
ALA A 749
LYS A 751
LEU A 794
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.74A 3ug2A-2r4bA:
35.6		 3ug2A-2r4bA:
73.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
VAL A  60
ALA A  73
LYS A  75
LEU A 116
LEU A 120
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
None
DKI  A1338 (-4.2A)
DKI  A1338 (-4.9A)
 0.88A 3ug2A-2w4oA:
19.7		 3ug2A-2w4oA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 226
VAL A 234
ALA A 247
LEU A 303
MET A 304
GLY A 307
ASP A 311
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.75A 3ug2A-2xk9A:
20.9		 3ug2A-2xk9A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 303
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.94A 3ug2A-2xk9A:
20.9		 3ug2A-2xk9A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  38
ALA A  51
LYS A  53
LEU A 105
LEU A 109
MET A 110
GLY A 113
ASP A 117
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.60A 3ug2A-2y7jA:
25.0		 3ug2A-2y7jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.87A 3ug2A-2z7rA:
21.4		 3ug2A-2z7rA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
MET A1076
LEU A1078
MET A1079
GLY A1082
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
S91  A   1 (-4.7A)
None
S91  A   1 (-3.3A)
 0.65A 3ug2A-2z8cA:
31.3		 3ug2A-2z8cA:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  91
LEU A  95
ASP A 103
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
4RB  A 401 (-4.4A)
None
 0.70A 3ug2A-3bqrA:
21.7		 3ug2A-3bqrA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  31
ALA A  44
LYS A  46
LEU A  90
MET A  92
LEU A  94
ASP A 102
 ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
None
 0.81A 3ug2A-3dakA:
20.8		 3ug2A-3dakA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  40
ALA A  53
LYS A  55
LEU A 106
MET A 108
LEU A 110
MET A 111
 35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
35F  A   1 ( 3.9A)
35F  A   1 (-4.5A)
None
 0.57A 3ug2A-3e7oA:
19.7		 3ug2A-3e7oA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
None
985  A   1 (-4.8A)
 0.95A 3ug2A-3f2aA:
18.3		 3ug2A-3f2aA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
VAL A  67
ALA A  80
LYS A  82
LEU A 131
MET A 132
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
STU  A   1 (-4.6A)
None
STU  A   1 (-4.4A)
 0.69A 3ug2A-3fmeA:
15.7		 3ug2A-3fmeA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
VAL A  67
ALA A  80
LYS A  82
MET A 132
ASP A 137
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
STU  A   1 (-3.5A)
STU  A   1 (-4.4A)
 0.91A 3ug2A-3fmeA:
15.7		 3ug2A-3fmeA:
28.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
VAL A 439
ALA A 455
MET A 502
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.74A 3ug2A-3fzpA:
31.9		 3ug2A-3fzpA:
35.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 217
ALA A 228
LYS A 230
LEU A 277
MET A 279
GLY A 285
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
None
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.87A 3ug2A-3g2fA:
21.3		 3ug2A-3g2fA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 LEU A 226
VAL A 234
ALA A 247
LEU A 303
MET A 304
GLY A 307
LEU A 354
 None
 0.71A 3ug2A-3i6uA:
19.9		 3ug2A-3i6uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
LEU A 127
GLY A 135
ASP A 139
LEU A 182
 None
 0.82A 3ug2A-3iecA:
24.6		 3ug2A-3iecA:
26.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
VAL A 704
LYS A 723
LEU A 766
GLY A 774
ASP A 778
LEU A 822
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.9A)
None
ANP  A   1 (-4.7A)
 0.67A 3ug2A-3kexA:
31.7		 3ug2A-3kexA:
53.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
 0.86A 3ug2A-3lm5A:
24.1		 3ug2A-3lm5A:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1005
VAL A1013
ALA A1031
LYS A1033
LEU A1081
MET A1082
GLY A1085
 None
None
None
CCX  A   1 ( 3.7A)
None
None
None
 0.73A 3ug2A-3lw0A:
28.2		 3ug2A-3lw0A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1005
VAL A1013
ALA A1031
MET A1079
LEU A1081
MET A1082
GLY A1085
 None
None
None
CCX  A   1 ( 3.9A)
None
None
None
 0.52A 3ug2A-3lw0A:
28.2		 3ug2A-3lw0A:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 261
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.74A 3ug2A-3nyoA:
22.9		 3ug2A-3nyoA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 796
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.68A 3ug2A-3pp0A:
38.3		 3ug2A-3pp0A:
77.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 734
ALA A 751
LYS A 753
LEU A 796
LEU A 800
MET A 801
GLY A 804
ASP A 808
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 0.76A 3ug2A-3pp0A:
38.3		 3ug2A-3pp0A:
77.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
VAL A 303
ALA A 315
LEU A 361
MET A 366
GLY A 369
LEU A 423
 None
 0.68A 3ug2A-3ulzA:
24.0		 3ug2A-3ulzA:
26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
VAL A 552
ALA A 570
LYS A 572
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.70A 3ug2A-3v5qA:
30.7		 3ug2A-3v5qA:
30.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
ALA A  80
LYS A  82
MET A 129
LEU A 131
MET A 132
LEU A 186
 None
ANK  A 401 (-3.0A)
ANK  A 401 (-2.4A)
ANK  A 401 (-3.7A)
None
None
ANK  A 401 ( 4.9A)
 0.85A 3ug2A-3vn9A:
21.0		 3ug2A-3vn9A:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
VAL A  67
ALA A  80
LYS A  82
LEU A 131
MET A 132
LEU A 186
 None
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-2.4A)
None
None
ANK  A 401 ( 4.9A)
 0.78A 3ug2A-3vn9A:
21.0		 3ug2A-3vn9A:
26.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2028
MET A2029
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.54A 3ug2A-3zbfA:
27.3		 3ug2A-3zbfA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
VAL A  91
ALA A 104
LYS A 106
LEU A 152
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.74A 3ug2A-4af3A:
19.2		 3ug2A-4af3A:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
VAL A 568
ALA A 586
LYS A 588
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.66A 3ug2A-4at3A:
30.7		 3ug2A-4at3A:
31.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
LEU A 152
MET A 154
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
 0.75A 3ug2A-4aw2A:
21.4		 3ug2A-4aw2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
MET A  86
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.5A)
BX7  A 401 (-3.5A)
 0.75A 3ug2A-4eutA:
15.0		 3ug2A-4eutA:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
ALA A 541
LYS A 543
MET A 591
GLY A 594
LEU A 656
 None
 0.58A 3ug2A-4f0iA:
23.3		 3ug2A-4f0iA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
ALA A 400
LEU A 446
MET A 448
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.65A 3ug2A-4f4pA:
34.3		 3ug2A-4f4pA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
ALA A 400
LYS A 402
LEU A 446
MET A 448
GLY A 454
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
 0.68A 3ug2A-4f4pA:
34.3		 3ug2A-4f4pA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.49A 3ug2A-4fodA:
31.1		 3ug2A-4fodA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 855
VAL A 863
ALA A 880
LYS A 882
LEU A 927
MET A 929
GLY A 935
ASP A 939
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-4.4A)
IZA  A2001 (-3.3A)
None
IZA  A2001 ( 4.7A)
 0.89A 3ug2A-4gl9A:
27.7		 3ug2A-4gl9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
ALA A 853
LYS A 855
LEU A 900
MET A 902
GLY A 908
ASP A 912
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-3.6A)
19S  A1201 ( 3.8A)
None
19S  A1201 (-4.5A)
 0.90A 3ug2A-4hviA:
33.6		 3ug2A-4hviA:
34.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
VAL A 836
ALA A 853
LYS A 855
LEU A 900
GLY A 908
ASP A 912
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
None
19S  A1201 (-4.5A)
 0.90A 3ug2A-4hviA:
33.6		 3ug2A-4hviA:
34.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
VAL A 140
ALA A 156
LYS A 158
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 None
 0.64A 3ug2A-4hzsA:
23.3		 3ug2A-4hzsA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
VAL A 140
ALA A 156
LYS A 158
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.77A 3ug2A-4id7A:
31.1		 3ug2A-4id7A:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
VAL A 414
ALA A 427
LYS A 429
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.96A 3ug2A-4idtA:
23.8		 3ug2A-4idtA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  87
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.75A 3ug2A-4jxfA:
17.9		 3ug2A-4jxfA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
ASP A 348
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
 0.83A 3ug2A-4k11A:
28.8		 3ug2A-4k11A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  36
ALA A  49
LYS A  51
LEU A  93
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
None
ANP  A 401 (-4.8A)
 0.66A 3ug2A-4m69A:
23.6		 3ug2A-4m69A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  78
VAL A  86
ALA A  99
LEU A 144
MET A 146
LEU A 148
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
 0.87A 3ug2A-4mvfA:
20.4		 3ug2A-4mvfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
VAL A  86
ALA A  99
LYS A 101
LEU A 144
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 1.06A 3ug2A-4mvfA:
20.4		 3ug2A-4mvfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
VAL A  54
ALA A  67
LYS A  69
LEU A 121
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.88A 3ug2A-4o38A:
20.2		 3ug2A-4o38A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 928
LYS A 930
LEU A 976
MET A 978
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 ( 3.9A)
None
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.91A 3ug2A-4oliA:
31.5		 3ug2A-4oliA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.96A 3ug2A-4rt7A:
25.6		 3ug2A-4rt7A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.63A 3ug2A-4ueuA:
31.9		 3ug2A-4ueuA:
35.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 262
MET A 264
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.76A 3ug2A-4wboA:
24.7		 3ug2A-4wboA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
VAL B 275
ALA B 288
LYS B 290
MET B 337
GLY B 340
ASP B 344
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
 0.61A 3ug2A-4xeyB:
28.5		 3ug2A-4xeyB:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.85A 3ug2A-4xufA:
23.1		 3ug2A-4xufA:
32.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 262
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.87A 3ug2A-4yhjA:
22.6		 3ug2A-4yhjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  38
ALA A  51
LYS A  53
LEU A 104
MET A 106
LEU A 108
MET A 109
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
ANP  A 401 ( 4.8A)
None
 0.53A 3ug2A-5awmA:
19.6		 3ug2A-5awmA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  44
LEU A  90
MET A  92
GLY A  98
ASP A 102
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.79A 3ug2A-5ci7A:
21.7		 3ug2A-5ci7A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  39
ALA A  52
LYS A  54
LEU A 103
MET A 105
GLY A 111
LEU A 160
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A 103 ( 0.6A)
MET  A 105 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.90A 3ug2A-5d7aA:
16.0		 3ug2A-5d7aA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.81A 3ug2A-5eykA:
25.1		 3ug2A-5eykA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 928
LYS A 930
LEU A 976
MET A 978
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.85A 3ug2A-5f1zA:
26.8		 3ug2A-5f1zA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.91A 3ug2A-5f1zA:
26.8		 3ug2A-5f1zA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
VAL A  28
ALA A  41
LYS A  43
LEU A  88
LEU A  92
GLY A  96
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
 0.89A 3ug2A-5hu3A:
24.8		 3ug2A-5hu3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
LYS A  43
LEU A  88
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.87A 3ug2A-5hu3A:
24.8		 3ug2A-5hu3A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 718
VAL A 726
ALA A 743
LYS A 745
LEU A 788
LEU A 792
MET A 793
GLY A 796
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.50A 3ug2A-5j9zA:
42.9		 3ug2A-5j9zA:
97.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 790
LEU A 792
ASP A 800
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.70A 3ug2A-5j9zA:
42.9		 3ug2A-5j9zA:
97.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 404
ALA A 417
LEU A 463
MET A 465
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.62A 3ug2A-5jznA:
23.7		 3ug2A-5jznA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
LYS A 299
MET A 344
GLY A 350
ASP A 354
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.78A 3ug2A-5kbrA:
20.0		 3ug2A-5kbrA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
ALA A 909
LYS A 911
LEU A 954
MET A 959
GLY A 962
LEU A1016
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.63A 3ug2A-5lpyA:
25.2		 3ug2A-5lpyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A 909
LYS A 911
LEU A 954
MET A 959
GLY A 962
ASP A 966
LEU A1016
 ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.2A)
ADP  A1200 (-4.7A)
 0.82A 3ug2A-5lpzA:
25.2		 3ug2A-5lpzA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
ALA A 909
LYS A 911
LEU A 954
MET A 959
GLY A 962
LEU A1016
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.60A 3ug2A-5lpzA:
25.2		 3ug2A-5lpzA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 7 VAL A  81
ALA A 103
LYS A 105
LEU A 148
MET A 153
GLY A 156
LEU A 209
 None
 0.66A 3ug2A-5tosA:
21.1		 3ug2A-5tosA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
7LK  A 401 (-3.0A)
7LK  A 401 (-4.8A)
 0.88A 3ug2A-5turA:
23.2		 3ug2A-5turA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 7 VAL A  36
ALA A  49
LEU A  94
MET A  96
MET A  99
GLY A 102
LEU A 150
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
None
VX6  A 402 (-3.7A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
 0.64A 3ug2A-5wnmA:
27.6		 3ug2A-5wnmA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
LYS A 908
LEU A 954
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.91A 3ug2A-6c7yA:
27.9		 3ug2A-6c7yA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 VAL A 142
ALA A 155
LYS A 157
LEU A 228
LEU A 232
GLY A 236
LEU A 282
 H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
None
H1N  A 501 (-4.3A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
 0.57A 3ug2A-6ccfA:
23.4		 3ug2A-6ccfA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 7 LEU A 275
VAL A 283
ALA A 296
LYS A 298
LEU A 341
MET A 346
GLY A 349
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
None
FE7  A 601 (-4.7A)
FE7  A 601 ( 3.7A)
 0.69A 3ug2A-6cthA:
12.8		 3ug2A-6cthA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
VAL A 205
ALA A 217
LYS A 219
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.91A 3ug2A-6cz4A:
28.4		 3ug2A-6cz4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 ALA A 211
LYS A 213
LEU A 260
MET A 265
GLY A 268
ASP A 272
LEU A 318
 CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-3.3A)
CJT  A 502 (-4.7A)
 0.60A 3ug2A-6f3dA:
24.2		 3ug2A-6f3dA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 VAL A 200
ALA A 211
LYS A 213
LEU A 260
MET A 265
GLY A 268
LEU A 318
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
 0.39A 3ug2A-6f3dA:
24.2		 3ug2A-6f3dA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.49A 3ug2A-6fdyU:
23.3		 3ug2A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
MET U  91
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
 0.62A 3ug2A-6fdyU:
23.3		 3ug2A-6fdyU:
undetectable