SIMILAR PATTERNS OF AMINO ACIDS FOR 3UFR_A_H4BA760

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 VAL A 667
TRP A 673
PHE A 681
GLU A 649
 None
 1.25A 3ufrA-1c4kA:
0.0
3ufrB-1c4kA:
0.0		 3ufrA-1c4kA:
19.07
3ufrB-1c4kA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyo CYTOCHROME B5

(Bos taurus) 		PF00173
(Cyt-b5) 		4 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
None
HEM  A 201 (-4.8A)
None
 1.26A 3ufrA-1cyoA:
0.0
3ufrB-1cyoA:
0.0		 3ufrA-1cyoA:
12.05
3ufrB-1cyoA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 VAL A  41
TRP A 521
PHE A 501
GLU A 519
 None
 1.22A 3ufrA-1flgA:
0.0
3ufrB-1flgA:
0.0		 3ufrA-1flgA:
19.67
3ufrB-1flgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ARG A 236
VAL A 150
TRP A 151
GLU A  86
 None
 1.47A 3ufrA-1idjA:
0.0
3ufrB-1idjA:
0.0		 3ufrA-1idjA:
21.60
3ufrB-1idjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
 None
 1.13A 3ufrA-1kh2A:
0.0
3ufrB-1kh2A:
0.6		 3ufrA-1kh2A:
22.65
3ufrB-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 VAL A 530
TRP A 558
PHE A 568
GLU A 566
 None
 1.50A 3ufrA-1knbA:
undetectable
3ufrB-1knbA:
0.0		 3ufrA-1knbA:
18.93
3ufrB-1knbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
 None
 1.48A 3ufrA-1l5jA:
0.0
3ufrB-1l5jA:
0.0		 3ufrA-1l5jA:
19.28
3ufrB-1l5jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m59 CYTOCHROME B5

(Bos taurus) 		PF00173
(Cyt-b5) 		4 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
None
HEM  A 201 (-4.7A)
None
 1.42A 3ufrA-1m59A:
0.0
3ufrB-1m59A:
undetectable		 3ufrA-1m59A:
10.60
3ufrB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN

(Pseudomonas
aeruginosa) 		PF01475
(FUR) 		4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
 None
 1.06A 3ufrA-1mzbA:
0.3
3ufrB-1mzbA:
0.4		 3ufrA-1mzbA:
16.59
3ufrB-1mzbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		4 VAL A 468
TRP A 714
PHE A 710
GLU A 538
 None
 1.49A 3ufrA-1u2lA:
undetectable
3ufrB-1u2lA:
1.8		 3ufrA-1u2lA:
21.10
3ufrB-1u2lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
 None
 1.43A 3ufrA-1vmkA:
undetectable
3ufrB-1vmkA:
undetectable		 3ufrA-1vmkA:
21.48
3ufrB-1vmkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
 None
 1.42A 3ufrA-1wqlB:
undetectable
3ufrB-1wqlB:
undetectable		 3ufrA-1wqlB:
19.79
3ufrB-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 ARG A 722
VAL A 685
PHE A 648
GLU A 646
 None
 1.39A 3ufrA-1xdvA:
undetectable
3ufrB-1xdvA:
undetectable		 3ufrA-1xdvA:
18.78
3ufrB-1xdvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
 None
 1.16A 3ufrA-2b39A:
undetectable
3ufrB-2b39A:
undetectable		 3ufrA-2b39A:
13.58
3ufrB-2b39A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.38A 3ufrA-2e9fA:
undetectable
3ufrB-2e9fA:
undetectable		 3ufrA-2e9fA:
20.24
3ufrB-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 ARG A  62
VAL A 367
TRP B 788
GLU A 360
 None
 1.48A 3ufrA-2fjaA:
undetectable
3ufrB-2fjaA:
0.6		 3ufrA-2fjaA:
22.29
3ufrB-2fjaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
 GUN  A 503 (-3.7A)
None
None
None
 1.45A 3ufrA-2i9uA:
undetectable
3ufrB-2i9uA:
undetectable		 3ufrA-2i9uA:
20.97
3ufrB-2i9uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		4 ARG A 174
VAL A  27
PHE A 172
GLU A 215
 None
None
None
NHE  A   1 (-2.7A)
 1.33A 3ufrA-2ichA:
undetectable
3ufrB-2ichA:
undetectable		 3ufrA-2ichA:
20.99
3ufrB-2ichA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 ARG A 293
VAL A 310
PHE A 176
GLU A 182
 None
 1.36A 3ufrA-2pbzA:
undetectable
3ufrB-2pbzA:
undetectable		 3ufrA-2pbzA:
22.25
3ufrB-2pbzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ARG A 255
VAL A 100
PHE A 250
GLU A 248
 None
 1.47A 3ufrA-2r9vA:
undetectable
3ufrB-2r9vA:
undetectable		 3ufrA-2r9vA:
20.48
3ufrB-2r9vA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rik TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		4 VAL A 127
TRP A 129
PHE A  97
GLU A 116
 None
 1.24A 3ufrA-2rikA:
undetectable
3ufrB-2rikA:
undetectable		 3ufrA-2rikA:
22.52
3ufrB-2rikA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.34A 3ufrA-2w4oA:
undetectable
3ufrB-2w4oA:
undetectable		 3ufrA-2w4oA:
20.26
3ufrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 ARG A 159
VAL A 164
PHE A  98
GLU A 108
 None
 1.44A 3ufrA-2xhyA:
undetectable
3ufrB-2xhyA:
undetectable		 3ufrA-2xhyA:
20.63
3ufrB-2xhyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ARG A 697
VAL A 717
PHE A 698
GLU A 722
 None
 1.42A 3ufrA-2xvgA:
undetectable
3ufrB-2xvgA:
0.3		 3ufrA-2xvgA:
19.68
3ufrB-2xvgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
 None
 1.04A 3ufrA-2ywbA:
undetectable
3ufrB-2ywbA:
0.0		 3ufrA-2ywbA:
21.54
3ufrB-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF13302
(Acetyltransf_3) 		4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
 None
 1.40A 3ufrA-2z11A:
undetectable
3ufrB-2z11A:
undetectable		 3ufrA-2z11A:
17.58
3ufrB-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b43 TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		4 VAL A 129
TRP A 131
PHE A 100
GLU A 118
 None
 1.40A 3ufrA-3b43A:
undetectable
3ufrB-3b43A:
undetectable		 3ufrA-3b43A:
21.12
3ufrB-3b43A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
 None
None
None
EDO  A 404 ( 3.8A)
 1.46A 3ufrA-3b7fA:
undetectable
3ufrB-3b7fA:
undetectable		 3ufrA-3b7fA:
20.87
3ufrB-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		4 VAL A  16
TRP A  70
PHE A  88
GLU A  71
 None
 1.46A 3ufrA-3ddlA:
undetectable
3ufrB-3ddlA:
undetectable		 3ufrA-3ddlA:
20.14
3ufrB-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 ARG A  66
VAL A 387
TRP B  88
GLU A 380
 None
 1.43A 3ufrA-3gyxA:
undetectable
3ufrB-3gyxA:
0.0		 3ufrA-3gyxA:
20.98
3ufrB-3gyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnm PUTATIVE CHITOBIASE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C) 		4 ARG A 137
VAL A  68
TRP A 111
GLU A 109
 None
 1.34A 3ufrA-3hnmA:
undetectable
3ufrB-3hnmA:
undetectable		 3ufrA-3hnmA:
16.96
3ufrB-3hnmA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE

(Deinococcus
radiodurans) 		PF01028
(Topoisom_I) 		4 ARG A 286
VAL A 266
PHE A 295
GLU A 260
 None
 1.42A 3ufrA-3m4aA:
undetectable
3ufrB-3m4aA:
undetectable		 3ufrA-3m4aA:
21.54
3ufrB-3m4aA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
 None
 1.44A 3ufrA-3ma6A:
undetectable
3ufrB-3ma6A:
undetectable		 3ufrA-3ma6A:
21.55
3ufrB-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 ARG A 944
TRP A1001
PHE A 946
GLU A 908
 None
 1.42A 3ufrA-3n3kA:
undetectable
3ufrB-3n3kA:
undetectable		 3ufrA-3n3kA:
19.83
3ufrB-3n3kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens) 		PF00173
(Cyt-b5) 		4 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
HEM  A 201 (-4.5A)
HEM  A 201 (-4.7A)
None
 1.47A 3ufrA-3nerA:
undetectable
3ufrB-3nerA:
undetectable		 3ufrA-3nerA:
14.93
3ufrB-3nerA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A  76
VAL A 104
PHE A  77
GLU A  73
 None
 1.46A 3ufrA-3nx4A:
undetectable
3ufrB-3nx4A:
undetectable		 3ufrA-3nx4A:
21.77
3ufrB-3nx4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
 None
 1.25A 3ufrA-3owcA:
undetectable
3ufrB-3owcA:
1.1		 3ufrA-3owcA:
16.47
3ufrB-3owcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		4 VAL A2274
TRP A2314
PHE A2329
GLU A2310
 None
 1.26A 3ufrA-3sbgA:
undetectable
3ufrB-3sbgA:
undetectable		 3ufrA-3sbgA:
21.60
3ufrB-3sbgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 240
TRP A 239
PHE A 305
GLU A 265
 None
 1.33A 3ufrA-3ti8A:
undetectable
3ufrB-3ti8A:
undetectable		 3ufrA-3ti8A:
22.64
3ufrB-3ti8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa) 		PF02223
(Thymidylate_kin) 		4 ARG A 109
VAL A 166
PHE A 162
GLU A 156
 None
None
None
MG  A 213 (-3.2A)
 1.48A 3ufrA-3uxmA:
undetectable
3ufrB-3uxmA:
undetectable		 3ufrA-3uxmA:
20.29
3ufrB-3uxmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 ARG A 149
VAL A 257
PHE A 223
GLU A 246
 None
 1.37A 3ufrA-4a6uA:
undetectable
3ufrB-4a6uA:
undetectable		 3ufrA-4a6uA:
21.59
3ufrB-4a6uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
 None
 1.29A 3ufrA-4bgdC:
undetectable
3ufrB-4bgdC:
undetectable		 3ufrA-4bgdC:
20.99
3ufrB-4bgdC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ARG A 630
VAL A 622
TRP A 433
GLU A 424
 None
 1.47A 3ufrA-4byfA:
undetectable
3ufrB-4byfA:
undetectable		 3ufrA-4byfA:
20.28
3ufrB-4byfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 ARG A1065
VAL A1046
PHE A1118
GLU A1032
 None
 1.26A 3ufrA-4d8oA:
undetectable
3ufrB-4d8oA:
undetectable		 3ufrA-4d8oA:
19.44
3ufrB-4d8oA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ARG A 373
VAL A 412
TRP A 383
PHE A 370
 None
 1.41A 3ufrA-4fnqA:
undetectable
3ufrB-4fnqA:
undetectable		 3ufrA-4fnqA:
20.73
3ufrB-4fnqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
 None
 0.98A 3ufrA-4l37B:
undetectable
3ufrB-4l37B:
undetectable		 3ufrA-4l37B:
20.69
3ufrB-4l37B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Cupriavidus
necator) 		PF03480
(DctP) 		4 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.33A 3ufrA-4p8bA:
undetectable
3ufrB-4p8bA:
undetectable		 3ufrA-4p8bA:
20.81
3ufrB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ARG A   9
TRP A 428
PHE A 431
GLU A 429
 None
 1.49A 3ufrA-4qbuA:
undetectable
3ufrB-4qbuA:
0.4		 3ufrA-4qbuA:
22.58
3ufrB-4qbuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
 None
 1.39A 3ufrA-4xj6A:
undetectable
3ufrB-4xj6A:
1.7		 3ufrA-4xj6A:
21.06
3ufrB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
 None
 1.08A 3ufrA-4xj6A:
undetectable
3ufrB-4xj6A:
1.7		 3ufrA-4xj6A:
21.06
3ufrB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 VAL A 288
TRP A 292
PHE A 277
GLU A 279
 None
 1.45A 3ufrA-4ylrA:
undetectable
3ufrB-4ylrA:
undetectable		 3ufrA-4ylrA:
22.81
3ufrB-4ylrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs1 CRRBCX-IIA

(Chlamydomonas
reinhardtii) 		PF02341
(RcbX) 		4 ARG A 123
VAL A 108
TRP A 104
GLU A 103
 ARG  A 123 ( 0.6A)
VAL  A 108 ( 0.6A)
TRP  A 104 ( 0.5A)
GLU  A 103 ( 0.6A)
 1.32A 3ufrA-5bs1A:
undetectable
3ufrB-5bs1A:
undetectable		 3ufrA-5bs1A:
14.45
3ufrB-5bs1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 VAL B  28
TRP A 401
PHE A 397
GLU A 402
 None
 1.45A 3ufrA-5c6gB:
undetectable
3ufrB-5c6gB:
undetectable		 3ufrA-5c6gB:
18.69
3ufrB-5c6gB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 VAL A 481
TRP A 736
PHE A 732
GLU A 560
 None
 1.47A 3ufrA-5kqiA:
undetectable
3ufrB-5kqiA:
undetectable		 3ufrA-5kqiA:
20.85
3ufrB-5kqiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 3ufrA-5m8tA:
undetectable
3ufrB-5m8tA:
undetectable		 3ufrA-5m8tA:
20.00
3ufrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A  53
VAL A 120
PHE A  79
GLU A 125
 None
 1.35A 3ufrA-6eonA:
undetectable
3ufrB-6eonA:
undetectable		 3ufrA-6eonA:
19.01
3ufrB-6eonA:
19.01