SIMILAR PATTERNS OF AMINO ACIDS FOR 3UFG_B_LEUB289_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 PHE A 331
SER A 349
SER A 350
 None
 0.95A 3ufgB-1dmwA:
0.0		 3ufgB-1dmwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dzt DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Salmonella
enterica) 		PF00908
(dTDP_sugar_isom) 		3 PHE A 122
SER A  52
SER A  54
 None
 0.99A 3ufgB-1dztA:
0.2		 3ufgB-1dztA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		3 PHE A 122
SER A  53
SER A  55
 None
 1.00A 3ufgB-1epzA:
0.5		 3ufgB-1epzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eww ANTIFREEZE PROTEIN

(Choristoneura
fumiferana) 		PF05264
(CfAFP) 		3 PHE A  42
SER A  50
SER A  52
 None
 0.73A 3ufgB-1ewwA:
0.0		 3ufgB-1ewwA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 PHE A  35
SER A  75
SER A  77
 None
 0.97A 3ufgB-1fy1A:
0.0		 3ufgB-1fy1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 PHE A 461
SER A 456
SER A 181
 None
None
ADP  A1100 ( 4.4A)
 0.90A 3ufgB-1g8xA:
0.0		 3ufgB-1g8xA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 PHE A 804
SER A 788
SER A 791
 None
 0.70A 3ufgB-1g8xA:
0.0		 3ufgB-1g8xA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 PHE A 314
SER A 284
SER A 300
 None
 0.92A 3ufgB-1hplA:
0.0		 3ufgB-1hplA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 3 PHE A 118
SER A 158
SER A 155
 None
 0.96A 3ufgB-1hz4A:
1.7		 3ufgB-1hz4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus) 		no annotation 3 PHE A 242
SER A 265
SER A 267
 None
 0.95A 3ufgB-1io0A:
0.0		 3ufgB-1io0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PHE A 472
SER A 467
SER A 192
 None
None
ADP  A1203 ( 4.7A)
 0.84A 3ufgB-1jx2A:
undetectable		 3ufgB-1jx2A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		3 PHE A 213
SER A  29
SER A  31
 NAD  A1201 (-3.4A)
None
None
 0.86A 3ufgB-1kaeA:
undetectable		 3ufgB-1kaeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A  73
SER A 203
SER A 242
 None
 1.00A 3ufgB-1kcwA:
undetectable		 3ufgB-1kcwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m76 3-HYDROXYACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 PHE A 298
SER A 278
SER A 280
 None
 0.91A 3ufgB-1m76A:
undetectable		 3ufgB-1m76A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		3 PHE A 257
SER A 282
SER A 252
 None
 1.01A 3ufgB-1pe9A:
undetectable		 3ufgB-1pe9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 PHE 1 119
SER 1 258
SER 1 126
 None
 0.92A 3ufgB-1poy1:
undetectable		 3ufgB-1poy1:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A  21
SER A  97
SER A  96
 None
 0.87A 3ufgB-1qorA:
undetectable		 3ufgB-1qorA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ti8 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 PHE A  82
SER A 265
SER A 115
 None
 0.96A 3ufgB-1ti8A:
undetectable		 3ufgB-1ti8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 PHE A 168
SER A 223
SER A 238
 None
 1.01A 3ufgB-1u6rA:
undetectable		 3ufgB-1u6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE A
CHAIN

(Bacillus
smithii) 		PF02979
(NHase_alpha) 		3 PHE A 179
SER A 174
SER A 175
 None
 0.97A 3ufgB-1v29A:
undetectable		 3ufgB-1v29A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		3 PHE A 122
SER A  52
SER A  54
 None
 1.02A 3ufgB-1wa4A:
undetectable		 3ufgB-1wa4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 PHE A 263
SER A 287
SER A 283
 None
 0.88A 3ufgB-1wr6A:
undetectable		 3ufgB-1wr6A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535

(Pseudomonas
aeruginosa) 		PF08682
(DUF1780) 		3 PHE A  67
SER A 171
SER A 173
 None
 0.86A 3ufgB-1y0kA:
undetectable		 3ufgB-1y0kA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 PHE G 263
SER G 287
SER G 283
 None
 0.85A 3ufgB-1yd8G:
undetectable		 3ufgB-1yd8G:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3s MYOCYTE NUCLEAR
FACTOR

(Mus musculus) 		PF00250
(Forkhead) 		3 PHE A  92
SER A  17
SER A  18
 None
 0.99A 3ufgB-2a3sA:
undetectable		 3ufgB-2a3sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb1 ENDORIBONUCLEASE
DICER

(Homo sapiens) 		PF00636
(Ribonuclease_3) 		3 PHE A 100
SER A  33
SER A 104
 None
 0.93A 3ufgB-2eb1A:
undetectable		 3ufgB-2eb1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		3 PHE B 113
SER A 865
SER A 862
 None
 1.02A 3ufgB-2ivfB:
undetectable		 3ufgB-2ivfB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Elizabethkingia
meningoseptica) 		PF01408
(GFO_IDH_MocA) 		3 PHE A 323
SER A 348
SER A 347
 None
 1.01A 3ufgB-2ixbA:
undetectable		 3ufgB-2ixbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Streptococcus
suis) 		PF00908
(dTDP_sugar_isom) 		3 PHE A 129
SER A  65
SER A  67
 None
TRH  A1198 ( 4.9A)
None
 0.98A 3ufgB-2ixlA:
undetectable		 3ufgB-2ixlA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1h TRANSCRIPTION
ELONGATION FACTOR
S-II

(Trypanosoma
brucei) 		PF00855
(PWWP) 		3 PHE A   7
SER A  69
SER A  67
 None
 0.93A 3ufgB-2m1hA:
undetectable		 3ufgB-2m1hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 PHE A 454
SER A 535
SER A 532
 None
 0.79A 3ufgB-2qr4A:
undetectable		 3ufgB-2qr4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		3 PHE A 142
SER A 130
SER A 126
 None
 1.02A 3ufgB-2rccA:
undetectable		 3ufgB-2rccA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		3 PHE A 377
SER A 395
SER A 396
 None
 0.96A 3ufgB-2tohA:
undetectable		 3ufgB-2tohA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 PHE A 684
SER A 827
SER A 824
 None
 0.97A 3ufgB-2vdaA:
undetectable		 3ufgB-2vdaA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 PHE A 392
SER A 111
SER A  81
 None
 0.98A 3ufgB-2wrdA:
undetectable		 3ufgB-2wrdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 PHE A 490
SER A 123
SER A 119
 3ES  A1611 (-4.7A)
None
None
 0.94A 3ufgB-2xydA:
undetectable		 3ufgB-2xydA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		3 PHE A 157
SER A 139
SER A 136
 None
 0.91A 3ufgB-2ybqA:
undetectable		 3ufgB-2ybqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		3 PHE A 268
SER A 136
SER A 134
 None
 0.99A 3ufgB-2ylnA:
undetectable		 3ufgB-2ylnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		3 PHE A  34
SER A 201
SER A  60
 None
 0.88A 3ufgB-2z02A:
undetectable		 3ufgB-2z02A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		3 PHE A 293
SER A 160
SER A 148
 None
 1.01A 3ufgB-3clkA:
undetectable		 3ufgB-3clkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 PHE A 180
SER A 203
SER A 201
 ONL  A 800 (-4.0A)
ONL  A 800 ( 4.6A)
ONL  A 800 ( 4.2A)
 0.95A 3ufgB-3dlaA:
undetectable		 3ufgB-3dlaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		3 PHE A 203
SER A 158
SER A 159
 None
 1.02A 3ufgB-3ei8A:
undetectable		 3ufgB-3ei8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 PHE A 263
SER A 183
SER A 211
 None
 0.97A 3ufgB-3fxiA:
undetectable		 3ufgB-3fxiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		3 PHE A  28
SER A 198
SER A  54
 None
 0.82A 3ufgB-3kreA:
undetectable		 3ufgB-3kreA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Legionella
pneumophila) 		no annotation 3 PHE A 109
SER A 120
SER A 117
 None
 0.97A 3ufgB-3ltoA:
undetectable		 3ufgB-3ltoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 PHE A  82
SER A 265
SER A 115
 None
 1.02A 3ufgB-3m5hA:
undetectable		 3ufgB-3m5hA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 PHE A 548
SER A 496
SER A 535
 None
 0.93A 3ufgB-3mkqA:
undetectable		 3ufgB-3mkqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 PHE A 467
SER A 368
SER A 332
 None
 0.82A 3ufgB-3nlcA:
undetectable		 3ufgB-3nlcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		3 PHE A 109
SER A 105
SER A  70
 None
 0.91A 3ufgB-3pftA:
undetectable		 3ufgB-3pftA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		3 PHE A 378
SER A 464
SER A 497
 None
 0.91A 3ufgB-3pgbA:
undetectable		 3ufgB-3pgbA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 PHE A 493
SER A 317
SER A 314
 None
 0.87A 3ufgB-3to3A:
undetectable		 3ufgB-3to3A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		3 PHE A 464
SER A 243
SER A 220
 None
 0.86A 3ufgB-3ty7A:
undetectable		 3ufgB-3ty7A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		3 PHE A 291
SER A 378
SER A 377
 None
 0.98A 3ufgB-3ukfA:
undetectable		 3ufgB-3ukfA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 PHE A 446
SER A 435
SER A 433
 None
 0.92A 3ufgB-3uszA:
undetectable		 3ufgB-3uszA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 PHE A 166
SER A 101
SER A 100
 None
 1.02A 3ufgB-3v8uA:
undetectable		 3ufgB-3v8uA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		3 PHE A  43
SER A  69
SER A  77
 None
 1.01A 3ufgB-3vvjA:
undetectable		 3ufgB-3vvjA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		3 PHE A 332
SER A 325
SER A 135
 None
 0.80A 3ufgB-3w08A:
undetectable		 3ufgB-3w08A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		3 PHE A 225
SER A 234
SER A 362
 None
 0.89A 3ufgB-3wq4A:
undetectable		 3ufgB-3wq4A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x37 ZYRO0C14696P

(Zygosaccharomyces
rouxii) 		no annotation 3 PHE A  85
SER A  38
SER A  40
 None
 0.95A 3ufgB-3x37A:
undetectable		 3ufgB-3x37A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 PHE B 162
SER B 134
SER B 130
 None
 0.88A 3ufgB-4ccyB:
undetectable		 3ufgB-4ccyB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		3 PHE A 488
SER A 527
SER A 529
 None
 1.01A 3ufgB-4cq1A:
undetectable		 3ufgB-4cq1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlq LATROPHILIN-1

(Rattus
norvegicus) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		3 PHE A 697
SER A 703
SER A 705
 None
 0.99A 3ufgB-4dlqA:
undetectable		 3ufgB-4dlqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		3 PHE A  80
SER A 270
SER A  88
 None
 0.87A 3ufgB-4dwqA:
undetectable		 3ufgB-4dwqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		3 PHE A 217
SER A 172
SER A 173
 None
 0.91A 3ufgB-4fl0A:
undetectable		 3ufgB-4fl0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gom DNA ADENINE
METHYLASE

(Escherichia
coli) 		PF02086
(MethyltransfD12) 		3 PHE D  35
SER D 168
SER D 164
 0Y0  D 301 (-4.4A)
None
0Y0  D 301 (-3.6A)
 1.01A 3ufgB-4gomD:
undetectable		 3ufgB-4gomD:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzj INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 PHE C 231
SER C 173
SER C 170
 None
 0.98A 3ufgB-4jzjC:
undetectable		 3ufgB-4jzjC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1x NADPH:FERREDOXIN
REDUCTASE

(Rhodobacter
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 PHE A  44
SER A 137
SER A  70
 None
 1.01A 3ufgB-4k1xA:
undetectable		 3ufgB-4k1xA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH) 		3 PHE A 445
SER A 658
SER A 660
 None
 0.93A 3ufgB-4k2pA:
undetectable		 3ufgB-4k2pA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 PHE A 424
SER A 483
SER A 420
 None
 0.92A 3ufgB-4kxbA:
undetectable		 3ufgB-4kxbA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ob1 COBALT-CONTAINING
NITRILE HYDRATASE
SUBUNIT ALPHA

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		3 PHE A 168
SER A 163
SER A 164
 None
 1.02A 3ufgB-4ob1A:
undetectable		 3ufgB-4ob1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		3 PHE A 179
SER A 173
SER A 174
 None
 1.01A 3ufgB-4p3gA:
2.0		 3ufgB-4p3gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 PHE A 824
SER A 808
SER A 811
 None
 0.83A 3ufgB-4pd3A:
undetectable		 3ufgB-4pd3A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		3 PHE A  49
SER A 221
SER A 281
 PYR  A 402 (-4.2A)
None
None
 0.88A 3ufgB-4petA:
undetectable		 3ufgB-4petA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 3 PHE B 131
SER B 213
SER B 233
 SF4  B 401 ( 4.6A)
SF4  B 401 (-3.1A)
SF4  B 401 ( 4.8A)
 0.96A 3ufgB-4pl2B:
undetectable		 3ufgB-4pl2B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		3 PHE A 350
SER A 255
SER A 252
 HEM  A 501 (-4.6A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.7A)
 0.92A 3ufgB-4pwvA:
undetectable		 3ufgB-4pwvA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		3 PHE A 571
SER A  48
SER A 201
 None
 0.93A 3ufgB-4r12A:
undetectable		 3ufgB-4r12A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis) 		PF02525
(Flavodoxin_2) 		3 PHE A   7
SER A  14
SER A  16
 None
FMN  A 300 (-3.3A)
FMN  A 300 (-2.7A)
 0.94A 3ufgB-4r81A:
undetectable		 3ufgB-4r81A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryi INTEGRAL MEMBRANE
PROTEIN

(Bacillus cereus) 		PF03073
(TspO_MBR) 		3 PHE A  55
SER A  21
SER A  22
 PKA  A 201 (-4.9A)
PKA  A 201 ( 4.0A)
PKA  A 201 (-2.9A)
 0.93A 3ufgB-4ryiA:
2.7		 3ufgB-4ryiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		3 PHE A 388
SER A 270
SER A 237
 None
 0.84A 3ufgB-4uzjA:
undetectable		 3ufgB-4uzjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 3 PHE C  96
SER C  90
SER C  91
 None
 0.81A 3ufgB-4wzsC:
undetectable		 3ufgB-4wzsC:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		3 PHE A 248
SER A 264
SER A 261
 None
HEM  A 504 ( 4.1A)
None
 0.89A 3ufgB-4xydA:
undetectable		 3ufgB-4xydA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5arm CSP3

(Methylosinus
trichosporium) 		no annotation 3 PHE A  29
SER A  73
SER A  70
 None
 0.77A 3ufgB-5armA:
undetectable		 3ufgB-5armA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF16585
(Lipocalin_8) 		3 PHE A  76
SER A 109
SER A 111
 None
 0.83A 3ufgB-5bypA:
undetectable		 3ufgB-5bypA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Pseudoalteromonas
atlantica) 		PF03480
(DctP) 		3 PHE A  43
SER A 215
SER A 275
 PYR  A 401 ( 4.2A)
None
None
 0.97A 3ufgB-5cm6A:
undetectable		 3ufgB-5cm6A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 3 PHE B  42
SER B 302
SER B 303
 None
 0.98A 3ufgB-5fbhB:
undetectable		 3ufgB-5fbhB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)

(Archaeoglobus
fulgidus) 		PF12697
(Abhydrolase_6) 		3 PHE A 158
SER A  29
SER A  30
 None
CL  A1258 ( 4.8A)
CL  A1258 (-2.9A)
 0.87A 3ufgB-5frdA:
undetectable		 3ufgB-5frdA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 3 PHE A 450
SER A 430
SER A 455
 None
 0.93A 3ufgB-5gqfA:
undetectable		 3ufgB-5gqfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		3 PHE A 131
SER A 213
SER A 233
 5AD  A 503 (-4.6A)
MET  A 501 ( 3.3A)
MET  A 501 ( 2.6A)
 0.95A 3ufgB-5hr6A:
undetectable		 3ufgB-5hr6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PHE A 428
SER A 147
SER A 145
 None
 1.01A 3ufgB-5i51A:
undetectable		 3ufgB-5i51A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		3 PHE A  64
SER A 189
SER A 185
 None
 0.99A 3ufgB-5jp9A:
undetectable		 3ufgB-5jp9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 PHE A1161
SER A1150
SER A1152
 None
 0.95A 3ufgB-5kf7A:
undetectable		 3ufgB-5kf7A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knl UBIQUITIN-CONJUGATIN
G ENZYME E2 15

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		3 PHE C  36
SER C   4
SER C   6
 None
 0.91A 3ufgB-5knlC:
undetectable		 3ufgB-5knlC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqs PROTEIN TOPLESS

(Arabidopsis
thaliana) 		no annotation 3 PHE A  34
SER A   3
SER A   5
 None
 0.88A 3ufgB-5nqsA:
undetectable		 3ufgB-5nqsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 PHE A  82
SER A 265
SER A 115
 None
 0.94A 3ufgB-5tg8A:
undetectable		 3ufgB-5tg8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz6 CURJ

(Moorea
producens) 		PF14765
(PS-DH) 		3 PHE A 974
SER A 993
SER A 990
 None
 0.65A 3ufgB-5tz6A:
undetectable		 3ufgB-5tz6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 3 PHE C 600
SER C 490
SER C 486
 None
None
EDO  C 902 ( 4.2A)
 0.96A 3ufgB-5x6xC:
undetectable		 3ufgB-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 3 PHE A 558
SER A 991
SER A 988
 None
 0.86A 3ufgB-6bhuA:
undetectable		 3ufgB-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c46 DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Elizabethkingia
anophelis) 		no annotation 3 PHE A 121
SER A  51
SER A  53
 None
 0.94A 3ufgB-6c46A:
undetectable		 3ufgB-6c46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY

(Thermobifida
fusca) 		no annotation 3 PHE B 231
SER B  15
SER B 227
 None
 0.70A 3ufgB-6c66B:
undetectable		 3ufgB-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6din DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Pseudomonas
aeruginosa) 		no annotation 3 PHE A 120
SER A  51
SER A  53
 None
 0.90A 3ufgB-6dinA:
undetectable		 3ufgB-6dinA:
undetectable