SIMILAR PATTERNS OF AMINO ACIDS FOR 3UE4_B_DB8B601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 None
 0.76A 3ue4B-1k2pA:
31.7		 3ue4B-1k2pA:
45.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.61A 3ue4B-1k9aA:
32.6		 3ue4B-1k9aA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.67A 3ue4B-1opkA:
37.8		 3ue4B-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
PHE A 336
GLY A 340
LEU A 389
PHE A 401
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
None
 0.89A 3ue4B-1opkA:
37.8		 3ue4B-1opkA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
VAL A  86
ALA A  99
VAL A 131
ILE A 145
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.63A 3ue4B-1s9iA:
22.4		 3ue4B-1s9iA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
VAL A 603
ALA A 621
VAL A 654
THR A 670
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.75A 3ue4B-1t46A:
32.8		 3ue4B-1t46A:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.72A 3ue4B-1u59A:
35.0		 3ue4B-1u59A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 3ue4B-1u59A:
35.0		 3ue4B-1u59A:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.76A 3ue4B-2bujA:
25.3		 3ue4B-2bujA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
VAL X  25
ALA X  37
MET X  58
VAL X  67
ILE X  80
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.60A 3ue4B-2dq7X:
36.1		 3ue4B-2dq7X:
45.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL X  25
ALA X  37
GLU X  54
MET X  58
ILE X  80
THR X  82
GLY X  88
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.67A 3ue4B-2dq7X:
36.1		 3ue4B-2dq7X:
45.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.50A 3ue4B-2h8hA:
31.1		 3ue4B-2h8hA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.62A 3ue4B-2hckA:
30.7		 3ue4B-2hckA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 643
ALA A 659
MET A 682
ILE A 705
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.88A 3ue4B-2henA:
26.3		 3ue4B-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.73A 3ue4B-2hk5A:
30.6		 3ue4B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.55A 3ue4B-2hk5A:
30.6		 3ue4B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
ILE A 313
THR A 315
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.74A 3ue4B-2hz0A:
35.5		 3ue4B-2hz0A:
98.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
MET A 290
VAL A 299
ILE A 313
THR A 315
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.65A 3ue4B-2hz0A:
35.5		 3ue4B-2hz0A:
98.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.78A 3ue4B-2j0jA:
33.8		 3ue4B-2j0jA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.66A 3ue4B-2j0jA:
33.8		 3ue4B-2j0jA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.57A 3ue4B-2jkmA:
33.6		 3ue4B-2jkmA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.75A 3ue4B-2og8A:
32.3		 3ue4B-2og8A:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.68A 3ue4B-2og8A:
32.3		 3ue4B-2og8A:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
GLY A 669
LEU A 785
 None
 0.92A 3ue4B-2ogvA:
30.4		 3ue4B-2ogvA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
MET A 637
THR A 663
GLY A 669
LEU A 785
 None
 0.78A 3ue4B-2ogvA:
30.4		 3ue4B-2ogvA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
GLY A 669
LEU A 785
 None
 0.87A 3ue4B-2ogvA:
30.4		 3ue4B-2ogvA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
MET A 637
VAL A 647
THR A 663
GLY A 669
LEU A 785
 None
 0.68A 3ue4B-2ogvA:
30.4		 3ue4B-2ogvA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.84A 3ue4B-2qobA:
27.4		 3ue4B-2qobA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.62A 3ue4B-2r2pA:
35.6		 3ue4B-2r2pA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.69A 3ue4B-2r4bA:
30.3		 3ue4B-2r4bA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.42A 3ue4B-2xyuA:
27.4		 3ue4B-2xyuA:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.81A 3ue4B-2z7rA:
22.9		 3ue4B-2z7rA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 253
VAL A 261
ALA A 273
MET A 294
VAL A 303
ILE A 317
THR A 319
PHE A 321
GLY A 325
LEU A 374
 None
 0.72A 3ue4B-2zv7A:
33.7		 3ue4B-2zv7A:
45.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.80A 3ue4B-3c4fA:
31.7		 3ue4B-3c4fA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.61A 3ue4B-3d7uA:
27.9		 3ue4B-3d7uA:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
MET A 686
VAL A 695
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.60A 3ue4B-3dkoA:
31.9		 3ue4B-3dkoA:
35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
GLU A 100
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.92A 3ue4B-3iecA:
25.2		 3ue4B-3iecA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.58A 3ue4B-3kulA:
35.9		 3ue4B-3kulA:
34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.85A 3ue4B-3mvjA:
23.4		 3ue4B-3mvjA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
GLU A 130
MET A 134
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
 0.70A 3ue4B-3nuuA:
25.0		 3ue4B-3nuuA:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 VAL A 565
ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.65A 3ue4B-3ppzA:
31.5		 3ue4B-3ppzA:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.90A 3ue4B-3q5iA:
22.7		 3ue4B-3q5iA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.54A 3ue4B-3sxsA:
34.6		 3ue4B-3sxsA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.86A 3ue4B-3tt0A:
31.8		 3ue4B-3tt0A:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.84A 3ue4B-3txoA:
19.6		 3ue4B-3txoA:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
VAL A 552
ALA A 570
GLU A 588
VAL A 601
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.85A 3ue4B-3v5qA:
26.9		 3ue4B-3v5qA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.72A 3ue4B-3vidA:
31.2		 3ue4B-3vidA:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.73A 3ue4B-3vidA:
31.2		 3ue4B-3vidA:
34.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
VAL A  83
ALA A  96
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.70A 3ue4B-3wigA:
23.1		 3ue4B-3wigA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.50A 3ue4B-3wzdA:
32.3		 3ue4B-3wzdA:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.64A 3ue4B-3wzdA:
32.3		 3ue4B-3wzdA:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
ALA A1978
GLU A1997
ILE A2024
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.78A 3ue4B-3zbfA:
26.5		 3ue4B-3zbfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
ALA A1978
GLU A1997
MET A2001
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.83A 3ue4B-3zbfA:
26.5		 3ue4B-3zbfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
MET A 672
ILE A 695
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.76A 3ue4B-3zfxA:
34.4		 3ue4B-3zfxA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.64A 3ue4B-4agdA:
31.5		 3ue4B-4agdA:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 105
ALA A 121
MET A 144
ILE A 167
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.70A 3ue4B-4aw5A:
27.1		 3ue4B-4aw5A:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
VAL A  50
ALA A  63
GLU A  81
ILE A 108
PHE A 112
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.83A 3ue4B-4bc6A:
22.6		 3ue4B-4bc6A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
VAL A  50
ALA A  63
VAL A  94
ILE A 108
PHE A 112
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.67A 3ue4B-4bc6A:
22.6		 3ue4B-4bc6A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 653
GLU A 672
MET A 676
THR A 701
LEU A 773
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
 0.83A 3ue4B-4ckrA:
31.0		 3ue4B-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.84A 3ue4B-4crsA:
23.2		 3ue4B-4crsA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
ALA A 541
GLU A 559
VAL A 572
GLY A 594
LEU A 656
 None
 0.73A 3ue4B-4f0iA:
31.4		 3ue4B-4f0iA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
ALA A 400
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.53A 3ue4B-4f4pA:
34.7		 3ue4B-4f4pA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 VAL A 335
ALA A 348
GLU A 366
MET A 370
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.94A 3ue4B-4fieA:
24.8		 3ue4B-4fieA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.76A 3ue4B-4fieA:
24.8		 3ue4B-4fieA:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.71A 3ue4B-4fodA:
31.0		 3ue4B-4fodA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
GLU A 871
VAL A 884
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.72A 3ue4B-4hviA:
33.6		 3ue4B-4hviA:
35.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 414
ALA A 427
GLU A 440
VAL A 453
ILE A 467
GLY A 475
LEU A 522
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
None
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.76A 3ue4B-4idtA:
23.6		 3ue4B-4idtA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.60A 3ue4B-4k11A:
30.7		 3ue4B-4k11A:
35.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 421
ALA A 434
GLU A 452
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.64A 3ue4B-4ks8A:
26.0		 3ue4B-4ks8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
VAL A  41
ALA A  54
MET A  74
VAL A  83
ILE A  97
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.73A 3ue4B-4lg4A:
18.0		 3ue4B-4lg4A:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.69A 3ue4B-4lggA:
30.7		 3ue4B-4lggA:
46.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.70A 3ue4B-4o38A:
21.7		 3ue4B-4o38A:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
ALA A  35
MET A  56
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.66A 3ue4B-4ueuA:
34.9		 3ue4B-4ueuA:
64.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
VAL A  22
ALA A  35
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.33A 3ue4B-4ueuA:
34.9		 3ue4B-4ueuA:
64.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  40
VAL A  48
ALA A  61
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.68A 3ue4B-4usfA:
23.7		 3ue4B-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
ATP  A 501 (-4.5A)
 0.83A 3ue4B-4wb7A:
23.4		 3ue4B-4wb7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.72A 3ue4B-4wsqA:
24.4		 3ue4B-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		8 VAL A 335
ALA A 348
GLU A 366
MET A 370
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 ( 3.7A)
None
None
ATP  A 601 (-4.6A)
None
None
 0.87A 3ue4B-4xbrA:
18.5		 3ue4B-4xbrA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 10 LEU B 267
VAL B 275
ALA B 288
MET B 309
VAL B 318
ILE B 332
THR B 334
PHE B 336
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.33A 3ue4B-4xeyB:
40.5		 3ue4B-4xeyB:
93.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 None
 0.85A 3ue4B-4xi2A:
30.1		 3ue4B-4xi2A:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
GLU A 661
MET A 665
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.79A 3ue4B-4xufA:
31.4		 3ue4B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
MET A 665
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.87A 3ue4B-4xufA:
31.4		 3ue4B-4xufA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.52A 3ue4B-4y93A:
31.2		 3ue4B-4y93A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
GLU A 509
ILE A 537
THR A 539
GLY A 545
LEU A 595
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.80A 3ue4B-4yffA:
27.1		 3ue4B-4yffA:
28.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.75A 3ue4B-5grnA:
26.4		 3ue4B-5grnA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
ALA A 625
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.73A 3ue4B-5grnA:
26.4		 3ue4B-5grnA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A  94
ALA A 105
VAL A 134
ILE A 146
THR A 148
GLY A 154
LEU A 215
 None
 0.43A 3ue4B-5gz8A:
21.6		 3ue4B-5gz8A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  57
VAL A  65
ALA A  77
GLU A  95
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.62A 3ue4B-5i3oA:
24.2		 3ue4B-5i3oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.54A 3ue4B-5j5tA:
22.5		 3ue4B-5j5tA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.66A 3ue4B-5kbrA:
23.4		 3ue4B-5kbrA:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 647
ALA A 663
MET A 686
ILE A 709
THR A 711
PHE A 713
LEU A 765
 None
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-4.5A)
 0.49A 3ue4B-5l6oA:
32.6		 3ue4B-5l6oA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.80A 3ue4B-5vefA:
25.2		 3ue4B-5vefA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.64A 3ue4B-5w5jA:
19.7		 3ue4B-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
VAL A 899
ALA A 917
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.56A 3ue4B-5wnoA:
28.6		 3ue4B-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 VAL A 212
ALA A 225
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.80A 3ue4B-5xzwA:
20.4		 3ue4B-5xzwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
VAL A  41
ALA A  54
VAL A  83
ILE A  97
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.55A 3ue4B-6ao5A:
22.3		 3ue4B-6ao5A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
PHE A 958
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 ( 4.1A)
 0.76A 3ue4B-6c7yA:
31.4		 3ue4B-6c7yA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.70A 3ue4B-6c7yA:
31.4		 3ue4B-6c7yA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 LEU A 197
VAL A 205
ALA A 217
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.74A 3ue4B-6cz4A:
29.9		 3ue4B-6cz4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
VAL U  28
ALA U  42
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.63A 3ue4B-6fdyU:
24.4		 3ue4B-6fdyU:
undetectable