SIMILAR PATTERNS OF AMINO ACIDS FOR 3UE4_A_DB8A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 None
 0.58A 3ue4A-1k2pA:
32.0		 3ue4A-1k2pA:
45.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
VAL A 249
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.69A 3ue4A-1k9aA:
27.1		 3ue4A-1k9aA:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		7 LEU A5948
ALA A5969
LYS A5971
GLU A5987
VAL A6000
PHE A6018
MET A6019
 None
 1.04A 3ue4A-1koaA:
23.2		 3ue4A-1koaA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
ALA A 288
GLU A 305
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
PHE A 401
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
None
 0.95A 3ue4A-1opkA:
37.4		 3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.73A 3ue4A-1opkA:
37.4		 3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
ALA A 288
LYS A 290
VAL A 318
ILE A 332
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.65A 3ue4A-1opkA:
37.4		 3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
ALA A 288
VAL A 318
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
PHE A 401
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
None
 0.78A 3ue4A-1opkA:
37.4		 3ue4A-1opkA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  78
ALA A  99
LYS A 101
VAL A 131
ILE A 145
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.62A 3ue4A-1s9iA:
6.9		 3ue4A-1s9iA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 389
LYS A 391
VAL A 419
PHE A 437
MET A 438
GLY A 441
LEU A 489
 None
 0.42A 3ue4A-1snxA:
31.5		 3ue4A-1snxA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
ALA A  47
LYS A  49
GLU A  65
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.76A 3ue4A-2bujA:
25.0		 3ue4A-2bujA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
ALA X  37
LYS X  39
GLU X  54
ILE X  80
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.90A 3ue4A-2dq7X:
36.6		 3ue4A-2dq7X:
45.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
ALA X  37
LYS X  39
VAL X  67
ILE X  80
THR X  82
MET X  85
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.71A 3ue4A-2dq7X:
36.6		 3ue4A-2dq7X:
45.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
ALA A 184
LYS A 186
GLU A 201
ILE A 234
GLY A 240
LEU A 290
 None
 1.29A 3ue4A-2eu9A:
24.3		 3ue4A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.48A 3ue4A-2h8hA:
31.6		 3ue4A-2h8hA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 3ue4A-2hckA:
31.1		 3ue4A-2hckA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 659
ILE A 705
THR A 707
PHE A 709
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.55A 3ue4A-2henA:
28.3		 3ue4A-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.81A 3ue4A-2hk5A:
29.8		 3ue4A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
ALA A 271
LYS A 273
VAL A 301
ILE A 314
THR A 316
PHE A 318
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.51A 3ue4A-2hk5A:
29.8		 3ue4A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
ALA A 269
LYS A 271
GLU A 286
ILE A 313
THR A 315
PHE A 317
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.7A)
 0.77A 3ue4A-2hz0A:
35.7		 3ue4A-2hz0A:
98.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
ALA A 269
VAL A 299
ILE A 313
THR A 315
PHE A 317
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.7A)
 0.65A 3ue4A-2hz0A:
35.7		 3ue4A-2hz0A:
98.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.79A 3ue4A-2og8A:
32.2		 3ue4A-2og8A:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
VAL A 301
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.70A 3ue4A-2og8A:
32.2		 3ue4A-2og8A:
45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
ALA A  46
LYS A  48
GLU A  73
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.61A 3ue4A-2phkA:
25.3		 3ue4A-2phkA:
28.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 651
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.26A 3ue4A-2qobA:
26.7		 3ue4A-2qobA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 705
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.34A 3ue4A-2r2pA:
35.5		 3ue4A-2r2pA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.73A 3ue4A-2r4bA:
30.3		 3ue4A-2r4bA:
37.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
ALA A 247
GLU A 273
ILE A 299
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-2.8A)
XK9  A1511 ( 4.9A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 1.07A 3ue4A-2xk9A:
21.7		 3ue4A-2xk9A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
ALA A 247
LYS A 249
ILE A 299
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 4.9A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.84A 3ue4A-2xk9A:
21.7		 3ue4A-2xk9A:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.39A 3ue4A-2xyuA:
33.3		 3ue4A-2xyuA:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
ALA A  92
LYS A  94
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.85A 3ue4A-2z7rA:
23.2		 3ue4A-2z7rA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 253
ALA A 273
LYS A 275
VAL A 303
ILE A 317
THR A 319
PHE A 321
MET A 322
GLY A 325
LEU A 374
 None
 0.59A 3ue4A-2zv7A:
34.0		 3ue4A-2zv7A:
45.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
VAL A 249
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.69A 3ue4A-3d7uA:
27.1		 3ue4A-3d7uA:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 663
LYS A 665
VAL A 695
ILE A 709
PHE A 713
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.36A 3ue4A-3dkoA:
31.7		 3ue4A-3dkoA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
ALA A 455
LYS A 457
GLU A 474
ILE A 500
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 1.00A 3ue4A-3fzpA:
33.1		 3ue4A-3fzpA:
41.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.57A 3ue4A-3kulA:
35.5		 3ue4A-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1005
ALA A1031
LYS A1033
GLU A1050
VAL A1063
MET A1082
GLY A1085
 None
None
CCX  A   1 ( 3.7A)
CCX  A   1 ( 4.3A)
CCX  A   1 (-4.1A)
None
None
 1.01A 3ue4A-3lw0A:
30.4		 3ue4A-3lw0A:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
ALA A  70
LYS A  72
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.97A 3ue4A-3mvjA:
23.8		 3ue4A-3mvjA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
ALA A 213
LYS A 215
VAL A 247
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.72A 3ue4A-3nyoA:
24.3		 3ue4A-3nyoA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.62A 3ue4A-3pp0A:
29.7		 3ue4A-3pp0A:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
GLU A 596
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.60A 3ue4A-3ppzA:
32.0		 3ue4A-3ppzA:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
ALA A  84
LYS A  86
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.98A 3ue4A-3q5iA:
22.7		 3ue4A-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  71
LYS A  73
GLU A  84
VAL A  98
ILE A 116
MET A 121
LEU A 173
 I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
None
None
None
None
 0.63A 3ue4A-3sheA:
20.3		 3ue4A-3sheA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  50
ALA A  71
LYS A  73
GLU A  84
ILE A 116
MET A 121
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
None
None
None
 0.79A 3ue4A-3sheA:
20.3		 3ue4A-3sheA:
24.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 423
ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.60A 3ue4A-3sxsA:
34.8		 3ue4A-3sxsA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
ALA A 570
GLU A 588
VAL A 601
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.79A 3ue4A-3v5qA:
31.6		 3ue4A-3v5qA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
ALA A 570
LYS A 572
VAL A 601
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.72A 3ue4A-3v5qA:
31.6		 3ue4A-3v5qA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
ALA A  80
LYS A  82
VAL A 113
ILE A 127
MET A 132
LEU A 186
 None
ANK  A 401 (-3.0A)
ANK  A 401 (-2.4A)
None
None
None
ANK  A 401 ( 4.9A)
 0.93A 3ue4A-3vn9A:
22.5		 3ue4A-3vn9A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.66A 3ue4A-3wigA:
23.1		 3ue4A-3wigA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
LYS A 868
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.58A 3ue4A-3wzdA:
31.8		 3ue4A-3wzdA:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
ALA A1978
LYS A1980
GLU A1997
ILE A2024
MET A2029
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.62A 3ue4A-3zbfA:
33.4		 3ue4A-3zbfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
ILE A 695
THR A 697
PHE A 699
MET A 700
GLY A 703
LEU A 751
 None
 0.68A 3ue4A-3zfxA:
34.3		 3ue4A-3zfxA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 121
LYS A 123
ILE A 167
THR A 169
PHE A 171
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.46A 3ue4A-4aw5A:
33.5		 3ue4A-4aw5A:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
ALA A  63
GLU A  81
ILE A 108
PHE A 112
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.86A 3ue4A-4bc6A:
22.7		 3ue4A-4bc6A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
ALA A  63
LYS A  65
VAL A  94
ILE A 108
PHE A 112
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.78A 3ue4A-4bc6A:
22.7		 3ue4A-4bc6A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LYS A 655
GLU A 672
THR A 701
MET A 704
LEU A 773
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
 0.64A 3ue4A-4ckrA:
30.8		 3ue4A-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
ALA A 541
GLU A 559
VAL A 572
MET A 591
GLY A 594
LEU A 656
 None
 0.59A 3ue4A-4f0iA:
31.2		 3ue4A-4f0iA:
36.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 ALA A 348
LYS A 350
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.84A 3ue4A-4fieA:
25.4		 3ue4A-4fieA:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
VAL A1180
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.45A 3ue4A-4fodA:
30.9		 3ue4A-4fodA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
GLU A1167
VAL A1180
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
None
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.83A 3ue4A-4fodA:
30.9		 3ue4A-4fodA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 429
LYS A 431
GLU A 442
VAL A 455
ILE A 469
GLY A 477
LEU A 524
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
None
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.95A 3ue4A-4g3fA:
23.4		 3ue4A-4g3fA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
ALA A 853
LYS A 855
GLU A 871
VAL A 884
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.79A 3ue4A-4hviA:
34.0		 3ue4A-4hviA:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
ALA A 156
LYS A 158
GLU A 177
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 1.10A 3ue4A-4id7A:
34.4		 3ue4A-4id7A:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 427
LYS A 429
GLU A 440
VAL A 453
ILE A 467
GLY A 475
LEU A 522
 T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.90A 3ue4A-4idtA:
23.9		 3ue4A-4idtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
ALA A 427
LYS A 429
GLU A 440
ILE A 467
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 1.07A 3ue4A-4idtA:
23.9		 3ue4A-4idtA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.52A 3ue4A-4k11A:
31.2		 3ue4A-4k11A:
35.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 434
LYS A 436
GLU A 452
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.61A 3ue4A-4ks8A:
26.6		 3ue4A-4ks8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  33
ALA A  54
LYS A  56
VAL A  83
ILE A  97
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.71A 3ue4A-4lg4A:
20.2		 3ue4A-4lg4A:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.64A 3ue4A-4lggA:
30.8		 3ue4A-4lggA:
46.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.69A 3ue4A-4o38A:
21.7		 3ue4A-4o38A:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 644
ILE A 690
THR A 692
MET A 695
GLY A 698
LEU A 746
 None
 0.39A 3ue4A-4p2kA:
34.0		 3ue4A-4p2kA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
ALA A  35
LYS A  37
VAL A  65
ILE A  79
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.49A 3ue4A-4ueuA:
34.8		 3ue4A-4ueuA:
64.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  40
ALA A  61
LYS A  63
VAL A  92
ILE A 106
PHE A 110
LEU A 162
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
 0.76A 3ue4A-4usfA:
17.7		 3ue4A-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  40
ALA A  61
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.58A 3ue4A-4usfA:
17.7		 3ue4A-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
ALA A 125
LYS A 127
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.93A 3ue4A-4wb7A:
23.9		 3ue4A-4wb7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
ALA A 214
LYS A 216
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.72A 3ue4A-4wboA:
25.4		 3ue4A-4wboA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
ALA A  72
GLU A  90
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.78A 3ue4A-4wsqA:
24.8		 3ue4A-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
ALA A  72
LYS A  74
GLU A  90
VAL A 104
ILE A 124
PHE A 128
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
 0.91A 3ue4A-4wsqA:
24.8		 3ue4A-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ALA A 348
LYS A 350
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
ATP  A 601 ( 3.7A)
None
ATP  A 601 (-4.6A)
None
None
 0.76A 3ue4A-4xbrA:
20.5		 3ue4A-4xbrA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 10 LEU B 267
ALA B 288
LYS B 290
VAL B 318
ILE B 332
THR B 334
PHE B 336
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.38A 3ue4A-4xeyB:
34.3		 3ue4A-4xeyB:
93.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 None
 0.78A 3ue4A-4xi2A:
30.3		 3ue4A-4xi2A:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
LYS A 430
VAL A 458
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.73A 3ue4A-4y93A:
31.4		 3ue4A-4y93A:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.49A 3ue4A-4y93A:
31.4		 3ue4A-4y93A:
29.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.73A 3ue4A-5grnA:
25.7		 3ue4A-5grnA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
ALA A 625
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.78A 3ue4A-5grnA:
25.7		 3ue4A-5grnA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
ALA A  77
LYS A  79
GLU A  95
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.74A 3ue4A-5i3oA:
24.4		 3ue4A-5i3oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.66A 3ue4A-5j5tA:
22.7		 3ue4A-5j5tA:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 663
LYS A 665
ILE A 709
THR A 711
PHE A 713
MET A 714
LEU A 765
 6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
None
6P6  A1001 (-4.5A)
 0.61A 3ue4A-5l6oA:
32.3		 3ue4A-5l6oA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 7 ALA A 103
LYS A 105
VAL A 134
PHE A 152
MET A 153
GLY A 156
LEU A 209
 None
 0.60A 3ue4A-5tosA:
22.8		 3ue4A-5tosA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
ALA A 707
LYS A 709
GLU A 725
ILE A 752
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.95A 3ue4A-5vilA:
18.9		 3ue4A-5vilA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
ALA A  45
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 3ue4A-5w5jA:
19.4		 3ue4A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
ALA A  45
LYS A  47
ILE A  93
THR A  95
MET A  98
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
 0.71A 3ue4A-5w5jA:
19.4		 3ue4A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.50A 3ue4A-5wnoA:
28.7		 3ue4A-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 ALA A 225
LYS A 227
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.86A 3ue4A-5xzwA:
20.8		 3ue4A-5xzwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
ALA A  54
LYS A  56
VAL A  83
ILE A  97
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.58A 3ue4A-6ao5A:
22.2		 3ue4A-6ao5A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.70A 3ue4A-6c7yA:
25.4		 3ue4A-6c7yA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
ALA A 217
LYS A 219
ILE A 262
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.95A 3ue4A-6cz4A:
23.0		 3ue4A-6cz4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
ALA U  42
GLU U  62
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 1.05A 3ue4A-6fdyU:
24.4		 3ue4A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
ALA U  42
LYS U  44
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.63A 3ue4A-6fdyU:
24.4		 3ue4A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
ALA A 191
LYS A 193
GLU A 208
ILE A 241
GLY A 247
LEU A 297
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
 1.23A 3ue4A-6fylA:
24.4		 3ue4A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 LEU A 167
ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 1.29A 3ue4A-6fyvA:
24.3		 3ue4A-6fyvA:
undetectable