SIMILAR PATTERNS OF AMINO ACIDS FOR 3UCJ_B_AZMB229_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLN A  63
PHE A  67
TYR A  59
 None
 0.96A 3ucjA-1cm8A:
undetectable		 3ucjA-1cm8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekj BETA-CARBONIC
ANHYDRASE

(Pisum sativum) 		PF00484
(Pro_CA) 		3 GLN A 151
PHE A 179
TYR A 205
 ACT  A3003 (-3.9A)
ACT  A3003 (-4.9A)
ACT  A3003 (-3.6A)
 0.54A 3ucjA-1ekjA:
21.9		 3ucjA-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLN A 387
PHE A 410
TYR A  66
 None
 0.95A 3ucjA-1geuA:
undetectable		 3ucjA-1geuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		3 GLN P  23
PHE P  28
TYR P 121
 None
 1.01A 3ucjA-1jcmP:
0.0		 3ucjA-1jcmP:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 GLN A 108
PHE A 192
TYR A 179
 None
 0.93A 3ucjA-1l6jA:
undetectable		 3ucjA-1l6jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		3 GLN E 106
PHE E 108
TYR D  35
 None
 1.00A 3ucjA-1mi5E:
undetectable		 3ucjA-1mi5E:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 GLN A 329
PHE A 325
TYR A  65
 None
 0.96A 3ucjA-1n76A:
undetectable		 3ucjA-1n76A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 GLN A   9
PHE A 185
TYR A  48
 None
 0.95A 3ucjA-1qpgA:
undetectable		 3ucjA-1qpgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		3 GLN A  44
PHE A  45
TYR A  82
 GLN  A  44 ( 0.6A)
PHE  A  45 ( 1.3A)
TYR  A  82 ( 1.3A)
 0.97A 3ucjA-1rynA:
undetectable		 3ucjA-1rynA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		3 GLN A 114
PHE A 112
TYR A 356
 None
 0.95A 3ucjA-1tdkA:
undetectable		 3ucjA-1tdkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 GLN A1394
PHE A1174
TYR A1112
 None
 0.97A 3ucjA-1xv5A:
2.4		 3ucjA-1xv5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 GLN A1094
PHE A1079
TYR A1050
 None
 1.00A 3ucjA-1yguA:
undetectable		 3ucjA-1yguA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		3 GLN A 378
PHE A 380
TYR A 412
 None
 1.00A 3ucjA-1yi7A:
undetectable		 3ucjA-1yi7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy7 STRINGENT STARVATION
PROTEIN A

(Yersinia pestis) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLN A  24
PHE A  21
TYR A 111
 None
 0.75A 3ucjA-1yy7A:
undetectable		 3ucjA-1yy7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		3 GLN A 308
PHE A  46
TYR A 134
 None
 0.94A 3ucjA-1zz3A:
1.9		 3ucjA-1zz3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		3 GLN A  42
PHE A  70
TYR A  89
 None
 0.29A 3ucjA-2a5vA:
19.1		 3ucjA-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF01041
(DegT_DnrJ_EryC1) 		3 GLN A 166
PHE A 140
TYR A 342
 PMP  A1416 (-3.7A)
None
None
 1.01A 3ucjA-2c81A:
undetectable		 3ucjA-2c81A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eke SUMO-CONJUGATING
ENZYME UBC9

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		3 GLN A 151
PHE A  81
TYR A  58
 None
 0.87A 3ucjA-2ekeA:
undetectable		 3ucjA-2ekeA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		3 GLN A 378
PHE A 380
TYR A 412
 None
 1.01A 3ucjA-2exhA:
undetectable		 3ucjA-2exhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		3 GLN A 185
PHE A 143
TYR A 149
 None
 0.98A 3ucjA-2i3oA:
undetectable		 3ucjA-2i3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		3 GLN A 128
PHE A  71
TYR A  86
 None
 0.97A 3ucjA-2jj7A:
undetectable		 3ucjA-2jj7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lig ASPARTATE RECEPTOR

(Salmonella
enterica) 		PF02203
(TarH) 		3 GLN A  49
PHE A 107
TYR A 168
 None
 0.91A 3ucjA-2ligA:
undetectable		 3ucjA-2ligA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3o YYCI PROTEIN

(Bacillus
subtilis) 		PF09648
(YycI) 		3 GLN A  85
PHE A 105
TYR A 184
 None
 0.99A 3ucjA-2o3oA:
undetectable		 3ucjA-2o3oA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 288
PHE A 239
TYR A 157
 None
 1.00A 3ucjA-2ppgA:
undetectable		 3ucjA-2ppgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkp UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF13596
(PAS_10) 		3 GLN A 372
PHE A 352
TYR A 355
 None
 0.95A 3ucjA-2qkpA:
undetectable		 3ucjA-2qkpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdf OUTER MEMBRANE
PROTEIN

(Neisseria
meningitidis) 		PF07239
(OpcA) 		3 GLN A 215
PHE A 191
TYR A 213
 None
 0.90A 3ucjA-2vdfA:
undetectable		 3ucjA-2vdfA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		3 GLN A  59
PHE A  87
TYR A 109
 None
 0.44A 3ucjA-2w3nA:
24.3		 3ucjA-2w3nA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		3 GLN A 258
PHE A 260
TYR A 441
 None
 1.02A 3ucjA-2w5sA:
undetectable		 3ucjA-2w5sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		3 GLN A 256
PHE A 258
TYR A 437
 None
 0.98A 3ucjA-2w8dA:
2.1		 3ucjA-2w8dA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 GLN B1248
PHE B1124
TYR B1059
 None
 0.98A 3ucjA-2xwbB:
undetectable		 3ucjA-2xwbB:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 GLN A 613
PHE A 581
TYR A 595
 None
 1.01A 3ucjA-2yfnA:
undetectable		 3ucjA-2yfnA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF02174
(IRS) 		3 GLN A 102
PHE A  98
TYR A  65
 None
 0.92A 3ucjA-2yt2A:
undetectable		 3ucjA-2yt2A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 GLN A 469
PHE A 468
TYR A 551
 None
 1.00A 3ucjA-3actA:
undetectable		 3ucjA-3actA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		3 GLN A 317
PHE A 320
TYR A   8
 None
 0.92A 3ucjA-3b4yA:
undetectable		 3ucjA-3b4yA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6l TCR 2W20 ALPHA CHAIN
TCR 2W20 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		3 GLN B  99
PHE B 101
TYR A  35
 None
 0.89A 3ucjA-3c6lB:
undetectable		 3ucjA-3c6lB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		3 GLN A 123
PHE A 570
TYR A 580
 None
 0.93A 3ucjA-3djaA:
undetectable		 3ucjA-3djaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		3 GLN X 390
PHE X 389
TYR X 387
 None
 0.90A 3ucjA-3dwoX:
undetectable		 3ucjA-3dwoX:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		3 GLN A 191
PHE A 168
TYR A 170
 None
 0.81A 3ucjA-3fipA:
undetectable		 3ucjA-3fipA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 GLN A 618
PHE A 615
TYR A 614
 None
 0.94A 3ucjA-3gm8A:
undetectable		 3ucjA-3gm8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		3 GLN A 424
PHE A 408
TYR A 442
 None
 0.95A 3ucjA-3h7nA:
undetectable		 3ucjA-3h7nA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd5 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Bordetella
parapertussis) 		PF00085
(Thioredoxin)
PF01323
(DSBA) 		3 GLN A  83
PHE A  54
TYR A  99
 None
 0.84A 3ucjA-3hd5A:
undetectable		 3ucjA-3hd5A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE

(Trypanosoma
brucei) 		no annotation 3 GLN A 355
PHE A 260
TYR A 331
 None
 1.00A 3ucjA-3hj4A:
undetectable		 3ucjA-3hj4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		3 GLN A 114
PHE A 112
TYR A 356
 None
 1.01A 3ucjA-3kveA:
undetectable		 3ucjA-3kveA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxt GLUTATHIONE S
TRANSFERASE

(Pseudomonas
protegens) 		PF13417
(GST_N_3) 		3 GLN A 171
PHE A 178
TYR A 138
 None
 0.96A 3ucjA-3lxtA:
undetectable		 3ucjA-3lxtA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		3 GLN E 112
PHE E 114
TYR D  42
 None
 0.99A 3ucjA-3pqyE:
undetectable		 3ucjA-3pqyE:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 GLN A 735
PHE A1112
TYR A 883
 None
 0.88A 3ucjA-3psfA:
undetectable		 3ucjA-3psfA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 GLN A 735
PHE A1112
TYR A 883
 None
 0.82A 3ucjA-3psiA:
undetectable		 3ucjA-3psiA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 256
PHE A 207
TYR A 117
 None
 0.86A 3ucjA-3rr1A:
undetectable		 3ucjA-3rr1A:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ucn CARBONIC ANHYDRASE

(Coccomyxa sp.
PA) 		PF00484
(Pro_CA) 		3 GLN A  38
PHE A  66
TYR A  88
 AZI  A 230 (-3.9A)
AZI  A 230 (-4.6A)
AZI  A 230 ( 4.9A)
 0.35A 3ucjA-3ucnA:
35.1		 3ucjA-3ucnA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 GLN A 309
PHE A 330
TYR A 237
 None
 0.85A 3ucjA-3wnpA:
2.0		 3ucjA-3wnpA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		3 GLN B 335
PHE B  90
TYR B 352
 None
 0.85A 3ucjA-4aczB:
undetectable		 3ucjA-4aczB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		3 GLN A 300
PHE A 293
TYR A 282
 None
 0.90A 3ucjA-4ap3A:
undetectable		 3ucjA-4ap3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1

(Homo sapiens) 		PF00043
(GST_C) 		3 GLN B 150
PHE B 146
TYR B 121
 None
 0.95A 3ucjA-4bvxB:
undetectable		 3ucjA-4bvxB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		3 GLN A 138
PHE A  85
TYR A 107
 None
 1.00A 3ucjA-4e4rA:
undetectable		 3ucjA-4e4rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		3 GLN A 244
PHE A 293
TYR A 326
 None
 0.95A 3ucjA-4haqA:
undetectable		 3ucjA-4haqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		3 GLN A 183
PHE A  24
TYR A  66
 None
 0.89A 3ucjA-4i9cA:
undetectable		 3ucjA-4i9cA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		3 GLN A 440
PHE A 499
TYR A 489
 None
 0.87A 3ucjA-4ifqA:
undetectable		 3ucjA-4ifqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		3 GLN A  26
PHE A  29
TYR A 430
 None
 1.00A 3ucjA-4il3A:
undetectable		 3ucjA-4il3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 GLN A 354
PHE A 357
TYR A 302
 None
 0.94A 3ucjA-4k6mA:
undetectable		 3ucjA-4k6mA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		3 GLN A 141
PHE A 135
TYR A  58
 None
 1.00A 3ucjA-4lm8A:
undetectable		 3ucjA-4lm8A:
17.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		3 GLN A  36
PHE A  64
TYR A  86
 None
 0.49A 3ucjA-4o1jA:
25.1		 3ucjA-4o1jA:
33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 GLN A 365
PHE A 362
TYR A 360
 None
 0.93A 3ucjA-4s3jA:
undetectable		 3ucjA-4s3jA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		3 GLN A 323
PHE A 305
TYR A 321
 None
 0.87A 3ucjA-4tn0A:
2.9		 3ucjA-4tn0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		3 GLN A 339
PHE A  91
TYR A 356
 None
 0.84A 3ucjA-4utfA:
undetectable		 3ucjA-4utfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 GLN A 399
PHE A  42
TYR A 451
 None
 0.94A 3ucjA-4uwaA:
undetectable		 3ucjA-4uwaA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 3 GLN E 424
PHE E 408
TYR E 442
 None
 1.01A 3ucjA-4xmmE:
undetectable		 3ucjA-4xmmE:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER

(Escherichia
coli) 		PF01554
(MatE) 		3 GLN A 375
PHE A 292
TYR A 277
 OLC  A 501 ( 4.0A)
OLC  A 501 ( 4.5A)
OLC  A 501 (-3.6A)
 0.90A 3ucjA-4z3nA:
undetectable		 3ucjA-4z3nA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02100
(ODC_AZ)
PF02784
(Orn_Arg_deC_N) 		3 GLN A 119
PHE B 218
TYR B 216
 None
 0.88A 3ucjA-4zgzA:
undetectable		 3ucjA-4zgzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN

(Methanosarcina
acetivorans) 		PF04446
(Thg1)
PF14413
(Thg1C) 		3 GLN A 131
PHE A 227
TYR A  65
 None
 0.89A 3ucjA-5axkA:
undetectable		 3ucjA-5axkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		3 GLN A 135
PHE A 131
TYR A 178
 None
 0.92A 3ucjA-5b0sA:
undetectable		 3ucjA-5b0sA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		3 GLN A 199
PHE A 197
TYR A 377
 None
 1.00A 3ucjA-5bukA:
undetectable		 3ucjA-5bukA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		3 GLN A1348
PHE A1368
TYR A1337
 None
 0.99A 3ucjA-5deuA:
undetectable		 3ucjA-5deuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))

(Clostridioides
difficile) 		PF08501
(Shikimate_dh_N) 		3 GLN A 244
PHE A  24
TYR A  33
 None
 0.99A 3ucjA-5dzsA:
undetectable		 3ucjA-5dzsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 GLN A 259
PHE A 395
TYR A 386
 None
 1.01A 3ucjA-5e6tA:
undetectable		 3ucjA-5e6tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		3 GLN A 149
PHE A 113
TYR A 176
 None
 0.92A 3ucjA-5ecjA:
undetectable		 3ucjA-5ecjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 GLN A 451
PHE A 464
TYR A 437
 None
 0.76A 3ucjA-5ficA:
undetectable		 3ucjA-5ficA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 GLN A 451
PHE A 464
TYR A 437
 None
 0.86A 3ucjA-5hqnA:
undetectable		 3ucjA-5hqnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		3 GLN A 453
PHE A 466
TYR A 439
 None
 0.81A 3ucjA-5i85A:
undetectable		 3ucjA-5i85A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 GLN A 351
PHE A 354
TYR A 299
 None
 0.90A 3ucjA-5iq6A:
undetectable		 3ucjA-5iq6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04390
(LptE)
PF04453
(OstA_C) 		3 GLN A 309
PHE B 107
TYR A 437
 None
 0.82A 3ucjA-5ixmA:
undetectable		 3ucjA-5ixmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1f PLECTIN,PLECTIN

(Homo sapiens) 		no annotation 3 GLN A 949
PHE A 941
TYR A 992
 None
 1.01A 3ucjA-5j1fA:
undetectable		 3ucjA-5j1fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 GLN A 209
PHE A 135
TYR A 158
 None
 0.99A 3ucjA-5jmdA:
undetectable		 3ucjA-5jmdA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 GLN A 273
PHE A 286
TYR A 259
 None
 0.82A 3ucjA-5karA:
undetectable		 3ucjA-5karA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1

(Rhodococcus
jostii) 		PF00296
(Bac_luciferase) 		3 GLN A 316
PHE A 319
TYR A   7
 None
 1.00A 3ucjA-5lxeA:
undetectable		 3ucjA-5lxeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 GLN A 247
PHE A 297
TYR A 336
 None
 0.90A 3ucjA-5mchA:
undetectable		 3ucjA-5mchA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr4 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 3 GLN C 291
PHE C 355
TYR C 217
 None
 0.96A 3ucjA-5mr4C:
undetectable		 3ucjA-5mr4C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr5 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 3 GLN C 291
PHE C 355
TYR C 217
 None
 0.96A 3ucjA-5mr5C:
undetectable		 3ucjA-5mr5C:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		3 GLN O 390
PHE O 386
TYR O 427
 None
 0.97A 3ucjA-5n5zO:
undetectable		 3ucjA-5n5zO:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 GLN A 496
PHE A 191
TYR A 447
 None
 0.79A 3ucjA-5nd1A:
undetectable		 3ucjA-5nd1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swc CARBONIC ANHYDRASE

(Synechocystis
sp. PCC 6803) 		PF00484
(Pro_CA) 		3 GLN A  30
PHE A  58
TYR A  83
 FMT  A 304 (-3.8A)
FMT  A 304 (-4.6A)
FMT  A 304 (-3.4A)
 0.25A 3ucjA-5swcA:
22.0		 3ucjA-5swcA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 GLN A 353
PHE A 356
TYR A 301
 None
 0.93A 3ucjA-5tmhA:
2.1		 3ucjA-5tmhA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB

(Geobacter
metallireducens) 		PF00437
(T2SSE) 		3 GLN A 365
PHE A 360
TYR A 336
 None
 0.93A 3ucjA-5tshA:
undetectable		 3ucjA-5tshA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0p MEDIATOR COMPLEX
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		3 GLN N 273
PHE N 224
TYR N 236
 None
 0.79A 3ucjA-5u0pN:
undetectable		 3ucjA-5u0pN:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		3 GLN A 183
PHE A 181
TYR A 148
 None
 0.74A 3ucjA-5vf3A:
undetectable		 3ucjA-5vf3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		3 GLN A 307
PHE A 347
TYR A 364
 None
 0.92A 3ucjA-5vldA:
undetectable		 3ucjA-5vldA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 383
PHE A 380
TYR A 379
 None
 0.92A 3ucjA-5vo1A:
undetectable		 3ucjA-5vo1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 GLN A 310
PHE A 331
TYR A 238
 None
 0.95A 3ucjA-5x7hA:
undetectable		 3ucjA-5x7hA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 3 GLN A 153
PHE A 134
TYR A 184
 None
 0.92A 3ucjA-6bqcA:
undetectable		 3ucjA-6bqcA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 3 GLN E 845
PHE E 789
TYR E1218
 None
 0.87A 3ucjA-6c3pE:
undetectable		 3ucjA-6c3pE:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 3 GLN A  76
PHE A 253
TYR A 178
 None
None
EDO  A 603 (-4.5A)
 0.87A 3ucjA-6eomA:
undetectable		 3ucjA-6eomA:
17.51