SIMILAR PATTERNS OF AMINO ACIDS FOR 3UCB_B_017B202
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6b | ZINC FINGER PROTEINNCP10 (Murine leukemiavirus) |
PF00098(zf-CCHC) | 4 | PRO B 40ARG B 44GLY B 45PRO B 46 | None | 1.09A | 3ucbB-1a6bB:undetectable | 3ucbB-1a6bB:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1an7 | RIBOSOMAL PROTEIN S8 (Thermusthermophilus) |
PF00410(Ribosomal_S8) | 4 | PRO A 67ARG A 69GLY A 71PRO A 72 | None | 1.30A | 3ucbB-1an7A:undetectable | 3ucbB-1an7A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ash | HEMOGLOBIN (OXY) (Ascaris suum) |
PF00042(Globin) | 4 | PRO A 59LYS A 63ARG A 23GLY A 26 | None | 1.32A | 3ucbB-1ashA:undetectable | 3ucbB-1ashA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dwu | RIBOSOMAL PROTEIN L1 (Methanothermococcusthermolithotrophicus) |
PF00687(Ribosomal_L1) | 4 | PRO A 113LYS A 117GLY A 120PRO A 121 | None | 1.36A | 3ucbB-1dwuA:undetectable | 3ucbB-1dwuA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eje | FMN-BINDING PROTEIN (Methanothermobacterthermautotrophicus) |
PF01613(Flavin_Reduct) | 4 | PRO A 122ARG A 123GLY A 129PRO A 128 | None | 1.24A | 3ucbB-1ejeA:undetectable | 3ucbB-1ejeA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnh | PROTEIN(FIBRONECTIN) (Homo sapiens) |
PF00041(fn3) | 4 | PRO A 229ARG A 230GLY A 212PRO A 233 | None | 1.36A | 3ucbB-1fnhA:undetectable | 3ucbB-1fnhA:17.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44MET A 46ARG A 57PRO A 79 | None | 0.98A | 3ucbB-1hvcA:13.2 | 3ucbB-1hvcA:38.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44MET A 46GLY A 78PRO A 79 | None | 0.63A | 3ucbB-1hvcA:13.2 | 3ucbB-1hvcA:38.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | TRP A 42PRO A 44MET A 46LYS A 55GLY A 78PRO A 79 | None | 0.60A | 3ucbB-1hvcA:13.2 | 3ucbB-1hvcA:38.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwg | BETA-GALACTOSIDASE (Thermusthermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | TRP A 11PRO A 356MET A 362ARG A 353GLY A 365 | CL A 801 (-4.4A)NoneNoneNoneNone | 1.46A | 3ucbB-1kwgA:undetectable | 3ucbB-1kwgA:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxy | FIMBRIN-LIKE PROTEIN (Arabidopsisthaliana) |
PF00307(CH) | 4 | PRO A 449LYS A 447ARG A 451PRO A 445 | None | 1.16A | 3ucbB-1pxyA:undetectable | 3ucbB-1pxyA:12.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 4 | MET A 46LYS A 55GLY A 78PRO A 79 | None | 1.38A | 3ucbB-1q9pA:9.6 | 3ucbB-1q9pA:80.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | PRO A 44MET A 46ARG A 57GLY A 78PRO A 79 | None | 0.95A | 3ucbB-1q9pA:9.6 | 3ucbB-1q9pA:80.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 4 | TRP A 42PRO A 44MET A 46PRO A 79 | None | 1.06A | 3ucbB-1q9pA:9.6 | 3ucbB-1q9pA:80.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t2w | SORTASE (Staphylococcusaureus) |
PF04203(Sortase) | 4 | TRP A 194PRO A 94GLY A 90PRO A 89 | GLY A 335 (-4.4A)NoneNoneNone | 1.39A | 3ucbB-1t2wA:undetectable | 3ucbB-1t2wA:25.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3t | ALCOHOLDEHYDROGENASE ALPHACHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 276ARG A 271GLY A 270PRO A 295 | NoneNAD A1377 ( 4.7A)NAD A1377 ( 3.8A)None | 1.37A | 3ucbB-1u3tA:undetectable | 3ucbB-1u3tA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjg | PUTATIVE LIPASE FROMTHE G-D-S-L FAMILY (Nostoc sp. PCC7120) |
PF13472(Lipase_GDSL_2) | 4 | PRO A 127ARG A 137GLY A 135PRO A 134 | None | 1.31A | 3ucbB-1vjgA:undetectable | 3ucbB-1vjgA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydw | AX110P-LIKE PROTEIN (Arabidopsisthaliana) |
PF01408(GFO_IDH_MocA) | 4 | PRO A 80LYS A 176ARG A 174GLY A 183 | None | 1.30A | 3ucbB-1ydwA:undetectable | 3ucbB-1ydwA:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amg | 1,4-ALPHA-D-GLUCANMALTOTETRAHYDROLASE (Pseudomonasstutzeri) |
PF00128(Alpha-amylase)PF09081(DUF1921) | 4 | PRO A 32ARG A 29GLY A 300PRO A 299 | None | 1.38A | 3ucbB-2amgA:undetectable | 3ucbB-2amgA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atm | HYALURONOGLUCOSAMINIDASE (Vespulavulgaris) |
PF01630(Glyco_hydro_56) | 4 | PRO A 75MET A 161GLY A 54PRO A 53 | None | 1.33A | 3ucbB-2atmA:undetectable | 3ucbB-2atmA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1z | UDP-GLUCOSEFLAVONOID 3-OGLYCOSYLTRANSFERASE (Vitis vinifera) |
PF00201(UDPGT) | 4 | LYS A 436ARG A 431GLY A 434PRO A 435 | None | 1.40A | 3ucbB-2c1zA:undetectable | 3ucbB-2c1zA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d8m | DNA-REPAIR PROTEINXRCC1 (Homo sapiens) |
PF00533(BRCT) | 4 | PRO A 9ARG A 11GLY A 15PRO A 16 | None | 1.08A | 3ucbB-2d8mA:undetectable | 3ucbB-2d8mA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2do5 | SPLICING FACTOR 3BSUBUNIT 2 (Homo sapiens) |
PF02037(SAP) | 4 | TRP A 4ARG A 44GLY A 47PRO A 48 | None | 1.16A | 3ucbB-2do5A:undetectable | 3ucbB-2do5A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2exr | CYTOKININDEHYDROGENASE 7 (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 4 | PRO A 157ARG A 158GLY A 185PRO A 186 | None | 1.36A | 3ucbB-2exrA:undetectable | 3ucbB-2exrA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h3j | HYPOTHETICAL PROTEINPA4359 (Pseudomonasaeruginosa) |
PF04023(FeoA) | 4 | PRO A 73ARG A 11GLY A 35PRO A 34 | None | 1.36A | 3ucbB-2h3jA:undetectable | 3ucbB-2h3jA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kkl | UNCHARACTERIZEDPROTEIN MB1858 (Mycobacteriumbovis) |
PF00498(FHA) | 4 | LYS A 141ARG A 62GLY A 63PRO A 64 | None | 1.25A | 3ucbB-2kklA:undetectable | 3ucbB-2kklA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kkl | UNCHARACTERIZEDPROTEIN MB1858 (Mycobacteriumbovis) |
PF00498(FHA) | 4 | LYS A 141ARG A 143GLY A 63PRO A 64 | None | 1.33A | 3ucbB-2kklA:undetectable | 3ucbB-2kklA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lqn | CRK-LIKE PROTEIN (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07653(SH3_2) | 4 | PRO A 103ARG A 104GLY A 17PRO A 18 | None | 1.18A | 3ucbB-2lqnA:undetectable | 3ucbB-2lqnA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nty | EMB|CAB41934.1RAC-LIKE GTP-BINDINGPROTEIN ARAC5 (Arabidopsisthaliana) |
PF00071(Ras)PF03759(PRONE) | 4 | PRO A 162ARG A 142GLY C 134PRO C 133 | None | 1.24A | 3ucbB-2ntyA:undetectable | 3ucbB-2ntyA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2osy | ENDOGLYCOCERAMIDASEII (Rhodococcus sp.) |
PF00150(Cellulase) | 4 | TRP A 195PRO A 234GLY A 241PRO A 242 | None | 1.19A | 3ucbB-2osyA:undetectable | 3ucbB-2osyA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2paj | PUTATIVECYTOSINE/GUANINEDEAMINASE (unidentified) |
PF01979(Amidohydro_1) | 4 | PRO A 422ARG A 423GLY A 433PRO A 434 | None | 1.24A | 3ucbB-2pajA:undetectable | 3ucbB-2pajA:12.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | PRO A 44LYS A 55ARG A 57PRO A 79 | None | 1.05A | 3ucbB-2rkfA:20.5 | 3ucbB-2rkfA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44LYS A 55GLY A 78PRO A 79 | None | 0.39A | 3ucbB-2rkfA:20.5 | 3ucbB-2rkfA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn8 | RETICULON-4-INTERACTING PROTEIN 1 (Homo sapiens) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 4 | PRO A 148MET A 344GLY A 347PRO A 348 | None | 0.90A | 3ucbB-2vn8A:undetectable | 3ucbB-2vn8A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wan | PULLULANASE (Bacillusacidopullulyticus) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | PRO A 309ARG A 310GLY A 363PRO A 334 | None | 1.24A | 3ucbB-2wanA:undetectable | 3ucbB-2wanA:8.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y3s | TAML (Streptomycessp. 307-9) |
PF01565(FAD_binding_4)PF08031(BBE) | 4 | PRO A 218ARG A 217GLY A 212PRO A 211 | None | 1.30A | 3ucbB-2y3sA:undetectable | 3ucbB-2y3sA:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | TRP A 194PRO A 210GLY A 94PRO A 95 | NoneNoneNoneHTL A 827 ( 4.7A) | 1.24A | 3ucbB-3ahiA:undetectable | 3ucbB-3ahiA:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | TRP A 194PRO A 210GLY A 94PRO A 95 | NoneNoneNoneTPP A 900 ( 4.6A) | 1.23A | 3ucbB-3ai7A:undetectable | 3ucbB-3ai7A:8.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 4 | PRO A 66ARG A 68GLY A 128PRO A 127 | None | 1.38A | 3ucbB-3b7fA:undetectable | 3ucbB-3b7fA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bio | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Porphyromonasgingivalis) |
PF01408(GFO_IDH_MocA)PF16654(DAPDH_C) | 4 | PRO A 256MET A 152GLY A 149PRO A 150 | ACT A3001 ( 4.1A)NoneNoneNone | 1.40A | 3ucbB-3bioA:undetectable | 3ucbB-3bioA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3byh | FIMBRIN ABD2 (Homo sapiens) |
PF00307(CH) | 4 | PRO B 449LYS B 447ARG B 451PRO B 445 | None | 1.16A | 3ucbB-3byhB:undetectable | 3ucbB-3byhB:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1j | GLYCOGEN SYNTHASE (Escherichiacoli) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 4 | TRP A 128PRO A 130ARG A 38PRO A 27 | None | 1.33A | 3ucbB-3d1jA:undetectable | 3ucbB-3d1jA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dip | ENOLASE (unidentified) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | PRO A 16ARG A 15GLY A 324PRO A 325 | None | 1.36A | 3ucbB-3dipA:undetectable | 3ucbB-3dipA:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 4 | MET A1107ARG A1112GLY A1114PRO A1115 | None | 1.32A | 3ucbB-3egwA:undetectable | 3ucbB-3egwA:5.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7q | VALINE-PYRUVATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00155(Aminotran_1_2) | 4 | TRP A 380PRO A 155GLY A 375PRO A 374 | None | 1.31A | 3ucbB-3g7qA:undetectable | 3ucbB-3g7qA:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ghg | FIBRINOGEN GAMMACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 4 | LYS C 273ARG C 275GLY C 268PRO C 269 | LYS C 273 ( 0.0A)ARG C 275 ( 0.6A)GLY C 268 ( 0.0A)PRO C 269 ( 1.1A) | 1.32A | 3ucbB-3ghgC:undetectable | 3ucbB-3ghgC:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3goa | 3-KETOACYL-COATHIOLASE (Salmonellaenterica) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | PRO A 277MET A 280GLY A 283PRO A 284 | None | 1.26A | 3ucbB-3goaA:undetectable | 3ucbB-3goaA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | MITOCHONDRIALUBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEXCORE PROTEIN 2 (Gallus gallus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 4 | TRP B 135PRO B 134ARG B 133PRO B 130 | None | 1.40A | 3ucbB-3h1lB:undetectable | 3ucbB-3h1lB:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l91 | ACYL-HOMOSERINELACTONE ACYLASE PVDQSUBUNIT BETA (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | TRP B 455ARG B 365GLY B 345PRO B 346 | NoneEDO B 912 (-2.8A)NoneNone | 1.26A | 3ucbB-3l91B:undetectable | 3ucbB-3l91B:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ml0 | PENICILLIN GACYLASE, BETASUBUNIT (Alcaligenesfaecalis) |
PF01804(Penicil_amidase) | 4 | TRP B 281MET B 495GLY B 21PRO B 22 | None | 1.29A | 3ucbB-3ml0B:undetectable | 3ucbB-3ml0B:11.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | TRP A 42PRO A 44MET A 46ARG A 57GLY A 78PRO A 79 | None | 0.43A | 3ucbB-3mwsA:20.2 | 3ucbB-3mwsA:70.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 4 | TRP A 294MET A 260ARG A 624PRO A 300 | None | 1.19A | 3ucbB-3nz4A:undetectable | 3ucbB-3nz4A:8.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oep | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA0988 (Thermusthermophilus) |
PF02626(CT_A_B)PF02682(CT_C_D) | 4 | PRO A 308ARG A 326GLY A 327PRO A 328 | None | 1.30A | 3ucbB-3oepA:undetectable | 3ucbB-3oepA:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcn | BETA-N-ACETYLHEXOSAMINIDASE (Paenarthrobacteraurescens) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b) | 4 | PRO A 56ARG A 36GLY A 37PRO A 38 | GOL A 563 (-3.6A)NoneGOL A 564 (-3.9A)GOL A 564 (-4.0A) | 1.37A | 3ucbB-3rcnA:undetectable | 3ucbB-3rcnA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slk | POLYKETIDE SYNTHASEEXTENDER MODULE 2 (Saccharopolysporaspinosa) |
PF08240(ADH_N)PF08659(KR)PF13602(ADH_zinc_N_2) | 4 | PRO A 276ARG A 191GLY A 280PRO A 281 | None | 1.14A | 3ucbB-3slkA:undetectable | 3ucbB-3slkA:8.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | PRO A 44MET A 46ARG A 57GLY A 78 | None | 0.82A | 3ucbB-3t3cA:18.7 | 3ucbB-3t3cA:69.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44ARG A 57GLY A 78PRO A 79 | None | 0.49A | 3ucbB-3t3cA:18.7 | 3ucbB-3t3cA:69.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t9p | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Roseovarius sp.TM1035) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 112LYS A 121GLY A 368PRO A 367 | None | 1.36A | 3ucbB-3t9pA:undetectable | 3ucbB-3t9pA:14.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | PRO A 44MET A 46LYS A 55ARG A 57 | None | 1.04A | 3ucbB-3ttpA:19.9 | 3ucbB-3ttpA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | TRP A 42PRO A 44MET A 46LYS A 55GLY A 78PRO A 79 | None | 0.50A | 3ucbB-3ttpA:19.9 | 3ucbB-3ttpA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tvt | DISKS LARGE 1 TUMORSUPPRESSOR PROTEIN (Drosophilamelanogaster) |
PF00018(SH3_1)PF00625(Guanylate_kin) | 4 | PRO A 787ARG A 786GLY A 964PRO A 965 | None | 1.37A | 3ucbB-3tvtA:undetectable | 3ucbB-3tvtA:16.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | TRP A 42PRO A 44GLY A 78PRO A 79 | None | 0.30A | 3ucbB-3u7sA:19.9 | 3ucbB-3u7sA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | TRP A 42LYS A 55GLY A 78PRO A 79 | None | 1.25A | 3ucbB-3uhlA:16.6 | 3ucbB-3uhlA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44ARG A 57GLY A 78PRO A 79 | None | 0.58A | 3ucbB-3uhlA:16.6 | 3ucbB-3uhlA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | TRP A 42PRO A 44MET A 46ARG A 57 | NoneNoneSO4 A 102 (-4.8A)None | 1.05A | 3ucbB-3uhlA:16.6 | 3ucbB-3uhlA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2q | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C)PF16739(CARD_2) | 4 | PRO A 118MET A 113GLY A 578PRO A 579 | None | 1.23A | 3ucbB-4a2qA:undetectable | 3ucbB-4a2qA:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2w | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C)PF16739(CARD_2) | 4 | PRO A 118MET A 113GLY A 578PRO A 579 | None | 1.33A | 3ucbB-4a2wA:undetectable | 3ucbB-4a2wA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyo | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 4 | PRO A 141MET A 138GLY A 269PRO A 270 | None | 1.17A | 3ucbB-4eyoA:undetectable | 3ucbB-4eyoA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f32 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Burkholderiavietnamiensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | PRO A 144MET A 78GLY A 122PRO A 121 | None | 1.35A | 3ucbB-4f32A:undetectable | 3ucbB-4f32A:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gj4 | SOLUBLE GUANYLYLCYCLASE ALPHA-1SUBUNIT (Manduca sexta) |
PF07701(HNOBA) | 4 | PRO A 348MET A 350LYS A 368GLY A 384 | None | 0.82A | 3ucbB-4gj4A:undetectable | 3ucbB-4gj4A:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 14 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 4 | PRO N 304ARG N 392GLY N 394PRO N 395 | None | 1.12A | 3ucbB-4heaN:undetectable | 3ucbB-4heaN:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ip4 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Ruegeria sp.TM1040) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 119LYS A 128GLY A 407PRO A 406 | None | 1.40A | 3ucbB-4ip4A:undetectable | 3ucbB-4ip4A:13.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nao | PUTATIVE OXYGENASE (Clavicepspurpurea) |
PF05721(PhyH) | 4 | LYS A 226ARG A 228GLY A 132PRO A 133 | NoneAKG A 402 (-2.9A)NoneNone | 1.30A | 3ucbB-4naoA:undetectable | 3ucbB-4naoA:17.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | TRP A 42PRO A 44GLY A 78PRO A 79 | None | 0.42A | 3ucbB-4njvA:20.0 | 3ucbB-4njvA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | TRP A 42PRO A 44MET A 46GLY A 78 | None | 0.57A | 3ucbB-4njvA:20.0 | 3ucbB-4njvA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nz0 | GENOME POLYPROTEIN (Cardiovirus A) |
PF00680(RdRP_1) | 4 | PRO A 393ARG A 392GLY A 388PRO A 389 | None | 1.09A | 3ucbB-4nz0A:undetectable | 3ucbB-4nz0A:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ol9 | PUTATIVE2-DEHYDROPANTOATE2-REDUCTASE (Mycobacteriumtuberculosis) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | TRP A 259PRO A 285GLY A 293PRO A 294 | None | 1.30A | 3ucbB-4ol9A:undetectable | 3ucbB-4ol9A:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6u | UNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 4 | MET A 1ARG A 66GLY A 88PRO A 89 | None | 1.02A | 3ucbB-4q6uA:undetectable | 3ucbB-4q6uA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjz | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (SUGAR) (Agrobacteriumfabrum) |
PF01547(SBP_bac_1) | 4 | PRO A 203ARG A 367GLY A 368PRO A 369 | None | 0.94A | 3ucbB-4rjzA:undetectable | 3ucbB-4rjzA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tym | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Streptococcusagalactiae) |
PF01048(PNP_UDP_1) | 4 | PRO A 44MET A 86ARG A 46GLY A 111 | NoneNoneNoneSO4 A 301 (-3.6A) | 1.36A | 3ucbB-4tymA:undetectable | 3ucbB-4tymA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x68 | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00144(Beta-lactamase) | 4 | PRO A 304ARG A 359GLY A 358PRO A 357 | None | 1.34A | 3ucbB-4x68A:undetectable | 3ucbB-4x68A:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfa | PROTEIN RELATED TOPENICILLIN ACYLASE (Acidovorax sp.MR-S7) |
PF01804(Penicil_amidase) | 4 | TRP C 248ARG C 152GLY C 129PRO C 130 | None | 1.30A | 3ucbB-4yfaC:undetectable | 3ucbB-4yfaC:9.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ay7 | XYLANASE (Aegilopsspeltoides) |
PF00331(Glyco_hydro_10) | 4 | PRO A 312ARG A 247GLY A 219PRO A 220 | None | 0.93A | 3ucbB-5ay7A:undetectable | 3ucbB-5ay7A:13.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44LYS A 55GLY A 78PRO A 79 | None | 0.73A | 3ucbB-5b18A:18.0 | 3ucbB-5b18A:73.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c9i | PROTEIN RELATED TOPENICILLIN ACYLASE (Acidovorax sp.MR-S7) |
PF01804(Penicil_amidase) | 4 | TRP A 450ARG A 354GLY A 331PRO A 332 | None | 1.35A | 3ucbB-5c9iA:undetectable | 3ucbB-5c9iA:6.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | MET A 779ARG A 784GLY A 786PRO A 787 | None | 1.30A | 3ucbB-5chcA:undetectable | 3ucbB-5chcA:7.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwj | HISTONE DEMETHYLASEJARID1C (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN)PF02928(zf-C5HC2) | 4 | PRO A 36LYS A 40GLY A 42PRO A 538 | None | 1.07A | 3ucbB-5fwjA:undetectable | 3ucbB-5fwjA:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gll | GLYCOSIDE HYDROLASEFAMILY 43 (unculturedbacterium) |
PF04616(Glyco_hydro_43) | 4 | PRO A 48ARG A 42GLY A 103PRO A 102 | None | 1.34A | 3ucbB-5gllA:undetectable | 3ucbB-5gllA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h71 | ALGQ2 (Sphingomonassp.) |
PF01547(SBP_bac_1) | 4 | TRP A 390ARG A 342GLY A 341PRO A 340 | None | 1.03A | 3ucbB-5h71A:undetectable | 3ucbB-5h71A:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7k | ELONGATION FACTOR 2 (Pyrococcushorikoshii) |
no annotation | 4 | PRO A 347MET A 345ARG A 349GLY A 342 | None | 1.16A | 3ucbB-5h7kA:undetectable | 3ucbB-5h7kA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE GAMMASUBUNIT (Aromatoleumaromaticum) |
PF01968(Hydantoinase_A)PF05378(Hydant_A_N) | 4 | TRP B 336PRO B 132GLY B 89PRO B 90 | None | 1.29A | 3ucbB-5l9wB:undetectable | 3ucbB-5l9wB:8.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | TRP A 42PRO A 44ARG A 57GLY A 78PRO A 79 | None | 0.27A | 3ucbB-5t2zA:20.7 | 3ucbB-5t2zA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | TRP A 42PRO A 44LYS A 55ARG A 57 | None | 0.65A | 3ucbB-5t2zA:20.7 | 3ucbB-5t2zA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2a | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Brucella canis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | PRO A 120MET A 201ARG A 133GLY A 214 | None | 1.16A | 3ucbB-5u2aA:undetectable | 3ucbB-5u2aA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | TRP A 239ARG A 149GLY A 129PRO A 130 | None | 1.14A | 3ucbB-5ubkA:undetectable | 3ucbB-5ubkA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhd | DNA-DIRECTED RNAPOLYMERASE SUBUNITALPHA (Mycobacteriumtuberculosis) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 4 | PRO A 67LYS A 131GLY A 101PRO A 102 | None | 1.27A | 3ucbB-5uhdA:undetectable | 3ucbB-5uhdA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wg6 | HISTONE-LYSINEN-METHYLTRANSFERASEEZH2,POLYCOMBPROTEIN SUZ12(E.C.2.1.1.43)CHIMERA (Homo sapiens) |
no annotation | 4 | TRP A 113PRO A 115ARG A 685GLY A 643 | NoneNoneA9G A9009 (-3.1A)None | 1.39A | 3ucbB-5wg6A:undetectable | 3ucbB-5wg6A:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xd2 | NUDIX FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF00293(NUDIX)PF00300(His_Phos_1) | 4 | PRO A 276ARG A 169GLY A 298PRO A 318 | NoneATP A 402 (-3.7A)NoneNone | 1.38A | 3ucbB-5xd2A:undetectable | 3ucbB-5xd2A:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ywp | JEV E PROTEIN (Japaneseencephalitisvirus) |
no annotation | 4 | TRP A 225PRO A 227ARG A 57GLY A 127 | None | 1.00A | 3ucbB-5ywpA:undetectable | 3ucbB-5ywpA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c80 | CYTOKININ OXIDASELUCKX1.1 (Linumusitatissimum) |
no annotation | 4 | PRO A 163ARG A 164GLY A 191PRO A 192 | None | 1.25A | 3ucbB-6c80A:undetectable | 3ucbB-6c80A:18.48 |