SIMILAR PATTERNS OF AMINO ACIDS FOR 3UA5_A_06XA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5u PROFILIN

(Hevea
brasiliensis) 		PF00235
(Profilin) 		5 LEU A1101
GLU A1046
LEU A1065
PRO A1040
PHE A1039
 None
 1.28A 3ua5A-1g5uA:
0.0		 3ua5A-1g5uA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		5 GLN A 383
GLU A 330
LEU A 347
PRO A 281
VAL A 379
 None
FE  A 501 ( 2.8A)
None
None
None
 1.45A 3ua5A-1phzA:
0.0		 3ua5A-1phzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		5 LEU A 122
ARG A 328
LEU A 325
GLU A 332
VAL A 102
 None
 1.49A 3ua5A-1ue8A:
12.8		 3ua5A-1ue8A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 ARG A 188
LEU A 187
PRO A 267
GLU A 262
VAL A 185
 None
 1.48A 3ua5A-2dulA:
0.0		 3ua5A-2dulA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 5 LEU B  81
ARG B 115
LEU B  67
GLU B 373
PHE B  85
 None
 1.31A 3ua5A-2pvcB:
undetectable		 3ua5A-2pvcB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ARG A 315
LEU A 317
GLU A 389
PHE A 272
VAL A 321
 None
 1.28A 3ua5A-2qb6A:
0.1		 3ua5A-2qb6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1022
ARG A 826
LEU A1073
GLU A1046
VAL A1001
 None
 1.31A 3ua5A-2vdcA:
0.0		 3ua5A-2vdcA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
coelicolor) 		PF00977
(His_biosynth) 		5 ARG A 100
GLU A   5
LEU A   7
PRO A 192
VAL A 212
 None
 1.26A 3ua5A-2x30A:
0.0		 3ua5A-2x30A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 LEU A 287
GLU A 264
GLU A 257
PHE A 256
VAL A 290
 None
 1.44A 3ua5A-3h5tA:
undetectable		 3ua5A-3h5tA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nul PROFILIN I

(Arabidopsis
thaliana) 		PF00235
(Profilin) 		5 LEU A 101
GLU A  46
LEU A  65
PRO A  40
PHE A  39
 None
 1.25A 3ua5A-3nulA:
undetectable		 3ua5A-3nulA:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 ARG A  73
GLN A 215
PRO A 368
GLU A 387
VAL A 477
 None
 1.44A 3ua5A-3tk3A:
53.5		 3ua5A-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 GLN A 215
GLU A 218
LEU A 219
PRO A 368
VAL A 477
 None
 1.28A 3ua5A-3tk3A:
53.5		 3ua5A-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 GLN A 215
GLU A 218
PRO A 368
GLU A 387
VAL A 477
 None
 1.27A 3ua5A-3tk3A:
53.5		 3ua5A-3tk3A:
79.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		5 ARG A 498
MET A 525
GLU A 680
PHE A 681
VAL A 500
 None
 1.48A 3ua5A-3up3A:
1.4		 3ua5A-3up3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esp PROFILIN

(Arachis
hypogaea) 		PF00235
(Profilin) 		5 LEU A 101
GLU A  46
LEU A  65
PRO A  40
PHE A  39
 None
 1.30A 3ua5A-4espA:
undetectable		 3ua5A-4espA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 GLU A  84
MET A  70
PRO A 109
GLU A  74
VAL A 106
 None
 1.23A 3ua5A-4fgwA:
1.5		 3ua5A-4fgwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ARG A 155
LEU A  22
PRO A 203
GLU A  32
PHE A  30
 None
 1.46A 3ua5A-4hj2A:
undetectable		 3ua5A-4hj2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 ARG A  27
LEU A  24
ARG A  68
PRO A 325
PHE A  74
 None
 1.35A 3ua5A-4hjwA:
undetectable		 3ua5A-4hjwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		5 ARG A 104
GLU A   9
LEU A  11
PRO A 196
VAL A 216
 None
 1.33A 3ua5A-4u28A:
undetectable		 3ua5A-4u28A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		6 LEU A 210
ARG A 102
GLU A   7
LEU A   9
PRO A 194
VAL A 214
 None
 1.50A 3ua5A-4x9sA:
undetectable		 3ua5A-4x9sA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		5 ARG A 120
LEU A 117
ARG A  93
GLU A  78
GLU A  97
 None
 1.33A 3ua5A-5dbkA:
undetectable		 3ua5A-5dbkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		5 LEU A 117
ARG A  93
GLU A  78
MET A 102
GLU A  97
 None
 1.36A 3ua5A-5dbkA:
undetectable		 3ua5A-5dbkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 5 LEU A 103
GLU A  48
LEU A  67
PRO A  42
PHE A  41
 None
 1.19A 3ua5A-5nzbA:
undetectable		 3ua5A-5nzbA:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 ARG A  73
GLN A 215
GLU A 218
PRO A 368
GLU A 387
 None
 1.09A 3ua5A-5wbgA:
54.8		 3ua5A-5wbgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 ARG A  73
GLN A 215
PRO A 368
GLU A 387
VAL A 477
 None
 1.20A 3ua5A-5wbgA:
54.8		 3ua5A-5wbgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 6 ARG A  73
MET A 365
PRO A 368
GLU A 387
PHE A 389
VAL A 477
 None
 0.83A 3ua5A-5wbgA:
54.8		 3ua5A-5wbgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 GLN A 215
GLU A 218
LEU A 219
PRO A 368
GLU A 387
 None
 1.07A 3ua5A-5wbgA:
54.8		 3ua5A-5wbgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 GLN A 215
LEU A 219
PRO A 368
GLU A 387
VAL A 477
 None
 1.12A 3ua5A-5wbgA:
54.8		 3ua5A-5wbgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 LEU A 219
PRO A 368
GLU A 387
PHE A 389
VAL A 477
 None
 1.03A 3ua5A-5wbgA:
54.8		 3ua5A-5wbgA:
100.00