SIMILAR PATTERNS OF AMINO ACIDS FOR 3UA5_A_06XA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		4 ILE A 261
ILE A 241
PHE A 243
LEU A 276
 None
 0.87A 3ua5A-1a7jA:
0.0		 3ua5A-1a7jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 ILE A 558
PHE A 542
SER A 507
GLU A 500
LEU A 519
 None
 1.24A 3ua5A-1bf5A:
2.4		 3ua5A-1bf5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		4 ILE A 141
ILE A  33
SER A 119
THR A 102
 None
 0.81A 3ua5A-1c3nA:
0.0		 3ua5A-1c3nA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 ILE A 160
ILE A 207
PHE A 164
LEU A 193
 None
 0.82A 3ua5A-1clxA:
0.0		 3ua5A-1clxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czv PROTEIN (COAGULATION
FACTOR V)

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 ILE A  71
ILE A 131
PHE A 127
GLU A  59
LEU A  62
 None
 1.36A 3ua5A-1czvA:
0.0		 3ua5A-1czvA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		4 ILE A 722
ILE A 702
PHE A 737
GLU A 686
 None
 0.87A 3ua5A-1d2nA:
0.0		 3ua5A-1d2nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 ILE A 548
ILE A 588
PHE A 570
LEU A 710
VAL A 706
 None
 1.13A 3ua5A-1e4oA:
1.4		 3ua5A-1e4oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 182
PHE A 157
GLU A 255
THR A 260
VAL A 235
 None
 1.41A 3ua5A-1ebdA:
0.0		 3ua5A-1ebdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ILE A 103
ILE A  60
PHE A  65
GLU A 134
 None
None
None
NAG  A 450 ( 3.0A)
 0.79A 3ua5A-1ethA:
0.0		 3ua5A-1ethA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 ILE A 201
THR A 159
LEU A  58
VAL A 105
 None
 0.81A 3ua5A-1eyyA:
1.2		 3ua5A-1eyyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyc DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(E2P)

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		4 ILE A  66
ILE A  84
LEU A  14
VAL A  26
 None
 0.85A 3ua5A-1fycA:
undetectable		 3ua5A-1fycA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE O 325
SER O 318
THR O  96
VAL O  15
 None
None
NAD  O 336 (-4.4A)
None
 0.80A 3ua5A-1gaeO:
undetectable		 3ua5A-1gaeO:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 231
PHE A  22
GLU A 188
LEU A 238
 None
ILE  A 500 (-4.8A)
None
None
 0.81A 3ua5A-1h74A:
undetectable		 3ua5A-1h74A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF01467
(CTP_transf_like) 		4 ILE A 157
PHE A  50
SER A 147
GLU A 134
 None
 0.87A 3ua5A-1hybA:
undetectable		 3ua5A-1hybA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ILE A1288
ILE A1128
SER A1294
LEU A1069
 None
 0.83A 3ua5A-1hzfA:
undetectable		 3ua5A-1hzfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 203
ILE A 147
SER A 134
GLU A 141
VAL A  94
 None
 1.49A 3ua5A-1ig8A:
undetectable		 3ua5A-1ig8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu1 GAMMA1-ADAPTIN

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 ILE A 735
ILE A 796
SER A 767
LEU A 715
VAL A 770
 None
 1.46A 3ua5A-1iu1A:
undetectable		 3ua5A-1iu1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8i MHC CLASS II H2-M
BETA 2 CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 ILE B 184
SER B 178
THR B 154
VAL B 126
 None
 0.81A 3ua5A-1k8iB:
undetectable		 3ua5A-1k8iB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ILE A  38
GLU A  60
THR A 185
LEU A 190
 None
 0.85A 3ua5A-1khdA:
undetectable		 3ua5A-1khdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3a P24: PLANT
TRANSCRIPTIONAL
REGULATOR PBF-2

(Solanum
tuberosum) 		PF08536
(Whirly) 		4 PHE A 227
GLU A 157
LEU A 132
VAL A 130
 None
 0.88A 3ua5A-1l3aA:
undetectable		 3ua5A-1l3aA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		4 PHE A 384
THR A  35
LEU A 371
VAL A 454
 None
 0.86A 3ua5A-1lrtA:
undetectable		 3ua5A-1lrtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 PHE A 384
THR A  35
LEU A 371
VAL A 454
 None
 0.86A 3ua5A-1mewA:
undetectable		 3ua5A-1mewA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs INTEGRAL MEMBRANE
PROTEIN SED5
SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1)
PF11416
(Syntaxin-5_N) 		4 ILE A 153
ILE A 112
SER B  13
LEU A 132
 None
 0.85A 3ua5A-1mqsA:
2.4		 3ua5A-1mqsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 ILE A 240
ILE A 275
SER A 244
LEU A 208
 None
 0.80A 3ua5A-1ny5A:
undetectable		 3ua5A-1ny5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		4 ILE A 430
ILE A 281
PHE A 283
GLU A 436
 None
 0.88A 3ua5A-1o5wA:
undetectable		 3ua5A-1o5wA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Escherichia
coli) 		PF02962
(CHMI) 		4 ILE A  68
ILE A  34
PHE A  35
GLU A  82
 SO4  A   1 ( 4.4A)
None
None
None
 0.80A 3ua5A-1otgA:
undetectable		 3ua5A-1otgA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		5 ILE A 155
ILE A 217
SER A  90
THR A 165
VAL A  93
 None
 1.24A 3ua5A-1p33A:
undetectable		 3ua5A-1p33A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk1 SEX COMB ON MIDLEG
CG9495-PA

(Drosophila
melanogaster) 		PF00536
(SAM_1) 		4 ILE B  26
ILE B  45
PHE B  40
VAL B  79
 None
 0.88A 3ua5A-1pk1B:
undetectable		 3ua5A-1pk1B:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		4 ILE A 315
GLU A  29
LEU A  34
VAL A  32
 None
 0.86A 3ua5A-1ps6A:
undetectable		 3ua5A-1ps6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		5 ILE A 181
PHE A 183
GLU A  85
THR A  81
LEU A 159
 None
 1.45A 3ua5A-1q14A:
undetectable		 3ua5A-1q14A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 273
PHE A 277
THR A 246
VAL A 260
 None
 0.83A 3ua5A-1r9jA:
0.5		 3ua5A-1r9jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		4 ILE A 295
PHE A 296
SER A 325
VAL A   4
 None
 0.80A 3ua5A-1ry6A:
undetectable		 3ua5A-1ry6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 ILE A1066
SER A1113
THR A1104
VAL A1121
 None
 0.79A 3ua5A-1sq5A:
undetectable		 3ua5A-1sq5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twu HYPOTHETICAL PROTEIN
YYCE

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 ILE A 120
ILE A  94
PHE A 130
GLU A  31
 None
 0.78A 3ua5A-1twuA:
undetectable		 3ua5A-1twuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 ILE C1008
ILE C 993
THR C1091
VAL C1048
 None
 0.82A 3ua5A-1u6gC:
undetectable		 3ua5A-1u6gC:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 ILE A 360
SER A 620
THR A 542
LEU A 510
 None
 0.84A 3ua5A-1uf2A:
0.0		 3ua5A-1uf2A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ILE A 149
ILE A 135
PHE A 133
LEU A 173
VAL A 179
 None
 1.35A 3ua5A-1v1pA:
undetectable		 3ua5A-1v1pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 163
ILE A 261
THR A 245
VAL A 283
 None
None
None
NAD  A 482 (-4.0A)
 0.86A 3ua5A-1v59A:
undetectable		 3ua5A-1v59A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 ILE A 222
PHE A  62
LEU A 271
VAL A 269
 ILE  A 222 ( 0.7A)
PHE  A  62 ( 1.3A)
LEU  A 271 ( 0.6A)
VAL  A 269 ( 0.6A)
 0.79A 3ua5A-1vhoA:
undetectable		 3ua5A-1vhoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 ILE A 299
ILE A 301
SER A 326
THR A   5
VAL A 181
 ILE  A 299 ( 0.7A)
ILE  A 301 ( 0.7A)
SER  A 326 ( 0.0A)
THR  A   5 ( 0.8A)
VAL  A 181 ( 0.6A)
 1.46A 3ua5A-1vhoA:
undetectable		 3ua5A-1vhoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ILE A 197
ILE A 233
GLU A 220
VAL A 279
 None
 0.88A 3ua5A-1vliA:
undetectable		 3ua5A-1vliA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS36P, YLR417W

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		4 ILE D 455
GLU D 465
LEU D 437
VAL D 487
 None
 0.85A 3ua5A-1w7pD:
undetectable		 3ua5A-1w7pD:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A2421
PHE A2459
SER A2393
VAL A2183
 None
 0.78A 3ua5A-1wchA:
undetectable		 3ua5A-1wchA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we8 TUDOR AND KH DOMAIN
CONTAINING PROTEIN

(Mus musculus) 		PF00013
(KH_1) 		4 ILE A  37
SER A  25
LEU A  19
VAL A  21
 None
 0.85A 3ua5A-1we8A:
undetectable		 3ua5A-1we8A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 ILE A 528
ILE A 538
PHE A 531
GLU A 506
VAL A 552
 None
 1.25A 3ua5A-1wmrA:
undetectable		 3ua5A-1wmrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ILE A 337
ILE A 343
LEU A 414
VAL A 417
 None
 0.69A 3ua5A-1wu7A:
undetectable		 3ua5A-1wu7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A   7
ILE A  85
GLU A  18
VAL A  71
 None
 0.88A 3ua5A-1wydA:
undetectable		 3ua5A-1wydA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF05362
(Lon_C) 		4 ILE A 462
ILE A 606
PHE A 572
LEU A 578
 None
 0.76A 3ua5A-1xhkA:
undetectable		 3ua5A-1xhkA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiq NUCLEOSIDE
DIPHOSPHATE KINASE B

(Plasmodium
falciparum) 		PF00334
(NDK) 		4 ILE A 129
THR A  41
LEU A  38
VAL A  70
 None
 0.85A 3ua5A-1xiqA:
undetectable		 3ua5A-1xiqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ILE A   7
SER A  20
LEU A  60
VAL A  18
 None
 0.87A 3ua5A-1xvxA:
undetectable		 3ua5A-1xvxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		4 ILE A  49
PHE A  59
LEU A  88
VAL A 122
 None
 0.84A 3ua5A-1ye8A:
undetectable		 3ua5A-1ye8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 ILE A 558
PHE A 542
SER A 507
GLU A 500
LEU A 519
 None
 1.29A 3ua5A-1yvlA:
undetectable		 3ua5A-1yvlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		4 PHE A 141
GLU A 116
LEU A 316
VAL A 314
 None
 0.70A 3ua5A-1yy5A:
0.9		 3ua5A-1yy5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ILE A 767
ILE A 750
PHE A 802
GLU A 738
 None
 0.85A 3ua5A-1z63A:
undetectable		 3ua5A-1z63A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A  19
ILE A  64
GLU A 145
VAL A 128
 None
 0.88A 3ua5A-1zejA:
undetectable		 3ua5A-1zejA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ILE A 297
ILE A  62
PHE A 105
GLU A 306
LEU A 222
 None
 1.42A 3ua5A-1zliA:
undetectable		 3ua5A-1zliA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		4 ILE A 276
ILE A  45
LEU A 233
VAL A 231
 None
 0.77A 3ua5A-1zupA:
undetectable		 3ua5A-1zupA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN

(Neisseria
meningitidis) 		PF00359
(PTS_EIIA_2) 		4 ILE A 100
SER A  21
GLU A  27
VAL A  19
 None
 0.81A 3ua5A-2a0jA:
undetectable		 3ua5A-2a0jA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN

(Neisseria
meningitidis) 		PF00359
(PTS_EIIA_2) 		4 ILE A 102
SER A  21
GLU A  27
VAL A  19
 None
 0.84A 3ua5A-2a0jA:
undetectable		 3ua5A-2a0jA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a38 TITIN

(Homo sapiens) 		PF07679
(I-set) 		5 ILE A 144
ILE A 163
PHE A 150
GLU A 190
LEU A 110
 None
 1.36A 3ua5A-2a38A:
undetectable		 3ua5A-2a38A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 ILE A 289
PHE A 283
GLU A 228
LEU A 311
 None
 0.87A 3ua5A-2af5A:
undetectable		 3ua5A-2af5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 266
SER A 328
GLU A 293
VAL A 290
 None
 0.69A 3ua5A-2avtA:
undetectable		 3ua5A-2avtA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ILE A  43
PHE A   4
SER A  87
THR A  18
 None
 0.73A 3ua5A-2awaA:
undetectable		 3ua5A-2awaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		4 ILE A  76
ILE A  58
PHE A  93
GLU A 247
 None
 0.83A 3ua5A-2bcoA:
undetectable		 3ua5A-2bcoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
SODIUM/HYDROGEN
EXCHANGER 1

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7)
no annotation 		5 ILE B 534
PHE A  90
GLU A  68
LEU A  51
VAL A  78
 None
 1.11A 3ua5A-2becB:
undetectable		 3ua5A-2becB:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1) 		4 ILE A 255
ILE A 313
LEU A 240
VAL A 329
 None
 0.87A 3ua5A-2bfwA:
undetectable		 3ua5A-2bfwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MAJOR PLASMODIAL
MYOSIN HEAVY CHAIN
MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF00612
(IQ)
PF13833
(EF-hand_8) 		5 ILE C 143
ILE A 813
PHE C  97
GLU C 128
LEU C 118
 None
 1.26A 3ua5A-2bl0C:
undetectable		 3ua5A-2bl0C:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 ILE A 183
ILE A  95
GLU A 210
LEU A 106
 None
 0.81A 3ua5A-2d4eA:
undetectable		 3ua5A-2d4eA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ILE A 335
PHE A 333
GLU A 381
VAL A 347
 None
 0.73A 3ua5A-2d7dA:
undetectable		 3ua5A-2d7dA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 ILE A 362
GLU A 355
THR A 304
LEU A 285
 None
 0.81A 3ua5A-2dbyA:
undetectable		 3ua5A-2dbyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehr INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  75
PHE A 104
SER A  87
GLU A  93
 None
 0.87A 3ua5A-2ehrA:
undetectable		 3ua5A-2ehrA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew7 PEPTIDE DEFORMYLASE

(Helicobacter
pylori) 		PF01327
(Pep_deformylase) 		4 ILE A  78
ILE A 140
GLU A  85
THR A  86
 None
 0.80A 3ua5A-2ew7A:
undetectable		 3ua5A-2ew7A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 106
ILE A 124
PHE A   5
LEU A  61
VAL A  42
 None
 1.45A 3ua5A-2f7lA:
undetectable		 3ua5A-2f7lA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A  33
PHE A  34
GLU A 131
THR A  75
 None
None
CO  A5367 ( 4.0A)
None
 0.87A 3ua5A-2f7vA:
undetectable		 3ua5A-2f7vA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		4 ILE A 108
SER A 175
THR A 166
LEU A  95
 None
 0.85A 3ua5A-2fb5A:
2.2		 3ua5A-2fb5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		4 ILE A 151
SER A 175
THR A 166
LEU A  95
 None
 0.81A 3ua5A-2fb5A:
2.2		 3ua5A-2fb5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb6 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02635
(DrsE) 		4 ILE A  71
ILE A   9
THR A  18
VAL A  51
 None
 0.87A 3ua5A-2fb6A:
undetectable		 3ua5A-2fb6A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkj OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 ILE A 358
PHE A 352
GLU A 297
LEU A 380
 None
 0.87A 3ua5A-2fkjA:
undetectable		 3ua5A-2fkjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ILE A  90
ILE A  97
THR A 232
LEU A 110
VAL A 156
 None
 1.46A 3ua5A-2fpqA:
undetectable		 3ua5A-2fpqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 ILE A 131
THR A 165
LEU A 113
VAL A 118
 None
 0.88A 3ua5A-2gduA:
undetectable		 3ua5A-2gduA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 ILE A  28
ILE A  80
GLU A 113
LEU A  87
 None
 0.86A 3ua5A-2go4A:
undetectable		 3ua5A-2go4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 ILE A 203
GLU A 148
LEU A 195
VAL A 193
 None
 0.82A 3ua5A-2gtxA:
undetectable		 3ua5A-2gtxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
delbrueckii) 		PF13419
(HAD_2) 		4 ILE A 114
ILE A 187
PHE A   8
GLU A 234
 None
 0.80A 3ua5A-2hi0A:
undetectable		 3ua5A-2hi0A:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 339
PHE A 427
GLU A 369
LEU A 433
 None
 0.81A 3ua5A-2hi4A:
40.1		 3ua5A-2hi4A:
32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ILE A 134
SER A 195
GLU A 156
VAL A 153
 None
 0.74A 3ua5A-2ijxA:
undetectable		 3ua5A-2ijxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 ILE A  26
PHE A 110
THR A 190
LEU A 203
 None
 0.74A 3ua5A-2in3A:
undetectable		 3ua5A-2in3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3e T7I23.11 PROTEIN

(Arabidopsis
thaliana) 		PF04548
(AIG1) 		5 ILE A  86
PHE A  26
SER A  55
LEU A 121
VAL A  53
 None
 1.39A 3ua5A-2j3eA:
undetectable		 3ua5A-2j3eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 ILE A  68
PHE A  67
THR A  77
LEU A 103
VAL A  90
 None
 1.25A 3ua5A-2jfnA:
undetectable		 3ua5A-2jfnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kks UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF14464
(Prok-JAB) 		4 ILE A 133
ILE A 108
GLU A  11
VAL A  39
 None
 0.87A 3ua5A-2kksA:
undetectable		 3ua5A-2kksA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		4 ILE A  83
ILE A  57
PHE A  59
GLU A 163
 None
 0.83A 3ua5A-2lkdA:
undetectable		 3ua5A-2lkdA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqj MG2+ TRANSPORT
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 167
ILE A 176
SER A 215
VAL A 223
 None
 0.87A 3ua5A-2lqjA:
undetectable		 3ua5A-2lqjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvz PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Geobacillus
kaustophilus) 		PF00160
(Pro_isomerase) 		4 ILE A   7
THR A  27
LEU A  19
VAL A 142
 None
 0.87A 3ua5A-2mvzA:
undetectable		 3ua5A-2mvzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1m PROBABLE AMINO-ACID
ABC TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YTMK

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		4 ILE A  46
ILE A  18
PHE A  58
LEU A  72
 None
 0.85A 3ua5A-2o1mA:
undetectable		 3ua5A-2o1mA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		4 ILE A  32
ILE A 184
PHE A 180
VAL A  50
 None
None
None
UNX  A2001 (-4.3A)
 0.82A 3ua5A-2o1zA:
undetectable		 3ua5A-2o1zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 352
ILE A 368
GLU A 313
THR A 314
 None
 0.88A 3ua5A-2oajA:
undetectable		 3ua5A-2oajA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 ILE O 241
PHE O 235
GLU O 180
LEU O 263
 None
 0.87A 3ua5A-2ol8O:
undetectable		 3ua5A-2ol8O:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owy RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Pseudomonas
aeruginosa) 		PF04381
(RdgC) 		4 ILE A  66
PHE A  44
SER A 160
LEU A  17
 None
 0.87A 3ua5A-2owyA:
undetectable		 3ua5A-2owyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 ILE A  19
ILE A 154
PHE A  43
LEU A 214
VAL A 220
 None
 1.49A 3ua5A-2p2vA:
undetectable		 3ua5A-2p2vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		4 ILE A 168
ILE A 222
SER A 203
GLU A 209
 CSF  A1001 (-4.3A)
None
None
None
 0.83A 3ua5A-2p2vA:
undetectable		 3ua5A-2p2vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 ILE A  62
ILE A  90
PHE A  66
VAL A  23
 None
 0.87A 3ua5A-2ph1A:
undetectable		 3ua5A-2ph1A:
20.21