SIMILAR PATTERNS OF AMINO ACIDS FOR 3U9F_R_CLMR221

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.27A 3u9fR-1auxA:
0.0		 3u9fR-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.31A 3u9fR-1auxA:
0.0		 3u9fR-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c28 PROTEIN (30 KD
ADIPOCYTE
COMPLEMENT-RELATED
PROTEIN PRECURSOR
(ACRP30))

(Mus musculus) 		PF00386
(C1q) 		5 PHE A 118
PHE A 163
LEU A 186
VAL A 185
VAL A 204
 None
 1.43A 3u9fR-1c28A:
undetectable		 3u9fR-1c28A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 SER A 388
PHE A 392
LEU A 284
VAL A 286
VAL A 210
 None
 1.25A 3u9fR-1c4kA:
3.4		 3u9fR-1c4kA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 TYR A 131
PHE A 310
LEU A 298
PHE A 240
VAL A 313
 None
 1.11A 3u9fR-1cvrA:
0.0		 3u9fR-1cvrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  33
SER A  51
LEU A  70
VAL A  66
VAL A  53
 None
 1.39A 3u9fR-1fcpA:
0.0		 3u9fR-1fcpA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 TYR A  45
PHE A 204
SER A  33
VAL A 106
VAL A 207
 None
 1.08A 3u9fR-1hr7A:
0.0		 3u9fR-1hr7A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Escherichia
coli) 		PF00392
(GntR)
PF07840
(FadR_C) 		5 PHE A  25
SER A  19
LEU A  48
VAL A  43
VAL A  51
 None
 1.36A 3u9fR-1hw2A:
0.0		 3u9fR-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		5 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
 None
 1.37A 3u9fR-1jg3A:
0.5		 3u9fR-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.34A 3u9fR-1kwgA:
0.0		 3u9fR-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 SER A 291
LEU A 303
VAL A 305
PHE A 310
VAL A 318
 None
 1.43A 3u9fR-1mdfA:
undetectable		 3u9fR-1mdfA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlf REGULATORY PROTEIN
REPA

(Escherichia
coli) 		PF13481
(AAA_25) 		5 SER A 210
PHE A 236
LEU A 136
VAL A  71
VAL A  23
 None
 1.24A 3u9fR-1nlfA:
undetectable		 3u9fR-1nlfA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npb FOSFOMYCIN-RESISTANC
E PROTEIN

(Serratia
marcescens) 		PF00903
(Glyoxalase) 		5 PHE A  70
PHE A 104
PHE A  21
LEU A  49
VAL A  12
 None
 1.25A 3u9fR-1npbA:
undetectable		 3u9fR-1npbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		5 SER A 219
PHE A 125
LEU A 132
VAL A 134
PHE A 172
 None
 1.36A 3u9fR-1o1yA:
undetectable		 3u9fR-1o1yA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		9 PHE A 102
SER A 104
TYR A 133
PHE A 134
PHE A 144
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.39A 3u9fR-1pd5A:
34.4		 3u9fR-1pd5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		9 PHE A 102
SER A 104
TYR A 133
PHE A 134
SER A 146
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.63A 3u9fR-1pd5A:
34.4		 3u9fR-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		5 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 0.98A 3u9fR-1pk6A:
undetectable		 3u9fR-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		5 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.50A 3u9fR-1sxlA:
undetectable		 3u9fR-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucr PROTEIN DSVD

(Desulfovibrio
vulgaris) 		PF08679
(DsrD) 		5 SER A  14
PHE A  11
LEU A  52
PHE A  27
VAL A   8
 None
 1.47A 3u9fR-1ucrA:
undetectable		 3u9fR-1ucrA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00307
(CH) 		5 PHE A 100
PHE A  89
SER A  38
LEU A  15
VAL A  44
 None
 1.33A 3u9fR-1wyrA:
undetectable		 3u9fR-1wyrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		5 SER A 330
PHE A 156
LEU A 193
VAL A 191
PHE A  97
 GOL  A 702 (-3.4A)
GOL  A 702 (-4.9A)
None
None
GOL  A 701 ( 4.7A)
 1.45A 3u9fR-1yjkA:
undetectable		 3u9fR-1yjkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A 213
LEU A 206
VAL A 195
PHE A 182
VAL A 210
 None
 1.34A 3u9fR-1yzyA:
undetectable		 3u9fR-1yzyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 SER A 275
PHE A 201
LEU A 316
VAL A 261
PHE A 227
 None
 1.36A 3u9fR-1zj9A:
undetectable		 3u9fR-1zj9A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		5 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.41A 3u9fR-2a1xA:
undetectable		 3u9fR-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 PHE A  44
SER A 265
LEU A 252
VAL A 281
VAL A 269
 None
 1.40A 3u9fR-2a7nA:
undetectable		 3u9fR-2a7nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.15A 3u9fR-2amcB:
3.2		 3u9fR-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 SER A 105
PHE A 308
LEU A 206
VAL A 474
VAL A 304
 None
 1.44A 3u9fR-2epgA:
1.0		 3u9fR-2epgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 TYR A 114
PHE A 117
LEU A 161
VAL A 165
VAL A 156
 None
 1.07A 3u9fR-2favA:
undetectable		 3u9fR-2favA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		5 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.36A 3u9fR-2fg5A:
undetectable		 3u9fR-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 PHE A 495
SER A 114
LEU A 586
VAL A 580
VAL A 590
 None
 1.42A 3u9fR-2hpiA:
undetectable		 3u9fR-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 SER A 590
LEU A 519
VAL A 523
PHE A 568
VAL A 515
 None
 1.48A 3u9fR-2iopA:
undetectable		 3u9fR-2iopA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH) 		5 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.32A 3u9fR-2ld7B:
undetectable		 3u9fR-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		5 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 1.02A 3u9fR-2pkhA:
undetectable		 3u9fR-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		5 SER A 235
SER A 160
LEU A 104
VAL A 107
PHE A  73
 None
 1.46A 3u9fR-2qvpA:
undetectable		 3u9fR-2qvpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
 None
 1.33A 3u9fR-2vdcA:
undetectable		 3u9fR-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 PHE A 658
SER A 653
LEU A 312
VAL A 295
VAL A 657
 None
 1.47A 3u9fR-2ww2A:
undetectable		 3u9fR-2ww2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME

(Candida
albicans) 		PF09084
(NMT1) 		5 PHE A  64
LEU A  17
VAL A 213
PHE A 209
VAL A   6
 None
 1.46A 3u9fR-2x7qA:
undetectable		 3u9fR-2x7qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd7 CORE HISTONE
MACRO-H2A.2

(Homo sapiens) 		PF01661
(Macro) 		5 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.31A 3u9fR-2xd7A:
undetectable		 3u9fR-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 PHE A 338
LEU A 636
VAL A 183
PHE A 349
VAL A 347
 None
 1.44A 3u9fR-2xr1A:
undetectable		 3u9fR-2xr1A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N

(Thermus
thermophilus) 		PF00578
(AhpC-TSA) 		5 SER A  11
PHE A 121
LEU A  28
PHE A  40
VAL A  38
 None
 1.37A 3u9fR-2ywoA:
undetectable		 3u9fR-2ywoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 SER A 218
LEU A 225
VAL A 228
PHE A 112
VAL A 165
 None
 1.44A 3u9fR-3a2qA:
undetectable		 3u9fR-3a2qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf SPIKE PROTEIN S1

(Severe acute
respiratory
syndrome-related
coronavirus) 		no annotation 5 PHE S 329
SER S 353
LEU S 374
VAL S 369
PHE S 501
 None
 1.43A 3u9fR-3bgfS:
undetectable		 3u9fR-3bgfS:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.10A 3u9fR-3e77A:
undetectable		 3u9fR-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		5 PHE A 164
LEU A 191
VAL A 206
PHE A 218
VAL A 135
 None
 1.46A 3u9fR-3fgbA:
undetectable		 3u9fR-3fgbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghj PUTATIVE INTEGRON
GENE CASSETTE
PROTEIN

(uncultured
bacterium) 		PF00903
(Glyoxalase) 		5 PHE A  70
PHE A 107
PHE A  24
LEU A  56
VAL A  15
 None
 1.33A 3u9fR-3ghjA:
undetectable		 3u9fR-3ghjA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		5 SER D 303
SER D 170
LEU D 352
PHE D 123
VAL D 168
 None
 1.18A 3u9fR-3k70D:
undetectable		 3u9fR-3k70D:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhx PUTATIVE FERROUS
IRON TRANSPORT
PROTEIN A

(Stenotrophomonas
maltophilia) 		PF04023
(FeoA) 		5 PHE A  63
LEU A   3
VAL A  73
PHE A  35
VAL A  56
 None
 1.44A 3u9fR-3mhxA:
undetectable		 3u9fR-3mhxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 PHE A 334
LEU A 378
VAL A 376
PHE A  59
VAL A 389
 None
 1.42A 3u9fR-3n2cA:
undetectable		 3u9fR-3n2cA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7v PIWI-LIKE PROTEIN 1

(Homo sapiens) 		PF02170
(PAZ) 		5 PHE X 295
PHE X 282
LEU X 362
VAL X 319
VAL X 279
 None
 1.38A 3u9fR-3o7vX:
undetectable		 3u9fR-3o7vX:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 PHE A 272
LEU A 310
VAL A 312
PHE A 317
VAL A 325
 None
 1.26A 3u9fR-3o82A:
undetectable		 3u9fR-3o82A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.06A 3u9fR-3o8lA:
undetectable		 3u9fR-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.28A 3u9fR-3p91A:
undetectable		 3u9fR-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnt NIEMANN-PICK C1-LIKE
PROTEIN 1

(Homo sapiens) 		PF16414
(NPC1_N) 		5 TYR A 156
PHE A  35
SER A  53
LEU A 103
VAL A 121
 None
 1.23A 3u9fR-3qntA:
undetectable		 3u9fR-3qntA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 SER A 228
TYR A 247
LEU A 178
VAL A 179
PHE A  83
 None
 1.17A 3u9fR-3r4vA:
undetectable		 3u9fR-3r4vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		5 SER N  84
PHE N 241
SER N  41
VAL J 153
VAL N  21
 None
 1.31A 3u9fR-3rkoN:
undetectable		 3u9fR-3rkoN:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1d ATLASTIN

(Drosophila
melanogaster) 		PF02263
(GBP) 		5 PHE A 189
TYR A 151
PHE A 139
PHE A 168
LEU A 228
 None
 1.37A 3u9fR-3x1dA:
undetectable		 3u9fR-3x1dA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A  15
PHE A  35
PHE A  80
LEU A 133
VAL A  64
 D15  A 500 ( 4.1A)
None
D15  A 500 ( 4.3A)
D15  A 500 (-4.5A)
None
 1.49A 3u9fR-4aguA:
undetectable		 3u9fR-4aguA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.32A 3u9fR-4cczA:
undetectable		 3u9fR-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8a POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Mus musculus) 		PF00027
(cNMP_binding) 		5 SER A 623
LEU A 626
VAL A 661
PHE A 644
VAL A 621
 None
 1.38A 3u9fR-4f8aA:
undetectable		 3u9fR-4f8aA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 SER N 262
TYR N 288
LEU N 299
VAL N 298
PHE N 326
 None
 1.34A 3u9fR-4heaN:
undetectable		 3u9fR-4heaN:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 PHE B 379
LEU B 324
VAL B 319
PHE B 315
VAL B 327
 None
 1.43A 3u9fR-4i6jB:
undetectable		 3u9fR-4i6jB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ

(Neisseria
meningitidis) 		PF07977
(FabA) 		5 PHE A  50
PHE A  54
VAL A 138
PHE A 100
VAL A  63
 None
 1.42A 3u9fR-4i83A:
undetectable		 3u9fR-4i83A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.32A 3u9fR-4itxA:
2.4		 3u9fR-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jh8 METALLOTHIOL
TRANSFERASE FOSB

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 PHE A  69
PHE A 106
PHE A  21
LEU A  49
VAL A  12
 None
 1.45A 3u9fR-4jh8A:
undetectable		 3u9fR-4jh8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.23A 3u9fR-4mrmA:
undetectable		 3u9fR-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nb0 METALLOTHIOL
TRANSFERASE FOSB

(Staphylococcus
aureus) 		PF00903
(Glyoxalase) 		5 PHE A  69
PHE A 106
PHE A  21
LEU A  49
VAL A  12
 None
 1.43A 3u9fR-4nb0A:
undetectable		 3u9fR-4nb0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvs PUTATIVE ENZYME,
GLYOXALASE FAMILY

(Clostridioides
difficile) 		PF12681
(Glyoxalase_2) 		5 PHE A  72
PHE A 108
PHE A  19
LEU A  44
VAL A  10
 None
 1.34A 3u9fR-4nvsA:
undetectable		 3u9fR-4nvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.37A 3u9fR-4od7A:
undetectable		 3u9fR-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovb PROTEIN OSA

(Shigella
flexneri) 		no annotation 5 PHE A 134
LEU A 165
VAL A 169
PHE A  74
VAL A 121
 None
 1.30A 3u9fR-4ovbA:
undetectable		 3u9fR-4ovbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhs FLAGELLAR REGULATORY
PROTEIN C

(Vibrio cholerae) 		PF00158
(Sigma54_activat) 		5 PHE A 284
LEU A 247
VAL A 246
PHE A 219
VAL A 267
 None
 1.09A 3u9fR-4qhsA:
undetectable		 3u9fR-4qhsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra0 TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		5 PHE C 119
SER C 121
LEU C  51
VAL C  53
VAL C 112
 None
 1.44A 3u9fR-4ra0C:
undetectable		 3u9fR-4ra0C:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 PHE A 203
SER A 201
LEU A 196
PHE A 156
VAL A 174
 None
 1.50A 3u9fR-4rvhA:
undetectable		 3u9fR-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946

(Branchiostoma
floridae) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PHE A  73
LEU A 139
VAL A 116
PHE A 121
VAL A 137
 None
 1.47A 3u9fR-4xsqA:
undetectable		 3u9fR-4xsqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER L 171
TYR L 140
LEU L  78
VAL L  19
VAL L  83
 None
 1.50A 3u9fR-4ydiL:
undetectable		 3u9fR-4ydiL:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 SER L 175
TYR L 177
PHE H 178
SER L 165
VAL H 164
 None
 1.47A 3u9fR-4yflL:
undetectable		 3u9fR-4yflL:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.33A 3u9fR-4yu5A:
undetectable		 3u9fR-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 PHE A 554
PHE A 741
VAL A 754
PHE A 315
VAL A 734
 None
 1.41A 3u9fR-5bs5A:
undetectable		 3u9fR-5bs5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 PHE A 193
SER A 191
LEU A 156
VAL A 119
VAL A 186
 None
 1.28A 3u9fR-5gt5A:
undetectable		 3u9fR-5gt5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 SER A  58
LEU A  64
VAL A 108
PHE A  24
VAL A  56
 None
 0.98A 3u9fR-5hkjA:
undetectable		 3u9fR-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		5 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.22A 3u9fR-5t2kA:
undetectable		 3u9fR-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 SER A  79
LEU A 104
VAL A  51
PHE A  36
VAL A 100
 None
 1.18A 3u9fR-5ti1A:
undetectable		 3u9fR-5ti1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 5 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.28A 3u9fR-5tjzA:
undetectable		 3u9fR-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 SER A 180
LEU A 160
VAL A 492
PHE A 464
VAL A 458
 None
 1.49A 3u9fR-5veuA:
undetectable		 3u9fR-5veuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 PHE C  11
SER C  13
LEU C  15
PHE C  80
VAL C  93
 None
 1.31A 3u9fR-5w4tC:
undetectable		 3u9fR-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woz REGULATOR OF TY1
TRANSPOSITION
PROTEIN 103

(Saccharomyces
cerevisiae) 		no annotation 5 SER A   1
LEU A  25
VAL A  63
PHE A  79
VAL A  35
 None
 1.47A 3u9fR-5wozA:
undetectable		 3u9fR-5wozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 5 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.32A 3u9fR-5xybA:
undetectable		 3u9fR-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.43A 3u9fR-6a91A:
undetectable		 3u9fR-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A  90
CYH A  84
HIS A  88
 HEM  A 601 (-4.3A)
HEM  A 601 (-1.9A)
HEM  A 601 (-3.2A)
 1.11A 3u9fS-1d4eA:
0.0		 3u9fS-1d4eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e96 NEUTROPHIL CYTOSOL
FACTOR 2 (NCF-2) TPR
DOMAIN, RESIDUES
1-203

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		3 PHE B 119
CYH B 121
HIS B 156
 None
 1.24A 3u9fS-1e96B:
undetectable		 3u9fS-1e96B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.04A 3u9fS-1f8fA:
0.0		 3u9fS-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		3 PHE A 260
CYH A 264
HIS A 261
 None
 0.97A 3u9fS-1fi4A:
0.0		 3u9fS-1fi4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 453
HIS A 458
 IPA  A1513 ( 4.9A)
CU  A1503 (-2.1A)
CU  A1503 (-3.1A)
 0.80A 3u9fS-1gycA:
0.0		 3u9fS-1gycA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 340
CYH A 452
HIS A 457
 None
CU  A 701 (-2.1A)
CU  A 701 (-3.1A)
 0.89A 3u9fS-1hfuA:
0.0		 3u9fS-1hfuA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		3 PHE A  80
CYH A  76
HIS A  88
 None
None
SO4  A 280 ( 4.7A)
 0.88A 3u9fS-1jovA:
0.0		 3u9fS-1jovA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khu SMAD1

(Homo sapiens) 		PF03166
(MH2) 		3 PHE A 366
CYH A 360
HIS A 364
 None
 1.15A 3u9fS-1khuA:
0.0		 3u9fS-1khuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 453
HIS A 458
 None
CU  A 500 (-2.2A)
CU  A 500 ( 3.3A)
 0.80A 3u9fS-1kyaA:
0.0		 3u9fS-1kyaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpv DOUBLESEX PROTEIN

(Drosophila
melanogaster) 		PF00751
(DM) 		3 PHE A  31
CYH A  34
HIS A  16
 None
ZN  A  53 (-2.2A)
ZN  A  53 (-3.3A)
 1.24A 3u9fS-1lpvA:
undetectable		 3u9fS-1lpvA:
10.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		3 PHE A  25
CYH A  31
HIS A 193
 None
 0.37A 3u9fS-1pd5A:
34.2		 3u9fS-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		3 PHE A 118
CYH A  87
HIS A 117
 NDP  A1003 ( 4.8A)
None
NDP  A1003 (-4.3A)
 1.08A 3u9fS-1q5mA:
undetectable		 3u9fS-1q5mA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A  85
CYH A  79
HIS A  83
 HEM  A 601 (-4.7A)
HEM  A 601 (-2.3A)
HEM  A 601 (-3.1A)
 1.13A 3u9fS-1qo8A:
undetectable		 3u9fS-1qo8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 343
CYH A 452
HIS A 457
 None
CU  A1503 (-2.1A)
CU  A1503 (-3.2A)
 0.82A 3u9fS-1v10A:
undetectable		 3u9fS-1v10A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfe RIKEN CDNA
2310008M20 PROTEIN

(Mus musculus) 		PF01428
(zf-AN1) 		3 PHE A  30
CYH A  28
HIS A  54
 None
ZN  A 201 (-2.3A)
ZN  A 201 (-3.2A)
 1.06A 3u9fS-1wfeA:
undetectable		 3u9fS-1wfeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6h TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 PHE A  35
CYH A  18
HIS A  20
 None
ZN  A 201 (-2.3A)
None
 1.19A 3u9fS-1x6hA:
undetectable		 3u9fS-1x6hA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 PHE A 110
CYH A  84
HIS A  86
 FES  A 500 (-4.1A)
FES  A 500 (-2.3A)
FES  A 500 (-3.2A)
 1.20A 3u9fS-1z01A:
undetectable		 3u9fS-1z01A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhv HYPOTHETICAL PROTEIN
ATU0741

(Agrobacterium
fabrum) 		PF13840
(ACT_7) 		3 PHE A  34
CYH A  65
HIS A 104
 None
 1.25A 3u9fS-1zhvA:
undetectable		 3u9fS-1zhvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		3 PHE A 141
CYH A  89
HIS A 139
 None
 0.89A 3u9fS-2bd0A:
undetectable		 3u9fS-2bd0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs3 PROTEIN C14ORF4

(Homo sapiens) 		PF00097
(zf-C3HC4) 		3 PHE A  41
CYH A  33
HIS A  39
 None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.1A)
 0.99A 3u9fS-2cs3A:
undetectable		 3u9fS-2cs3A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 PHE A  16
CYH A 306
HIS A 303
 None
 1.09A 3u9fS-2cy7A:
undetectable		 3u9fS-2cy7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlt MYOSIN BINDING
PROTEIN C, FAST-TYPE

(Mus musculus) 		PF07679
(I-set) 		3 PHE A  80
CYH A  30
HIS A  63
 None
 0.72A 3u9fS-2dltA:
undetectable		 3u9fS-2dltA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6r JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD) 		3 PHE A  44
CYH A  45
HIS A  42
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-2.9A)
 0.85A 3u9fS-2e6rA:
undetectable		 3u9fS-2e6rA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		3 PHE A  66
CYH A 105
HIS A 113
 None
 1.26A 3u9fS-2he3A:
undetectable		 3u9fS-2he3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 PHE A 249
CYH A 246
HIS A 184
 None
 1.27A 3u9fS-2hpiA:
undetectable		 3u9fS-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		3 PHE A  84
CYH A  80
HIS A  95
 None
 0.79A 3u9fS-2htbA:
undetectable		 3u9fS-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7j TRANSCRIPTION FACTOR
IIIA

(Xenopus laevis) 		PF00096
(zf-C2H2) 		3 PHE A   6
CYH A   4
HIS A   5
 None
ZN  A1086 (-2.2A)
None
 1.22A 3u9fS-2j7jA:
undetectable		 3u9fS-2j7jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 PHE A 418
CYH A 341
HIS A 422
 None
 0.95A 3u9fS-2oajA:
undetectable		 3u9fS-2oajA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		3 PHE A 172
CYH A  93
HIS A  97
 None
 1.21A 3u9fS-2oyoA:
undetectable		 3u9fS-2oyoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 PHE A 563
CYH A 626
HIS A 564
 None
 0.63A 3u9fS-2ozuA:
undetectable		 3u9fS-2ozuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 PHE A 391
CYH A 182
HIS A 321
 None
 1.22A 3u9fS-2p0uA:
undetectable		 3u9fS-2p0uA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfx UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Ruegeria sp.
TM1040) 		PF02627
(CMD) 		3 PHE A 167
CYH A  88
HIS A  92
 None
 1.22A 3u9fS-2pfxA:
undetectable		 3u9fS-2pfxA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 336
CYH A 452
HIS A 457
 None
CU  A 499 (-2.2A)
CU  A 499 (-3.1A)
 0.83A 3u9fS-2qt6A:
undetectable		 3u9fS-2qt6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		3 PHE A 481
CYH A 511
HIS A 486
 None
 0.77A 3u9fS-2vpjA:
undetectable		 3u9fS-2vpjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 451
HIS A 456
 None
CU  A 501 (-2.2A)
CU  A 501 ( 3.1A)
 0.80A 3u9fS-2xybA:
undetectable		 3u9fS-2xybA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys2 CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF00779
(BTK) 		3 PHE A  25
CYH A  27
HIS A  16
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 1.04A 3u9fS-2ys2A:
undetectable		 3u9fS-2ys2A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysm MYELOID/LYMPHOID OR
MIXED-LINEAGE
LEUKEMIA PROTEIN 3
HOMOLOG

(Homo sapiens) 		PF00628
(PHD) 		3 PHE A  82
CYH A  83
HIS A  80
 ZN  A 701 ( 4.9A)
ZN  A 701 (-2.3A)
ZN  A 701 (-3.0A)
 0.99A 3u9fS-2ysmA:
undetectable		 3u9fS-2ysmA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuz MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A  78
CYH A  29
HIS A  61
 None
 0.98A 3u9fS-2yuzA:
undetectable		 3u9fS-2yuzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		3 PHE A 164
CYH A  85
HIS A  89
 None
PEG  A 188 ( 3.9A)
PEG  A 188 (-4.4A)
 1.14A 3u9fS-3c1lA:
undetectable		 3u9fS-3c1lA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 PHE A  98
CYH A  93
HIS A  96
 None
CU  A 107 (-2.1A)
CU  A 107 (-3.3A)
 1.20A 3u9fS-3c75A:
undetectable		 3u9fS-3c75A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		3 PHE A 263
CYH A 267
HIS A 264
 None
 0.99A 3u9fS-3d4jA:
undetectable		 3u9fS-3d4jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dit PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		PF03166
(MH2) 		3 PHE A 356
CYH A 350
HIS A 354
 None
 1.07A 3u9fS-3ditA:
undetectable		 3u9fS-3ditA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		3 PHE A 263
CYH A 267
HIS A 264
 None
 0.95A 3u9fS-3f0nA:
undetectable		 3u9fS-3f0nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		no annotation 3 PHE D 356
CYH D 350
HIS D 354
 None
 1.00A 3u9fS-3gmjD:
undetectable		 3u9fS-3gmjD:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A 224
CYH A 191
HIS A 189
 None
 1.01A 3u9fS-3grfA:
undetectable		 3u9fS-3grfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kde TRANSPOSABLE ELEMENT
P TRANSPOSASE

(Drosophila
melanogaster) 		PF05485
(THAP) 		3 PHE C   6
CYH C   4
HIS C  47
 None
ZN  C  78 (-2.3A)
ZN  C  78 (-3.2A)
 1.24A 3u9fS-3kdeC:
undetectable		 3u9fS-3kdeC:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		3 PHE A  31
CYH A 126
HIS A 148
 None
 1.24A 3u9fS-3kkjA:
undetectable		 3u9fS-3kkjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 PHE A 462
CYH A 471
HIS A 460
 None
 0.96A 3u9fS-3ksyA:
undetectable		 3u9fS-3ksyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 456
HIS A 461
 None
CU  A 601 (-2.1A)
CU  A 601 (-3.1A)
 0.85A 3u9fS-3kw7A:
undetectable		 3u9fS-3kw7A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld1 REPLICASE
POLYPROTEIN 1A

(Avian
coronavirus) 		no annotation 3 PHE A 286
CYH A 331
HIS A 329
 None
 1.03A 3u9fS-3ld1A:
undetectable		 3u9fS-3ld1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 453
HIS A 458
 None
CU  A1503 (-2.1A)
CU  A1503 (-3.1A)
 0.78A 3u9fS-3pxlA:
undetectable		 3u9fS-3pxlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.24A 3u9fS-3rl3A:
undetectable		 3u9fS-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 341
CYH A 453
HIS A 458
 None
CU  A 501 (-2.0A)
CU  A 501 (-3.3A)
 0.71A 3u9fS-3t6wA:
undetectable		 3u9fS-3t6wA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		3 PHE A 134
CYH A 133
HIS A 264
 None
None
PHE  A 400 ( 4.5A)
 1.19A 3u9fS-3td9A:
undetectable		 3u9fS-3td9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		3 PHE A 214
CYH A 154
HIS A 212
 None
 1.09A 3u9fS-3tqrA:
undetectable		 3u9fS-3tqrA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 359
CYH A 475
HIS A 480
 None
CU  A 617 (-2.2A)
CU  A 617 (-3.1A)
 0.85A 3u9fS-3x1bA:
undetectable		 3u9fS-3x1bA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		3 PHE A 238
CYH A 234
HIS A  30
 None
 1.25A 3u9fS-3zs7A:
undetectable		 3u9fS-3zs7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 PHE A 156
CYH A  94
HIS A 154
 None
 1.15A 3u9fS-4ggjA:
undetectable		 3u9fS-4ggjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp4 EAG-LIKE K[+]
CHANNEL

(Drosophila
melanogaster) 		PF13426
(PAS_9) 		3 PHE A 110
CYH A 108
HIS A 129
 None
MLY  A 130 ( 3.9A)
None
 0.93A 3u9fS-4hp4A:
undetectable		 3u9fS-4hp4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 336
CYH A 450
HIS A 455
 None
CU  A 503 (-2.2A)
CU  A 503 (-3.1A)
 0.85A 3u9fS-4jhvA:
undetectable		 3u9fS-4jhvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k00 1,4-DIHYDROXY-2-NAPH
THOYL-COA HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF03061
(4HBT) 		3 PHE A  89
CYH A  91
HIS A 111
 None
 0.94A 3u9fS-4k00A:
undetectable		 3u9fS-4k00A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A   9
CYH A  33
HIS A   7
 None
 1.15A 3u9fS-4k0rA:
undetectable		 3u9fS-4k0rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmg IRON-REGULATED
TRANSCRIPTIONAL
ACTIVATOR AFT2

(Saccharomyces
cerevisiae) 		PF08731
(AFT) 		3 PHE A 111
CYH A  86
HIS A 133
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 1.25A 3u9fS-4lmgA:
undetectable		 3u9fS-4lmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmg IRON-REGULATED
TRANSCRIPTIONAL
ACTIVATOR AFT2

(Saccharomyces
cerevisiae) 		PF08731
(AFT) 		3 PHE A 111
CYH A 109
HIS A 133
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 1.15A 3u9fS-4lmgA:
undetectable		 3u9fS-4lmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 PHE A 283
CYH A 285
HIS A 275
 None
 1.11A 3u9fS-4nlbA:
undetectable		 3u9fS-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o64 LYSINE-SPECIFIC
DEMETHYLASE 2B

(Homo sapiens) 		PF02008
(zf-CXXC)
PF16866
(PHD_4) 		3 PHE A 629
CYH A 627
HIS A 628
 None
ZN  A2002 (-2.3A)
None
 1.18A 3u9fS-4o64A:
undetectable		 3u9fS-4o64A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeg TITIN

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A2907
CYH A2857
HIS A2890
 None
 1.25A 3u9fS-4qegA:
undetectable		 3u9fS-4qegA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvu UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF16285
(DUF4931) 		3 PHE A 222
CYH A 200
HIS A 197
 None
 0.97A 3u9fS-4qvuA:
undetectable		 3u9fS-4qvuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 3 PHE A 592
CYH A 562
HIS A 579
 HEM  A 813 ( 4.9A)
HEM  A 813 (-2.0A)
HEM  A 813 (-3.2A)
 1.03A 3u9fS-4rkmA:
undetectable		 3u9fS-4rkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A  27
CYH A  51
HIS A  25
 None
 1.00A 3u9fS-4u8hA:
undetectable		 3u9fS-4u8hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  91
CYH L  90
HIS L  32
 None
 1.14A 3u9fS-4xnyL:
undetectable		 3u9fS-4xnyL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxe ACCESSORY GENE
REGULATOR A

(Staphylococcus
aureus) 		PF04397
(LytTR) 		3 PHE A 203
CYH A 199
HIS A 200
 None
 1.03A 3u9fS-4xxeA:
undetectable		 3u9fS-4xxeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 PHE A  40
CYH A 268
HIS A  35
 None
 0.98A 3u9fS-4xzbA:
undetectable		 3u9fS-4xzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 PHE A 467
CYH A 465
HIS A 466
 None
 0.88A 3u9fS-4xzcA:
undetectable		 3u9fS-4xzcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 PHE A  40
CYH A 267
HIS A  35
 None
 1.03A 3u9fS-4xzwA:
undetectable		 3u9fS-4xzwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		3 PHE E 243
CYH E 145
HIS E 241
 None
 1.18A 3u9fS-5b04E:
undetectable		 3u9fS-5b04E:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 PHE A 664
CYH A 693
HIS A 605
 None
 0.95A 3u9fS-5d0fA:
undetectable		 3u9fS-5d0fA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 339
CYH A 451
HIS A 456
 None
CU  A 510 (-2.0A)
CU  A 510 (-3.1A)
 0.76A 3u9fS-5ehfA:
undetectable		 3u9fS-5ehfA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0f HDAC6

(Danio rerio) 		PF02148
(zf-UBP) 		3 PHE A1013
CYH A1011
HIS A1036
 None
ZN  A2083 (-2.3A)
ZN  A2083 (-3.2A)
 1.12A 3u9fS-5g0fA:
undetectable		 3u9fS-5g0fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdg HEAT SHOCK FACTOR
PROTEIN 1

(Homo sapiens) 		PF00447
(HSF_DNA-bind) 		3 PHE A  47
CYH A  36
HIS A  45
 None
 1.15A 3u9fS-5hdgA:
undetectable		 3u9fS-5hdgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2

(Homo sapiens) 		PF00400
(WD40) 		3 PHE A 573
CYH A 575
HIS A 581
 None
 1.14A 3u9fS-5igqA:
undetectable		 3u9fS-5igqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		3 PHE A 128
CYH A 101
HIS A  92
 None
 1.23A 3u9fS-5infA:
undetectable		 3u9fS-5infA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdd TITIN

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A 162
CYH A 112
HIS A 145
 None
 0.98A 3u9fS-5jddA:
undetectable		 3u9fS-5jddA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lug SPINDLIN-LIKE
PROTEIN 2, ISOFORM
CRA_A

(Homo sapiens) 		PF02513
(Spin-Ssty) 		3 PHE A 247
CYH A  92
HIS A 248
 None
 0.98A 3u9fS-5lugA:
undetectable		 3u9fS-5lugA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 341
CYH A 453
HIS A 458
 None
CU  A 504 (-2.1A)
CU  A 504 (-3.1A)
 0.72A 3u9fS-5mewA:
undetectable		 3u9fS-5mewA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		3 PHE 1 249
CYH 1 695
HIS 1 648
 None
 1.07A 3u9fS-5mz61:
undetectable		 3u9fS-5mz61:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 PHE A 331
CYH A  28
HIS A  30
 None
 1.24A 3u9fS-5n6uA:
undetectable		 3u9fS-5n6uA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 3 PHE A4556
CYH A4631
HIS A4552
 None
ZN  A4704 (-2.3A)
ZN  A4704 (-3.2A)
 0.96A 3u9fS-5o6cA:
undetectable		 3u9fS-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 3 PHE A4570
CYH A4572
HIS A4583
 None
 1.01A 3u9fS-5o6cA:
undetectable		 3u9fS-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile) 		no annotation 3 PHE B 164
CYH B 167
HIS B 169
 None
 1.04A 3u9fS-5ol2B:
undetectable		 3u9fS-5ol2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A   9
CYH A  33
HIS A   7
 None
 1.13A 3u9fS-5t5xA:
undetectable		 3u9fS-5t5xA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A 143
CYH A 176
HIS A  68
 None
 0.85A 3u9fS-5tnxA:
undetectable		 3u9fS-5tnxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzm OBSCURIN

(Homo sapiens) 		no annotation 3 PHE A  78
CYH A  25
HIS A  61
 None
 1.18A 3u9fS-5tzmA:
undetectable		 3u9fS-5tzmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vab ATXR5 PHD DOMAIN

(Glycine max) 		PF00628
(PHD) 		3 PHE A  50
CYH A  51
HIS A  48
 None
ZN  A 101 (-2.2A)
ZN  A 101 (-3.2A)
 0.73A 3u9fS-5vabA:
undetectable		 3u9fS-5vabA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 3 PHE A 156
CYH A 139
HIS A 154
 None
 1.27A 3u9fS-5w1aA:
undetectable		 3u9fS-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 3 PHE A 333
CYH A 336
HIS A 191
 None
 0.87A 3u9fS-5wa3A:
undetectable		 3u9fS-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x42 DOTN

(Legionella
pneumophila) 		no annotation 3 PHE A  57
CYH A  55
HIS A 122
 None
ZN  A 301 (-2.4A)
None
 1.20A 3u9fS-5x42A:
undetectable		 3u9fS-5x42A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5w SPINDLIN-1

(Homo sapiens) 		no annotation 3 PHE A 251
CYH A  96
HIS A 252
 None
 1.13A 3u9fS-5y5wA:
undetectable		 3u9fS-5y5wA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 3 PHE A 170
CYH A 168
HIS A 169
 None
 1.06A 3u9fS-6ejjA:
undetectable		 3u9fS-6ejjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		3 PHE A  86
CYH A  84
HIS A  72
 None
 1.06A 3u9fS-6fivA:
undetectable		 3u9fS-6fivA:
17.51