SIMILAR PATTERNS OF AMINO ACIDS FOR 3U9F_M_CLMM221

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.31A 3u9fM-1auxA:
0.0
3u9fN-1auxA:
0.0		 3u9fM-1auxA:
19.29
3u9fN-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cns CHITINASE

(Hordeum vulgare) 		PF00182
(Glyco_hydro_19) 		5 SER A  65
TYR A  84
VAL A   2
PHE A  44
PHE A  11
 None
 1.36A 3u9fM-1cnsA:
undetectable
3u9fN-1cnsA:
undetectable		 3u9fM-1cnsA:
19.92
3u9fN-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis) 		PF00182
(Glyco_hydro_19) 		5 SER A  66
TYR A  85
VAL A   3
PHE A  45
PHE A  12
 None
 1.40A 3u9fM-1dxjA:
undetectable
3u9fN-1dxjA:
undetectable		 3u9fM-1dxjA:
21.13
3u9fN-1dxjA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		7 PHE A 102
SER A 104
TYR A 133
SER A 146
VAL A 160
PHE A 166
VAL A 170
 None
 0.61A 3u9fM-1pd5A:
34.5
3u9fN-1pd5A:
34.8		 3u9fM-1pd5A:
100.00
3u9fN-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.35A 3u9fM-1pk8A:
0.0
3u9fN-1pk8A:
0.0		 3u9fM-1pk8A:
19.66
3u9fN-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 PHE B 208
SER B 232
TYR B 228
SER B 212
VAL B  29
 None
 1.40A 3u9fM-3r7wB:
0.0
3u9fN-3r7wB:
0.0		 3u9fM-3r7wB:
19.70
3u9fN-3r7wB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 SER A 211
SER A 250
VAL A 445
VAL A 402
CYH A 438
 None
 1.03A 3u9fM-3rblA:
0.0
3u9fN-3rblA:
0.0		 3u9fM-3rblA:
18.50
3u9fN-3rblA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		5 SER A  66
TYR A  85
VAL A   3
PHE A  45
PHE A  12
 None
 1.41A 3u9fM-3w3eA:
undetectable
3u9fN-3w3eA:
undetectable		 3u9fM-3w3eA:
22.47
3u9fN-3w3eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h17 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		PF00857
(Isochorismatase) 		5 SER A 134
VAL A  68
VAL A 136
PHE A  78
HIS A  70
 SO4  A 201 (-2.7A)
None
None
SO4  A 203 (-4.2A)
SO4  A 201 ( 3.8A)
 1.43A 3u9fM-4h17A:
0.0
3u9fN-4h17A:
0.0		 3u9fM-4h17A:
22.41
3u9fN-4h17A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 PHE A  31
VAL A 278
PHE A 245
VAL A  14
PHE A  43
 None
 1.39A 3u9fM-5y4gA:
0.0
3u9fN-5y4gA:
0.0		 3u9fM-5y4gA:
undetectable
3u9fN-5y4gA:
undetectable