SIMILAR PATTERNS OF AMINO ACIDS FOR 3U9F_I_CLMI221

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A  90
CYH A  84
HIS A  88
 HEM  A 601 (-4.3A)
HEM  A 601 (-1.9A)
HEM  A 601 (-3.2A)
 1.12A 3u9fG-1d4eA:
0.0		 3u9fG-1d4eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.10A 3u9fG-1f8fA:
0.0		 3u9fG-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		3 PHE A 260
CYH A 264
HIS A 261
 None
 0.90A 3u9fG-1fi4A:
undetectable		 3u9fG-1fi4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 453
HIS A 458
 IPA  A1513 ( 4.9A)
CU  A1503 (-2.1A)
CU  A1503 (-3.1A)
 0.88A 3u9fG-1gycA:
0.0		 3u9fG-1gycA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 340
CYH A 452
HIS A 457
 None
CU  A 701 (-2.1A)
CU  A 701 (-3.1A)
 0.97A 3u9fG-1hfuA:
0.0		 3u9fG-1hfuA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		3 PHE A  80
CYH A  76
HIS A  88
 None
None
SO4  A 280 ( 4.7A)
 0.96A 3u9fG-1jovA:
0.0		 3u9fG-1jovA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE X 216
CYH X 190
HIS X 218
 None
 1.23A 3u9fG-1jpdX:
0.0		 3u9fG-1jpdX:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 453
HIS A 458
 None
CU  A 500 (-2.2A)
CU  A 500 ( 3.3A)
 0.87A 3u9fG-1kyaA:
0.0		 3u9fG-1kyaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A  88
CYH A  82
HIS A  86
 HEM  A 804 (-4.6A)
HEM  A 804 (-2.5A)
HEM  A 804 (-3.3A)
 1.18A 3u9fG-1m64A:
undetectable		 3u9fG-1m64A:
17.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		3 PHE A  25
CYH A  31
HIS A 193
 None
 0.30A 3u9fG-1pd5A:
34.3		 3u9fG-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		3 PHE A 118
CYH A  87
HIS A 117
 NDP  A1003 ( 4.8A)
None
NDP  A1003 (-4.3A)
 1.04A 3u9fG-1q5mA:
undetectable		 3u9fG-1q5mA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A  85
CYH A  79
HIS A  83
 HEM  A 601 (-4.7A)
HEM  A 601 (-2.3A)
HEM  A 601 (-3.1A)
 1.15A 3u9fG-1qo8A:
undetectable		 3u9fG-1qo8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 343
CYH A 452
HIS A 457
 None
CU  A1503 (-2.1A)
CU  A1503 (-3.2A)
 0.88A 3u9fG-1v10A:
undetectable		 3u9fG-1v10A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfe RIKEN CDNA
2310008M20 PROTEIN

(Mus musculus) 		PF01428
(zf-AN1) 		3 PHE A  30
CYH A  28
HIS A  54
 None
ZN  A 201 (-2.3A)
ZN  A 201 (-3.2A)
 1.06A 3u9fG-1wfeA:
undetectable		 3u9fG-1wfeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6h TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 PHE A  35
CYH A  18
HIS A  20
 None
ZN  A 201 (-2.3A)
None
 1.16A 3u9fG-1x6hA:
undetectable		 3u9fG-1x6hA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 PHE A 110
CYH A  84
HIS A  86
 FES  A 500 (-4.1A)
FES  A 500 (-2.3A)
FES  A 500 (-3.2A)
 1.11A 3u9fG-1z01A:
0.9		 3u9fG-1z01A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhv HYPOTHETICAL PROTEIN
ATU0741

(Agrobacterium
fabrum) 		PF13840
(ACT_7) 		3 PHE A  34
CYH A  65
HIS A 104
 None
 1.20A 3u9fG-1zhvA:
undetectable		 3u9fG-1zhvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		3 PHE A 141
CYH A  89
HIS A 139
 None
 0.85A 3u9fG-2bd0A:
undetectable		 3u9fG-2bd0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs3 PROTEIN C14ORF4

(Homo sapiens) 		PF00097
(zf-C3HC4) 		3 PHE A  41
CYH A  33
HIS A  39
 None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.1A)
 1.04A 3u9fG-2cs3A:
undetectable		 3u9fG-2cs3A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 PHE A  16
CYH A 306
HIS A 303
 None
 1.14A 3u9fG-2cy7A:
undetectable		 3u9fG-2cy7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlt MYOSIN BINDING
PROTEIN C, FAST-TYPE

(Mus musculus) 		PF07679
(I-set) 		3 PHE A  80
CYH A  30
HIS A  63
 None
 0.73A 3u9fG-2dltA:
undetectable		 3u9fG-2dltA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6r JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD) 		3 PHE A  44
CYH A  45
HIS A  42
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-2.9A)
 0.86A 3u9fG-2e6rA:
undetectable		 3u9fG-2e6rA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 PHE A 249
CYH A 246
HIS A 184
 None
 1.17A 3u9fG-2hpiA:
undetectable		 3u9fG-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		3 PHE A  84
CYH A  80
HIS A  95
 None
 0.86A 3u9fG-2htbA:
undetectable		 3u9fG-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7j TRANSCRIPTION FACTOR
IIIA

(Xenopus laevis) 		PF00096
(zf-C2H2) 		3 PHE A   6
CYH A   4
HIS A   5
 None
ZN  A1086 (-2.2A)
None
 1.20A 3u9fG-2j7jA:
undetectable		 3u9fG-2j7jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 PHE A 418
CYH A 341
HIS A 422
 None
 0.94A 3u9fG-2oajA:
undetectable		 3u9fG-2oajA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		3 PHE A 172
CYH A  93
HIS A  97
 None
 1.26A 3u9fG-2oyoA:
undetectable		 3u9fG-2oyoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 PHE A 563
CYH A 626
HIS A 564
 None
 0.60A 3u9fG-2ozuA:
undetectable		 3u9fG-2ozuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 336
CYH A 452
HIS A 457
 None
CU  A 499 (-2.2A)
CU  A 499 (-3.1A)
 0.90A 3u9fG-2qt6A:
undetectable		 3u9fG-2qt6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		3 PHE A 481
CYH A 511
HIS A 486
 None
 0.84A 3u9fG-2vpjA:
undetectable		 3u9fG-2vpjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 451
HIS A 456
 None
CU  A 501 (-2.2A)
CU  A 501 ( 3.1A)
 0.88A 3u9fG-2xybA:
undetectable		 3u9fG-2xybA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01128
(IspD) 		3 PHE A 116
CYH A 176
HIS A 178
 None
 1.20A 3u9fG-2ycmA:
undetectable		 3u9fG-2ycmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys2 CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF00779
(BTK) 		3 PHE A  25
CYH A  27
HIS A  16
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 1.02A 3u9fG-2ys2A:
undetectable		 3u9fG-2ys2A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysm MYELOID/LYMPHOID OR
MIXED-LINEAGE
LEUKEMIA PROTEIN 3
HOMOLOG

(Homo sapiens) 		PF00628
(PHD) 		3 PHE A  82
CYH A  83
HIS A  80
 ZN  A 701 ( 4.9A)
ZN  A 701 (-2.3A)
ZN  A 701 (-3.0A)
 0.98A 3u9fG-2ysmA:
undetectable		 3u9fG-2ysmA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuz MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A  78
CYH A  29
HIS A  61
 None
 0.95A 3u9fG-2yuzA:
undetectable		 3u9fG-2yuzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		3 PHE A 164
CYH A  85
HIS A  89
 None
PEG  A 188 ( 3.9A)
PEG  A 188 (-4.4A)
 1.20A 3u9fG-3c1lA:
undetectable		 3u9fG-3c1lA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		3 PHE A  65
CYH A 120
HIS A 116
 None
 1.24A 3u9fG-3c6cA:
undetectable		 3u9fG-3c6cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		3 PHE A 263
CYH A 267
HIS A 264
 None
 0.92A 3u9fG-3d4jA:
undetectable		 3u9fG-3d4jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dit PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		PF03166
(MH2) 		3 PHE A 356
CYH A 350
HIS A 354
 None
 1.16A 3u9fG-3ditA:
undetectable		 3u9fG-3ditA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		3 PHE A 263
CYH A 267
HIS A 264
 None
 0.88A 3u9fG-3f0nA:
undetectable		 3u9fG-3f0nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		3 PHE A 139
CYH A 231
HIS A  72
 None
 1.22A 3u9fG-3fjyA:
undetectable		 3u9fG-3fjyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		no annotation 3 PHE D 356
CYH D 350
HIS D 354
 None
 1.11A 3u9fG-3gmjD:
undetectable		 3u9fG-3gmjD:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A 224
CYH A 191
HIS A 189
 None
 0.94A 3u9fG-3grfA:
undetectable		 3u9fG-3grfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 PHE A3109
CYH A3149
HIS A3201
 None
 1.07A 3u9fG-3hwcA:
undetectable		 3u9fG-3hwcA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 PHE A 462
CYH A 471
HIS A 460
 None
 0.90A 3u9fG-3ksyA:
undetectable		 3u9fG-3ksyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 456
HIS A 461
 None
CU  A 601 (-2.1A)
CU  A 601 (-3.1A)
 0.93A 3u9fG-3kw7A:
undetectable		 3u9fG-3kw7A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld1 REPLICASE
POLYPROTEIN 1A

(Avian
coronavirus) 		no annotation 3 PHE A 286
CYH A 331
HIS A 329
 None
 0.98A 3u9fG-3ld1A:
undetectable		 3u9fG-3ld1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		3 PHE A  95
CYH A  99
HIS A  96
 None
 1.21A 3u9fG-3nwoA:
undetectable		 3u9fG-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 337
CYH A 453
HIS A 458
 None
CU  A1503 (-2.1A)
CU  A1503 (-3.1A)
 0.86A 3u9fG-3pxlA:
undetectable		 3u9fG-3pxlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.21A 3u9fG-3rl3A:
undetectable		 3u9fG-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 341
CYH A 453
HIS A 458
 None
CU  A 501 (-2.0A)
CU  A 501 (-3.3A)
 0.78A 3u9fG-3t6wA:
undetectable		 3u9fG-3t6wA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		3 PHE A 134
CYH A 133
HIS A 264
 None
None
PHE  A 400 ( 4.5A)
 1.24A 3u9fG-3td9A:
undetectable		 3u9fG-3td9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		3 PHE A 214
CYH A 154
HIS A 212
 None
 1.04A 3u9fG-3tqrA:
undetectable		 3u9fG-3tqrA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 359
CYH A 475
HIS A 480
 None
CU  A 617 (-2.2A)
CU  A 617 (-3.1A)
 0.92A 3u9fG-3x1bA:
undetectable		 3u9fG-3x1bA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		3 PHE A 238
CYH A 234
HIS A  30
 None
 1.23A 3u9fG-3zs7A:
undetectable		 3u9fG-3zs7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 PHE A 156
CYH A  94
HIS A 154
 None
 1.09A 3u9fG-4ggjA:
undetectable		 3u9fG-4ggjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp4 EAG-LIKE K[+]
CHANNEL

(Drosophila
melanogaster) 		PF13426
(PAS_9) 		3 PHE A 110
CYH A 108
HIS A 129
 None
MLY  A 130 ( 3.9A)
None
 0.92A 3u9fG-4hp4A:
undetectable		 3u9fG-4hp4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 336
CYH A 450
HIS A 455
 None
CU  A 503 (-2.2A)
CU  A 503 (-3.1A)
 0.92A 3u9fG-4jhvA:
undetectable		 3u9fG-4jhvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k00 1,4-DIHYDROXY-2-NAPH
THOYL-COA HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF03061
(4HBT) 		3 PHE A  89
CYH A  91
HIS A 111
 None
 1.00A 3u9fG-4k00A:
undetectable		 3u9fG-4k00A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A   9
CYH A  33
HIS A   7
 None
 1.11A 3u9fG-4k0rA:
undetectable		 3u9fG-4k0rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmg IRON-REGULATED
TRANSCRIPTIONAL
ACTIVATOR AFT2

(Saccharomyces
cerevisiae) 		PF08731
(AFT) 		3 PHE A 111
CYH A  86
HIS A 133
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 1.23A 3u9fG-4lmgA:
undetectable		 3u9fG-4lmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmg IRON-REGULATED
TRANSCRIPTIONAL
ACTIVATOR AFT2

(Saccharomyces
cerevisiae) 		PF08731
(AFT) 		3 PHE A 111
CYH A 109
HIS A 133
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 1.18A 3u9fG-4lmgA:
undetectable		 3u9fG-4lmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 PHE A 283
CYH A 285
HIS A 275
 None
 1.03A 3u9fG-4nlbA:
undetectable		 3u9fG-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o64 LYSINE-SPECIFIC
DEMETHYLASE 2B

(Homo sapiens) 		PF02008
(zf-CXXC)
PF16866
(PHD_4) 		3 PHE A 629
CYH A 627
HIS A 628
 None
ZN  A2002 (-2.3A)
None
 1.21A 3u9fG-4o64A:
undetectable		 3u9fG-4o64A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00198
(2-oxoacid_dh) 		3 PHE A  32
CYH A 193
HIS A 195
 None
 1.04A 3u9fG-4ofsA:
16.6		 3u9fG-4ofsA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		3 PHE A 154
CYH A 161
HIS A 151
 None
 1.21A 3u9fG-4ovyA:
undetectable		 3u9fG-4ovyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeg TITIN

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A2907
CYH A2857
HIS A2890
 None
 1.20A 3u9fG-4qegA:
undetectable		 3u9fG-4qegA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvu UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF16285
(DUF4931) 		3 PHE A 222
CYH A 200
HIS A 197
 None
 0.93A 3u9fG-4qvuA:
undetectable		 3u9fG-4qvuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 3 PHE A 592
CYH A 562
HIS A 579
 HEM  A 813 ( 4.9A)
HEM  A 813 (-2.0A)
HEM  A 813 (-3.2A)
 1.05A 3u9fG-4rkmA:
undetectable		 3u9fG-4rkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsv OBSCURIN

(Homo sapiens) 		no annotation 3 PHE A  78
CYH A  25
HIS A  61
 None
 1.10A 3u9fG-4rsvA:
undetectable		 3u9fG-4rsvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A  27
CYH A  51
HIS A  25
 None
 0.98A 3u9fG-4u8hA:
undetectable		 3u9fG-4u8hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  91
CYH L  90
HIS L  32
 None
 1.06A 3u9fG-4xnyL:
undetectable		 3u9fG-4xnyL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxe ACCESSORY GENE
REGULATOR A

(Staphylococcus
aureus) 		PF04397
(LytTR) 		3 PHE A 203
CYH A 199
HIS A 200
 None
 1.04A 3u9fG-4xxeA:
undetectable		 3u9fG-4xxeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 PHE A  40
CYH A 268
HIS A  35
 None
 0.92A 3u9fG-4xzbA:
undetectable		 3u9fG-4xzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 PHE A 467
CYH A 465
HIS A 466
 None
 0.91A 3u9fG-4xzcA:
undetectable		 3u9fG-4xzcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 PHE A  40
CYH A 267
HIS A  35
 None
 0.97A 3u9fG-4xzwA:
undetectable		 3u9fG-4xzwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		3 PHE E 243
CYH E 145
HIS E 241
 None
 1.22A 3u9fG-5b04E:
undetectable		 3u9fG-5b04E:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 PHE A 664
CYH A 693
HIS A 605
 None
 0.85A 3u9fG-5d0fA:
undetectable		 3u9fG-5d0fA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 339
CYH A 451
HIS A 456
 None
CU  A 510 (-2.0A)
CU  A 510 (-3.1A)
 0.84A 3u9fG-5ehfA:
undetectable		 3u9fG-5ehfA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdg HEAT SHOCK FACTOR
PROTEIN 1

(Homo sapiens) 		PF00447
(HSF_DNA-bind) 		3 PHE A  47
CYH A  36
HIS A  45
 None
 1.13A 3u9fG-5hdgA:
undetectable		 3u9fG-5hdgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2

(Homo sapiens) 		PF00400
(WD40) 		3 PHE A 573
CYH A 575
HIS A 581
 None
 1.18A 3u9fG-5igqA:
undetectable		 3u9fG-5igqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		3 PHE A 128
CYH A 101
HIS A  92
 None
 1.19A 3u9fG-5infA:
undetectable		 3u9fG-5infA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdd TITIN

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A 162
CYH A 112
HIS A 145
 None
 0.93A 3u9fG-5jddA:
undetectable		 3u9fG-5jddA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		3 PHE A 221
CYH A 427
HIS A 413
 None
ZN  A 601 ( 4.2A)
None
 1.24A 3u9fG-5lb8A:
undetectable		 3u9fG-5lb8A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lug SPINDLIN-LIKE
PROTEIN 2, ISOFORM
CRA_A

(Homo sapiens) 		PF02513
(Spin-Ssty) 		3 PHE A 247
CYH A  92
HIS A 248
 None
 1.02A 3u9fG-5lugA:
undetectable		 3u9fG-5lugA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PHE A 341
CYH A 453
HIS A 458
 None
CU  A 504 (-2.1A)
CU  A 504 (-3.1A)
 0.79A 3u9fG-5mewA:
undetectable		 3u9fG-5mewA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		3 PHE 1 249
CYH 1 695
HIS 1 648
 None
 1.07A 3u9fG-5mz61:
undetectable		 3u9fG-5mz61:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 PHE A 331
CYH A  28
HIS A  30
 None
 1.23A 3u9fG-5n6uA:
undetectable		 3u9fG-5n6uA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 3 PHE A4556
CYH A4631
HIS A4552
 None
ZN  A4704 (-2.3A)
ZN  A4704 (-3.2A)
 0.99A 3u9fG-5o6cA:
undetectable		 3u9fG-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 3 PHE A4570
CYH A4572
HIS A4583
 None
 1.03A 3u9fG-5o6cA:
undetectable		 3u9fG-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile) 		no annotation 3 PHE B 164
CYH B 167
HIS B 169
 None
 1.07A 3u9fG-5ol2B:
undetectable		 3u9fG-5ol2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A   9
CYH A  33
HIS A   7
 None
 1.10A 3u9fG-5t5xA:
undetectable		 3u9fG-5t5xA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A 143
CYH A 176
HIS A  68
 None
 0.90A 3u9fG-5tnxA:
undetectable		 3u9fG-5tnxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzm OBSCURIN

(Homo sapiens) 		no annotation 3 PHE A  78
CYH A  25
HIS A  61
 None
 1.12A 3u9fG-5tzmA:
undetectable		 3u9fG-5tzmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vab ATXR5 PHD DOMAIN

(Glycine max) 		PF00628
(PHD) 		3 PHE A  50
CYH A  51
HIS A  48
 None
ZN  A 101 (-2.2A)
ZN  A 101 (-3.2A)
 0.72A 3u9fG-5vabA:
undetectable		 3u9fG-5vabA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 3 PHE A 156
CYH A 139
HIS A 154
 None
 1.26A 3u9fG-5w1aA:
undetectable		 3u9fG-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 3 PHE A 333
CYH A 336
HIS A 191
 None
 0.93A 3u9fG-5wa3A:
undetectable		 3u9fG-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5w SPINDLIN-1

(Homo sapiens) 		no annotation 3 PHE A 251
CYH A  96
HIS A 252
 None
 1.19A 3u9fG-5y5wA:
undetectable		 3u9fG-5y5wA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 3 PHE A 170
CYH A 168
HIS A 169
 None
 1.08A 3u9fG-6ejjA:
undetectable		 3u9fG-6ejjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		3 PHE A  86
CYH A  84
HIS A  72
 None
 1.11A 3u9fG-6fivA:
undetectable		 3u9fG-6fivA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agr RGS4

(Rattus
norvegicus) 		PF00615
(RGS) 		5 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.45A 3u9fI-1agrE:
undetectable		 3u9fI-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.29A 3u9fI-1auxA:
0.0		 3u9fI-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.31A 3u9fI-1auxA:
0.0		 3u9fI-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 THR A  33
SER A 399
PHE A 394
PHE A 374
VAL A 339
 None
 1.49A 3u9fI-1c4oA:
0.9		 3u9fI-1c4oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 TYR A 131
PHE A 310
LEU A 298
PHE A 240
VAL A 313
 None
 1.13A 3u9fI-1cvrA:
0.0		 3u9fI-1cvrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  33
SER A  51
LEU A  70
VAL A  66
VAL A  53
 None
 1.44A 3u9fI-1fcpA:
0.0		 3u9fI-1fcpA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 THR A  56
LEU A  17
VAL A  47
PHE A  37
VAL A  30
 None
 1.34A 3u9fI-1hdfA:
undetectable		 3u9fI-1hdfA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 TYR A  45
PHE A 204
SER A  33
VAL A 106
VAL A 207
 None
 1.03A 3u9fI-1hr7A:
0.0		 3u9fI-1hr7A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Escherichia
coli) 		PF00392
(GntR)
PF07840
(FadR_C) 		5 PHE A  25
SER A  19
LEU A  48
VAL A  43
VAL A  51
 None
 1.33A 3u9fI-1hw2A:
0.0		 3u9fI-1hw2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		5 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
 None
 1.47A 3u9fI-1jg3A:
0.0		 3u9fI-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		5 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.35A 3u9fI-1kr1A:
0.0		 3u9fI-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.37A 3u9fI-1kwgA:
undetectable		 3u9fI-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 SER A 487
LEU A 461
VAL A 403
PHE A 472
VAL A 464
 None
 1.50A 3u9fI-1kwgA:
undetectable		 3u9fI-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		5 SER A 219
PHE A 125
LEU A 132
VAL A 134
PHE A 172
 None
 1.28A 3u9fI-1o1yA:
undetectable		 3u9fI-1o1yA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		10 THR A  93
PHE A 102
SER A 104
TYR A 133
PHE A 144
SER A 146
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.56A 3u9fI-1pd5A:
34.4		 3u9fI-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		5 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.03A 3u9fI-1pk6A:
undetectable		 3u9fI-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.34A 3u9fI-1pk8A:
undetectable		 3u9fI-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.36A 3u9fI-1pk8A:
undetectable		 3u9fI-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		5 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.47A 3u9fI-1sxlA:
undetectable		 3u9fI-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmm HYPOTHETICAL UPF0310
PROTEIN PH1033

(Pyrococcus
horikoshii) 		PF01878
(EVE) 		5 THR A  67
SER A  68
LEU A  32
VAL A  24
VAL A  35
 None
 1.41A 3u9fI-1wmmA:
undetectable		 3u9fI-1wmmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		5 THR R  57
SER R  59
LEU R  62
VAL R  65
VAL R  38
 None
 1.39A 3u9fI-1y6nR:
undetectable		 3u9fI-1y6nR:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A 213
LEU A 206
VAL A 195
PHE A 182
VAL A 210
 None
 1.31A 3u9fI-1yzyA:
undetectable		 3u9fI-1yzyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.07A 3u9fI-1zybA:
undetectable		 3u9fI-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 PHE A  44
SER A 265
LEU A 252
VAL A 281
VAL A 269
 None
 1.43A 3u9fI-2a7nA:
undetectable		 3u9fI-2a7nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.31A 3u9fI-2ag8A:
undetectable		 3u9fI-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.10A 3u9fI-2amcB:
3.2		 3u9fI-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		5 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.39A 3u9fI-2fg5A:
undetectable		 3u9fI-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		5 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.98A 3u9fI-2pkhA:
undetectable		 3u9fI-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 THR A 306
SER A 260
LEU A  32
VAL A  35
VAL A 191
 None
 1.48A 3u9fI-2q1yA:
undetectable		 3u9fI-2q1yA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		5 SER A   6
LEU A  84
VAL A  39
PHE A  53
VAL A  27
 None
 1.49A 3u9fI-2qsvA:
undetectable		 3u9fI-2qsvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
 None
 1.36A 3u9fI-2vdcA:
undetectable		 3u9fI-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9z G1/S-SPECIFIC
CYCLIN-D1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 SER A  90
PHE A  45
LEU A  99
VAL A  60
VAL A  52
 None
 1.45A 3u9fI-2w9zA:
undetectable		 3u9fI-2w9zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		5 PHE A 148
PHE A  58
SER A  57
LEU A 131
VAL A 120
 FAD  A2762 (-3.0A)
None
None
None
None
 1.49A 3u9fI-2wsiA:
undetectable		 3u9fI-2wsiA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 THR A 670
PHE A 632
PHE A 684
VAL A 644
PHE A 649
 None
 1.45A 3u9fI-2x6kA:
undetectable		 3u9fI-2x6kA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.35A 3u9fI-2yevB:
undetectable		 3u9fI-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		5 THR A 210
PHE A 187
LEU A 156
VAL A 244
VAL A 228
 None
 1.43A 3u9fI-2zbwA:
undetectable		 3u9fI-2zbwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 THR A 218
LEU A 203
VAL A 418
PHE A 421
VAL A 321
 None
 1.49A 3u9fI-2zygA:
undetectable		 3u9fI-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 SER A 218
LEU A 225
VAL A 228
PHE A 112
VAL A 165
 None
 1.41A 3u9fI-3a2qA:
undetectable		 3u9fI-3a2qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 SER A 230
LEU A 225
VAL A 165
PHE A 112
VAL A 228
 None
 1.50A 3u9fI-3a2qA:
undetectable		 3u9fI-3a2qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		5 THR A 175
PHE A 199
LEU A 218
PHE A 251
VAL A 214
 None
 1.44A 3u9fI-3a3hA:
undetectable		 3u9fI-3a3hA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 PHE A 304
LEU A 159
VAL A 132
PHE A 134
VAL A 163
 None
 1.48A 3u9fI-3ak5A:
undetectable		 3u9fI-3ak5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 THR A 349
SER A 345
SER A  61
VAL A 268
PHE A 319
 None
 1.50A 3u9fI-3be7A:
undetectable		 3u9fI-3be7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 THR A3042
SER A3041
SER A3044
LEU A3277
VAL A3323
 None
 1.42A 3u9fI-3cmvA:
undetectable		 3u9fI-3cmvA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.11A 3u9fI-3e77A:
1.9		 3u9fI-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		5 PHE A 164
LEU A 191
VAL A 206
PHE A 218
VAL A 135
 None
 1.45A 3u9fI-3fgbA:
undetectable		 3u9fI-3fgbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.01A 3u9fI-3mc2A:
undetectable		 3u9fI-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhx PUTATIVE FERROUS
IRON TRANSPORT
PROTEIN A

(Stenotrophomonas
maltophilia) 		PF04023
(FeoA) 		5 PHE A  63
LEU A   3
VAL A  73
PHE A  35
VAL A  56
 None
 1.48A 3u9fI-3mhxA:
undetectable		 3u9fI-3mhxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 PHE A 334
LEU A 378
VAL A 376
PHE A  59
VAL A 389
 None
 1.46A 3u9fI-3n2cA:
undetectable		 3u9fI-3n2cA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7v PIWI-LIKE PROTEIN 1

(Homo sapiens) 		PF02170
(PAZ) 		5 PHE X 295
PHE X 282
LEU X 362
VAL X 319
VAL X 279
 None
 1.46A 3u9fI-3o7vX:
undetectable		 3u9fI-3o7vX:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 PHE A 272
LEU A 310
VAL A 312
PHE A 317
VAL A 325
 None
 1.24A 3u9fI-3o82A:
undetectable		 3u9fI-3o82A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.04A 3u9fI-3o8lA:
undetectable		 3u9fI-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1i EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 THR A  45
LEU A 132
VAL A 157
PHE A 181
VAL A 107
 None
 1.49A 3u9fI-3p1iA:
undetectable		 3u9fI-3p1iA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.33A 3u9fI-3p91A:
undetectable		 3u9fI-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 SER A   7
LEU A  94
VAL A  41
PHE A  19
VAL A  53
 None
 1.34A 3u9fI-3qc0A:
undetectable		 3u9fI-3qc0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		5 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.19A 3u9fI-3r2jA:
undetectable		 3u9fI-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 PHE B 208
SER B 232
TYR B 228
SER B 212
VAL B  29
 None
 1.45A 3u9fI-3r7wB:
undetectable		 3u9fI-3r7wB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
 None
 1.32A 3u9fI-3tefA:
undetectable		 3u9fI-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 THR A 525
PHE A 520
LEU A 413
VAL A 449
VAL A 517
 None
 1.16A 3u9fI-3ua4A:
undetectable		 3u9fI-3ua4A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jus HEAT SHOCK PROTEIN
BETA-6

(Homo sapiens) 		PF00011
(HSP20) 		5 PHE A  83
LEU A 142
VAL A  99
PHE A 117
VAL A  80
 None
 1.30A 3u9fI-4jusA:
undetectable		 3u9fI-4jusA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		5 THR A 343
SER A  49
LEU A 309
VAL A  97
PHE A 326
 None
 1.20A 3u9fI-4mfiA:
undetectable		 3u9fI-4mfiA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.31A 3u9fI-4mrmA:
undetectable		 3u9fI-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A  93
LEU A  62
VAL A  64
PHE A 102
VAL A  30
 None
 1.39A 3u9fI-4nfnA:
undetectable		 3u9fI-4nfnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.33A 3u9fI-4od7A:
undetectable		 3u9fI-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		5 THR A 157
SER A 162
LEU A   9
VAL A 148
VAL A  34
 FDA  A 501 (-3.8A)
FDA  A 501 (-2.9A)
None
None
None
 1.27A 3u9fI-4opuA:
undetectable		 3u9fI-4opuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 5 PHE E  25
SER E  19
LEU E  48
VAL E  43
VAL E  51
 None
 1.38A 3u9fI-4p9uE:
undetectable		 3u9fI-4p9uE:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 PHE A  26
LEU A 333
VAL A  56
PHE A  52
VAL A 125
 None
 1.50A 3u9fI-4q3rA:
undetectable		 3u9fI-4q3rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhs FLAGELLAR REGULATORY
PROTEIN C

(Vibrio cholerae) 		PF00158
(Sigma54_activat) 		5 PHE A 284
LEU A 247
VAL A 246
PHE A 219
VAL A 267
 None
 1.10A 3u9fI-4qhsA:
undetectable		 3u9fI-4qhsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra0 TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		5 PHE C 119
SER C 121
LEU C  51
VAL C  53
VAL C 112
 None
 1.50A 3u9fI-4ra0C:
undetectable		 3u9fI-4ra0C:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 PHE A 203
SER A 201
LEU A 196
PHE A 156
VAL A 174
 None
 1.50A 3u9fI-4rvhA:
undetectable		 3u9fI-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		5 THR A 329
PHE A  44
SER A 284
TYR A 250
PHE A 253
 None
None
None
None
MAN  A 510 (-4.6A)
 1.49A 3u9fI-4utfA:
undetectable		 3u9fI-4utfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w91 AMINOTRANSFERASE

(Brucella suis) 		PF00266
(Aminotran_5) 		5 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.19A 3u9fI-4w91A:
undetectable		 3u9fI-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 THR A 265
SER A 268
LEU A  33
VAL A 250
VAL A 272
 None
 1.45A 3u9fI-4wcjA:
undetectable		 3u9fI-4wcjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 PHE A 179
TYR A 113
LEU A  46
VAL A 224
VAL A  50
 2A1  A 403 (-4.5A)
None
2A1  A 403 (-4.9A)
None
None
 1.48A 3u9fI-4xf5A:
0.9		 3u9fI-4xf5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwj PHOSPHOCARRIER
PROTEIN HPR

(Escherichia
coli) 		PF00381
(PTS-HPr) 		5 THR B  59
SER B  37
LEU B  50
VAL B  23
VAL B  35
 None
 1.38A 3u9fI-4xwjB:
undetectable		 3u9fI-4xwjB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 SER L 175
TYR L 177
PHE H 178
SER L 165
VAL H 164
 None
 1.38A 3u9fI-4yflL:
undetectable		 3u9fI-4yflL:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.32A 3u9fI-4yu5A:
undetectable		 3u9fI-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR A 274
SER A 273
PHE A 499
SER A 482
LEU A 492
 None
 1.37A 3u9fI-5c9iA:
undetectable		 3u9fI-5c9iA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7z LACTOYLGLUTATHIONE
LYASE

(Zea mays) 		PF00903
(Glyoxalase) 		5 THR A 231
TYR A 198
SER A 237
PHE A 171
VAL A 241
 None
 1.44A 3u9fI-5d7zA:
undetectable		 3u9fI-5d7zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eur UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		no annotation 5 THR A  43
SER A  42
LEU A   8
VAL A  21
PHE A  31
 None
 1.01A 3u9fI-5eurA:
undetectable		 3u9fI-5eurA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 PHE A 169
SER A 191
LEU A 156
VAL A 119
VAL A 186
 None
 1.33A 3u9fI-5gt5A:
undetectable		 3u9fI-5gt5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 PHE A 193
SER A 191
LEU A 156
VAL A 119
VAL A 186
 None
 1.33A 3u9fI-5gt5A:
undetectable		 3u9fI-5gt5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtq LUCIFERIN
REGENERATING ENZYME

(Photinus
pyralis) 		PF08450
(SGL) 		5 THR A 122
LEU A  75
VAL A  54
PHE A  39
VAL A  73
 None
None
None
HG  A 402 (-4.2A)
None
 1.47A 3u9fI-5gtqA:
undetectable		 3u9fI-5gtqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 SER A  58
LEU A  64
VAL A 108
PHE A  24
VAL A  56
 None
 1.04A 3u9fI-5hkjA:
undetectable		 3u9fI-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lum HEAT SHOCK PROTEIN
BETA-6

(Homo sapiens) 		PF00011
(HSP20) 		5 PHE A  83
LEU A 142
VAL A  99
PHE A 117
VAL A  80
 None
None
None
SO4  A 201 ( 4.6A)
None
 1.31A 3u9fI-5lumA:
undetectable		 3u9fI-5lumA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ola TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 THR A 332
LEU A 344
VAL A 191
PHE A 317
VAL A 300
 None
 1.45A 3u9fI-5olaA:
undetectable		 3u9fI-5olaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		5 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.23A 3u9fI-5t2kA:
undetectable		 3u9fI-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 SER A  79
LEU A 104
VAL A  51
PHE A  36
VAL A 100
 None
 1.16A 3u9fI-5ti1A:
undetectable		 3u9fI-5ti1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN

(Zea mays) 		PF07714
(Pkinase_Tyr) 		5 THR A 787
SER A 836
SER A 775
LEU A 791
PHE A 802
 None
None
ANP  A1101 (-2.6A)
None
None
 1.45A 3u9fI-5uv4A:
undetectable		 3u9fI-5uv4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 THR A 261
SER A 224
TYR A 254
VAL A 209
PHE A 167
 None
 1.46A 3u9fI-5w19A:
0.6		 3u9fI-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 PHE C  11
SER C  13
LEU C  15
PHE C  80
VAL C  93
 None
 1.31A 3u9fI-5w4tC:
undetectable		 3u9fI-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woz REGULATOR OF TY1
TRANSPOSITION
PROTEIN 103

(Saccharomyces
cerevisiae) 		no annotation 5 SER A   1
LEU A  25
VAL A  63
PHE A  79
VAL A  35
 None
 1.45A 3u9fI-5wozA:
undetectable		 3u9fI-5wozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 THR C 790
SER C 562
LEU C 500
VAL C 499
PHE C 515
 None
 1.43A 3u9fI-5x6xC:
undetectable		 3u9fI-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.40A 3u9fI-6a91A:
undetectable		 3u9fI-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.40A 3u9fI-6cajC:
undetectable		 3u9fI-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 5 THR A 539
SER A 537
TYR A 578
SER A 541
PHE A 279
 None
 1.40A 3u9fI-6coyA:
undetectable		 3u9fI-6coyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 5 THR B 138
PHE B 207
LEU B 271
VAL B 275
PHE B 288
 None
 1.22A 3u9fI-6fpeB:
undetectable		 3u9fI-6fpeB:
undetectable