SIMILAR PATTERNS OF AMINO ACIDS FOR 3U9F_A_CLMA221_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 PHE A  80
ALA A 148
CYH A  76
HIS A  88
 None
None
None
SO4  A 280 ( 4.7A)
 1.04A 3u9fB-1jovA:
0.0		 3u9fB-1jovA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 PHE A  25
ALA A  29
CYH A  31
HIS A 193
 None
 0.25A 3u9fB-1pd5A:
34.4		 3u9fB-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		4 PHE A  84
ALA A 162
CYH A  80
HIS A  95
 None
 0.94A 3u9fB-2htbA:
0.0		 3u9fB-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 PHE A 594
ALA A 203
CYH A 213
HIS A 604
 None
 1.49A 3u9fB-3egwA:
0.0		 3u9fB-3egwA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens) 		PF00644
(PARP) 		4 PHE A1197
ALA A1300
CYH A1252
HIS A1184
 None
None
None
2XS  A1402 (-4.2A)
 1.46A 3u9fB-4oa7A:
0.0		 3u9fB-4oa7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 4 PHE 1  75
ALA 1 134
CYH 1  77
HIS 1  71
 None
 1.50A 3u9fB-6epd1:
0.0		 3u9fB-6epd1:
undetectable