SIMILAR PATTERNS OF AMINO ACIDS FOR 3U8Q_A_NPUA7231_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1arl | APO-CARBOXYPEPTIDASEA=ALPHA= (COX) (Bos taurus) |
PF00246(Peptidase_M14) | 4 | THR A 129GLY A 115PRO A 113ASN A 112 | None | 0.87A | 3u8qA-1arlA:undetectable | 3u8qA-1arlA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aye | PROCARBOXYPEPTIDASEA2 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | THR A 129GLY A 115PRO A 113ASN A 112 | None | 0.88A | 3u8qA-1ayeA:undetectable | 3u8qA-1ayeA:23.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1biy | LACTOFERRIN (Bubalus bubalis) |
PF00405(Transferrin) | 5 | THR A 430GLY A 432PRO A 593ASN A 594TYR A 660 | None | 0.46A | 3u8qA-1biyA:41.1 | 3u8qA-1biyA:91.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dtd | CARBOXYPEPTIDASE A2 (Homo sapiens) |
PF00246(Peptidase_M14) | 4 | THR A 484GLY A 470PRO A 468ASN A 467 | None | 0.87A | 3u8qA-1dtdA:undetectable | 3u8qA-1dtdA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gvl | KALLIKREIN 6 (Homo sapiens) |
PF00089(Trypsin) | 4 | GLY A 221PRO A 225ASN A 217TYR A 172 | None | 1.01A | 3u8qA-1gvlA:undetectable | 3u8qA-1gvlA:18.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h76 | SEROTRANSFERRIN (Sus scrofa) |
PF00405(Transferrin) | 4 | GLY A 430PRO A 592ASN A 593TYR A 658 | None | 0.29A | 3u8qA-1h76A:43.6 | 3u8qA-1h76A:31.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hbz | CATALASE (Micrococcusluteus) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | THR A 449GLY A 491PRO A 493ASN A 232 | None | 1.29A | 3u8qA-1hbzA:undetectable | 3u8qA-1hbzA:21.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1i6q | LACTOFERRIN (Camelusdromedarius) |
PF00405(Transferrin) | 4 | GLY A 432PRO A 593ASN A 594TYR A 660 | None | 0.61A | 3u8qA-1i6qA:27.2 | 3u8qA-1i6qA:55.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jhd | SULFATEADENYLYLTRANSFERASE (Sulfur-oxidizingendosymbiont ofRiftiapachyptila) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 4 | THR A 179GLY A 50PRO A 12TYR A 16 | None | 1.09A | 3u8qA-1jhdA:undetectable | 3u8qA-1jhdA:22.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jnf | SEROTRANSFERRIN (Oryctolaguscuniculus) |
PF00405(Transferrin) | 4 | GLY A 424PRO A 580ASN A 581TYR A 647 | None | 0.42A | 3u8qA-1jnfA:50.4 | 3u8qA-1jnfA:30.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k4q | GLUTATHIONEREDUCTASE (Homo sapiens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | THR A 156GLY A 158PRO A 293ASN A 294 | FAD A 499 (-3.9A)NoneNoneFAD A 499 ( 4.5A) | 0.87A | 3u8qA-1k4qA:undetectable | 3u8qA-1k4qA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1luf | MUSCLE-SPECIFICTYROSINE KINASERECEPTOR MUSK (Rattusnorvegicus) |
PF07714(Pkinase_Tyr) | 4 | THR A 603GLY A 595PRO A 598TYR A 599 | None | 1.19A | 3u8qA-1lufA:undetectable | 3u8qA-1lufA:22.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n76 | LACTOFERRIN (Homo sapiens) |
PF00405(Transferrin) | 4 | GLY A 434PRO A 595ASN A 596TYR A 662 | None | 0.30A | 3u8qA-1n76A:52.9 | 3u8qA-1n76A:68.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n94 | PROTEINFARNESYLTRANSFERASEBETA SUBUNIT (Rattusnorvegicus) |
PF00432(Prenyltrans) | 4 | THR B 153GLY B 141PRO B 148TYR B 180 | None | 0.94A | 3u8qA-1n94B:undetectable | 3u8qA-1n94B:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pca | PROCARBOXYPEPTIDASEA PCPA (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | THR A 129GLY A 115PRO A 113ASN A 112 | None | 0.92A | 3u8qA-1pcaA:undetectable | 3u8qA-1pcaA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1r | PUTIDAREDOXINREDUCTASE (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 4 | THR A 110GLY A 112PRO A 250ASN A 251 | FAD A 749 (-4.2A)FAD A 749 (-4.6A)NoneFAD A 749 ( 4.6A) | 0.70A | 3u8qA-1q1rA:undetectable | 3u8qA-1q1rA:22.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qjm | LACTOFERRIN (Equus caballus) |
PF00405(Transferrin) | 4 | GLY A 432PRO A 593ASN A 594TYR A 660 | None | 0.36A | 3u8qA-1qjmA:53.4 | 3u8qA-1qjmA:45.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r3f | TRNA PSEUDOURIDINESYNTHASE B (Escherichiacoli) |
PF01509(TruB_N)PF09157(TruB-C_2)PF16198(TruB_C_2) | 4 | THR A 284GLY A 286PRO A 257ASN A 255 | None | 1.04A | 3u8qA-1r3fA:undetectable | 3u8qA-1r3fA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry6 | INTERNAL KINESIN (Plasmodiumfalciparum) |
PF00225(Kinesin) | 4 | GLY A 104PRO A 114ASN A 64TYR A 119 | None | 1.06A | 3u8qA-1ry6A:undetectable | 3u8qA-1ry6A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgq | STREPTOMYCES GRISEUSPROTEINASE B (Streptomycesgriseus) |
PF00089(Trypsin) | 4 | THR E 157GLY E 140PRO E 198TYR E 200 | None | 1.09A | 3u8qA-1sgqE:undetectable | 3u8qA-1sgqE:19.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1suv | SEROTRANSFERRIN,C-LOBE (Homo sapiens) |
PF00405(Transferrin) | 4 | GLY E 424PRO E 580ASN E 581TYR E 647 | None | 0.42A | 3u8qA-1suvE:50.2 | 3u8qA-1suvE:58.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u1h | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Arabidopsisthaliana) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 4 | THR A 669GLY A 696PRO A 731ASN A 730 | None | 0.96A | 3u8qA-1u1hA:undetectable | 3u8qA-1u1hA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASESUBUNIT 2(P-PROTEIN) (Thermusthermophilus) |
PF02347(GDC-P) | 4 | THR B 214GLY B 216PRO B 212ASN B 213 | None | 1.25A | 3u8qA-1wytB:undetectable | 3u8qA-1wytB:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfg | GLUCOSAMINE--FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE[ISOMERIZING] (Escherichiacoli) |
PF13522(GATase_6) | 4 | THR A 122GLY A 78PRO A 80ASN A 84 | HGA A5300 ( 4.6A)NoneNoneNone | 1.05A | 3u8qA-1xfgA:undetectable | 3u8qA-1xfgA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0r | POSSIBLE ADENYLCYCLASE-ASSOCIATEDPROTEIN (Cryptosporidiumparvum) |
PF08603(CAP_C) | 4 | THR A 39GLY A 41PRO A 43ASN A 56 | None | 1.03A | 3u8qA-2b0rA:undetectable | 3u8qA-2b0rA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4i | OUTER CAPSID PROTEINVP4 (Rotavirus A) |
PF17477(Rota_VP4_MID) | 4 | THR A 381GLY A 383ASN A 457TYR A 462 | None | 1.26A | 3u8qA-2b4iA:undetectable | 3u8qA-2b4iA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boa | CARBOXYPEPTIDASE A4 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | THR A1129GLY A1115PRO A1113ASN A1112 | None | 0.87A | 3u8qA-2boaA:undetectable | 3u8qA-2boaA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1c | CARBOXYPEPTIDASE B (Helicoverpa zea) |
PF00246(Peptidase_M14) | 4 | THR A 129GLY A 115PRO A 113ASN A 112 | None | 0.83A | 3u8qA-2c1cA:undetectable | 3u8qA-2c1cA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn3 | BETA-1,4-XYLOGLUCANHYDROLASE (Ruminiclostridiumthermocellum) |
PF02012(BNR) | 4 | THR A 232GLY A 234PRO A 236ASN A 235 | None | 1.26A | 3u8qA-2cn3A:undetectable | 3u8qA-2cn3A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d40 | PUTATIVE GENTISATE1,2-DIOXYGENASE (Escherichiacoli) |
PF07883(Cupin_2) | 4 | GLY A 250PRO A 252ASN A 245TYR A 215 | None | 1.20A | 3u8qA-2d40A:undetectable | 3u8qA-2d40A:21.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hau | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 4 | GLY A 425PRO A 583ASN A 584TYR A 650 | None | 0.77A | 3u8qA-2hauA:27.0 | 3u8qA-2hauA:31.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inr | DNA TOPOISOMERASE 4SUBUNIT A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV) | 4 | THR A 169GLY A 167PRO A 181TYR A 262 | None | 1.26A | 3u8qA-2inrA:undetectable | 3u8qA-2inrA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6h | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF01380(SIS)PF13522(GATase_6) | 4 | THR A 122GLY A 78PRO A 80ASN A 84 | ONL A1609 ( 4.7A)NoneNoneNone | 1.02A | 3u8qA-2j6hA:undetectable | 3u8qA-2j6hA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcu | CARBOXYPEPTIDASE A4 (Homo sapiens) |
PF00246(Peptidase_M14) | 4 | THR A 129GLY A 115PRO A 113ASN A 112 | None | 0.86A | 3u8qA-2pcuA:undetectable | 3u8qA-2pcuA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | GLY A 37PRO A 35ASN A 34TYR A 30 | None | 1.24A | 3u8qA-2v4jA:undetectable | 3u8qA-2v4jA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsi | FAD SYNTHETASE (Saccharomycescerevisiae) |
PF01507(PAPS_reduct) | 4 | THR A 222GLY A 302PRO A 232ASN A 233 | None | 1.16A | 3u8qA-2wsiA:undetectable | 3u8qA-2wsiA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x2i | ALPHA-1,4-GLUCANLYASE ISOZYME 1 (Gracilariopsislemaneiformis) |
PF01055(Glyco_hydro_31) | 4 | THR A 838GLY A 858PRO A 835TYR A 793 | None | 1.25A | 3u8qA-2x2iA:undetectable | 3u8qA-2x2iA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7i | MEVALONATE KINASE (Staphylococcusaureus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | THR A 146GLY A 143PRO A 141ASN A 131 | None | 1.24A | 3u8qA-2x7iA:undetectable | 3u8qA-2x7iA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x9a | ATTACHMENT PROTEING3P (Escherichiavirus If1) |
PF05357(Phage_Coat_A) | 4 | THR A 16GLY A 53ASN A 52TYR A 45 | None | 1.22A | 3u8qA-2x9aA:undetectable | 3u8qA-2x9aA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 4 | GLY A 925PRO A 929ASN A 930TYR A 873 | None | 1.25A | 3u8qA-3aibA:undetectable | 3u8qA-3aibA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjx | PROTEIN OF UNKNOWNFUNCTION WITH ACUPIN-LIKE FOLD (Cupriaviduspinatubonensis) |
no annotation | 4 | THR A 58GLY A 56PRO A 106TYR A 78 | None | 0.81A | 3u8qA-3cjxA:undetectable | 3u8qA-3cjxA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euc | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE 2 (Cupriaviduspinatubonensis) |
PF00155(Aminotran_1_2) | 4 | THR A 169GLY A 117PRO A 114ASN A 166 | None | 1.17A | 3u8qA-3eucA:undetectable | 3u8qA-3eucA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fju | CARBOXYPEPTIDASE A1 (Homo sapiens) |
PF00246(Peptidase_M14) | 4 | THR A 129GLY A 115PRO A 113ASN A 112 | None | 0.87A | 3u8qA-3fjuA:undetectable | 3u8qA-3fjuA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5a | FMNADENYLYLTRANSFERASE ([Candida]glabrata) |
PF01507(PAPS_reduct) | 4 | THR A 221GLY A 299PRO A 231ASN A 232 | None | 1.17A | 3u8qA-3g5aA:undetectable | 3u8qA-3g5aA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hia | CHOLINE BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01473(CW_binding_1) | 4 | THR A 106GLY A 108ASN A 105TYR A 103 | None | 1.26A | 3u8qA-3hiaA:undetectable | 3u8qA-3hiaA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzg | THYMIDYLATE SYNTHASETHYX (Mycobacteriumtuberculosis) |
PF02511(Thy1) | 4 | THR A 15GLY A 31PRO A 33TYR A 189 | None | 1.25A | 3u8qA-3hzgA:undetectable | 3u8qA-3hzgA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 4 | GLY A 232PRO A 245ASN A 284TYR A 313 | ADP A 510 (-4.1A)NoneADP A 510 (-3.7A)None | 1.07A | 3u8qA-3in1A:undetectable | 3u8qA-3in1A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ioq | CMS1MS2 (Vasconcelleacundinamarcensis) |
PF00112(Peptidase_C1) | 4 | THR A 155GLY A 198PRO A 196ASN A 195 | None | 1.10A | 3u8qA-3ioqA:undetectable | 3u8qA-3ioqA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ld8 | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
PF02373(JmjC) | 4 | THR A 281GLY A 178PRO A 180ASN A 277 | None | 1.05A | 3u8qA-3ld8A:undetectable | 3u8qA-3ld8A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldr | FRUCTOSYLTRANSFERASE (Aspergillusjaponicus) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | THR A 187GLY A 237PRO A 244ASN A 290 | None | 0.95A | 3u8qA-3ldrA:undetectable | 3u8qA-3ldrA:19.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mc2 | INHIBITOR OFCARBONIC ANHYDRASE (Mus musculus) |
PF00405(Transferrin) | 4 | GLY A 426PRO A 586ASN A 587TYR A 652 | None | 0.83A | 3u8qA-3mc2A:17.1 | 3u8qA-3mc2A:33.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naw | SECRETED EFFECTORPROTEIN (Escherichiacoli) |
PF00805(Pentapeptide)PF13979(SopA_C)PF13981(SopA) | 4 | GLY A 514PRO A 522ASN A 533TYR A 495 | None | 1.28A | 3u8qA-3nawA:undetectable | 3u8qA-3nawA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oj0 | GLUTAMYL-TRNAREDUCTASE (Thermoplasmavolcanium) |
PF01488(Shikimate_DH) | 4 | THR A 83GLY A 107PRO A 110ASN A 111 | NoneGOL A 146 (-3.9A)NoneNone | 0.78A | 3u8qA-3oj0A:undetectable | 3u8qA-3oj0A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os6 | ISOCHORISMATESYNTHASE DHBC (Bacillusanthracis) |
PF00425(Chorismate_bind) | 4 | THR A 175GLY A 173PRO A 196ASN A 170 | None | 1.14A | 3u8qA-3os6A:undetectable | 3u8qA-3os6A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4d | LACTOSEPHOSPHORYLASE (Cellulomonasuda) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | THR A 145GLY A 233PRO A 230ASN A 75 | None | 1.25A | 3u8qA-3s4dA:undetectable | 3u8qA-3s4dA:16.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3skp | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 4 | GLY A 425PRO A 583ASN A 584TYR A 650 | None | 0.60A | 3u8qA-3skpA:25.8 | 3u8qA-3skpA:59.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4p | INTEGRIN ALPHA-4 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | THR A 67GLY A 65PRO A 64ASN A 63 | None | 1.10A | 3u8qA-3v4pA:undetectable | 3u8qA-3v4pA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9a | PUTATIVEUNCHARACTERIZEDPROTEIN (Coprinopsiscinerea) |
no annotation | 4 | THR A 194GLY A 196PRO A 198ASN A 197 | None | 1.21A | 3u8qA-3w9aA:undetectable | 3u8qA-3w9aA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bv6 | APOPTOSIS-INDUCINGFACTOR 1,MITOCHONDRIAL (Homo sapiens) |
PF07992(Pyr_redox_2)PF14721(AIF_C) | 4 | THR A 260GLY A 262PRO A 402ASN A 403 | FAD A1449 (-4.1A)NoneNoneFAD A1449 ( 4.5A) | 0.83A | 3u8qA-4bv6A:undetectable | 3u8qA-4bv6A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddd | IMMUNOGENIC PROTEIN (Ehrlichiachaffeensis) |
PF16868(NMT1_3) | 4 | GLY A 202PRO A 204ASN A 205TYR A 247 | None | 1.04A | 3u8qA-4dddA:8.7 | 3u8qA-4dddA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnx | SULFATEADENYLYLTRANSFERASE (Allochromatiumvinosum) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 4 | THR A 179GLY A 50PRO A 12TYR A 16 | None | 1.09A | 3u8qA-4dnxA:undetectable | 3u8qA-4dnxA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpg | LYSINE--TRNA LIGASE (Homo sapiens) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | GLY A 377PRO A 375ASN A 562TYR A 373 | None | 0.99A | 3u8qA-4dpgA:undetectable | 3u8qA-4dpgA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egj | D-ALANINE--D-ALANINELIGASE (Paraburkholderiaxenovorans) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | GLY A 269PRO A 271ASN A 270TYR A 272 | None | 1.17A | 3u8qA-4egjA:undetectable | 3u8qA-4egjA:20.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fim | LACTOTRANSFERRIN (Bos taurus) |
PF00405(Transferrin) | 5 | THR A 430GLY A 432PRO A 593ASN A 594TYR A 660 | NoneCEL A 711 (-3.7A)CEL A 711 (-4.3A)NoneCEL A 711 (-4.4A) | 0.21A | 3u8qA-4fimA:60.7 | 3u8qA-4fimA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hq1 | PROBABLE RECEPTORPROTEIN KINASE TMK1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 4 | THR A 437GLY A 439PRO A 441ASN A 440 | None | 1.19A | 3u8qA-4hq1A:undetectable | 3u8qA-4hq1A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irt | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF15892(BNR_4) | 4 | GLY A 279PRO A 281ASN A 280TYR A 282 | None | 1.29A | 3u8qA-4irtA:undetectable | 3u8qA-4irtA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofz | TREHALOSE-PHOSPHATASE (Brugia malayi) |
no annotation | 4 | THR A 253GLY A 278PRO A 256TYR A 225 | None | 1.28A | 3u8qA-4ofzA:undetectable | 3u8qA-4ofzA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 4 | GLY A 310PRO A 308ASN A 309TYR A 302 | None | 1.17A | 3u8qA-4pmhA:undetectable | 3u8qA-4pmhA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 4 | THR A 166GLY A 164PRO A 130ASN A 129 | None | 1.18A | 3u8qA-4s3jA:undetectable | 3u8qA-4s3jA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uf4 | CARBOXYPEPTIDASE A1 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | THR A 239GLY A 225PRO A 223ASN A 222 | None | 0.87A | 3u8qA-4uf4A:undetectable | 3u8qA-4uf4A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ug4 | CHOLINE SULFATASE (Sinorhizobiummeliloti) |
PF00884(Sulfatase)PF12411(Choline_sulf_C) | 4 | THR A 2GLY A 4PRO A 6TYR A 95 | None | 1.24A | 3u8qA-4ug4A:undetectable | 3u8qA-4ug4A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yam | BETA-ETHERASE (Sphingobium sp.SYK-6) |
PF13417(GST_N_3) | 4 | GLY A 180PRO A 184ASN A 185TYR A 189 | None | 0.94A | 3u8qA-4yamA:undetectable | 3u8qA-4yamA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bul | FLAVIN-DEPENDENTHALOGENASE TRIPLEMUTANT (Streptomyces) |
PF04820(Trp_halogenase) | 4 | GLY A 360PRO A 356ASN A 86TYR A 205 | None | 1.12A | 3u8qA-5bulA:undetectable | 3u8qA-5bulA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5g | SPHERULIN-4 (Aspergillusclavatus) |
PF12138(Spherulin4) | 4 | GLY A 95PRO A 94ASN A 93TYR A 146 | None | 1.20A | 3u8qA-5c5gA:undetectable | 3u8qA-5c5gA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cg9 | TET-LIKE DIOXYGENASE (Naegleriagruberi) |
no annotation | 4 | THR A 211GLY A 143PRO A 209ASN A 204 | None | 1.29A | 3u8qA-5cg9A:undetectable | 3u8qA-5cg9A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7t | MINOR STRUCTURALPROTEIN 4MINOR STRUCTURALPROTEIN 5 (Lactococcusphage Tuc2009) |
no annotation | 4 | GLY A 321PRO A 301ASN A 320TYR B 231 | None | 1.18A | 3u8qA-5e7tA:undetectable | 3u8qA-5e7tA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es6 | LINEAR GRAMICIDINSYNTHASE SUBUNIT A (Brevibacillusparabrevis) |
PF00501(AMP-binding)PF00551(Formyl_trans_N) | 4 | THR A 487GLY A 539ASN A 367TYR A 347 | None | 1.23A | 3u8qA-5es6A:undetectable | 3u8qA-5es6A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es9 | LINEAR GRAMICIDINSYNTHETASE SUBUNIT A (Brevibacillusparabrevis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00551(Formyl_trans_N)PF13193(AMP-binding_C) | 4 | THR A 487GLY A 539ASN A 367TYR A 347 | None | 1.27A | 3u8qA-5es9A:undetectable | 3u8qA-5es9A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey9 | LONG-CHAIN-FATTY-ACID--AMP LIGASE FADD32 (Mycobacteriummarinum) |
PF00501(AMP-binding) | 4 | THR A 348GLY A 427ASN A 202TYR A 182 | None | 1.15A | 3u8qA-5ey9A:undetectable | 3u8qA-5ey9A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8e | METHYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF13847(Methyltransf_31) | 4 | THR A 304GLY A 129PRO A 131TYR A 135 | None | 1.25A | 3u8qA-5f8eA:undetectable | 3u8qA-5f8eA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgq | LYSINE--TRNA LIGASE (Loa loa) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | GLY A 309PRO A 307ASN A 495TYR A 305 | None | 0.93A | 3u8qA-5hgqA:undetectable | 3u8qA-5hgqA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd4 | LAE6 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 4 | THR A 252GLY A 254PRO A 282ASN A 280 | None | 1.20A | 3u8qA-5jd4A:undetectable | 3u8qA-5jd4A:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnf | LINEAR GRAMICIDINSYNTHASE SUBUNIT A (Brevibacillusparabrevis) |
no annotation | 4 | THR C 487GLY C 539ASN C 367TYR C 347 | None | 1.22A | 3u8qA-5jnfC:undetectable | 3u8qA-5jnfC:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jow | NON-REDUCING ENDALPHA-L-ARABINOFURANOSIDASE BOGH43A (Bacteroidesovatus) |
PF04616(Glyco_hydro_43) | 4 | THR A 183GLY A 229PRO A 231ASN A 233 | None | 1.24A | 3u8qA-5jowA:undetectable | 3u8qA-5jowA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mul | NEURAMINIDASE (Bacteroidesthetaiotaomicron) |
PF15892(BNR_4) | 4 | GLY A 279PRO A 281ASN A 280TYR A 282 | None | 1.23A | 3u8qA-5mulA:undetectable | 3u8qA-5mulA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mvh | BACCELL_00856 (Bacteroidescellulosilyticus) |
PF15892(BNR_4) | 4 | GLY A 279PRO A 281ASN A 280TYR A 282 | None | 1.26A | 3u8qA-5mvhA:undetectable | 3u8qA-5mvhA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6v | AMYLOSUCRASE (Neisseriapolysaccharea) |
no annotation | 4 | THR A 478GLY A 480PRO A 482ASN A 387 | None | 1.00A | 3u8qA-5n6vA:undetectable | 3u8qA-5n6vA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nri | D-ALANINE--D-ALANINELIGASE (Burkholderiapseudomallei) |
no annotation | 4 | GLY A 269PRO A 271ASN A 270TYR A 272 | None | 1.22A | 3u8qA-5nriA:undetectable | 3u8qA-5nriA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | TFIIH BASALTRANSCRIPTION FACTORCOMPLEX HELICASE XPDSUBUNIT (Homo sapiens) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 4 | THR B 457GLY B 459PRO B 43TYR B 24 | None | 1.06A | 3u8qA-5of4B:undetectable | 3u8qA-5of4B:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2d | DIOXYGENASE (Pseudomonasbrassicacearum) |
no annotation | 4 | THR A 108GLY A 245PRO A 247ASN A 105 | None | 1.00A | 3u8qA-5v2dA:undetectable | 3u8qA-5v2dA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhj | 26S PROTEASOMEREGULATORY SUBUNIT 4 (Homo sapiens) |
PF00004(AAA) | 4 | THR B 331GLY B 229PRO B 227ASN B 332 | None | 0.86A | 3u8qA-5vhjB:undetectable | 3u8qA-5vhjB:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xct | VH(S112C)-SARAHCHIMERA (Homo sapiens;Mus musculus) |
PF07686(V-set)PF11629(Mst1_SARAH) | 4 | THR A 52GLY A 55PRO A 57ASN A 52 | None | 1.27A | 3u8qA-5xctA:undetectable | 3u8qA-5xctA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xh9 | EXTRACELLULARINVERTASE (Aspergilluskawachii) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | THR A 190GLY A 220PRO A 227ASN A 269 | None | 1.00A | 3u8qA-5xh9A:undetectable | 3u8qA-5xh9A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvt | C-TERMINUS OF OUTERCAPSID PROTEIN VP5 (Aquareovirus C) |
no annotation | 4 | GLY B 413PRO B 415ASN B 410TYR B 360 | None | 1.27A | 3u8qA-5zvtB:undetectable | 3u8qA-5zvtB:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4o | GLUTATHIONEREDUCTASE (Enterococcusfaecalis) |
no annotation | 4 | THR A 138GLY A 140PRO A 264ASN A 265 | FAD A 501 (-3.9A)NoneNoneFAD A 501 ( 4.8A) | 0.76A | 3u8qA-6b4oA:undetectable | 3u8qA-6b4oA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bni | LYSINE--TRNA LIGASE (Cryptosporidiumparvum) |
no annotation | 4 | GLY A 349PRO A 347ASN A 532TYR A 345 | None | 0.94A | 3u8qA-6bniA:undetectable | 3u8qA-6bniA:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f45 | - (-) |
no annotation | 4 | THR D 118GLY D 126PRO D 128ASN D 127 | None | 1.27A | 3u8qA-6f45D:undetectable | 3u8qA-6f45D:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f9m | SERINE PROTEASE (Planococcusplakortidis) |
no annotation | 4 | THR A 70GLY A 75PRO A 77ASN A 68 | None | 1.14A | 3u8qA-6f9mA:undetectable | 3u8qA-6f9mA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fqc | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
no annotation | 4 | THR A 281GLY A 178PRO A 180ASN A 277 | None | 1.10A | 3u8qA-6fqcA:undetectable | 3u8qA-6fqcA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gt1 | SERINE/THREONINE-PROTEIN KINASE NEK7 (Homo sapiens) |
no annotation | 4 | THR A 30GLY A 27PRO A 24ASN A 33 | None | 1.06A | 3u8qA-6gt1A:undetectable | 3u8qA-6gt1A:undetectable |