SIMILAR PATTERNS OF AMINO ACIDS FOR 3U6T_A_KANA4699_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		5 TYR A  74
ILE A  68
ALA A 163
GLU A 164
ARG A 167
 None
 1.39A 3u6tA-1abrA:
33.7		 3u6tA-1abrA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		6 TYR A  74
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
 None
 0.58A 3u6tA-1abrA:
33.7		 3u6tA-1abrA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		9 ILE A  71
GLU A  85
SER A 108
ASN A 110
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 (-3.9A)
None
None
None
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.68A 3u6tA-1ahaA:
43.7		 3u6tA-1ahaA:
94.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		8 TYR A  70
ILE A  71
GLU A  85
SER A 108
ASN A 110
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
None
None
None
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.85A 3u6tA-1ahaA:
43.7		 3u6tA-1ahaA:
94.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bb1 DESIGNED,
THERMOSTABLE
HETEROTRIMERIC
COILED COIL

(synthetic
construct) 		no annotation 5 ILE C  17
GLU B  14
ILE C  20
ALA C  19
GLU C  23
 None
 1.26A 3u6tA-1bb1C:
undetectable		 3u6tA-1bb1C:
12.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		10 TYR Y  70
ILE Y  71
GLU Y  85
SER Y 108
ASN Y 110
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
 None
 0.55A 3u6tA-1bryY:
41.8		 3u6tA-1bryY:
66.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		7 TYR A  70
ASN A 108
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
 None
 0.75A 3u6tA-1cf5A:
38.2		 3u6tA-1cf5A:
52.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 490
SER A 116
TYR A 232
ALA A 494
GLU A 495
 FAD  A 510 ( 4.3A)
None
None
None
None
 1.46A 3u6tA-1coyA:
undetectable		 3u6tA-1coyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ILE A  44
SER A   8
ILE A 151
ALA A 147
GLU A 150
 None
 1.28A 3u6tA-1d6sA:
undetectable		 3u6tA-1d6sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 ILE A  93
ASN A 441
TYR A 442
ILE A   2
ALA A   6
 None
 1.37A 3u6tA-1dq3A:
undetectable		 3u6tA-1dq3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		5 SER A 191
ASN A 187
ILE A 138
ALA A 135
GLU A 134
 None
 1.16A 3u6tA-1eceA:
undetectable		 3u6tA-1eceA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		6 TYR A  77
ASN A 115
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 1.00A 3u6tA-1hwnA:
32.6		 3u6tA-1hwnA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 TYR A 306
ILE A 305
SER A 309
ILE A 265
ALA A 303
 None
 1.35A 3u6tA-1inpA:
undetectable		 3u6tA-1inpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 197
GLU A 113
ILE A  36
ALA A  49
GLU A  51
 None
 1.16A 3u6tA-1j3nA:
undetectable		 3u6tA-1j3nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeg TYROSINE-PROTEIN
KINASE CSK

(Mus musculus) 		PF00018
(SH3_1) 		5 TYR A  48
ILE A  59
ASN A  63
ILE A  60
ALA A  50
 None
 1.29A 3u6tA-1jegA:
undetectable		 3u6tA-1jegA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 5 ILE O 125
SER O 148
ILE O 118
ALA O 105
GLU O  94
 None
SO4  O6337 (-3.5A)
None
None
None
 1.42A 3u6tA-1jn0O:
undetectable		 3u6tA-1jn0O:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 ILE A  53
SER A  70
ILE A 306
GLU A 304
ARG A 284
 None
 1.44A 3u6tA-1k32A:
undetectable		 3u6tA-1k32A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 ILE A 234
ASN A 269
TYR A 268
ILE A 217
GLU A 218
 None
 1.40A 3u6tA-1lnzA:
undetectable		 3u6tA-1lnzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		6 TYR A  73
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.56A 3u6tA-1lpcA:
27.6		 3u6tA-1lpcA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 TYR A 217
ILE A 219
SER A 226
ILE A 233
ALA A 237
 None
 1.22A 3u6tA-1nbwA:
undetectable		 3u6tA-1nbwA:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nio B-LUFFIN

(Luffa
aegyptiaca) 		PF00161
(RIP) 		10 TYR A  71
ILE A  72
GLU A  86
SER A 108
ASN A 110
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 None
 0.71A 3u6tA-1nioA:
40.9		 3u6tA-1nioA:
68.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		5 ILE A  16
SER A 195
TYR A 228
ILE A 138
ALA A 188
 None
 1.29A 3u6tA-1npmA:
undetectable		 3u6tA-1npmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oww FIBRONECTIN FIRST
TYPE III MODULE

(Homo sapiens) 		PF00041
(fn3) 		5 ILE A  51
SER A  31
ILE A  34
ALA A  49
GLU A  48
 None
 1.30A 3u6tA-1owwA:
undetectable		 3u6tA-1owwA:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		5 TYR A  72
TYR A 123
ILE A 171
GLU A 176
ARG A 179
 APT  A 901 (-3.9A)
APT  A 901 (-4.7A)
APT  A 901 (-3.7A)
APT  A 901 ( 3.6A)
APT  A 901 (-3.0A)
 0.59A 3u6tA-1qcjA:
30.9		 3u6tA-1qcjA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		6 TYR A  72
TYR A 120
ILE A 171
ALA A 175
GLU A 176
ARG A 179
 None
 0.52A 3u6tA-1qi7A:
27.6		 3u6tA-1qi7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 TYR A  77
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 FMT  A3015 (-4.7A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
 0.77A 3u6tA-1r4pA:
23.2		 3u6tA-1r4pA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		9 TYR A  70
ILE A  71
GLU A  85
SER A 108
ASN A 110
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 NDP  A 280 ( 4.7A)
NDP  A 280 (-4.5A)
None
None
None
NDP  A 280 ( 3.7A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 2.7A)
NDP  A 280 ( 2.6A)
 0.60A 3u6tA-1tcsA:
40.5		 3u6tA-1tcsA:
64.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2l CYTOCHROME OXIDASE
SUBUNIT II

(Rhodothermus
marinus) 		PF00034
(Cytochrom_C) 		5 TYR A  38
ILE A  95
ASN A  55
ILE A  92
GLU A  93
 ACT  A1102 (-4.4A)
None
None
None
None
 1.15A 3u6tA-1w2lA:
undetectable		 3u6tA-1w2lA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		5 TYR J 206
ILE J 208
SER J 241
ILE J 308
ALA J 232
 None
 1.29A 3u6tA-1wcdJ:
undetectable		 3u6tA-1wcdJ:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 ILE A   5
ASN A  25
ILE A  12
ALA A   8
GLU A  11
 None
 1.06A 3u6tA-1xszA:
undetectable		 3u6tA-1xszA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 ILE B   5
ASN B  25
ILE B  12
ALA B   8
GLU B  11
 None
 1.03A 3u6tA-1xt0B:
undetectable		 3u6tA-1xt0B:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a90 DELTEX PROTEIN

(Drosophila
melanogaster) 		PF02825
(WWE) 		5 ILE A 157
SER A 171
ASN A 172
GLU A 165
ARG A 163
 None
 1.26A 3u6tA-2a90A:
undetectable		 3u6tA-2a90A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		5 GLU A 127
ASN A 128
TYR A  40
ALA A  45
GLU A  46
 None
 1.43A 3u6tA-2atfA:
undetectable		 3u6tA-2atfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0v NUDIX HYDROLASE

(Nitrosomonas
europaea) 		PF00293
(NUDIX) 		5 ILE A  46
ASN A   6
ALA A  49
GLU A  53
ARG A  52
 None
None
None
EDO  A 201 (-3.3A)
None
 1.24A 3u6tA-2b0vA:
undetectable		 3u6tA-2b0vA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		5 TYR A  24
ILE A 201
SER A  26
ILE A 188
ALA A 197
 None
 1.44A 3u6tA-2czdA:
undetectable		 3u6tA-2czdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 TYR A 215
ILE A 217
SER A 224
ILE A 231
ALA A 235
 None
 1.15A 3u6tA-2d0oA:
undetectable		 3u6tA-2d0oA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A  27
GLU A  94
ASN A  70
ILE A  67
ALA A  65
 None
 1.43A 3u6tA-2f00A:
undetectable		 3u6tA-2f00A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		5 TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
 None
 0.61A 3u6tA-2g5xA:
25.5		 3u6tA-2g5xA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 201
GLU A 117
ILE A  39
ALA A  52
GLU A  54
 None
 1.25A 3u6tA-2gqdA:
undetectable		 3u6tA-2gqdA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 TYR A  81
ILE A  95
TYR A  34
ILE A  96
GLU A 100
 None
 1.31A 3u6tA-2kyrA:
undetectable		 3u6tA-2kyrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		5 ILE A 354
ASN A 370
TYR A 387
ILE A 366
ARG A 410
 None
 1.24A 3u6tA-2lf8A:
undetectable		 3u6tA-2lf8A:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		5 TYR A  70
ILE A  64
ALA A 158
GLU A 159
ARG A 162
 None
 1.38A 3u6tA-2oqaA:
40.7		 3u6tA-2oqaA:
69.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		10 TYR A  70
ILE A  71
GLU A  85
SER A 107
ASN A 109
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
 None
 0.58A 3u6tA-2oqaA:
40.7		 3u6tA-2oqaA:
69.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		5 ILE A1081
ASN A1027
ILE A1041
ALA A1045
GLU A1044
 None
 1.45A 3u6tA-2p3vA:
undetectable		 3u6tA-2p3vA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7v REGULATOR OF SIGMA D

(Escherichia
coli) 		PF04353
(Rsd_AlgQ) 		5 ILE A 103
SER A  60
TYR A  33
ILE A 130
ALA A 133
 None
 1.22A 3u6tA-2p7vA:
undetectable		 3u6tA-2p7vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		5 TYR A  72
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.67A 3u6tA-2q8wA:
31.0		 3u6tA-2q8wA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.) 		PF00502
(Phycobilisome) 		5 ILE A 115
SER A 162
ASN A 159
TYR A 156
ILE A 112
 None
 1.28A 3u6tA-2uunA:
undetectable		 3u6tA-2uunA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		6 SER A 112
TYR A 115
ILE A 162
ALA A 166
GLU A 167
ARG A 170
 None
 0.58A 3u6tA-2vlcA:
30.8		 3u6tA-2vlcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		6 TYR A  75
TYR A 115
ILE A 162
ALA A 166
GLU A 167
ARG A 170
 None
 0.71A 3u6tA-2vlcA:
30.8		 3u6tA-2vlcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		5 ILE A 161
GLU A 141
SER A  41
ILE A 159
ALA A 181
 None
 1.35A 3u6tA-2wsmA:
undetectable		 3u6tA-2wsmA:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius) 		PF00161
(RIP) 		6 ASN A 111
TYR A 112
ILE A 158
ALA A 162
GLU A 163
ARG A 166
 None
 0.99A 3u6tA-2zr1A:
33.5		 3u6tA-2zr1A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		5 ILE A 363
ASN A 299
TYR A 302
ILE A 412
ALA A 361
 None
 1.30A 3u6tA-3b8zA:
undetectable		 3u6tA-3b8zA:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		7 TYR A  70
ILE A  71
ASN A 108
TYR A 109
ILE A 153
GLU A 158
ARG A 161
 EDO  A 253 ( 4.5A)
None
None
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.6A)
EDO  A 253 (-2.9A)
 0.82A 3u6tA-3bwhA:
39.3		 3u6tA-3bwhA:
58.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		5 ILE A  30
SER A  52
ILE A  57
ALA A  32
GLU A  59
 None
 1.31A 3u6tA-3c1oA:
undetectable		 3u6tA-3c1oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		5 ILE A 149
SER A  78
ASN A  54
ILE A 109
ALA A 183
 None
 1.29A 3u6tA-3cdkA:
undetectable		 3u6tA-3cdkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 TYR A 143
ILE A 145
TYR A 168
ILE A 134
ALA A 133
 None
 1.45A 3u6tA-3cgxA:
undetectable		 3u6tA-3cgxA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		5 TYR A  70
TYR A 114
ILE A 160
GLU A 165
ARG A 168
 None
 0.51A 3u6tA-3ctkA:
33.2		 3u6tA-3ctkA:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 ILE P  32
ILE P  75
ALA P  30
GLU P  73
ARG P  28
 FAD  P 449 ( 4.5A)
None
None
None
None
 0.89A 3u6tA-3fg2P:
undetectable		 3u6tA-3fg2P:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 TYR A 214
GLU A 215
SER A 250
ALA A 230
GLU A 232
 None
 1.41A 3u6tA-3i4jA:
undetectable		 3u6tA-3i4jA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A 191
SER A 212
TYR A 393
ALA A 223
GLU A 222
 None
 1.43A 3u6tA-3jq0A:
undetectable		 3u6tA-3jq0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A  76
SER A  68
TYR A  64
ILE A  33
GLU A  62
 None
 1.42A 3u6tA-3ngxA:
undetectable		 3u6tA-3ngxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 261
ILE A 258
SER A 388
ILE A 171
ALA A 174
 None
None
K  A 408 (-2.9A)
None
None
 1.42A 3u6tA-3oytA:
undetectable		 3u6tA-3oytA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p83 RIBONUCLEASE HII

(Archaeoglobus
fulgidus) 		PF01351
(RNase_HII) 		5 ILE D  78
SER D  65
ASN D  68
ILE D  81
GLU D  84
 None
 1.41A 3u6tA-3p83D:
undetectable		 3u6tA-3p83D:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		5 SER A 350
ASN A 396
TYR A 395
ILE A   5
GLU A   4
 None
 1.45A 3u6tA-3qkiA:
undetectable		 3u6tA-3qkiA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ILE A 181
SER A 129
TYR A  84
ILE A 182
GLU A 235
 None
 1.45A 3u6tA-3sdqA:
undetectable		 3u6tA-3sdqA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger) 		PF00445
(Ribonuclease_T2) 		5 ILE A 142
TYR A 150
ILE A 145
GLU A 158
ARG A  93
 None
 1.26A 3u6tA-3tbjA:
undetectable		 3u6tA-3tbjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 TYR A 359
ILE A 321
ASN A  26
ILE A 322
GLU A 174
 None
 1.29A 3u6tA-3ty7A:
undetectable		 3u6tA-3ty7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 TYR A 194
ILE A 198
ILE A  11
ALA A 224
GLU A  69
 None
 1.36A 3u6tA-3whiA:
undetectable		 3u6tA-3whiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 TYR A  68
ILE A  65
ASN A  23
ILE A  19
ALA A  30
 None
 1.24A 3u6tA-4atyA:
undetectable		 3u6tA-4atyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 ILE A1059
SER A1199
ASN A1130
ILE A1405
GLU A1443
 None
 1.04A 3u6tA-4aygA:
undetectable		 3u6tA-4aygA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLU A 414
SER A 441
ASN A 439
ILE A 445
ALA A 449
 None
 1.26A 3u6tA-4b3iA:
undetectable		 3u6tA-4b3iA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 111
SER A  46
ASN A  44
ILE A  38
ALA A  37
 None
 1.21A 3u6tA-4e1lA:
undetectable		 3u6tA-4e1lA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex9 ALNA

(Streptomyces
sp. CM020) 		PF04227
(Indigoidine_A) 		5 ILE A  33
SER A  43
ILE A  75
ALA A  79
GLU A  76
 None
 1.41A 3u6tA-4ex9A:
undetectable		 3u6tA-4ex9A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 ILE A 115
ASN A 171
TYR A 168
ILE A 112
ALA A 113
 None
 1.24A 3u6tA-4f0tA:
undetectable		 3u6tA-4f0tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 ILE A 115
SER A 174
ASN A 171
TYR A 168
ILE A 112
 None
 1.28A 3u6tA-4f0tA:
undetectable		 3u6tA-4f0tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 TYR E 141
ILE E 143
GLU E 200
ILE E 133
ALA E 146
 None
 1.35A 3u6tA-4f52E:
undetectable		 3u6tA-4f52E:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc8 TRANSCRIPTION
PROTEIN RTR1

(Kluyveromyces
lactis) 		PF04181
(RPAP2_Rtr1) 		5 ILE A  51
ASN A  32
ILE A   7
ALA A   2
GLU A   6
 None
 1.16A 3u6tA-4fc8A:
undetectable		 3u6tA-4fc8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE

(Escherichia
coli) 		PF04227
(Indigoidine_A) 		5 ILE A  81
GLU A  79
ILE A  49
GLU A  53
ARG A  56
 None
 0.94A 3u6tA-4gijA:
undetectable		 3u6tA-4gijA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		5 ILE A 559
ASN A 342
TYR A 343
ILE A 330
GLU A 332
 None
 1.07A 3u6tA-4gkpA:
undetectable		 3u6tA-4gkpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		5 ILE A 212
SER A  95
ASN A 200
ILE A  82
ALA A 210
 None
 1.42A 3u6tA-4glfA:
undetectable		 3u6tA-4glfA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		5 TYR A  76
ASN A 112
ILE A 160
GLU A 165
ARG A 168
 H35  A 305 (-4.2A)
NAG  A 302 (-1.9A)
H35  A 305 ( 4.5A)
H35  A 305 (-3.5A)
H35  A 305 (-3.3A)
 1.17A 3u6tA-4jkxA:
32.4		 3u6tA-4jkxA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		5 ILE A 197
SER A 108
ASN A  84
ILE A 139
ALA A 231
 None
 1.34A 3u6tA-4kgbA:
undetectable		 3u6tA-4kgbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A  98
ILE A  97
ASN A 407
TYR A 405
ILE A 415
 None
 1.44A 3u6tA-4mmoA:
undetectable		 3u6tA-4mmoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C

(Methylocystis
sp. ATCC 49242) 		no annotation 5 TYR K 119
ILE K 118
ASN K  32
TYR K  35
ALA K 122
 None
 1.46A 3u6tA-4phzK:
undetectable		 3u6tA-4phzK:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 ILE B  77
GLU B  59
ALA B  79
GLU B  81
ARG B 154
 None
 1.16A 3u6tA-4pl2B:
undetectable		 3u6tA-4pl2B:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		5 TYR A 312
ILE A 317
ASN A 140
ILE A 368
ALA A 308
 None
 1.31A 3u6tA-4rulA:
undetectable		 3u6tA-4rulA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trk C. ELEGANS HIM-3

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		5 SER A 136
ASN A 139
TYR A 214
ILE A 141
ALA A 240
 None
 1.38A 3u6tA-4trkA:
undetectable		 3u6tA-4trkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 ILE A 228
TYR A 431
ILE A 241
ALA A 235
GLU A 240
 None
 1.24A 3u6tA-4y23A:
undetectable		 3u6tA-4y23A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 ASN A 122
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.87A 3u6tA-5ddzA:
34.2		 3u6tA-5ddzA:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		5 TYR A 130
ILE A  99
ASN A 151
TYR A 175
GLU A 105
 None
 0.96A 3u6tA-5ev7A:
undetectable		 3u6tA-5ev7A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ILE A 121
SER A 140
ASN A 138
ILE A 164
ALA A 157
 None
 1.42A 3u6tA-5ffnA:
undetectable		 3u6tA-5ffnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 ILE A 114
TYR A  41
ILE A  38
ALA A  33
GLU A  37
 None
 1.37A 3u6tA-5fq6A:
undetectable		 3u6tA-5fq6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLU A 758
SER A 754
ASN A 751
GLU A 765
ARG A 451
 SO4  A1004 ( 4.9A)
SO4  A1004 (-3.5A)
SO4  A1004 (-3.6A)
None
None
 1.37A 3u6tA-5k6oA:
undetectable		 3u6tA-5k6oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 125
SER A 149
ASN A 121
ILE A  60
ALA A  71
 None
 1.39A 3u6tA-5necA:
undetectable		 3u6tA-5necA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 SER A 781
ASN A 721
TYR A 720
ILE A 683
GLU A 691
 None
 1.35A 3u6tA-5opjA:
undetectable		 3u6tA-5opjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		5 SER E 189
TYR E 230
ILE E 227
ALA E 223
GLU E 226
 None
 1.25A 3u6tA-5t9cE:
undetectable		 3u6tA-5t9cE:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4b GTPASE DER

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 ILE A  42
GLU A  26
SER A  45
ILE A  56
GLU A  82
 None
 1.41A 3u6tA-5x4bA:
undetectable		 3u6tA-5x4bA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
 None
 1.32A 3u6tA-5xtcd:
undetectable		 3u6tA-5xtcd:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4

(Trichomonas
vaginalis) 		PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		5 GLU E  97
SER E  95
ILE E  64
ALA E  55
GLU E  60
 None
 1.40A 3u6tA-5xyiE:
undetectable		 3u6tA-5xyiE:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 ILE A 345
SER A 396
ILE A 391
ALA A 356
GLU A 353
 None
 1.40A 3u6tA-5zb8A:
undetectable		 3u6tA-5zb8A:
15.07