SIMILAR PATTERNS OF AMINO ACIDS FOR 3U5K_D_08JD4_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1e6i | TRANSCRIPTIONALACTIVATOR GCN5 (Saccharomycescerevisiae) |
PF00439(Bromodomain) | 4 | TRP A 350PRO A 351VAL A 356ASN A 407 | None | 0.57A | 3u5kD-1e6iA:16.2 | 3u5kD-1e6iA:34.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 4 | VAL A 239LEU A 211LEU A 204ILE A 258 | None | 0.92A | 3u5kD-1kczA:undetectable | 3u5kD-1kczA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzh | PHOSPHOFRUCTOKINASE (Borreliellaburgdorferi) |
PF00365(PFK) | 4 | PRO A 202LEU A 482ASN A 211ILE A 214 | None | 0.87A | 3u5kD-1kzhA:undetectable | 3u5kD-1kzhA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldj | CULLIN HOMOLOG 1 (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 4 | VAL A 49LEU A 88ASN A 141ILE A 159 | None | 0.91A | 3u5kD-1ldjA:undetectable | 3u5kD-1ldjA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdf | THIOREDOXINREDUCTASE (Escherichiacoli) |
PF07992(Pyr_redox_2) | 5 | PRO A 53VAL A 49LEU A 64LEU A 43ILE A 296 | NoneFAD A 500 (-3.4A)NoneFAD A 500 (-3.3A)None | 1.09A | 3u5kD-1tdfA:undetectable | 3u5kD-1tdfA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ue8 | 367AA LONGHYPOTHETICALCYTOCHROME P450 (Sulfurisphaeratokodaii) |
PF00067(p450) | 4 | PRO A 123LEU A 104LEU A 105ILE A 219 | None | 0.75A | 3u5kD-1ue8A:undetectable | 3u5kD-1ue8A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 4 | VAL A 206LEU A 194LEU A 197ILE A 343 | None | 0.84A | 3u5kD-1vheA:undetectable | 3u5kD-1vheA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xe7 | HYPOTHETICAL 22.5KDA PROTEIN INTUB1-CPR3 INTERGENICREGION (Saccharomycescerevisiae) |
PF06172(Cupin_5) | 4 | PRO A 63VAL A 74ASN A 100ILE A 99 | NoneNoneEDO A 306 (-3.7A)None | 0.93A | 3u5kD-1xe7A:undetectable | 3u5kD-1xe7A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr4 | PUTATIVE CITRATELYASE ALPHACHAIN/CITRATE-ACPTRANSFERASE (Salmonellaenterica) |
PF04223(CitF) | 4 | VAL A 433LEU A 449LEU A 453ILE A 258 | None | 0.83A | 3u5kD-1xr4A:undetectable | 3u5kD-1xr4A:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfy | 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE (Cupriavidusmetallidurans) |
PF06052(3-HAO) | 4 | TRP A 31VAL A 40LEU A 107LEU A 62 | None | 0.90A | 3u5kD-1yfyA:undetectable | 3u5kD-1yfyA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bac | PUTATIVEAMINOOXIDASE (Cutibacteriumacnes) |
PF01593(Amino_oxidase) | 4 | VAL A 181LEU A 185ILE A 162MET A 302 | None | 0.92A | 3u5kD-2bacA:undetectable | 3u5kD-2bacA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdw | HYPOTHETICAL PROTEINK11E8.1D (Caenorhabditiselegans) |
PF00069(Pkinase) | 4 | VAL A 152LEU A 97LEU A 141ILE A 116 | None | 0.93A | 3u5kD-2bdwA:undetectable | 3u5kD-2bdwA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bv8 | C-PHYCOCYANIN ALPHASUBUNITC-PHYCOCYANIN BETASUBUNIT (Gracilariachilensis) |
PF00502(Phycobilisome) | 4 | VAL B 41LEU A 24LEU B 38ILE A 5 | NonePEB B1175 ( 4.6A)PEB B1175 ( 4.0A)None | 0.90A | 3u5kD-2bv8B:undetectable | 3u5kD-2bv8B:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dcq | PUTATIVE PROTEINAT4G01050 (Arabidopsisthaliana) |
no annotation | 4 | VAL A 94LEU A 62LEU A 65ILE A 27 | None | 0.76A | 3u5kD-2dcqA:undetectable | 3u5kD-2dcqA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dld | D-LACTATEDEHYDROGENASE (Lactobacillushelveticus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | VAL A 52LEU A 36ASN A 83ILE A 84 | None | 0.90A | 3u5kD-2dldA:undetectable | 3u5kD-2dldA:16.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dvr | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 31PRO A 32VAL A 37LEU A 42LEU A 44ASN A 90ILE A 96MET A 99 | None | 0.59A | 3u5kD-2dvrA:20.8 | 3u5kD-2dvrA:70.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4z | TGTWINSCAN_2721 - E2DOMAIN (Toxoplasmagondii) |
PF00179(UQ_con) | 4 | PRO A 109LEU A 37ILE A 98MET A 111 | None | 0.93A | 3u5kD-2f4zA:undetectable | 3u5kD-2f4zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsk | VITAMIN B12TRANSPORTER BTUB (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | PRO A 412LEU A 401LEU A 398ASN A 362 | None | 0.92A | 3u5kD-2gskA:undetectable | 3u5kD-2gskA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2it1 | 362AA LONGHYPOTHETICALMALTOSE/MALTODEXTRINTRANSPORTATP-BINDING PROTEIN (Pyrococcushorikoshii) |
PF00005(ABC_tran) | 4 | VAL A 172LEU A 161LEU A 164ILE A 144 | None | 0.93A | 3u5kD-2it1A:undetectable | 3u5kD-2it1A:15.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2l5e | BROMODOMAIN-CONTAINING PROTEIN 3 (Mus musculus) |
PF00439(Bromodomain) | 7 | TRP A 57PRO A 58LEU A 68LEU A 70ASN A 116ILE A 122MET A 125 | None | 0.93A | 3u5kD-2l5eA:16.8 | 3u5kD-2l5eA:77.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okc | TYPE I RESTRICTIONENZYME STYSJI MPROTEIN (Bacteroidesthetaiotaomicron) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | PRO A 177LEU A 185ILE A 256MET A 292 | None | 0.84A | 3u5kD-2okcA:undetectable | 3u5kD-2okcA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqd | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Agrobacteriumsp.) |
PF00275(EPSP_synthase) | 4 | PRO A 329VAL A 333LEU A 365ILE A 406 | None | 0.81A | 3u5kD-2pqdA:undetectable | 3u5kD-2pqdA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qip | PROTEIN OF UNKNOWNFUNCTION VPA0982 (Vibrioparahaemolyticus) |
PF01936(NYN) | 4 | PRO A 104VAL A 109LEU A 12ILE A 100 | None | 0.88A | 3u5kD-2qipA:undetectable | 3u5kD-2qipA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v1n | PROTEIN KIN HOMOLOG (Homo sapiens) |
PF10357(Kin17_mid) | 4 | TRP A 72LEU A 28LEU A 31ASN A 42 | None | 0.93A | 3u5kD-2v1nA:undetectable | 3u5kD-2v1nA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vgq | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN,MITOCHONDRIALANTIVIRAL-SIGNALINGPROTEIN (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8)PF16739(CARD_2) | 4 | VAL A 391LEU A 453LEU A 445ILE A 381 | None | 0.72A | 3u5kD-2vgqA:undetectable | 3u5kD-2vgqA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vml | PHYCOCYANIN ALPHACHAINPHYCOCYANIN BETACHAIN (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 4 | VAL B 41LEU A 24LEU B 38ILE A 5 | NoneCYC B1153 (-4.1A)CYC B1153 (-3.8A)None | 0.86A | 3u5kD-2vmlB:undetectable | 3u5kD-2vmlB:17.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wp1 | BROMODOMAINTESTIS-SPECIFICPROTEIN (Mus musculus) |
PF00439(Bromodomain) | 6 | TRP A 292PRO A 293VAL A 298LEU A 305ASN A 351MET A 360 | None | 0.62A | 3u5kD-2wp1A:16.8 | 3u5kD-2wp1A:38.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wp1 | BROMODOMAINTESTIS-SPECIFICPROTEIN (Mus musculus) |
PF00439(Bromodomain) | 6 | TRP A 292VAL A 298LEU A 303LEU A 305ASN A 351MET A 360 | None | 0.77A | 3u5kD-2wp1A:16.8 | 3u5kD-2wp1A:38.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yek | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 97PRO A 98VAL A 103LEU A 108LEU A 110ASN A 156ILE A 162MET A 165 | NoneEAM A1188 (-4.6A)EAM A1188 (-4.4A)EAM A1188 ( 3.8A)EAM A1188 (-4.5A)EAM A1188 (-3.2A)EAM A1188 (-3.8A)EAM A1188 ( 4.1A) | 0.56A | 3u5kD-2yekA:20.5 | 3u5kD-2yekA:70.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bwt | PROTEIN PUF4 (Saccharomycescerevisiae) |
PF00806(PUF) | 4 | PRO A 865LEU A 832LEU A 841ILE A 862 | None | 0.92A | 3u5kD-3bwtA:undetectable | 3u5kD-3bwtA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcx | PROTEIN OF UNKNOWNFUNCTION (DUF1696)WITHPLECKSTRIN-HOMOLOGYDOMAINS (Shewanellaloihica) |
PF08000(bPH_1) | 4 | VAL A 45LEU A 19LEU A 33ILE A 26 | None | 0.89A | 3u5kD-3dcxA:undetectable | 3u5kD-3dcxA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dls | PASDOMAIN-CONTAININGSERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A1265LEU A1104LEU A1100ILE A1136 | None | 0.89A | 3u5kD-3dlsA:undetectable | 3u5kD-3dlsA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gt0 | PYRROLINE-5-CARBOXYLATE REDUCTASE (Bacillus cereus) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 4 | VAL A 147LEU A 133ILE A 96MET A 13 | None | 0.80A | 3u5kD-3gt0A:undetectable | 3u5kD-3gt0A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmh | TRANSCRIPTIONINITIATION FACTORTFIID 210 KDASUBUNIT (Homo sapiens) |
PF00439(Bromodomain) | 4 | TRP A1545PRO A1546VAL A1551ASN A1602 | None | 0.78A | 3u5kD-3hmhA:12.7 | 3u5kD-3hmhA:26.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT ALPHA (Moorellathermoacetica) |
PF03598(CdhC) | 4 | VAL M 53LEU M 119LEU M 116ILE M 44 | None | 0.93A | 3u5kD-3i04M:undetectable | 3u5kD-3i04M:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivr | PUTATIVELONG-CHAIN-FATTY-ACID COA LIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding) | 4 | VAL A 118LEU A 100ILE A 62MET A 70 | None | 0.85A | 3u5kD-3ivrA:undetectable | 3u5kD-3ivrA:11.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2k | PUTATIVECARBOXYPEPTIDASE (Burkholderiamallei) |
PF00246(Peptidase_M14) | 4 | VAL A 212LEU A 148LEU A 137ILE A 256 | None | 0.93A | 3u5kD-3k2kA:undetectable | 3u5kD-3k2kA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8d | METHYLTRANSFERASE (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 4 | VAL A 200ASN A 124ILE A 123MET A 121 | None | 0.80A | 3u5kD-3l8dA:undetectable | 3u5kD-3l8dA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mal | STROMAL CELL-DERIVEDFACTOR 2-LIKEPROTEIN (Arabidopsisthaliana) |
PF02815(MIR) | 4 | VAL A 163LEU A 148LEU A 165ILE A 43 | None | 0.81A | 3u5kD-3malA:undetectable | 3u5kD-3malA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3niv | GLUTATHIONES-TRANSFERASE (Legionellapneumophila) |
PF13417(GST_N_3) | 4 | VAL A 15LEU A 3LEU A 57ILE A 24 | None | 0.90A | 3u5kD-3nivA:undetectable | 3u5kD-3nivA:19.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nxb | CAT EYE SYNDROMECRITICAL REGIONPROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 5 | TRP A 457PRO A 458VAL A 463ASN A 514MET A 523 | NoneNoneEDO A 1 (-4.3A)EDO A 1 (-3.3A)None | 0.50A | 3u5kD-3nxbA:16.6 | 3u5kD-3nxbA:32.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oep | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA0988 (Thermusthermophilus) |
PF02626(CT_A_B)PF02682(CT_C_D) | 4 | VAL A 445LEU A 408LEU A 394ILE A 489 | None | 0.86A | 3u5kD-3oepA:undetectable | 3u5kD-3oepA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owt | DNA-BINDING PROTEINRAP1 (Saccharomycescerevisiae) |
PF11626(Rap1_C) | 4 | PRO A 766LEU A 758LEU A 755ILE A 724 | None | 0.89A | 3u5kD-3owtA:undetectable | 3u5kD-3owtA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9z | UROPORPHYRINOGEN IIICOSYNTHASE (HEMD) (Helicobacterpylori) |
PF02602(HEM4) | 4 | VAL A 110LEU A 126ILE A 101MET A 88 | None | 0.72A | 3u5kD-3p9zA:undetectable | 3u5kD-3p9zA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pkj | NAD-DEPENDENTDEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 4 | PRO A 290VAL A 102LEU A 104LEU A 99 | None | 0.93A | 3u5kD-3pkjA:undetectable | 3u5kD-3pkjA:17.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3q2e | BROMODOMAIN AND WDREPEAT-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00439(Bromodomain) | 4 | PRO A1337VAL A1342ILE A1400MET A1403 | None | 0.41A | 3u5kD-3q2eA:16.5 | 3u5kD-3q2eA:33.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q98 | TRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | PRO A 154LEU A 87LEU A 82ILE A 119 | None | 0.77A | 3u5kD-3q98A:undetectable | 3u5kD-3q98A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5x | D-ALANINE--D-ALANINELIGASE (Bacillusanthracis) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | VAL A 70LEU A 58LEU A 60ILE A 38 | None | 0.80A | 3u5kD-3r5xA:undetectable | 3u5kD-3r5xA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpe | TOLL-LIKE RECEPTOR 9 (Bos taurus) |
PF13516(LRR_6)PF13855(LRR_8) | 4 | VAL A 419LEU A 397LEU A 421ILE A 409 | None | 0.88A | 3u5kD-3wpeA:undetectable | 3u5kD-3wpeA:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad8 | DNA REPAIR PROTEINRECN (Deinococcusradiodurans) |
PF02463(SMC_N) | 4 | VAL A 530LEU A 50LEU A 48ILE A 70 | None | 0.93A | 3u5kD-4ad8A:undetectable | 3u5kD-4ad8A:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aef | NEOPULLULANASE(ALPHA-AMYLASE II) (Pyrococcusfuriosus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16561(AMPK1_CBM) | 4 | TRP A 400VAL A 302LEU A 292ILE A 261 | None | 0.82A | 3u5kD-4aefA:undetectable | 3u5kD-4aefA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aij | TRANSCRIPTIONALREGULATOR SLYA (Yersiniapseudotuberculosis) |
PF01047(MarR) | 4 | PRO A 98VAL A 103LEU A 27LEU A 29 | None | 0.89A | 3u5kD-4aijA:undetectable | 3u5kD-4aijA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6z | FAMILY M14UNASSIGNED PEPTIDASE (Burkholderiacenocepacia) |
PF00246(Peptidase_M14) | 4 | VAL A 212LEU A 148LEU A 137ILE A 256 | None | 0.92A | 3u5kD-4b6zA:undetectable | 3u5kD-4b6zA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ei8 | PLASMID REPLICATIONPROTEIN REPX (Bacillus cereus) |
PF00091(Tubulin) | 4 | VAL A 366LEU A 150LEU A 121ILE A 180 | None | 0.89A | 3u5kD-4ei8A:undetectable | 3u5kD-4ei8A:16.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hbx | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | None14X A 201 (-4.4A)14X A 201 (-4.7A)14X A 201 (-4.4A)None14X A 201 (-3.1A)14X A 201 ( 4.0A)14X A 201 (-3.5A) | 0.58A | 3u5kD-4hbxA:24.2 | 3u5kD-4hbxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | BAG FAMILY MOLECULARCHAPERONE REGULATOR1 (Arabidopsisthaliana) |
PF02179(BAG)PF14560(Ubiquitin_2) | 4 | PRO B 98LEU B 134LEU B 108ILE B 80 | None | 0.65A | 3u5kD-4hwiB:2.3 | 3u5kD-4hwiB:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA 1 (Lactobacillusbrevis) |
PF00005(ABC_tran) | 4 | PRO B 59LEU B 80LEU B 83ILE B 64 | None | 0.91A | 3u5kD-4hzuB:undetectable | 3u5kD-4hzuB:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1t | RNA-DIRECTED RNAPOLYMERASE L (Calimammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | PRO A 87LEU A 125LEU A 129ILE A 71 | None | 0.91A | 3u5kD-4i1tA:2.9 | 3u5kD-4i1tA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i62 | AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDINGPROTEIN, PUTATIVE (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 4 | PRO A 86VAL A 42LEU A 82ILE A 63 | None | 0.87A | 3u5kD-4i62A:undetectable | 3u5kD-4i62A:17.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ldf | GCN5 LIKE ACETYLASE+ BROMODOMAIN (Cryptosporidiumparvum) |
PF00439(Bromodomain) | 4 | TRP A 31PRO A 32VAL A 37ASN A 88 | NoneNoneGOL A 201 ( 4.9A)GOL A 201 (-2.7A) | 0.57A | 3u5kD-4ldfA:15.2 | 3u5kD-4ldfA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u09 | LIC12759 (Leptospirainterrogans) |
PF13855(LRR_8) | 4 | VAL A 313LEU A 299LEU A 322ILE A 306 | None | 0.92A | 3u5kD-4u09A:undetectable | 3u5kD-4u09A:14.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyd | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | NoneV1T A1171 (-4.2A)V1T A1171 (-4.9A)V1T A1171 (-3.8A)NoneV1T A1171 (-3.1A)DMS A1169 ( 4.3A)DMS A1169 ( 3.8A) | 0.36A | 3u5kD-4uydA:23.7 | 3u5kD-4uydA:92.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyg | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 370PRO A 371VAL A 376LEU A 381LEU A 383ASN A 429MET A 438 | NoneNone73B A1456 (-4.0A)73B A1456 (-4.9A)73B A1456 (-4.9A)73B A1456 (-3.3A)73B A1456 ( 3.8A) | 0.65A | 3u5kD-4uygA:18.0 | 3u5kD-4uygA:34.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wk0 | INTEGRIN BETA-1 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 4 | VAL B 436LEU B 101LEU B 438ILE B 375 | None | 0.88A | 3u5kD-4wk0B:undetectable | 3u5kD-4wk0B:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgm | MITOCHONDRIALRIBONUCLEASE PPROTEIN 3 (Homo sapiens) |
PF16953(PRORP) | 4 | PRO A 210LEU A 216ASN A 246ILE A 236 | None | 0.89A | 3u5kD-4xgmA:undetectable | 3u5kD-4xgmA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpz | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | PRO A 355LEU A 376LEU A 377ILE A 321 | PG4 A 603 (-4.5A)NoneNoneNone | 0.93A | 3u5kD-4xpzA:undetectable | 3u5kD-4xpzA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz3 | ACYL-COA SYNTHETASE(NDP FORMING) (CandidatusKorarchaeumcryptofilum) |
PF13380(CoA_binding_2)PF13607(Succ_CoA_lig) | 4 | PRO A 328VAL A 374LEU A 377ILE A 350 | None | 0.82A | 3u5kD-4xz3A:undetectable | 3u5kD-4xz3A:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzz | TRAP TRANSPORTERSOLUTE BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 4 | VAL A 311LEU A 191LEU A 188ILE A 167 | None | 0.85A | 3u5kD-4yzzA:undetectable | 3u5kD-4yzzA:16.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z93 | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 374PRO A 375VAL A 380LEU A 385LEU A 387ASN A 433MET A 442 | 4LD A 501 (-3.9A)4LD A 501 (-3.9A)4LD A 501 ( 3.8A)4LD A 501 (-4.1A)4LD A 501 (-4.4A)4LD A 501 (-2.8A)4LD A 501 ( 3.4A) | 0.59A | 3u5kD-4z93A:17.8 | 3u5kD-4z93A:36.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zw0 | 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN]DEHYDRATASE FABZ (CandidatusLiberibacterasiaticus) |
PF07977(FabA) | 4 | VAL A 28LEU A 15LEU A 19ILE A 79 | None | 0.83A | 3u5kD-4zw0A:undetectable | 3u5kD-4zw0A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4p | UBIQUITIN-CONJUGATING ENZYME E2 Z (Homo sapiens) |
PF00179(UQ_con) | 4 | VAL A 187LEU A 189LEU A 192MET A 119 | None | 0.88A | 3u5kD-5a4pA:undetectable | 3u5kD-5a4pA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f3y | UNCONVENTIONALMYOSIN-VIIB (Mus musculus) |
PF00784(MyTH4) | 4 | VAL A1433LEU A1450LEU A1436ILE A1410 | None | 0.90A | 3u5kD-5f3yA:2.5 | 3u5kD-5f3yA:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqf | LACTO-N-BIOSIDASE (Bifidobacteriumlongum) |
no annotation | 4 | VAL A 214LEU A 229LEU A 232ILE A 116 | None | 0.79A | 3u5kD-5gqfA:undetectable | 3u5kD-5gqfA:12.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hjc | BROMODOMAIN-CONTAINING PROTEIN 3 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 332PRO A 333VAL A 338LEU A 343LEU A 345ASN A 391MET A 400 | None | 0.75A | 3u5kD-5hjcA:18.0 | 3u5kD-5hjcA:39.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5izh | RNA-DIRECTED RNAPOLYMERASE L (Lassamammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | PRO A 88LEU A 126LEU A 130ILE A 72 | None | 0.92A | 3u5kD-5izhA:4.5 | 3u5kD-5izhA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j68 | ASTROTACTIN-2 (Homo sapiens) |
PF01823(MACPF) | 4 | PRO A 767VAL A 815LEU A 763ILE A 753 | None | 0.93A | 3u5kD-5j68A:undetectable | 3u5kD-5j68A:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k66 | NTA1P (Saccharomycescerevisiae) |
PF00795(CN_hydrolase) | 4 | PRO A 219VAL A 387LEU A 215ILE A 105 | None | 0.89A | 3u5kD-5k66A:undetectable | 3u5kD-5k66A:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN2, MITOCHONDRIAL (Bos taurus) |
PF00346(Complex1_49kDa) | 4 | VAL D 184LEU D 207LEU D 203ILE D 144 | None | 0.67A | 3u5kD-5lc5D:undetectable | 3u5kD-5lc5D:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lew | DNA POLYMERASE IIISUBUNIT ALPHA (Mycobacteriumtuberculosis) |
no annotation | 4 | VAL A 724LEU A 700LEU A 696ILE A 775 | None | 0.92A | 3u5kD-5lewA:undetectable | 3u5kD-5lewA:8.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lpk | HISTONEACETYLTRANSFERASEP300 (Homo sapiens) |
PF00439(Bromodomain) | 4 | PRO A1074VAL A1079LEU A1084ASN A1132 | XDM A1201 (-3.9A)XDM A1201 (-4.7A)XDM A1201 ( 4.4A)XDM A1201 (-3.1A) | 0.68A | 3u5kD-5lpkA:17.3 | 3u5kD-5lpkA:31.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg2 | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 1 (Homo sapiens) |
PF00439(Bromodomain) | 4 | TRP A1526PRO A1527VAL A1532ASN A1583 | None7M8 A1704 (-3.8A)7M8 A1704 (-3.5A)7M8 A1704 (-3.1A) | 0.48A | 3u5kD-5mg2A:13.1 | 3u5kD-5mg2A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ml0 | HISTONEACETYLTRANSFERASEKAT2B (Mus musculus) |
no annotation | 4 | TRP A 745PRO A 746VAL A 751ASN A 802 | NoneP2L A 901 (-4.7A)P2L A 901 ( 4.2A)P2L A 901 (-3.2A) | 0.67A | 3u5kD-5ml0A:15.9 | 3u5kD-5ml0A:26.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n15 | BROMODOMAIN-CONTAINING FACTOR 1 (Candidaalbicans) |
PF00439(Bromodomain) | 5 | PRO A 233VAL A 238ASN A 291ILE A 297MET A 300 | IOD A 405 ( 4.4A)NoneIOD A 404 (-3.9A)IOD A 404 ( 4.8A)None | 0.44A | 3u5kD-5n15A:18.2 | 3u5kD-5n15A:35.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmi | CYTOCHROME B-C1COMPLEX SUBUNIT 1,MITOCHONDRIAL (Bos taurus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 4 | VAL A 366LEU A 392LEU A 8ILE A 399 | None | 0.80A | 3u5kD-5nmiA:undetectable | 3u5kD-5nmiA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn8 | LYSOSOMALALPHA-GLUCOSIDASE (Homo sapiens) |
no annotation | 4 | VAL A 939LEU A 941LEU A 901ILE A 885 | CSO A 938 ( 2.8A)NoneNoneNone | 0.81A | 3u5kD-5nn8A:undetectable | 3u5kD-5nn8A:9.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 4 | TRP A 492VAL A 415LEU A 405ILE A 374 | None | 0.87A | 3u5kD-5ot1A:undetectable | 3u5kD-5ot1A:17.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tpx | HISTONEACETYLTRANSFERASEGCN5 (Plasmodiumfalciparum) |
PF00439(Bromodomain) | 4 | TRP A1379PRO A1380VAL A1385ASN A1436 | NoneNone7H7 A1505 (-4.0A)7H7 A1505 (-3.1A) | 0.70A | 3u5kD-5tpxA:15.9 | 3u5kD-5tpxA:30.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6v | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
no annotation | 7 | TRP A 370PRO A 371VAL A 376LEU A 381LEU A 383ASN A 429MET A 438 | None7WY A 501 (-4.4A)7WY A 501 ( 4.5A)7WY A 501 (-4.9A)None7WY A 501 (-3.4A)7WY A 501 ( 3.9A) | 0.48A | 3u5kD-5u6vA:18.0 | 3u5kD-5u6vA:40.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7g | CREB-BINDING PROTEIN (Mus musculus) |
PF00439(Bromodomain)PF00569(ZZ)PF06001(DUF902)PF08214(HAT_KAT11) | 4 | PRO A1111VAL A1116LEU A1121ASN A1169 | None | 0.78A | 3u5kD-5u7gA:16.7 | 3u5kD-5u7gA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uib | OXIDOREDUCTASEPROTEIN (Agrobacteriumtumefaciens) |
PF01408(GFO_IDH_MocA) | 4 | PRO A 242LEU A 179ASN A 126ILE A 291 | NoneTLA A 402 (-4.0A)NAD A 401 (-3.0A)NAD A 401 ( 4.7A) | 0.82A | 3u5kD-5uibA:undetectable | 3u5kD-5uibA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usx | THIOREDOXINREDUCTASE (Vibriovulnificus) |
PF07992(Pyr_redox_2) | 5 | PRO A 54VAL A 50LEU A 65LEU A 44ILE A 296 | NoneFAD A 402 (-3.4A)NoneFAD A 402 (-4.1A)None | 1.10A | 3u5kD-5usxA:undetectable | 3u5kD-5usxA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v84 | CAT EYE SYNDROMECRITICAL REGIONPROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 5 | TRP A 457PRO A 458VAL A 463ASN A 514MET A 523 | None96V A 602 (-4.5A)96V A 602 (-3.9A)96V A 602 (-2.6A)None | 0.33A | 3u5kD-5v84A:16.7 | 3u5kD-5v84A:28.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vbr | BROMODOMAINTESTIS-SPECIFICPROTEIN (Homo sapiens) |
no annotation | 8 | TRP A 50PRO A 51VAL A 56LEU A 61LEU A 63ASN A 109ILE A 115MET A 118 | CL A 208 (-4.9A)IBI A 201 (-4.3A)IBI A 201 ( 4.6A)IBI A 201 (-4.2A)IBI A 201 (-4.9A)IBI A 201 (-3.3A)IBI A 201 ( 3.8A)None | 0.49A | 3u5kD-5vbrA:19.4 | 3u5kD-5vbrA:68.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4c | THIOREDOXINREDUCTASE (Cryptococcusneoformans) |
no annotation | 4 | PRO A 83VAL A 79LEU A 73ILE A 326 | NoneFAD A 401 ( 3.8A)FAD A 401 (-3.9A)None | 0.88A | 3u5kD-5w4cA:undetectable | 3u5kD-5w4cA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvh | 6-PHOSPHOGLUCONATEDEHYDROGENASE,NAD-BINDING PROTEIN (Pyrobaculumcalidifontis) |
no annotation | 4 | PRO A 38VAL A 44LEU A 20LEU A 25 | None | 0.80A | 3u5kD-5xvhA:undetectable | 3u5kD-5xvhA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 4 | VAL A 420LEU A 398LEU A 422ILE A 410 | None | 0.93A | 3u5kD-5zlnA:undetectable | 3u5kD-5zlnA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | VP2 (Aquareovirus C) |
no annotation | 4 | PRO 2 183LEU 2 160LEU 2 157ILE 2 52 | None | 0.83A | 3u5kD-5zvs2:undetectable | 3u5kD-5zvs2:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bvp | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidusmetallidurans) |
no annotation | 4 | TRP A 31VAL A 40LEU A 107LEU A 62 | None | 0.93A | 3u5kD-6bvpA:undetectable | 3u5kD-6bvpA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byo | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
no annotation | 4 | PRO A 172VAL A 176LEU A 565ILE A 572 | None | 0.93A | 3u5kD-6byoA:undetectable | 3u5kD-6byoA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dne | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
no annotation | 8 | TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | NoneH1V A 501 (-4.6A)H1V A 501 ( 4.4A)H1V A 501 (-4.2A)H1V A 501 (-4.7A)H1V A 501 (-3.2A)H1V A 501 (-3.8A)H1V A 501 ( 3.8A) | 0.50A | 3u5kD-6dneA:23.4 | 3u5kD-6dneA:undetectable |