SIMILAR PATTERNS OF AMINO ACIDS FOR 3U5K_B_08JB2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 TRP A 350
PRO A 351
VAL A 356
ASN A 407
 None
 0.52A 3u5kB-1e6iA:
16.1		 3u5kB-1e6iA:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 VAL H   4
LEU H   6
LEU H  13
ILE H 168
 None
 0.96A 3u5kB-1q5qH:
0.6		 3u5kB-1q5qH:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		4 PRO A  53
VAL A  49
LEU A  64
LEU A  43
 None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.3A)
 0.91A 3u5kB-1tdfA:
undetectable		 3u5kB-1tdfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 VAL A  25
LEU A 250
ASN A  78
ILE A  41
 None
 0.99A 3u5kB-1uz4A:
undetectable		 3u5kB-1uz4A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		4 VAL A 128
LEU A  47
LEU A   6
ILE A  60
 None
 0.98A 3u5kB-1xntA:
undetectable		 3u5kB-1xntA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		4 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.85A 3u5kB-1yfyA:
undetectable		 3u5kB-1yfyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 VAL A 302
LEU A 280
LEU A  63
ILE A  77
 None
 0.88A 3u5kB-2aazA:
undetectable		 3u5kB-2aazA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 VAL A 224
LEU A 137
LEU A 142
ILE A 167
 None
 0.99A 3u5kB-2avtA:
undetectable		 3u5kB-2avtA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.98A 3u5kB-2cb1A:
undetectable		 3u5kB-2cb1A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PRO A  49
VAL A  41
LEU A  66
ILE A  55
 None
 0.95A 3u5kB-2cukA:
undetectable		 3u5kB-2cukA:
15.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A  31
PRO A  32
VAL A  37
LEU A  42
LEU A  44
ASN A  90
ILE A  96
 None
 0.39A 3u5kB-2dvrA:
20.6		 3u5kB-2dvrA:
70.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A 253
LEU A 257
LEU A 259
ASN A 233
 None
 0.98A 3u5kB-2gqtA:
undetectable		 3u5kB-2gqtA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.82A 3u5kB-2gskA:
undetectable		 3u5kB-2gskA:
11.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		6 TRP A  57
PRO A  58
LEU A  68
LEU A  70
ASN A 116
ILE A 122
 None
 0.85A 3u5kB-2l5eA:
17.0		 3u5kB-2l5eA:
77.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH)
PF13867
(SAP30_Sin3_bdg) 		4 VAL A 182
LEU A 150
LEU A 153
ILE B 490
 None
 0.94A 3u5kB-2ld7A:
undetectable		 3u5kB-2ld7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.65A 3u5kB-2mbgA:
undetectable		 3u5kB-2mbgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 VAL A 114
LEU A  95
LEU A 119
ILE A 102
 None
 0.96A 3u5kB-2o6qA:
undetectable		 3u5kB-2o6qA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		4 VAL X 173
LEU X 170
LEU X 115
ILE X 197
 None
 0.90A 3u5kB-2p5zX:
undetectable		 3u5kB-2p5zX:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PRO A 770
VAL A 678
LEU A 696
ILE A 823
 None
 0.96A 3u5kB-2pffA:
undetectable		 3u5kB-2pffA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 PRO A 329
VAL A 333
LEU A 365
ILE A 406
 None
 0.92A 3u5kB-2pqdA:
undetectable		 3u5kB-2pqdA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 PRO A 212
VAL A 217
ASN A 268
ILE A 274
 None
 0.65A 3u5kB-2r0vA:
12.8		 3u5kB-2r0vA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		4 PRO A  34
VAL A  54
LEU A 107
ILE A 314
 None
 0.92A 3u5kB-2rg2A:
undetectable		 3u5kB-2rg2A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 VAL A 115
LEU A 137
LEU A 133
ILE A 146
 None
 0.98A 3u5kB-2v1uA:
undetectable		 3u5kB-2v1uA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 VAL A 391
LEU A 453
LEU A 445
ILE A 381
 None
 0.54A 3u5kB-2vgqA:
undetectable		 3u5kB-2vgqA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvx PROTEIN A52

(Vaccinia virus) 		PF06227
(Poxvirus) 		4 VAL A 144
LEU A 100
LEU A 104
ILE A 119
 None
 0.95A 3u5kB-2vvxA:
undetectable		 3u5kB-2vvxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjz IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Thermotoga
maritima) 		PF00117
(GATase) 		4 PRO B  49
LEU B  89
LEU B 103
ILE B   6
 None
 0.98A 3u5kB-2wjzB:
undetectable		 3u5kB-2wjzB:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		5 TRP A 292
PRO A 293
VAL A 298
LEU A 305
ASN A 351
 None
 0.63A 3u5kB-2wp1A:
16.8		 3u5kB-2wp1A:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		5 TRP A 292
VAL A 298
LEU A 303
LEU A 305
ASN A 351
 None
 0.68A 3u5kB-2wp1A:
16.8		 3u5kB-2wp1A:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb5 PUTATIVE FUSIDIC
ACID RESISTANCE
PROTEIN

(Staphylococcus
aureus) 		PF07299
(EF-G-binding_N)
PF16571
(FBP_C) 		4 VAL A  12
LEU A  74
LEU A  77
ILE A  60
 None
 0.91A 3u5kB-2yb5A:
undetectable		 3u5kB-2yb5A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A  97
PRO A  98
VAL A 103
LEU A 108
LEU A 110
ASN A 156
ILE A 162
 None
EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-4.5A)
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
 0.39A 3u5kB-2yekA:
20.3		 3u5kB-2yekA:
70.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 PRO A 449
VAL A 446
LEU A 413
LEU A 473
ILE A 491
 None
 1.16A 3u5kB-3aiiA:
undetectable		 3u5kB-3aiiA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 VAL A  51
LEU A  63
LEU A  66
ILE A 155
 None
 0.97A 3u5kB-3cdkA:
undetectable		 3u5kB-3cdkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.80A 3u5kB-3ctzA:
undetectable		 3u5kB-3ctzA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A1265
LEU A1104
LEU A1100
ILE A1136
 None
 0.91A 3u5kB-3dlsA:
undetectable		 3u5kB-3dlsA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 PRO A 227
VAL A 222
LEU A 109
ILE A 199
 None
 0.91A 3u5kB-3e3aA:
undetectable		 3u5kB-3e3aA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		4 TRP A 584
PRO A 581
ASN A  96
ILE A  98
 None
 0.98A 3u5kB-3fgwA:
undetectable		 3u5kB-3fgwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		4 VAL B 288
LEU B 241
LEU B 272
ILE B 248
 None
 1.00A 3u5kB-3fhcB:
undetectable		 3u5kB-3fhcB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe) 		PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		4 VAL E 179
LEU E 183
LEU E 185
ILE E 193
 None
 1.00A 3u5kB-3h0gE:
undetectable		 3u5kB-3h0gE:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmh TRANSCRIPTION
INITIATION FACTOR
TFIID 210 KDA
SUBUNIT

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TRP A1545
PRO A1546
VAL A1551
ASN A1602
 None
 0.75A 3u5kB-3hmhA:
12.5		 3u5kB-3hmhA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		4 VAL A 309
LEU A 347
LEU A 343
ILE A 352
 None
 1.00A 3u5kB-3igfA:
undetectable		 3u5kB-3igfA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.83A 3u5kB-3k2kA:
undetectable		 3u5kB-3k2kA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 VAL A  56
LEU A 154
LEU A 156
ASN A 635
 None
 0.95A 3u5kB-3lvvA:
undetectable		 3u5kB-3lvvA:
10.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxb CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TRP A 457
PRO A 458
VAL A 463
ASN A 514
 None
None
EDO  A   1 (-4.3A)
EDO  A   1 (-3.3A)
 0.41A 3u5kB-3nxbA:
16.6		 3u5kB-3nxbA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 VAL A  54
LEU A  51
LEU A  50
ILE A  39
 None
 0.92A 3u5kB-3oc6A:
undetectable		 3u5kB-3oc6A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr6 TRAPP-ASSOCIATED
PROTEIN TCA17

(Saccharomyces
cerevisiae) 		PF04628
(Sedlin_N) 		4 VAL A   8
LEU A  10
LEU A  19
ILE A 115
 None
 0.96A 3u5kB-3pr6A:
undetectable		 3u5kB-3pr6A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 PRO A  11
LEU A  55
LEU A  17
ILE A 154
 None
 0.93A 3u5kB-3s6dA:
undetectable		 3u5kB-3s6dA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aij TRANSCRIPTIONAL
REGULATOR SLYA

(Yersinia
pseudotuberculosis) 		PF01047
(MarR) 		4 PRO A  98
VAL A 103
LEU A  27
LEU A  29
 None
 0.91A 3u5kB-4aijA:
undetectable		 3u5kB-4aijA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.80A 3u5kB-4b6zA:
undetectable		 3u5kB-4b6zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		4 VAL A 366
LEU A 150
LEU A 121
ILE A 180
 None
 0.98A 3u5kB-4ei8A:
undetectable		 3u5kB-4ei8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.84A 3u5kB-4g9kA:
undetectable		 3u5kB-4g9kA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.72A 3u5kB-4glxA:
undetectable		 3u5kB-4glxA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 None
14X  A 201 (-4.4A)
14X  A 201 (-4.7A)
14X  A 201 (-4.4A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
 0.49A 3u5kB-4hbxA:
24.6		 3u5kB-4hbxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		4 VAL A 254
LEU A 251
LEU A 237
ILE A 269
 None
 0.99A 3u5kB-4hseA:
undetectable		 3u5kB-4hseA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		4 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.87A 3u5kB-4hvqA:
undetectable		 3u5kB-4hvqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 PRO B  59
LEU B  80
LEU B  83
ILE B  64
 None
 0.86A 3u5kB-4hzuB:
undetectable		 3u5kB-4hzuB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1t RNA-DIRECTED RNA
POLYMERASE L

(Cali
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		4 PRO A  87
LEU A 125
LEU A 129
ILE A  71
 None
 0.95A 3u5kB-4i1tA:
3.1		 3u5kB-4i1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		4 VAL A  51
LEU A  25
LEU A  23
ILE A   6
 None
 1.01A 3u5kB-4inzA:
undetectable		 3u5kB-4inzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 VAL A  50
LEU A  92
LEU A  90
ASN A 597
 None
 0.97A 3u5kB-4k0eA:
undetectable		 3u5kB-4k0eA:
7.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ldf GCN5 LIKE ACETYLASE
+ BROMODOMAIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		4 TRP A  31
PRO A  32
VAL A  37
ASN A  88
 None
None
GOL  A 201 ( 4.9A)
GOL  A 201 (-2.7A)
 0.67A 3u5kB-4ldfA:
15.1		 3u5kB-4ldfA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 PRO A1110
VAL A1115
LEU A1120
ASN A1168
 None
 0.51A 3u5kB-4n3wA:
13.5		 3u5kB-4n3wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		4 VAL A 294
LEU A 248
LEU A 296
ILE A 334
 None
 0.98A 3u5kB-4pmdA:
undetectable		 3u5kB-4pmdA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		4 TRP A  25
PRO A  24
LEU A  21
LEU A  82
 BMA  A 503 ( 4.1A)
None
None
None
 0.94A 3u5kB-4r9gA:
undetectable		 3u5kB-4r9gA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		4 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.87A 3u5kB-4tkmA:
undetectable		 3u5kB-4tkmA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 VAL A 313
LEU A 299
LEU A 322
ILE A 306
 None
 0.97A 3u5kB-4u09A:
undetectable		 3u5kB-4u09A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 TRP A 681
VAL A 764
LEU A 710
ILE A 688
 None
 0.84A 3u5kB-4uw2A:
undetectable		 3u5kB-4uw2A:
9.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.28A 3u5kB-4uydA:
24.3		 3u5kB-4uydA:
92.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		6 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
 None
None
73B  A1456 (-4.0A)
73B  A1456 (-4.9A)
73B  A1456 (-4.9A)
73B  A1456 (-3.3A)
 0.43A 3u5kB-4uygA:
18.0		 3u5kB-4uygA:
34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 PRO A 355
LEU A 376
LEU A 377
ILE A 321
 PG4  A 603 (-4.5A)
None
None
None
 0.98A 3u5kB-4xpzA:
undetectable		 3u5kB-4xpzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 PRO A 328
VAL A 374
LEU A 377
ILE A 350
 None
 0.98A 3u5kB-4xz3A:
undetectable		 3u5kB-4xz3A:
12.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		6 TRP A 374
PRO A 375
VAL A 380
LEU A 385
LEU A 387
ASN A 433
 4LD  A 501 (-3.9A)
4LD  A 501 (-3.9A)
4LD  A 501 ( 3.8A)
4LD  A 501 (-4.1A)
4LD  A 501 (-4.4A)
4LD  A 501 (-2.8A)
 0.48A 3u5kB-4z93A:
17.8		 3u5kB-4z93A:
36.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.76A 3u5kB-4zkeA:
undetectable		 3u5kB-4zkeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfe EXODEOXYRIBONUCLEASE

(Bacillus
subtilis) 		PF03372
(Exo_endo_phos) 		4 PRO A 139
VAL A 102
LEU A   3
ILE A 252
 None
 0.85A 3u5kB-5cfeA:
undetectable		 3u5kB-5cfeA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 VAL A1433
LEU A1450
LEU A1436
ILE A1410
 None
 0.87A 3u5kB-5f3yA:
undetectable		 3u5kB-5f3yA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 PRO A 236
VAL A 250
LEU A 248
ILE A 215
 None
 1.00A 3u5kB-5gr8A:
undetectable		 3u5kB-5gr8A:
10.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Homo sapiens) 		PF00439
(Bromodomain) 		6 TRP A 332
PRO A 333
VAL A 338
LEU A 343
LEU A 345
ASN A 391
 None
 0.58A 3u5kB-5hjcA:
18.0		 3u5kB-5hjcA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8g CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 PRO A1110
VAL A1115
LEU A1120
ASN A1168
 69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-3.0A)
 0.56A 3u5kB-5i8gA:
16.1		 3u5kB-5i8gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 VAL A 545
LEU A 640
LEU A 645
ILE A 595
 None
 0.93A 3u5kB-5iy9A:
undetectable		 3u5kB-5iy9A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izh RNA-DIRECTED RNA
POLYMERASE L

(Lassa
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		4 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.92A 3u5kB-5izhA:
4.4		 3u5kB-5izhA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k66 NTA1P

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.84A 3u5kB-5k66A:
undetectable		 3u5kB-5k66A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		4 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.84A 3u5kB-5lc5D:
undetectable		 3u5kB-5lc5D:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpk HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A1074
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.46A 3u5kB-5lpkA:
17.1		 3u5kB-5lpkA:
31.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TRP A1526
PRO A1527
VAL A1532
ASN A1583
 None
7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 (-3.1A)
 0.41A 3u5kB-5mg2A:
12.9		 3u5kB-5mg2A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B

(Mus musculus) 		no annotation 4 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.56A 3u5kB-5ml0A:
15.7		 3u5kB-5ml0A:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		4 PRO A 233
VAL A 238
ASN A 291
ILE A 297
 IOD  A 405 ( 4.4A)
None
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
 0.25A 3u5kB-5n15A:
18.5		 3u5kB-5n15A:
35.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		4 PRO A 233
VAL A 238
LEU A 243
ILE A 297
 IOD  A 405 ( 4.4A)
None
None
IOD  A 404 ( 4.8A)
 0.58A 3u5kB-5n15A:
18.5		 3u5kB-5n15A:
35.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 VAL A 181
LEU A 132
LEU A 135
ILE A 169
 None
 0.95A 3u5kB-5n6vA:
undetectable		 3u5kB-5n6vA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.91A 3u5kB-5nn8A:
undetectable		 3u5kB-5nn8A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 4 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.98A 3u5kB-5nxkA:
undetectable		 3u5kB-5nxkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S7, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 PRO Q  44
VAL Q  76
LEU Q  98
ASN Q  49
 None
 0.94A 3u5kB-5optQ:
undetectable		 3u5kB-5optQ:
16.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tpx HISTONE
ACETYLTRANSFERASE
GCN5

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 TRP A1379
PRO A1380
VAL A1385
ASN A1436
 None
None
7H7  A1505 (-4.0A)
7H7  A1505 (-3.1A)
 0.62A 3u5kB-5tpxA:
15.8		 3u5kB-5tpxA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		no annotation 6 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
 None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
 0.38A 3u5kB-5u6vA:
18.1		 3u5kB-5u6vA:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 PRO A1111
VAL A1116
LEU A1121
ASN A1169
 None
 0.48A 3u5kB-5u7gA:
16.6		 3u5kB-5u7gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		4 VAL A 332
LEU A 338
ASN A 413
ILE A 422
 BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
 0.78A 3u5kB-5u9nA:
14.2		 3u5kB-5u9nA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v84 CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TRP A 457
PRO A 458
VAL A 463
ASN A 514
 None
96V  A 602 (-4.5A)
96V  A 602 (-3.9A)
96V  A 602 (-2.6A)
 0.27A 3u5kB-5v84A:
16.5		 3u5kB-5v84A:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 6 TRP A  50
PRO A  51
VAL A  56
LEU A  61
ASN A 109
ILE A 115
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.55A 3u5kB-5vbrA:
19.4		 3u5kB-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 6 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
 0.50A 3u5kB-5vbrA:
19.4		 3u5kB-5vbrA:
68.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 VAL A 420
LEU A 398
LEU A 422
ILE A 410
 None
 0.87A 3u5kB-5zlnA:
undetectable		 3u5kB-5zlnA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvp 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		no annotation 4 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.79A 3u5kB-6bvpA:
undetectable		 3u5kB-6bvpA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw0 CGD2_2690 PROTEIN

(Cryptosporidium
parvum) 		no annotation 4 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.49A 3u5kB-6cw0A:
16.7		 3u5kB-6cw0A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 7 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.48A 3u5kB-6dneA:
23.9		 3u5kB-6dneA:
undetectable