SIMILAR PATTERNS OF AMINO ACIDS FOR 3U5K_A_08JA1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1e6i | TRANSCRIPTIONALACTIVATOR GCN5 (Saccharomycescerevisiae) |
PF00439(Bromodomain) | 4 | TRP A 350PRO A 351VAL A 356ASN A 407 | None | 0.56A | 3u5kA-1e6iA:16.0 | 3u5kA-1e6iA:34.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1im4 | DBH (Sulfolobussolfataricus) |
PF00817(IMS)PF11798(IMS_HHH) | 5 | PRO A 185LEU A 179LEU A 176ASN A 148ILE A 150 | None | 1.37A | 3u5kA-1im4A:undetectable | 3u5kA-1im4A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 4 | VAL A 239LEU A 211LEU A 204ILE A 258 | None | 0.87A | 3u5kA-1kczA:0.0 | 3u5kA-1kczA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzh | PHOSPHOFRUCTOKINASE (Borreliellaburgdorferi) |
PF00365(PFK) | 4 | PRO A 202LEU A 482ASN A 211ILE A 214 | None | 0.90A | 3u5kA-1kzhA:0.0 | 3u5kA-1kzhA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mr2 | ADPR PYROPHOSPHATASE (Mycobacteriumtuberculosis) |
PF00293(NUDIX) | 4 | VAL A 98LEU A 100LEU A 94ILE A 57 | None | 0.85A | 3u5kA-1mr2A:1.0 | 3u5kA-1mr2A:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1q | SULFOTRANSFERASEFAMILY, CYTOSOLIC,2B, MEMBER 1 ISOFORMA (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | VAL A 225LEU A 222LEU A 217ILE A 209 | None | 0.89A | 3u5kA-1q1qA:undetectable | 3u5kA-1q1qA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdf | THIOREDOXINREDUCTASE (Escherichiacoli) |
PF07992(Pyr_redox_2) | 5 | PRO A 53VAL A 49LEU A 64LEU A 43ILE A 296 | NoneFAD A 500 (-3.4A)NoneFAD A 500 (-3.3A)None | 0.98A | 3u5kA-1tdfA:undetectable | 3u5kA-1tdfA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdc | NADPH DEPENDENTTHIOREDOXINREDUCTASE (Arabidopsisthaliana) |
PF07992(Pyr_redox_2) | 4 | PRO A 53LEU A 64LEU A 43ILE A 296 | NoneNoneFAD A 400 (-4.1A)None | 0.89A | 3u5kA-1vdcA:undetectable | 3u5kA-1vdcA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfy | 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE (Cupriavidusmetallidurans) |
PF06052(3-HAO) | 4 | TRP A 31VAL A 40LEU A 107LEU A 62 | None | 0.85A | 3u5kA-1yfyA:undetectable | 3u5kA-1yfyA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 4 | VAL A 302LEU A 280LEU A 63ILE A 77 | None | 0.83A | 3u5kA-2aazA:undetectable | 3u5kA-2aazA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bac | PUTATIVEAMINOOXIDASE (Cutibacteriumacnes) |
PF01593(Amino_oxidase) | 4 | VAL A 181LEU A 185ILE A 162MET A 302 | None | 0.83A | 3u5kA-2bacA:undetectable | 3u5kA-2bacA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb1 | O-ACETYL HOMOSERINESULFHYDRYLASE (Thermusthermophilus) |
PF01053(Cys_Met_Meta_PP) | 4 | VAL A 389LEU A 333LEU A 335ILE A 348 | None | 0.89A | 3u5kA-2cb1A:undetectable | 3u5kA-2cb1A:13.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dvr | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 31PRO A 32VAL A 37LEU A 42LEU A 44ASN A 90ILE A 96MET A 99 | None | 0.39A | 3u5kA-2dvrA:20.8 | 3u5kA-2dvrA:70.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsk | VITAMIN B12TRANSPORTER BTUB (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | PRO A 412LEU A 401LEU A 398ASN A 362 | None | 0.79A | 3u5kA-2gskA:undetectable | 3u5kA-2gskA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i88 | COLICIN-E1 (Escherichiacoli) |
PF01024(Colicin) | 4 | TRP A 460VAL A 447LEU A 486ILE A 503 | None | 0.88A | 3u5kA-2i88A:undetectable | 3u5kA-2i88A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2it1 | 362AA LONGHYPOTHETICALMALTOSE/MALTODEXTRINTRANSPORTATP-BINDING PROTEIN (Pyrococcushorikoshii) |
PF00005(ABC_tran) | 4 | VAL A 172LEU A 161LEU A 164ILE A 144 | None | 0.85A | 3u5kA-2it1A:undetectable | 3u5kA-2it1A:15.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2l5e | BROMODOMAIN-CONTAINING PROTEIN 3 (Mus musculus) |
PF00439(Bromodomain) | 6 | PRO A 58LEU A 68LEU A 70ASN A 116ILE A 122MET A 125 | None | 0.87A | 3u5kA-2l5eA:17.3 | 3u5kA-2l5eA:77.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2l5e | BROMODOMAIN-CONTAINING PROTEIN 3 (Mus musculus) |
PF00439(Bromodomain) | 6 | TRP A 57PRO A 58LEU A 70ASN A 116ILE A 122MET A 125 | None | 0.87A | 3u5kA-2l5eA:17.3 | 3u5kA-2l5eA:77.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okc | TYPE I RESTRICTIONENZYME STYSJI MPROTEIN (Bacteroidesthetaiotaomicron) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | PRO A 177LEU A 185ILE A 256MET A 292 | None | 0.89A | 3u5kA-2okcA:undetectable | 3u5kA-2okcA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2s | PUTATIVEOXIDOREDUCTASE (Pectobacteriumatrosepticum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | VAL A 108LEU A 105LEU A 99ILE A 317 | None | 0.83A | 3u5kA-2p2sA:undetectable | 3u5kA-2p2sA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqd | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Agrobacteriumsp.) |
PF00275(EPSP_synthase) | 4 | PRO A 329VAL A 333LEU A 365ILE A 406 | None | 0.90A | 3u5kA-2pqdA:undetectable | 3u5kA-2pqdA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vgq | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN,MITOCHONDRIALANTIVIRAL-SIGNALINGPROTEIN (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8)PF16739(CARD_2) | 4 | VAL A 391LEU A 453LEU A 445ILE A 381 | None | 0.69A | 3u5kA-2vgqA:undetectable | 3u5kA-2vgqA:14.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wp1 | BROMODOMAINTESTIS-SPECIFICPROTEIN (Mus musculus) |
PF00439(Bromodomain) | 6 | TRP A 292PRO A 293VAL A 298LEU A 305ASN A 351MET A 360 | None | 0.58A | 3u5kA-2wp1A:16.8 | 3u5kA-2wp1A:38.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wp1 | BROMODOMAINTESTIS-SPECIFICPROTEIN (Mus musculus) |
PF00439(Bromodomain) | 6 | TRP A 292VAL A 298LEU A 303LEU A 305ASN A 351MET A 360 | None | 0.65A | 3u5kA-2wp1A:16.8 | 3u5kA-2wp1A:38.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yek | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 97PRO A 98VAL A 103LEU A 108LEU A 110ASN A 156ILE A 162MET A 165 | NoneEAM A1188 (-4.6A)EAM A1188 (-4.4A)EAM A1188 ( 3.8A)EAM A1188 (-4.5A)EAM A1188 (-3.2A)EAM A1188 (-3.8A)EAM A1188 ( 4.1A) | 0.39A | 3u5kA-2yekA:20.6 | 3u5kA-2yekA:70.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrr | AMINOTRANSFERASE,CLASS V (Thermusthermophilus) |
PF00266(Aminotran_5) | 4 | PRO A 294VAL A 291LEU A 325LEU A 327 | None | 0.89A | 3u5kA-2yrrA:undetectable | 3u5kA-2yrrA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7x | TOLL-LIKE RECEPTOR1, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13855(LRR_8) | 4 | PRO B 40LEU B 68LEU B 71ILE B 52 | None | 0.91A | 3u5kA-2z7xB:undetectable | 3u5kA-2z7xB:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a75 | GAMMA-GLUTAMYLTRANSPEPTIDASE LARGE CHAIN (Bacillussubtilis) |
PF01019(G_glu_transpept) | 4 | VAL A 83LEU A 225ILE A 170MET A 166 | None | 0.90A | 3u5kA-3a75A:undetectable | 3u5kA-3a75A:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctz | XAA-PROAMINOPEPTIDASE 1 (Homo sapiens) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 4 | VAL A 247LEU A 251LEU A 253ILE A 237 | None | 0.74A | 3u5kA-3ctzA:undetectable | 3u5kA-3ctzA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4w | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumavium) |
PF00199(Catalase) | 4 | VAL A 219LEU A 214LEU A 210ILE A 62 | None | 0.89A | 3u5kA-3e4wA:undetectable | 3u5kA-3e4wA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ef1 | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | PRO A 417LEU A 438LEU A 439ILE A 321 | None | 0.89A | 3u5kA-3ef1A:undetectable | 3u5kA-3ef1A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gt0 | PYRROLINE-5-CARBOXYLATE REDUCTASE (Bacillus cereus) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 4 | VAL A 147LEU A 133ILE A 96MET A 13 | None | 0.82A | 3u5kA-3gt0A:undetectable | 3u5kA-3gt0A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmh | TRANSCRIPTIONINITIATION FACTORTFIID 210 KDASUBUNIT (Homo sapiens) |
PF00439(Bromodomain) | 4 | TRP A1545PRO A1546VAL A1551ASN A1602 | None | 0.77A | 3u5kA-3hmhA:12.6 | 3u5kA-3hmhA:26.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivr | PUTATIVELONG-CHAIN-FATTY-ACID COA LIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding) | 4 | VAL A 118LEU A 100ILE A 62MET A 70 | None | 0.86A | 3u5kA-3ivrA:undetectable | 3u5kA-3ivrA:11.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1r | HARMONINUSHER SYNDROMETYPE-1G PROTEIN (Homo sapiens) |
PF00536(SAM_1)PF00595(PDZ) | 4 | VAL A 102LEU B 461LEU A 100ILE A 137 | None | 0.86A | 3u5kA-3k1rA:undetectable | 3u5kA-3k1rA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2k | PUTATIVECARBOXYPEPTIDASE (Burkholderiamallei) |
PF00246(Peptidase_M14) | 4 | VAL A 212LEU A 148LEU A 137ILE A 256 | None | 0.76A | 3u5kA-3k2kA:undetectable | 3u5kA-3k2kA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8d | METHYLTRANSFERASE (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 4 | VAL A 200ASN A 124ILE A 123MET A 121 | None | 0.79A | 3u5kA-3l8dA:undetectable | 3u5kA-3l8dA:19.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nxb | CAT EYE SYNDROMECRITICAL REGIONPROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 5 | TRP A 457PRO A 458VAL A 463ASN A 514MET A 523 | NoneNoneEDO A 1 (-4.3A)EDO A 1 (-3.3A)None | 0.44A | 3u5kA-3nxbA:16.6 | 3u5kA-3nxbA:32.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc6 | 6-PHOSPHOGLUCONOLACTONASE (Mycolicibacteriumsmegmatis) |
PF01182(Glucosamine_iso) | 4 | VAL A 54LEU A 51LEU A 50ILE A 39 | None | 0.90A | 3u5kA-3oc6A:undetectable | 3u5kA-3oc6A:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohe | HISTIDINE TRIAD(HIT) PROTEIN (Marinobacterhydrocarbonoclasticus) |
PF01230(HIT) | 4 | PRO A 32VAL A 34LEU A 25LEU A 15 | None | 0.81A | 3u5kA-3oheA:undetectable | 3u5kA-3oheA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9z | UROPORPHYRINOGEN IIICOSYNTHASE (HEMD) (Helicobacterpylori) |
PF02602(HEM4) | 4 | VAL A 110LEU A 126ILE A 101MET A 88 | None | 0.82A | 3u5kA-3p9zA:undetectable | 3u5kA-3p9zA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pkj | NAD-DEPENDENTDEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 4 | PRO A 290VAL A 102LEU A 104LEU A 99 | None | 0.88A | 3u5kA-3pkjA:undetectable | 3u5kA-3pkjA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pr6 | TRAPP-ASSOCIATEDPROTEIN TCA17 (Saccharomycescerevisiae) |
PF04628(Sedlin_N) | 4 | VAL A 8LEU A 10LEU A 19ILE A 115 | None | 0.88A | 3u5kA-3pr6A:undetectable | 3u5kA-3pr6A:24.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3q2e | BROMODOMAIN AND WDREPEAT-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00439(Bromodomain) | 4 | PRO A1337VAL A1342ILE A1400MET A1403 | None | 0.40A | 3u5kA-3q2eA:16.4 | 3u5kA-3q2eA:33.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3son | HYPOTHETICAL NUDIXHYDROLASE (Listeriamonocytogenes) |
PF00293(NUDIX) | 4 | VAL A 103LEU A 112ILE A 94MET A 65 | None | 0.89A | 3u5kA-3sonA:undetectable | 3u5kA-3sonA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | VAL A4688LEU A4705LEU A4654ILE A4664 | None | 0.89A | 3u5kA-3vkgA:undetectable | 3u5kA-3vkgA:3.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vti | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | PRO C 237LEU C 217LEU C 220ILE C 186 | None | 0.90A | 3u5kA-3vtiC:undetectable | 3u5kA-3vtiC:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxo | REDOX SENSORHISTIDINE KINASERESPONSE REGULATORDEVS (Mycobacteriumtuberculosis) |
PF02518(HATPase_c) | 4 | VAL A 485LEU A 456LEU A 482ILE A 525 | NoneNoneNoneOCS A 524 ( 4.0A) | 0.87A | 3u5kA-3zxoA:undetectable | 3u5kA-3zxoA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aef | NEOPULLULANASE(ALPHA-AMYLASE II) (Pyrococcusfuriosus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16561(AMPK1_CBM) | 4 | TRP A 400VAL A 302LEU A 292ILE A 261 | None | 0.87A | 3u5kA-4aefA:undetectable | 3u5kA-4aefA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aij | TRANSCRIPTIONALREGULATOR SLYA (Yersiniapseudotuberculosis) |
PF01047(MarR) | 4 | PRO A 98VAL A 103LEU A 27LEU A 29 | None | 0.90A | 3u5kA-4aijA:undetectable | 3u5kA-4aijA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6z | FAMILY M14UNASSIGNED PEPTIDASE (Burkholderiacenocepacia) |
PF00246(Peptidase_M14) | 4 | VAL A 212LEU A 148LEU A 137ILE A 256 | None | 0.75A | 3u5kA-4b6zA:undetectable | 3u5kA-4b6zA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmz | INTERNALIN (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4)PF13855(LRR_8) | 4 | VAL A 294LEU A 281LEU A 303ILE A 288 | None | 0.81A | 3u5kA-4fmzA:undetectable | 3u5kA-4fmzA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glx | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 4 | VAL A 444LEU A 474LEU A 500ILE A 458 | None | 0.82A | 3u5kA-4glxA:undetectable | 3u5kA-4glxA:12.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hbx | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | None14X A 201 (-4.4A)14X A 201 (-4.7A)14X A 201 (-4.4A)None14X A 201 (-3.1A)14X A 201 ( 4.0A)14X A 201 (-3.5A) | 0.48A | 3u5kA-4hbxA:25.0 | 3u5kA-4hbxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvq | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidusmetallidurans) |
PF06052(3-HAO) | 4 | TRP A 31VAL A 40LEU A 107LEU A 62 | None | 0.88A | 3u5kA-4hvqA:undetectable | 3u5kA-4hvqA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1t | RNA-DIRECTED RNAPOLYMERASE L (Calimammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | PRO A 87LEU A 125LEU A 129ILE A 71 | None | 0.79A | 3u5kA-4i1tA:3.1 | 3u5kA-4i1tA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i62 | AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDINGPROTEIN, PUTATIVE (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 4 | PRO A 86VAL A 42LEU A 82ILE A 63 | None | 0.85A | 3u5kA-4i62A:undetectable | 3u5kA-4i62A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgf | GAMMA-CRYSTALLIN D (Homo sapiens) |
PF00030(Crystall) | 4 | VAL A 75LEU A 25LEU A 29ILE A 3 | None | 0.88A | 3u5kA-4jgfA:undetectable | 3u5kA-4jgfA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 4 | VAL A 50LEU A 92LEU A 90ASN A 597 | None | 0.87A | 3u5kA-4k0eA:undetectable | 3u5kA-4k0eA:7.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ldf | GCN5 LIKE ACETYLASE+ BROMODOMAIN (Cryptosporidiumparvum) |
PF00439(Bromodomain) | 4 | TRP A 31PRO A 32VAL A 37ASN A 88 | NoneNoneGOL A 201 ( 4.9A)GOL A 201 (-2.7A) | 0.62A | 3u5kA-4ldfA:15.2 | 3u5kA-4ldfA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4raa | PUTATIVE EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF17170(DUF5128) | 4 | VAL A 182LEU A 164LEU A 158ILE A 235 | None | 0.86A | 3u5kA-4raaA:undetectable | 3u5kA-4raaA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u09 | LIC12759 (Leptospirainterrogans) |
PF13855(LRR_8) | 4 | VAL A 313LEU A 299LEU A 322ILE A 306 | None | 0.87A | 3u5kA-4u09A:undetectable | 3u5kA-4u09A:14.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyd | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 8 | TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | NoneV1T A1171 (-4.2A)V1T A1171 (-4.9A)V1T A1171 (-3.8A)NoneV1T A1171 (-3.1A)DMS A1169 ( 4.3A)DMS A1169 ( 3.8A) | 0.25A | 3u5kA-4uydA:24.5 | 3u5kA-4uydA:92.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyg | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 370PRO A 371VAL A 376LEU A 381LEU A 383ASN A 429MET A 438 | NoneNone73B A1456 (-4.0A)73B A1456 (-4.9A)73B A1456 (-4.9A)73B A1456 (-3.3A)73B A1456 ( 3.8A) | 0.52A | 3u5kA-4uygA:17.9 | 3u5kA-4uygA:34.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpz | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | PRO A 355LEU A 376LEU A 377ILE A 321 | PG4 A 603 (-4.5A)NoneNoneNone | 0.85A | 3u5kA-4xpzA:undetectable | 3u5kA-4xpzA:18.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z93 | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 374PRO A 375VAL A 380LEU A 385LEU A 387ASN A 433MET A 442 | 4LD A 501 (-3.9A)4LD A 501 (-3.9A)4LD A 501 ( 3.8A)4LD A 501 (-4.1A)4LD A 501 (-4.4A)4LD A 501 (-2.8A)4LD A 501 ( 3.4A) | 0.48A | 3u5kA-4z93A:17.8 | 3u5kA-4z93A:36.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 4 | VAL A 272LEU A 276LEU A 278ILE A 150 | None | 0.89A | 3u5kA-4zdkA:undetectable | 3u5kA-4zdkA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 4 | VAL A 708LEU A 687LEU A 674ILE A 659 | VAL A 708 ( 0.6A)LEU A 687 ( 0.6A)LEU A 674 ( 0.6A)ILE A 659 ( 0.7A) | 0.85A | 3u5kA-4zkeA:undetectable | 3u5kA-4zkeA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zw0 | 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN]DEHYDRATASE FABZ (CandidatusLiberibacterasiaticus) |
PF07977(FabA) | 4 | VAL A 28LEU A 15LEU A 19ILE A 79 | None | 0.85A | 3u5kA-4zw0A:undetectable | 3u5kA-4zw0A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4p | UBIQUITIN-CONJUGATING ENZYME E2 Z (Homo sapiens) |
PF00179(UQ_con) | 4 | VAL A 187LEU A 189LEU A 192MET A 119 | None | 0.84A | 3u5kA-5a4pA:undetectable | 3u5kA-5a4pA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | VAL C 504LEU C 508LEU C 510ILE C 180 | None | 0.89A | 3u5kA-5fseC:undetectable | 3u5kA-5fseC:10.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hjc | BROMODOMAIN-CONTAINING PROTEIN 3 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 332PRO A 333VAL A 338LEU A 343LEU A 345ASN A 391MET A 400 | None | 0.61A | 3u5kA-5hjcA:17.9 | 3u5kA-5hjcA:39.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2c | GATS-LIKE PROTEIN 3 (Homo sapiens) |
PF13840(ACT_7) | 4 | VAL A 133LEU A 137ILE A 123MET A 114 | None | 0.83A | 3u5kA-5i2cA:undetectable | 3u5kA-5i2cA:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iy9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Homo sapiens) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | VAL A 545LEU A 640LEU A 645ILE A 595 | None | 0.91A | 3u5kA-5iy9A:undetectable | 3u5kA-5iy9A:4.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5izh | RNA-DIRECTED RNAPOLYMERASE L (Lassamammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | PRO A 88LEU A 126LEU A 130ILE A 72 | None | 0.79A | 3u5kA-5izhA:4.6 | 3u5kA-5izhA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k66 | NTA1P (Saccharomycescerevisiae) |
PF00795(CN_hydrolase) | 4 | PRO A 219VAL A 387LEU A 215ILE A 105 | None | 0.88A | 3u5kA-5k66A:undetectable | 3u5kA-5k66A:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9h | 0940_GH29 (unidentified) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 4 | TRP A 188LEU A 146LEU A 150ILE A 204 | None | 0.87A | 3u5kA-5k9hA:undetectable | 3u5kA-5k9hA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN2, MITOCHONDRIAL (Bos taurus) |
PF00346(Complex1_49kDa) | 4 | VAL D 184LEU D 207LEU D 203ILE D 144 | None | 0.67A | 3u5kA-5lc5D:undetectable | 3u5kA-5lc5D:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lew | DNA POLYMERASE IIISUBUNIT ALPHA (Mycobacteriumtuberculosis) |
no annotation | 4 | VAL A 724LEU A 700LEU A 696ILE A 775 | None | 0.89A | 3u5kA-5lewA:undetectable | 3u5kA-5lewA:8.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lpk | HISTONEACETYLTRANSFERASEP300 (Homo sapiens) |
PF00439(Bromodomain) | 4 | PRO A1074VAL A1079LEU A1084ASN A1132 | XDM A1201 (-3.9A)XDM A1201 (-4.7A)XDM A1201 ( 4.4A)XDM A1201 (-3.1A) | 0.60A | 3u5kA-5lpkA:17.2 | 3u5kA-5lpkA:31.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg2 | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 1 (Homo sapiens) |
PF00439(Bromodomain) | 4 | TRP A1526PRO A1527VAL A1532ASN A1583 | None7M8 A1704 (-3.8A)7M8 A1704 (-3.5A)7M8 A1704 (-3.1A) | 0.46A | 3u5kA-5mg2A:13.1 | 3u5kA-5mg2A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ml0 | HISTONEACETYLTRANSFERASEKAT2B (Mus musculus) |
no annotation | 4 | TRP A 745PRO A 746VAL A 751ASN A 802 | NoneP2L A 901 (-4.7A)P2L A 901 ( 4.2A)P2L A 901 (-3.2A) | 0.63A | 3u5kA-5ml0A:15.8 | 3u5kA-5ml0A:26.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n15 | BROMODOMAIN-CONTAINING FACTOR 1 (Candidaalbicans) |
PF00439(Bromodomain) | 5 | PRO A 233VAL A 238ASN A 291ILE A 297MET A 300 | IOD A 405 ( 4.4A)NoneIOD A 404 (-3.9A)IOD A 404 ( 4.8A)None | 0.40A | 3u5kA-5n15A:18.6 | 3u5kA-5n15A:35.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n15 | BROMODOMAIN-CONTAINING FACTOR 1 (Candidaalbicans) |
PF00439(Bromodomain) | 4 | PRO A 233VAL A 238LEU A 243MET A 300 | IOD A 405 ( 4.4A)NoneNoneNone | 0.53A | 3u5kA-5n15A:18.6 | 3u5kA-5n15A:35.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn8 | LYSOSOMALALPHA-GLUCOSIDASE (Homo sapiens) |
no annotation | 4 | VAL A 939LEU A 941LEU A 901ILE A 885 | CSO A 938 ( 2.8A)NoneNoneNone | 0.90A | 3u5kA-5nn8A:undetectable | 3u5kA-5nn8A:9.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxk | SERINE-RICH SECRETEDCELL WALL ANCHORED(LPXTG-MOTIF )PROTEIN (Lactobacillusreuteri) |
no annotation | 4 | VAL A 534LEU A 536LEU A 562ILE A 526 | None | 0.90A | 3u5kA-5nxkA:undetectable | 3u5kA-5nxkA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 4 | TRP A 492VAL A 415LEU A 405ILE A 374 | None | 0.83A | 3u5kA-5ot1A:undetectable | 3u5kA-5ot1A:17.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tpx | HISTONEACETYLTRANSFERASEGCN5 (Plasmodiumfalciparum) |
PF00439(Bromodomain) | 4 | TRP A1379PRO A1380VAL A1385ASN A1436 | NoneNone7H7 A1505 (-4.0A)7H7 A1505 (-3.1A) | 0.67A | 3u5kA-5tpxA:15.9 | 3u5kA-5tpxA:30.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6v | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
no annotation | 7 | TRP A 370PRO A 371VAL A 376LEU A 381LEU A 383ASN A 429MET A 438 | None7WY A 501 (-4.4A)7WY A 501 ( 4.5A)7WY A 501 (-4.9A)None7WY A 501 (-3.4A)7WY A 501 ( 3.9A) | 0.41A | 3u5kA-5u6vA:18.0 | 3u5kA-5u6vA:40.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7g | CREB-BINDING PROTEIN (Mus musculus) |
PF00439(Bromodomain)PF00569(ZZ)PF06001(DUF902)PF08214(HAT_KAT11) | 4 | PRO A1111VAL A1116LEU A1121ASN A1169 | None | 0.56A | 3u5kA-5u7gA:16.6 | 3u5kA-5u7gA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u9n | BROMO DOMAINCONTAINING PROTEIN (Cryptosporidiumparvum) |
PF00439(Bromodomain) | 4 | VAL A 332LEU A 338ASN A 413ILE A 422 | BMF A 501 (-4.2A)BMF A 501 ( 4.9A)BMF A 501 (-2.8A)BMF A 501 ( 4.4A) | 0.77A | 3u5kA-5u9nA:14.3 | 3u5kA-5u9nA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usx | THIOREDOXINREDUCTASE (Vibriovulnificus) |
PF07992(Pyr_redox_2) | 4 | PRO A 54VAL A 50LEU A 65ILE A 296 | NoneFAD A 402 (-3.4A)NoneNone | 0.91A | 3u5kA-5usxA:undetectable | 3u5kA-5usxA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v84 | CAT EYE SYNDROMECRITICAL REGIONPROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 5 | TRP A 457PRO A 458VAL A 463ASN A 514MET A 523 | None96V A 602 (-4.5A)96V A 602 (-3.9A)96V A 602 (-2.6A)None | 0.28A | 3u5kA-5v84A:16.6 | 3u5kA-5v84A:28.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vbr | BROMODOMAINTESTIS-SPECIFICPROTEIN (Homo sapiens) |
no annotation | 8 | TRP A 50PRO A 51VAL A 56LEU A 61LEU A 63ASN A 109ILE A 115MET A 118 | CL A 208 (-4.9A)IBI A 201 (-4.3A)IBI A 201 ( 4.6A)IBI A 201 (-4.2A)IBI A 201 (-4.9A)IBI A 201 (-3.3A)IBI A 201 ( 3.8A)None | 0.49A | 3u5kA-5vbrA:19.3 | 3u5kA-5vbrA:68.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4c | THIOREDOXINREDUCTASE (Cryptococcusneoformans) |
no annotation | 4 | PRO A 83VAL A 79LEU A 73ILE A 326 | NoneFAD A 401 ( 3.8A)FAD A 401 (-3.9A)None | 0.89A | 3u5kA-5w4cA:undetectable | 3u5kA-5w4cA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 4 | VAL A 420LEU A 398LEU A 422ILE A 410 | None | 0.82A | 3u5kA-5zlnA:undetectable | 3u5kA-5zlnA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | VP2 (Aquareovirus C) |
no annotation | 4 | PRO 2 183LEU 2 160LEU 2 157ILE 2 52 | None | 0.87A | 3u5kA-5zvs2:undetectable | 3u5kA-5zvs2:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bvp | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidusmetallidurans) |
no annotation | 4 | TRP A 31VAL A 40LEU A 107LEU A 62 | None | 0.80A | 3u5kA-6bvpA:undetectable | 3u5kA-6bvpA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw0 | CGD2_2690 PROTEIN (Cryptosporidiumparvum) |
no annotation | 4 | VAL A 30LEU A 35LEU A 37ASN A 83 | R78 A 201 (-4.5A)R78 A 201 (-4.9A)NoneR78 A 201 (-3.3A) | 0.54A | 3u5kA-6cw0A:16.7 | 3u5kA-6cw0A:26.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dne | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
no annotation | 8 | TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | NoneH1V A 501 (-4.6A)H1V A 501 ( 4.4A)H1V A 501 (-4.2A)H1V A 501 (-4.7A)H1V A 501 (-3.2A)H1V A 501 (-3.8A)H1V A 501 ( 3.8A) | 0.36A | 3u5kA-6dneA:24.0 | 3u5kA-6dneA:undetectable |