SIMILAR PATTERNS OF AMINO ACIDS FOR 3U5J_A_08HA1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1di6 | MOLYBDENUM COFACTORBIOSYNTHETIC ENZYME (Escherichiacoli) |
PF00994(MoCF_biosynth) | 4 | TRP A 31LEU A 69LEU A 128ILE A 158 | None | 1.02A | 3u5jA-1di6A:undetectable | 3u5jA-1di6A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ef4 | DNA-DIRECTED RNAPOLYMERASE (Methanothermobacterthermautotrophicus) |
PF01194(RNA_pol_N) | 4 | PRO A 30LEU A 37LEU A 39ILE A 49 | None | 0.92A | 3u5jA-1ef4A:undetectable | 3u5jA-1ef4A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkg | HEXOKINASE A (Saccharomycescerevisiae) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 4 | TRP A 51PRO A 49ILE A 225MET A 240 | None | 1.03A | 3u5jA-1hkgA:undetectable | 3u5jA-1hkgA:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ikp | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 4 | TRP A 190LEU A 199LEU A 202ILE A 132 | None | 0.83A | 3u5jA-1ikpA:undetectable | 3u5jA-1ikpA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1im4 | DBH (Sulfolobussolfataricus) |
PF00817(IMS)PF11798(IMS_HHH) | 5 | PRO A 185LEU A 179LEU A 176ASN A 148ILE A 150 | None | 1.31A | 3u5jA-1im4A:undetectable | 3u5jA-1im4A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfi | PHOSPHOGLUCOMUTASE 1 (Parameciumtetraurelia) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | LEU A 329LEU A 357ILE A 387MET A 382 | None | 0.98A | 3u5jA-1kfiA:undetectable | 3u5jA-1kfiA:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzh | PHOSPHOFRUCTOKINASE (Borreliellaburgdorferi) |
PF00365(PFK) | 4 | PRO A 202LEU A 482ASN A 211ILE A 214 | None | 0.91A | 3u5jA-1kzhA:undetectable | 3u5jA-1kzhA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oxj | RNA-BINDING PROTEINSMAUG (Drosophilamelanogaster) |
PF00536(SAM_1)PF09246(PHAT) | 4 | PRO A 688LEU A 608ILE A 601MET A 598 | None | 0.93A | 3u5jA-1oxjA:undetectable | 3u5jA-1oxjA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 4 | PRO A 201LEU A 139ILE A 221MET A 169 | None | 1.03A | 3u5jA-1t6pA:undetectable | 3u5jA-1t6pA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdf | THIOREDOXINREDUCTASE (Escherichiacoli) |
PF07992(Pyr_redox_2) | 4 | PRO A 53LEU A 64LEU A 43ILE A 296 | NoneNoneFAD A 500 (-3.3A)None | 1.03A | 3u5jA-1tdfA:undetectable | 3u5jA-1tdfA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ue8 | 367AA LONGHYPOTHETICALCYTOCHROME P450 (Sulfurisphaeratokodaii) |
PF00067(p450) | 4 | PRO A 123LEU A 104LEU A 105ILE A 219 | None | 0.76A | 3u5jA-1ue8A:undetectable | 3u5jA-1ue8A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdc | NADPH DEPENDENTTHIOREDOXINREDUCTASE (Arabidopsisthaliana) |
PF07992(Pyr_redox_2) | 4 | PRO A 53LEU A 64LEU A 43ILE A 296 | NoneNoneFAD A 400 (-4.1A)None | 0.99A | 3u5jA-1vdcA:undetectable | 3u5jA-1vdcA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vk9 | CONSERVEDHYPOTHETICAL PROTEINTM1506 (Thermotogamaritima) |
PF08973(TM1506) | 4 | PRO A 72LEU A 42LEU A 20ILE A 75 | NoneNoneUNL A 201 ( 3.7A)None | 1.04A | 3u5jA-1vk9A:undetectable | 3u5jA-1vk9A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z45 | GAL10 BIFUNCTIONALPROTEIN (Saccharomycescerevisiae) |
PF01263(Aldose_epim)PF16363(GDP_Man_Dehyd) | 4 | PRO A 531LEU A 448ASN A 674ILE A 673 | None | 1.04A | 3u5jA-1z45A:undetectable | 3u5jA-1z45A:11.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 4 | PRO A 446LEU A 371ASN A 417MET A 318 | None | 0.98A | 3u5jA-2bf6A:undetectable | 3u5jA-2bf6A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2y | METHYLENETETRAHYDROFOLATEDEHYDROGENASE-METHENYLTETRAHYDROFOLATECYCLOHYDROLASE (Mycobacteriumtuberculosis) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 4 | LEU A 100LEU A 104ASN A 79ILE A 82 | None | 0.88A | 3u5jA-2c2yA:undetectable | 3u5jA-2c2yA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1f | THREONINE SYNTHASE (Mycobacteriumtuberculosis) |
PF00291(PALP) | 4 | PRO A 243LEU A 146ASN A 197ILE A 252 | NoneNonePLP A 500 (-4.8A)None | 1.02A | 3u5jA-2d1fA:undetectable | 3u5jA-2d1fA:14.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dvr | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 31PRO A 32LEU A 42LEU A 44ASN A 90ILE A 96MET A 99 | None | 0.33A | 3u5jA-2dvrA:20.5 | 3u5jA-2dvrA:70.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e6m | WERNER SYNDROMEATP-DEPENDENTHELICASE HOMOLOG (Mus musculus) |
PF01612(DNA_pol_A_exo1) | 4 | PRO A 115LEU A 122ILE A 108MET A 111 | None | 0.99A | 3u5jA-2e6mA:undetectable | 3u5jA-2e6mA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eql | HORSE MILK LYSOZYME (Equus caballus) |
PF00062(Lys) | 4 | TRP A 28LEU A 59LEU A 83ILE A 92 | None | 1.02A | 3u5jA-2eqlA:undetectable | 3u5jA-2eqlA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4z | TGTWINSCAN_2721 - E2DOMAIN (Toxoplasmagondii) |
PF00179(UQ_con) | 4 | PRO A 109LEU A 37ILE A 98MET A 111 | None | 0.95A | 3u5jA-2f4zA:undetectable | 3u5jA-2f4zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsk | VITAMIN B12TRANSPORTER BTUB (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | PRO A 412LEU A 401LEU A 398ASN A 362 | None | 0.81A | 3u5jA-2gskA:undetectable | 3u5jA-2gskA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6c | CHLOROPHENOLREDUCTION GENE K (Desulfitobacteriumdehalogenans) |
PF13545(HTH_Crp_2) | 4 | LEU A 222LEU A 219ILE A 174MET A 176 | None | 1.03A | 3u5jA-2h6cA:undetectable | 3u5jA-2h6cA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iqf | CATALASE (Helicobacterpylori) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | TRP A 179PRO A 132LEU A 291ILE A 283 | NoneNoneMHO A 292 ( 4.1A)None | 1.04A | 3u5jA-2iqfA:undetectable | 3u5jA-2iqfA:12.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixn | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AACTIVATOR 2 (Saccharomycescerevisiae) |
PF03095(PTPA) | 4 | TRP A 266PRO A 216LEU A 250ILE A 260 | None | 0.95A | 3u5jA-2ixnA:undetectable | 3u5jA-2ixnA:18.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2l5e | BROMODOMAIN-CONTAINING PROTEIN 3 (Mus musculus) |
PF00439(Bromodomain) | 7 | TRP A 57PRO A 58LEU A 68LEU A 70ASN A 116ILE A 122MET A 125 | None | 1.01A | 3u5jA-2l5eA:17.4 | 3u5jA-2l5eA:77.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lav | VACCINIA-RELATEDKINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | PRO A 296LEU A 155LEU A 324ILE A 299MET A 286 | None | 1.47A | 3u5jA-2lavA:undetectable | 3u5jA-2lavA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okc | TYPE I RESTRICTIONENZYME STYSJI MPROTEIN (Bacteroidesthetaiotaomicron) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | PRO A 177LEU A 185ILE A 256MET A 292 | None | 0.94A | 3u5jA-2okcA:undetectable | 3u5jA-2okcA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2m | ACETYL-COENZYME ASYNTHETASE (Salmonellaenterica) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 4 | PRO A 143LEU A 317LEU A 321ILE A 108 | None | 1.05A | 3u5jA-2p2mA:undetectable | 3u5jA-2p2mA:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfy | PUTATIVE EXPORTEDPROTEIN (Bordetellapertussis) |
PF03480(DctP) | 4 | PRO A 83LEU A 269ILE A 276MET A 280 | None | 0.94A | 3u5jA-2pfyA:undetectable | 3u5jA-2pfyA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r0v | CHROMATINSTRUCTURE-REMODELINGCOMPLEX PROTEIN RSC4 (Saccharomycescerevisiae) |
PF00439(Bromodomain) | 4 | PRO A 212LEU A 222ASN A 268ILE A 274 | None | 0.86A | 3u5jA-2r0vA:12.7 | 3u5jA-2r0vA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | LEU A 65LEU A 68ILE A 125MET A 80 | None | 0.88A | 3u5jA-2v7bA:undetectable | 3u5jA-2v7bA:13.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whd | THIOREDOXINREDUCTASE (Hordeum vulgare) |
PF07992(Pyr_redox_2) | 4 | PRO A 63LEU A 74LEU A 53ILE A 303 | NoneNoneFAD A 400 (-4.0A)None | 1.01A | 3u5jA-2whdA:undetectable | 3u5jA-2whdA:16.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wp1 | BROMODOMAINTESTIS-SPECIFICPROTEIN (Mus musculus) |
PF00439(Bromodomain) | 6 | TRP A 292PRO A 293LEU A 303LEU A 305ASN A 351MET A 360 | None | 0.70A | 3u5jA-2wp1A:16.7 | 3u5jA-2wp1A:38.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 4 | LEU A 719ASN A 416ILE A 339MET A 308 | None | 1.04A | 3u5jA-2xaxA:2.9 | 3u5jA-2xaxA:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xij | METHYLMALONYL-COAMUTASE,MITOCHONDRIAL (Homo sapiens) |
PF01642(MM_CoA_mutase)PF02310(B12-binding) | 4 | LEU A 549ASN A 219ILE A 217MET A 186 | None | 0.99A | 3u5jA-2xijA:undetectable | 3u5jA-2xijA:9.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwg | SORTASE (Actinomycesoris) |
PF04203(Sortase) | 4 | PRO A 191LEU A 263ILE A 169MET A 155 | None | 1.00A | 3u5jA-2xwgA:undetectable | 3u5jA-2xwgA:18.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yek | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 97PRO A 98LEU A 108LEU A 110ASN A 156ILE A 162MET A 165 | NoneEAM A1188 (-4.6A)EAM A1188 ( 3.8A)EAM A1188 (-4.5A)EAM A1188 (-3.2A)EAM A1188 (-3.8A)EAM A1188 ( 4.1A) | 0.47A | 3u5jA-2yekA:20.4 | 3u5jA-2yekA:70.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7x | TOLL-LIKE RECEPTOR1, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13855(LRR_8) | 4 | PRO B 40LEU B 68LEU B 71ILE B 52 | None | 0.96A | 3u5jA-2z7xB:undetectable | 3u5jA-2z7xB:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzg | ALANYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF01411(tRNA-synt_2c)PF07973(tRNA_SAD) | 4 | LEU A 310LEU A 313ASN A 295ILE A 332 | None | 0.94A | 3u5jA-2zzgA:undetectable | 3u5jA-2zzgA:9.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8x | THIOREDOXINREDUCTASE 1 (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 4 | PRO A 56LEU A 67LEU A 46ILE A 298 | NoneNoneFAD A1001 (-4.3A)None | 1.01A | 3u5jA-3d8xA:undetectable | 3u5jA-3d8xA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ef1 | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | PRO A 417LEU A 438LEU A 439ILE A 321 | None | 0.98A | 3u5jA-3ef1A:undetectable | 3u5jA-3ef1A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fha | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE (Glutamicibacterprotophormiae) |
PF03644(Glyco_hydro_85) | 4 | TRP A 204LEU A 138LEU A 135ILE A 214 | None | 1.00A | 3u5jA-3fhaA:undetectable | 3u5jA-3fhaA:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyj | MAJOR CAPSID PROTEINL1 (Deltapapillomavirus4) |
no annotation | 4 | LEU F 389LEU F 392ASN F 317ILE F 320 | None | 1.04A | 3u5jA-3iyjF:undetectable | 3u5jA-3iyjF:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwj | HEN1 (Trichormusvariabilis) |
PF08242(Methyltransf_12) | 4 | LEU A 324LEU A 327ILE A 297MET A 269 | None | 0.95A | 3u5jA-3jwjA:undetectable | 3u5jA-3jwjA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m16 | TRANSALDOLASE (Oleispiraantarctica) |
PF00923(TAL_FSA) | 4 | PRO A 184LEU A 243LEU A 270ILE A 216 | None | 0.92A | 3u5jA-3m16A:undetectable | 3u5jA-3m16A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n1b | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 54 (Mus musculus) |
PF07928(Vps54) | 4 | LEU A 959LEU A 962ILE A 917MET A 865 | None | 0.82A | 3u5jA-3n1bA:undetectable | 3u5jA-3n1bA:18.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nxb | CAT EYE SYNDROMECRITICAL REGIONPROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 4 | TRP A 457PRO A 458ASN A 514MET A 523 | NoneNoneEDO A 1 (-3.3A)None | 0.46A | 3u5jA-3nxbA:16.2 | 3u5jA-3nxbA:32.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pr2 | TRYPTOPHAN SYNTHASEALPHA CHAINTRYPTOPHAN SYNTHASEBETA CHAIN (Salmonellaenterica) |
PF00290(Trp_syntA)PF00291(PALP) | 4 | PRO B 18LEU A 162ASN A 157ILE B 20 | F9F A 1 (-4.1A)NoneNoneNone | 0.96A | 3u5jA-3pr2B:undetectable | 3u5jA-3pr2B:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r3q | SUPPRESSOR PROTEINSTP22 OFTEMPERATURE-SENSITIVE ALPHA-FACTORRECEPTOR ANDARGININE PERMEASE (Saccharomycescerevisiae) |
PF05743(UEV) | 4 | PRO A 96LEU A 38LEU A 45ILE A 98 | None | 1.04A | 3u5jA-3r3qA:undetectable | 3u5jA-3r3qA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6d | PUTATIVETRIOSEPHOSPHATEISOMERASE (Coccidioidesimmitis) |
PF00121(TIM) | 4 | PRO A 11LEU A 55LEU A 17ILE A 154 | None | 0.96A | 3u5jA-3s6dA:undetectable | 3u5jA-3s6dA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3soz | CYTOPLASMIC PROTEINSTM1381 (Salmonellaenterica) |
PF07090(GATase1_like) | 4 | LEU A 98LEU A 134ILE A 6MET A 49 | None | 1.00A | 3u5jA-3sozA:undetectable | 3u5jA-3sozA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vti | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | PRO C 237LEU C 217LEU C 220ILE C 186 | None | 0.93A | 3u5jA-3vtiC:undetectable | 3u5jA-3vtiC:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiw | GLYCOSYL HYDROLASEFAMILY 88 (Pedobacterheparinus) |
PF07470(Glyco_hydro_88) | 4 | PRO A 290LEU A 340LEU A 337ILE A 312 | None | 0.84A | 3u5jA-3wiwA:undetectable | 3u5jA-3wiwA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpe | TOLL-LIKE RECEPTOR 9 (Bos taurus) |
PF13516(LRR_6)PF13855(LRR_8) | 4 | TRP A 302LEU A 314LEU A 340ILE A 328 | None | 0.98A | 3u5jA-3wpeA:undetectable | 3u5jA-3wpeA:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aq9 | ACETYLCHOLINERECEPTOR GAMMASUBUNIT (Torpedomarmorata) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 4 | TRP E 85PRO E 87LEU E 157ILE E 57 | None | 1.00A | 3u5jA-4aq9E:undetectable | 3u5jA-4aq9E:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bjt | DNA-BINDING PROTEINRAP1 (Saccharomycescerevisiae) |
PF11626(Rap1_C) | 4 | PRO A 766LEU A 758LEU A 755ILE A 724 | None | 0.95A | 3u5jA-4bjtA:undetectable | 3u5jA-4bjtA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4w | DNA POLYMERASE IV (Sulfolobusacidocaldarius;Sulfolobussolfataricus) |
PF00817(IMS)PF11798(IMS_HHH) | 5 | PRO A 185LEU A 179LEU A 176ASN A 148ILE A 150 | None | 1.40A | 3u5jA-4f4wA:undetectable | 3u5jA-4f4wA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcg | UNCHARACTERIZEDPROTEIN (Xanthomonaseuvesicatoria) |
PF13855(LRR_8) | 4 | PRO A 289LEU A 285LEU A 261ILE A 268 | None | 1.02A | 3u5jA-4fcgA:undetectable | 3u5jA-4fcgA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gud | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISH (Vibrio cholerae) |
PF00117(GATase) | 4 | PRO A 47LEU A 84LEU A 103ILE A 8 | None | 0.97A | 3u5jA-4gudA:undetectable | 3u5jA-4gudA:18.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hbx | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 81PRO A 82LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | None14X A 201 (-4.4A)14X A 201 (-4.4A)None14X A 201 (-3.1A)14X A 201 ( 4.0A)14X A 201 (-3.5A) | 0.37A | 3u5jA-4hbxA:25.2 | 3u5jA-4hbxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | BAG FAMILY MOLECULARCHAPERONE REGULATOR1 (Arabidopsisthaliana) |
PF02179(BAG)PF14560(Ubiquitin_2) | 4 | PRO B 98LEU B 134LEU B 108ILE B 80 | None | 0.83A | 3u5jA-4hwiB:2.4 | 3u5jA-4hwiB:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyk | DNA POLYMERASE IV (Sulfolobusacidocaldarius) |
PF00817(IMS)PF11798(IMS_HHH) | 4 | PRO A 185LEU A 176ASN A 148ILE A 150 | None | 0.99A | 3u5jA-4hykA:undetectable | 3u5jA-4hykA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA 1 (Lactobacillusbrevis) |
PF00005(ABC_tran) | 4 | PRO B 59LEU B 80LEU B 83ILE B 64 | None | 0.82A | 3u5jA-4hzuB:undetectable | 3u5jA-4hzuB:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1t | RNA-DIRECTED RNAPOLYMERASE L (Calimammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | PRO A 87LEU A 125LEU A 129ILE A 71 | None | 0.88A | 3u5jA-4i1tA:3.1 | 3u5jA-4i1tA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irn | PROLYL-ACPDEHYDROGENASE ([Oscillatoria]sp. PCC 6506) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | PRO A 54LEU A 76ASN A 90ILE A 93 | None | 0.96A | 3u5jA-4irnA:2.3 | 3u5jA-4irnA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k17 | LEUCINE-RICHREPEAT-CONTAININGPROTEIN 16A (Mus musculus) |
PF13516(LRR_6) | 4 | LEU A 445LEU A 441ASN A 496ILE A 493 | None | 1.04A | 3u5jA-4k17A:undetectable | 3u5jA-4k17A:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9d | RIK1-ASSOCIATEDFACTOR 1 (Schizosaccharomycespombe) |
no annotation | 4 | PRO B 339LEU B 366LEU B 354ILE B 343 | None | 0.94A | 3u5jA-4o9dB:undetectable | 3u5jA-4o9dB:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6p | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF17033(Peptidase_M99)PF17129(Peptidase_M99_C)PF17130(Peptidase_M99_m) | 4 | LEU A 283LEU A 271ASN A 57ILE A 312 | None | 0.92A | 3u5jA-4q6pA:undetectable | 3u5jA-4q6pA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9g | MBP1 (Caldanaerobiuspolysaccharolyticus) |
PF13416(SBP_bac_8) | 4 | TRP A 25PRO A 24LEU A 21LEU A 82 | BMA A 503 ( 4.1A)NoneNoneNone | 0.89A | 3u5jA-4r9gA:undetectable | 3u5jA-4r9gA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnz | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF01551(Peptidase_M23) | 4 | TRP A 46LEU A 55LEU A 64ILE A 108 | None | 1.03A | 3u5jA-4rnzA:undetectable | 3u5jA-4rnzA:16.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyd | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 7 | TRP A 81PRO A 82LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | NoneV1T A1171 (-4.2A)V1T A1171 (-3.8A)NoneV1T A1171 (-3.1A)DMS A1169 ( 4.3A)DMS A1169 ( 3.8A) | 0.14A | 3u5jA-4uydA:25.8 | 3u5jA-4uydA:92.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uyg | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 6 | TRP A 370PRO A 371LEU A 381LEU A 383ASN A 429MET A 438 | NoneNone73B A1456 (-4.9A)73B A1456 (-4.9A)73B A1456 (-3.3A)73B A1456 ( 3.8A) | 0.53A | 3u5jA-4uygA:17.8 | 3u5jA-4uygA:34.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpz | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | PRO A 355LEU A 376LEU A 377ILE A 321 | PG4 A 603 (-4.5A)NoneNoneNone | 0.94A | 3u5jA-4xpzA:undetectable | 3u5jA-4xpzA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z61 | PHYTOSULFOKINERECEPTOR 1 (Daucus carota) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | TRP A 444PRO A 442LEU A 454ASN A 459 | None | 1.03A | 3u5jA-4z61A:undetectable | 3u5jA-4z61A:11.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z93 | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
PF00439(Bromodomain) | 6 | TRP A 374PRO A 375LEU A 385LEU A 387ASN A 433MET A 442 | 4LD A 501 (-3.9A)4LD A 501 (-3.9A)4LD A 501 (-4.1A)4LD A 501 (-4.4A)4LD A 501 (-2.8A)4LD A 501 ( 3.4A) | 0.44A | 3u5jA-4z93A:17.7 | 3u5jA-4z93A:36.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7c | S-CRYSTALLIN OCTVUS4 (Octopusvulgaris) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | PRO A 176LEU A 184LEU A 190ILE A 99 | None | 1.03A | 3u5jA-5b7cA:undetectable | 3u5jA-5b7cA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b86 | TUMOR NECROSISFACTOR ALPHA-INDUCEDPROTEIN 2 (Mus musculus) |
PF06046(Sec6) | 4 | PRO A 289LEU A 295LEU A 300ILE A 285 | None | 1.03A | 3u5jA-5b86A:undetectable | 3u5jA-5b86A:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnc | AVH146 (Phytophthorasojae) |
no annotation | 4 | TRP A 572LEU A 623LEU A 607ILE A 563 | None | 1.02A | 3u5jA-5gncA:undetectable | 3u5jA-5gncA:12.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hjc | BROMODOMAIN-CONTAINING PROTEIN 3 (Homo sapiens) |
PF00439(Bromodomain) | 6 | TRP A 332PRO A 333LEU A 343LEU A 345ASN A 391MET A 400 | None | 0.58A | 3u5jA-5hjcA:17.9 | 3u5jA-5hjcA:39.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikf | CHROMATIN REMODELINGFACTOR MIT1 (Schizosaccharomycespombe) |
no annotation | 4 | PRO A1275LEU A1286LEU A1330ILE A1279 | None | 0.99A | 3u5jA-5ikfA:undetectable | 3u5jA-5ikfA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iz3 | PREDICTED PROTEIN (Physcomitrellapatens) |
PF00316(FBPase) | 4 | PRO B 298LEU B 332LEU B 335ILE B 219 | None | 1.04A | 3u5jA-5iz3B:undetectable | 3u5jA-5iz3B:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5izh | RNA-DIRECTED RNAPOLYMERASE L (Lassamammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | PRO A 88LEU A 126LEU A 130ILE A 72 | None | 0.82A | 3u5jA-5izhA:4.6 | 3u5jA-5izhA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9h | 0940_GH29 (unidentified) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 4 | TRP A 188LEU A 146LEU A 150ILE A 204 | None | 0.85A | 3u5jA-5k9hA:undetectable | 3u5jA-5k9hA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Bos taurus) |
PF00361(Proton_antipo_M)PF01059(Oxidored_q5_N) | 4 | LEU M 351LEU M 352ASN M 333ILE M 337 | None | 1.01A | 3u5jA-5lc5M:undetectable | 3u5jA-5lc5M:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lst | ATP-DEPENDENT DNAHELICASE Q4 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | PRO A 597LEU A 528LEU A 579ILE A 569 | None | 1.04A | 3u5jA-5lstA:undetectable | 3u5jA-5lstA:10.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n15 | BROMODOMAIN-CONTAINING FACTOR 1 (Candidaalbicans) |
PF00439(Bromodomain) | 5 | PRO A 233LEU A 243ASN A 291ILE A 297MET A 300 | IOD A 405 ( 4.4A)NoneIOD A 404 (-3.9A)IOD A 404 ( 4.8A)None | 0.66A | 3u5jA-5n15A:18.5 | 3u5jA-5n15A:35.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6v | BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) |
no annotation | 6 | TRP A 370PRO A 371LEU A 381LEU A 383ASN A 429MET A 438 | None7WY A 501 (-4.4A)7WY A 501 (-4.9A)None7WY A 501 (-3.4A)7WY A 501 ( 3.9A) | 0.39A | 3u5jA-5u6vA:17.9 | 3u5jA-5u6vA:40.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uib | OXIDOREDUCTASEPROTEIN (Agrobacteriumtumefaciens) |
PF01408(GFO_IDH_MocA) | 4 | PRO A 242LEU A 179ASN A 126ILE A 291 | NoneTLA A 402 (-4.0A)NAD A 401 (-3.0A)NAD A 401 ( 4.7A) | 0.98A | 3u5jA-5uibA:undetectable | 3u5jA-5uibA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usx | THIOREDOXINREDUCTASE (Vibriovulnificus) |
PF07992(Pyr_redox_2) | 4 | PRO A 54LEU A 65LEU A 44ILE A 296 | NoneNoneFAD A 402 (-4.1A)None | 1.04A | 3u5jA-5usxA:undetectable | 3u5jA-5usxA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v84 | CAT EYE SYNDROMECRITICAL REGIONPROTEIN 2 (Homo sapiens) |
PF00439(Bromodomain) | 4 | TRP A 457PRO A 458ASN A 514MET A 523 | None96V A 602 (-4.5A)96V A 602 (-2.6A)None | 0.41A | 3u5jA-5v84A:16.2 | 3u5jA-5v84A:28.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vbr | BROMODOMAINTESTIS-SPECIFICPROTEIN (Homo sapiens) |
no annotation | 7 | TRP A 50PRO A 51LEU A 61LEU A 63ASN A 109ILE A 115MET A 118 | CL A 208 (-4.9A)IBI A 201 (-4.3A)IBI A 201 (-4.2A)IBI A 201 (-4.9A)IBI A 201 (-3.3A)IBI A 201 ( 3.8A)None | 0.48A | 3u5jA-5vbrA:19.3 | 3u5jA-5vbrA:68.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7k | LIPASE B (Serratiamarcescens) |
no annotation | 4 | LEU A 443LEU A 482ILE A 510MET A 532 | None | 0.99A | 3u5jA-5x7kA:undetectable | 3u5jA-5x7kA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbl | CRISPR-ASSOCIATEDENDONUCLEASECAS9/CSN1 (Streptococcuspyogenes) |
PF13395(HNH_4)PF16592(Cas9_REC)PF16593(Cas9-BH)PF16595(Cas9_PI) | 4 | PRO A 871LEU A 908ASN A 854ILE A 841 | None | 1.01A | 3u5jA-5xblA:undetectable | 3u5jA-5xblA:6.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF01257(2Fe-2S_thioredx)PF01512(Complex1_51K)PF10589(NADH_4Fe-4S) | 4 | LEU A 102ASN A 122ILE A 121MET A 126 | None | 0.90A | 3u5jA-5xfaA:undetectable | 3u5jA-5xfaA:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S21 (Trichomonasvaginalis) |
PF01249(Ribosomal_S21e) | 4 | LEU V 77LEU V 78ILE V 71MET V 18 | None | 0.99A | 3u5jA-5xyiV:undetectable | 3u5jA-5xyiV:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | VP2 (Aquareovirus C) |
no annotation | 4 | PRO 2 183LEU 2 160LEU 2 157ILE 2 52 | None | 1.00A | 3u5jA-5zvs2:undetectable | 3u5jA-5zvs2:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bja | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 4 | PRO A 296LEU A 334LEU A 336ILE A 319 | None | 1.03A | 3u5jA-6bjaA:undetectable | 3u5jA-6bjaA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dne | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) |
no annotation | 7 | TRP A 81PRO A 82LEU A 92LEU A 94ASN A 140ILE A 146MET A 149 | NoneH1V A 501 (-4.6A)H1V A 501 (-4.2A)H1V A 501 (-4.7A)H1V A 501 (-3.2A)H1V A 501 (-3.8A)H1V A 501 ( 3.8A) | 0.42A | 3u5jA-6dneA:23.4 | 3u5jA-6dneA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fnw | VOLUME-REGULATEDANION CHANNELSUBUNIT LRRC8A (Mus musculus) |
no annotation | 4 | PRO A 509LEU A 515LEU A 518ILE A 500 | None | 0.87A | 3u5jA-6fnwA:undetectable | 3u5jA-6fnwA:25.00 |