SIMILAR PATTERNS OF AMINO ACIDS FOR 3U2C_A_SUZA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		5 TRP A  20
TYR A  48
HIS A 110
PHE A 122
CYH A 298
 NAP  A 350 (-4.4A)
NAP  A 350 (-4.8A)
NAP  A 350 (-4.0A)
None
NAP  A 350 ( 4.1A)
 0.82A 3u2cA-1c9wA:
50.5		 3u2cA-1c9wA:
70.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		9 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
TRP A 219
CYH A 298
SER A 302
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
2CL  A 317 (-3.5A)
None
 0.20A 3u2cA-2is7A:
54.6		 3u2cA-2is7A:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 TRP A  24
TYR A  52
HIS A 114
TRP A 115
SER A 294
 ACT  A 501 ( 3.2A)
ACT  A 501 ( 4.4A)
ACT  A 501 ( 3.8A)
NAP  A 401 ( 3.9A)
None
 1.16A 3u2cA-3h7uA:
44.5		 3u2cA-3h7uA:
42.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 TRP A  24
TYR A  52
HIS A 114
TRP A 115
TRP A 216
 ACT  A 501 ( 3.2A)
ACT  A 501 ( 4.4A)
ACT  A 501 ( 3.8A)
NAP  A 401 ( 3.9A)
None
 1.08A 3u2cA-3h7uA:
44.5		 3u2cA-3h7uA:
42.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		6 TRP A  12
VAL A  39
TYR A  40
HIS A 104
PHE A 118
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
None
NAP  A 400 ( 4.0A)
 1.05A 3u2cA-3krbA:
41.6		 3u2cA-3krbA:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		6 TRP A  12
VAL A  39
TYR A  40
HIS A 104
TRP A 105
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
NAP  A 400 ( 4.0A)
 0.55A 3u2cA-3krbA:
41.6		 3u2cA-3krbA:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		5 VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
 None
 0.62A 3u2cA-4hbkA:
46.1		 3u2cA-4hbkA:
46.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.03A 3u2cA-5liyX:
50.7		 3u2cA-5liyX:
70.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TRP X  21
VAL X  48
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.63A 3u2cA-5liyX:
50.7		 3u2cA-5liyX:
70.89