SIMILAR PATTERNS OF AMINO ACIDS FOR 3TZF_B_08DB280_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		5 PRO A  64
GLY A 189
PHE A 190
LYS A 221
SER A 222
 None
None
None
SO4  A 283 ( 4.2A)
SO4  A 284 (-2.7A)
 0.93A 3tzfB-1ajzA:
41.9		 3tzfB-1ajzA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		5 THR A  62
PRO A  64
GLY A 189
PHE A 190
SER A 222
 SO4  A 283 ( 4.9A)
None
None
None
SO4  A 284 (-2.7A)
 0.81A 3tzfB-1ajzA:
41.9		 3tzfB-1ajzA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdo ALCOHOL
DEHYDROGENASE

(Gadus morhua) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 141
GLY A  61
PHE A  62
SER A 125
 None
 1.04A 3tzfB-1cdoA:
undetectable		 3tzfB-1cdoA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddv GLGF-DOMAIN PROTEIN
HOMER

(Rattus
norvegicus) 		PF00568
(WH1) 		4 THR A   9
ARG A  10
GLY A  89
PHE A  90
 None
 1.08A 3tzfB-1ddvA:
undetectable		 3tzfB-1ddvA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		4 THR A 222
PRO A 224
GLY A 296
PHE A 291
 None
 0.88A 3tzfB-1g0vA:
undetectable		 3tzfB-1g0vA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 THR A 593
ARG A 594
PRO A 595
SER A  29
 SO4  A 734 (-3.7A)
SO4  A 734 (-4.2A)
None
None
 1.09A 3tzfB-1itkA:
undetectable		 3tzfB-1itkA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 PHE A  29
THR A  25
PRO A  27
GLY A  14
 None
 0.95A 3tzfB-1jkmA:
3.0		 3tzfB-1jkmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 PHE A 235
PRO A 233
GLY A 286
PHE A 287
 None
 1.02A 3tzfB-1jmyA:
undetectable		 3tzfB-1jmyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1n GENOME POLYPROTEIN:
PICORNAIN 3C

(Enterovirus C) 		PF00548
(Peptidase_C3) 		4 PHE A  25
THR A  39
LYS A  22
SER A  21
 None
 1.06A 3tzfB-1l1nA:
undetectable		 3tzfB-1l1nA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 THR A 244
ARG A  21
GLY A  99
SER A  16
 None
 1.10A 3tzfB-1p8rA:
undetectable		 3tzfB-1p8rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 455
THR A 273
GLY A 345
PHE A 269
 G24  A 462 (-3.8A)
G24  A 462 (-4.5A)
G24  A 462 ( 4.1A)
G24  A 462 (-4.2A)
 1.05A 3tzfB-1q4xA:
undetectable		 3tzfB-1q4xA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 PHE G 183
PRO G 251
GLY G 248
SER G 179
 None
 0.95A 3tzfB-1rgiG:
undetectable		 3tzfB-1rgiG:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus) 		PF01413
(C4) 		4 ARG A  10
PRO A  18
GLY A  30
SER A  32
 None
 1.09A 3tzfB-1t61A:
undetectable		 3tzfB-1t61A:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		4 GLY A 188
PHE A 189
LYS A 220
SER A 221
 None
HH2  A 282 (-4.8A)
HH2  A 282 (-2.9A)
SO4  A 281 (-3.7A)
 0.57A 3tzfB-1twwA:
36.3		 3tzfB-1twwA:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 PHE A 144
PRO A 160
GLY A 251
SER A 142
 None
 1.10A 3tzfB-1z8lA:
undetectable		 3tzfB-1z8lA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 THR A 597
PRO A 599
GLY A 759
PHE A 760
LYS A 807
 PMM  A1865 (-3.9A)
None
None
PMM  A1865 (-4.7A)
PMM  A1865 (-2.8A)
 0.43A 3tzfB-2bmbA:
35.8		 3tzfB-2bmbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 PHE A 427
THR A 420
GLY A 417
SER A 362
 None
 1.10A 3tzfB-2g29A:
undetectable		 3tzfB-2g29A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		4 PHE A 200
THR A 346
ARG A 347
PRO A 348
 None
 0.87A 3tzfB-2gh8A:
undetectable		 3tzfB-2gh8A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 THR A  80
ARG A 331
GLY A  83
LYS A 243
 FAD  A 611 ( 4.7A)
FAD  A 611 (-4.1A)
FAD  A 611 (-3.9A)
None
 1.08A 3tzfB-2gmhA:
undetectable		 3tzfB-2gmhA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8l PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 PHE A 148
GLY A 158
PHE A 159
SER A 136
 None
 0.96A 3tzfB-2h8lA:
undetectable		 3tzfB-2h8lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		4 PHE A 435
THR A 428
GLY A 425
SER A 367
 None
 1.10A 3tzfB-2i4cA:
undetectable		 3tzfB-2i4cA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 THR A 125
PRO A 127
GLY A 104
SER A 119
 None
 0.92A 3tzfB-2iuyA:
undetectable		 3tzfB-2iuyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3s FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 THR A2263
ARG A2264
GLY A2236
PHE A2311
 DIO  A3331 ( 4.0A)
None
None
None
 0.98A 3tzfB-2j3sA:
undetectable		 3tzfB-2j3sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kp0 NASONIN-1M

(synthetic
construct) 		no annotation 4 THR A  31
ARG A  30
GLY A  19
PHE A  18
 None
 1.11A 3tzfB-2kp0A:
undetectable		 3tzfB-2kp0A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 THR A 147
ARG A 248
GLY A 151
SER A 253
 None
 0.96A 3tzfB-2mprA:
undetectable		 3tzfB-2mprA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		4 THR A 133
PRO A 131
GLY A  40
SER A 106
 None
 1.01A 3tzfB-2q7xA:
undetectable		 3tzfB-2q7xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wg3 DESERT HEDGEHOG
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01085
(HH_signal) 		4 THR A  56
ARG A  55
PRO A  62
LYS A 187
 None
 1.09A 3tzfB-2wg3A:
undetectable		 3tzfB-2wg3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 PHE A 183
THR A 179
GLY A 242
PHE A 243
 None
 1.05A 3tzfB-2x7vA:
9.5		 3tzfB-2x7vA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		4 GLY A 195
PHE A 196
LYS A 233
SER A 234
 None
 0.68A 3tzfB-2y5jA:
34.4		 3tzfB-2y5jA:
47.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 THR A 297
ARG A 296
GLY A 234
PHE A 272
 None
 1.03A 3tzfB-2yijA:
undetectable		 3tzfB-2yijA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymo PF12

(Plasmodium
falciparum) 		PF07422
(s48_45) 		4 PHE A 237
THR A 267
GLY A 178
PHE A 189
 None
 0.94A 3tzfB-2ymoA:
undetectable		 3tzfB-2ymoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		4 THR D  56
PRO D  54
PHE D  84
SER D  51
 None
 1.08A 3tzfB-2ynmD:
undetectable		 3tzfB-2ynmD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 THR A 388
GLY A 440
PHE A 441
SER A 343
 None
 0.90A 3tzfB-2yxlA:
undetectable		 3tzfB-2yxlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 THR A 355
ARG A 356
PRO A 357
GLY A 278
 None
 0.97A 3tzfB-2yxxA:
9.2		 3tzfB-2yxxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 PHE A  16
PRO A  14
GLY A  29
SER A  18
 None
 1.08A 3tzfB-2zbzA:
undetectable		 3tzfB-2zbzA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 THR A  74
PRO A  76
GLY A 188
PHE A 243
 None
 1.08A 3tzfB-3anxA:
undetectable		 3tzfB-3anxA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 THR A 355
ARG A 356
GLY A 187
PHE A 188
 None
 1.10A 3tzfB-3cp8A:
undetectable		 3tzfB-3cp8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 THR A 343
ARG A 342
GLY A 313
PHE A 312
 None
SO4  A 402 (-3.0A)
None
None
 1.04A 3tzfB-3cq5A:
undetectable		 3tzfB-3cq5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crw XPD/RAD3 RELATED DNA
HELICASE

(Sulfolobus
acidocaldarius) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 PHE 1 167
PRO 1 157
GLY 1  83
SER 1  97
 None
 1.08A 3tzfB-3crw1:
undetectable		 3tzfB-3crw1:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		4 THR A 101
ARG A 104
PRO A 103
SER A  37
 None
 0.87A 3tzfB-3dnhA:
undetectable		 3tzfB-3dnhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 THR A 521
ARG A 520
GLY A 502
SER A 482
 None
 0.95A 3tzfB-3fahA:
undetectable		 3tzfB-3fahA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gy9 GCN5-RELATED
N-ACETYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13673
(Acetyltransf_10) 		4 PHE A 144
GLY A 126
PHE A 127
SER A 147
 None
 0.89A 3tzfB-3gy9A:
undetectable		 3tzfB-3gy9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0t FAB FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  94
PRO B  91
GLY B 183
SER B 122
 None
 1.04A 3tzfB-3h0tB:
undetectable		 3tzfB-3h0tB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		4 THR A  16
GLY A  31
PHE A 141
SER A   2
 None
 1.10A 3tzfB-3h4yA:
undetectable		 3tzfB-3h4yA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 PHE A 271
THR A 573
PRO A 575
PHE A 655
 None
 1.11A 3tzfB-3hjeA:
3.9		 3tzfB-3hjeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 THR A 125
PRO A 146
GLY A  99
SER A  91
 NAD  A 402 (-2.7A)
None
None
None
 1.04A 3tzfB-3hl0A:
2.4		 3tzfB-3hl0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 PHE A  95
THR A  97
GLY A 144
PHE A 145
 None
 0.80A 3tzfB-3jxeA:
undetectable		 3tzfB-3jxeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ARG A 176
PRO A  30
GLY A 158
SER A 160
 None
 1.11A 3tzfB-3k1dA:
9.2		 3tzfB-3k1dA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 PHE A 136
THR A 152
ARG A 155
PRO A 154
 None
 1.10A 3tzfB-3ks5A:
11.7		 3tzfB-3ks5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		4 PHE A 362
PRO A 459
GLY A 373
PHE A 454
 None
 1.09A 3tzfB-3l3pA:
undetectable		 3tzfB-3l3pA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		4 PHE A 280
THR A 191
GLY A 302
SER A 331
 None
 1.05A 3tzfB-3menA:
undetectable		 3tzfB-3menA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 THR A 333
ARG A 334
PRO A 335
GLY A 412
 None
 1.03A 3tzfB-3qo6A:
undetectable		 3tzfB-3qo6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rob UNCHARACTERIZED
CONSERVED PROTEIN

(Planctopirus
limnophila) 		PF14534
(DUF4440) 		4 THR A  47
PRO A  52
GLY A  54
PHE A  53
 None
 1.05A 3tzfB-3robA:
undetectable		 3tzfB-3robA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		4 PHE A  41
GLY A 203
LYS A 238
SER A 239
 PT1  A1001 ( 3.6A)
PT1  A1001 (-3.6A)
PT1  A1001 (-2.6A)
PT1  A1001 (-2.7A)
 0.66A 3tzfB-3tr9A:
37.7		 3tzfB-3tr9A:
40.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 PHE A 244
GLY A 193
PHE A 255
SER A 141
 None
 1.04A 3tzfB-3wrfA:
undetectable		 3tzfB-3wrfA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 PHE B 262
THR B 418
GLY B 111
PHE B 110
 None
None
None
H2S  B 503 (-4.8A)
 0.72A 3tzfB-3ze7B:
undetectable		 3tzfB-3ze7B:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 ARG A 142
GLY A 258
PHE A 138
SER A  91
 None
 1.05A 3tzfB-3zgjA:
undetectable		 3tzfB-3zgjA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 THR A 201
ARG A 208
GLY A 368
SER A 363
 None
 0.99A 3tzfB-3zk4A:
2.2		 3tzfB-3zk4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 PHE A 328
THR A 380
ARG A 381
SER A 350
 None
 1.08A 3tzfB-4a5qA:
7.5		 3tzfB-4a5qA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 THR A 904
GLY A 995
PHE A 902
SER A 993
 None
 0.97A 3tzfB-4d72A:
11.9		 3tzfB-4d72A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  87
PRO H  84
GLY H 174
SER H 113
 None
 1.05A 3tzfB-4f58H:
undetectable		 3tzfB-4f58H:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 4 THR A 174
PRO A  88
GLY A 136
PHE A 137
 None
 0.92A 3tzfB-4gqzA:
undetectable		 3tzfB-4gqzA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 THR A 297
PRO A 301
GLY A 166
PHE A 167
 None
 1.02A 3tzfB-4hpvA:
undetectable		 3tzfB-4hpvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 ARG A 283
GLY A 181
PHE A 182
SER A 286
 None
 0.91A 3tzfB-4idmA:
undetectable		 3tzfB-4idmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
thailandensis) 		PF02222
(ATP-grasp) 		4 ARG A 282
PRO A 283
GLY A 260
SER A  80
 None
 1.02A 3tzfB-4izoA:
undetectable		 3tzfB-4izoA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 THR A 118
PRO A 120
GLY A 232
PHE A 124
 None
 1.08A 3tzfB-4llfA:
undetectable		 3tzfB-4llfA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 298
ARG A 300
GLY A 320
PHE A 332
 None
 0.84A 3tzfB-4mjuA:
undetectable		 3tzfB-4mjuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkq CYTOKINE RECEPTOR
COMMON SUBUNIT BETA

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		4 ARG A 327
GLY A 275
PHE A 277
SER A 273
 None
 1.10A 3tzfB-4nkqA:
undetectable		 3tzfB-4nkqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 PHE A 345
GLY A 249
PHE A 248
SER A 253
 None
 1.00A 3tzfB-4nleA:
undetectable		 3tzfB-4nleA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 PHE A 125
THR A 281
GLY A 171
PHE A 173
 PMK  A 401 ( 4.2A)
CL  A 402 (-3.6A)
None
None
 0.95A 3tzfB-4onoA:
undetectable		 3tzfB-4onoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		5 THR A 349
PRO A  51
GLY A 110
PHE A  52
SER A 393
 None
 1.41A 3tzfB-4r85A:
5.8		 3tzfB-4r85A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		4 THR A 119
ARG A 121
GLY A  70
PHE A 126
 None
 0.94A 3tzfB-4rk1A:
undetectable		 3tzfB-4rk1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3

(Homo sapiens) 		PF10421
(OAS1_C) 		4 PHE A 131
THR A 119
PRO A 121
SER A 145
 None
 0.98A 3tzfB-4s3nA:
undetectable		 3tzfB-4s3nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		4 THR A 222
GLY A 342
PHE A 218
SER A 346
 None
 1.05A 3tzfB-4usqA:
undetectable		 3tzfB-4usqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzg SURFACE PROTEIN SPB1

(Streptococcus
agalactiae) 		no annotation 4 PHE A 384
THR A 410
GLY A 352
SER A 195
 EDO  A1472 ( 4.8A)
EDO  A1472 (-4.7A)
None
None
 1.09A 3tzfB-4uzgA:
undetectable		 3tzfB-4uzgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		4 PHE A 306
THR A 100
GLY A 245
SER A 243
 None
 0.90A 3tzfB-4x9tA:
undetectable		 3tzfB-4x9tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		4 THR A  16
GLY A   7
PHE A  46
SER A  73
 None
None
None
FON  A 402 ( 4.0A)
 1.04A 3tzfB-4xd0A:
undetectable		 3tzfB-4xd0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 ARG A 303
GLY A  24
PHE A  25
SER A 297
 None
 1.11A 3tzfB-4z9nA:
undetectable		 3tzfB-4z9nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE

(Lactobacillus
plantarum) 		PF00291
(PALP) 		4 PHE A 143
PRO A 226
GLY A 179
PHE A 228
 None
None
LLP  A  42 ( 3.8A)
None
 1.10A 3tzfB-5b1hA:
undetectable		 3tzfB-5b1hA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 PHE A 145
THR A 147
ARG A 153
PRO A 149
 None
 1.07A 3tzfB-5d6nA:
undetectable		 3tzfB-5d6nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		4 PHE A 264
THR A 330
GLY A  56
SER A 267
 None
 0.99A 3tzfB-5ftfA:
undetectable		 3tzfB-5ftfA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 PHE A 168
THR A 133
PRO A 131
GLY A 127
 None
 1.04A 3tzfB-5fwsA:
undetectable		 3tzfB-5fwsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 PHE B 168
THR B 133
PRO B 131
GLY B 127
 None
 1.02A 3tzfB-5fwwB:
undetectable		 3tzfB-5fwwB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it6 GALECTIN-RELATED
PROTEIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 ARG A  62
GLY A  32
PHE A  31
SER A  34
 EDO  A 206 ( 3.6A)
PGE  A 205 ( 3.1A)
None
PGE  A 205 ( 3.5A)
 1.03A 3tzfB-5it6A:
undetectable		 3tzfB-5it6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		4 PHE A 204
PRO A 201
GLY A 172
PHE A 194
 None
None
NAD  A 501 ( 4.5A)
None
 1.10A 3tzfB-5jcnA:
undetectable		 3tzfB-5jcnA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 404
GLY A 315
PHE A 314
SER A 319
 None
6L1  A 601 (-4.7A)
6L1  A 601 (-4.4A)
None
 1.08A 3tzfB-5jjqA:
undetectable		 3tzfB-5jjqA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		4 GLY A 189
PHE A 190
LYS A 221
SER A 222
 6MB  A 301 (-3.6A)
6MB  A 301 (-3.9A)
6MB  A 301 (-2.7A)
6MB  A 301 (-2.6A)
 0.10A 3tzfB-5jq9A:
44.4		 3tzfB-5jq9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh1 INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 PHE A 400
PRO A 497
GLY A 411
PHE A 492
 None
 1.09A 3tzfB-5kh1A:
undetectable		 3tzfB-5kh1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 4 ARG A 476
GLY A 481
PHE A 482
SER A 479
 None
 1.07A 3tzfB-5n7fA:
undetectable		 3tzfB-5n7fA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oac MAJOR CAPSID PROTEIN

(unidentified
phage) 		no annotation 4 THR A 115
PRO A 118
GLY A  20
SER A 156
 None
 1.07A 3tzfB-5oacA:
undetectable		 3tzfB-5oacA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 4 PHE A  48
THR A  53
GLY A 103
PHE A 263
 OOG  A 401 (-4.0A)
None
None
None
 0.79A 3tzfB-5oeiA:
undetectable		 3tzfB-5oeiA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4z ANTIBODY DH501 FAB
HEAVY CHAIN

(Macaca mulatta) 		no annotation 4 THR H  87
PRO H  84
GLY H 174
SER H 113
 None
 1.01A 3tzfB-5t4zH:
undetectable		 3tzfB-5t4zH:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 THR A  84
GLY A 144
PHE A  80
SER A 139
 None
 1.10A 3tzfB-5udyA:
undetectable		 3tzfB-5udyA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		4 GLY A 189
PHE A 190
LYS A 221
SER A 222
 None
 0.30A 3tzfB-5umgA:
40.4		 3tzfB-5umgA:
76.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5usw DIHYDROPTEROATE
SYNTHASE

(Aliivibrio
fischeri) 		PF00809
(Pterin_bind) 		4 GLY A 189
PHE A 190
LYS A 221
SER A 222
 None
GOL  A 303 (-4.7A)
GOL  A 303 (-2.8A)
None
 0.39A 3tzfB-5uswA:
36.5		 3tzfB-5uswA:
60.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		5 PRO A  53
GLY A 181
PHE A 183
LYS A 215
SER A 216
 None
 1.06A 3tzfB-5visA:
34.2		 3tzfB-5visA:
34.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		5 THR A  51
PRO A  53
PHE A 183
LYS A 215
SER A 216
 None
 0.96A 3tzfB-5visA:
34.2		 3tzfB-5visA:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 4 THR A  84
GLY A 435
PHE A 438
SER A 418
 GLU  A 502 (-3.5A)
None
None
None
 1.03A 3tzfB-5wmlA:
undetectable		 3tzfB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S15A
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00163
(Ribosomal_S4)
PF00410
(Ribosomal_S8)
PF01479
(S4) 		4 THR J  59
ARG J  67
PRO J  61
GLY W  84
 None
 0.89A 3tzfB-5xyiJ:
undetectable		 3tzfB-5xyiJ:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN

(Mus musculus) 		no annotation 4 THR A 298
ARG A 299
GLY A 269
SER A 266
 None
 0.92A 3tzfB-5z1wA:
undetectable		 3tzfB-5z1wA:
15.36