SIMILAR PATTERNS OF AMINO ACIDS FOR 3TYO_A_H4BA760
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fhu | O-SUCCINYLBENZOATESYNTHASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 4 | ARG A 2VAL A 87TRP A 66GLU A 76 | None | 1.50A | 3tyoA-1fhuA:0.03tyoB-1fhuA:0.0 | 3tyoA-1fhuA:25.233tyoB-1fhuA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | VAL A 41TRP A 521PHE A 501GLU A 519 | None | 1.27A | 3tyoA-1flgA:0.03tyoB-1flgA:0.0 | 3tyoA-1flgA:19.673tyoB-1flgA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gh2 | THIOREDOXIN-LIKEPROTEIN (Homo sapiens) |
PF00085(Thioredoxin) | 4 | MET A 47VAL A 26PHE A 79GLU A 100 | None | 1.49A | 3tyoA-1gh2A:0.03tyoB-1gh2A:0.0 | 3tyoA-1gh2A:12.223tyoB-1gh2A:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2t | 80 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF02854(MIF4G)PF09088(MIF4G_like)PF09090(MIF4G_like_2) | 4 | MET C 291VAL C 216PHE C 360GLU C 353 | None | 1.39A | 3tyoA-1h2tC:0.03tyoB-1h2tC:0.0 | 3tyoA-1h2tC:19.483tyoB-1h2tC:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kex | NEUROPILIN-1 (Homo sapiens) |
PF00754(F5_F8_type_C) | 4 | ARG A 130TRP A 97PHE A 131GLU A 95 | None | 1.43A | 3tyoA-1kexA:undetectable3tyoB-1kexA:undetectable | 3tyoA-1kexA:16.833tyoB-1kexA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kh2 | ARGININOSUCCINATESYNTHETASE (Thermusthermophilus) |
PF00764(Arginosuc_synth) | 4 | ARG A 282VAL A 226PHE A 220GLU A 222 | None | 1.31A | 3tyoA-1kh2A:0.63tyoB-1kh2A:0.1 | 3tyoA-1kh2A:22.653tyoB-1kh2A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | ARG A 340TRP A 155PHE A 156GLU A 154 | None | 1.33A | 3tyoA-1l5jA:0.03tyoB-1l5jA:0.0 | 3tyoA-1l5jA:19.283tyoB-1l5jA:19.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 4 | MET A 336ARG A 596VAL A 677TRP A 678 | H4B A 760 ( 3.8A)H4B A 760 (-3.5A)H4B A 760 (-4.6A)H4B A 760 ( 3.6A) | 0.17A | 3tyoA-1lzxA:63.33tyoB-1lzxA:62.5 | 3tyoA-1lzxA:100.003tyoB-1lzxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 4 | VAL D 28TRP D 31PHE D 35GLU D 132 | None | 1.39A | 3tyoA-1mhzD:0.03tyoB-1mhzD:0.0 | 3tyoA-1mhzD:20.853tyoB-1mhzD:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mns | MANDELATE RACEMASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ARG A 318VAL A 163PHE A 160GLU A 157 | None | 1.41A | 3tyoA-1mnsA:undetectable3tyoB-1mnsA:undetectable | 3tyoA-1mnsA:21.593tyoB-1mnsA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzb | FERRIC UPTAKEREGULATION PROTEIN (Pseudomonasaeruginosa) |
PF01475(FUR) | 4 | ARG A 69VAL A 54PHE A 79GLU A 36 | None | 1.03A | 3tyoA-1mzbA:undetectable3tyoB-1mzbA:undetectable | 3tyoA-1mzbA:16.593tyoB-1mzbA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdu | NUCLEAR HORMONERECEPTOR HR38 (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 4 | MET A 440VAL A 401TRP A 435PHE A 432 | None | 0.89A | 3tyoA-1pduA:undetectable3tyoB-1pduA:undetectable | 3tyoA-1pduA:21.053tyoB-1pduA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qb4 | PHOSPHOENOLPYRUVATECARBOXYLASE (Escherichiacoli) |
PF00311(PEPcase) | 4 | MET A 249VAL A 267PHE A 206GLU A 201 | None | 1.28A | 3tyoA-1qb4A:0.73tyoB-1qb4A:undetectable | 3tyoA-1qb4A:19.223tyoB-1qb4A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1j | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF09152(DUF1937) | 4 | ARG A 2VAL A 28TRP A 110PHE A 117 | None | 1.48A | 3tyoA-1t1jA:undetectable3tyoB-1t1jA:undetectable | 3tyoA-1t1jA:16.383tyoB-1t1jA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmk | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermotogamaritima) |
PF01048(PNP_UDP_1) | 4 | VAL A 221TRP A 162PHE A 265GLU A 161 | None | 1.44A | 3tyoA-1vmkA:undetectable3tyoB-1vmkA:undetectable | 3tyoA-1vmkA:21.483tyoB-1vmkA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wf0 | TAR DNA-BINDINGPROTEIN-43 (Homo sapiens) |
PF00076(RRM_1) | 4 | MET A 17VAL A 35PHE A 26GLU A 21 | None | 1.25A | 3tyoA-1wf0A:undetectable3tyoB-1wf0A:undetectable | 3tyoA-1wf0A:11.853tyoB-1wf0A:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | ETHYLBENZENEDIOXYGENASE SMALLSUBUNIT (Pseudomonasfluorescens) |
PF00866(Ring_hydroxyl_B) | 4 | ARG B 156VAL B 128PHE B 163GLU B 26 | None | 1.17A | 3tyoA-1wqlB:undetectable3tyoB-1wqlB:undetectable | 3tyoA-1wqlB:19.793tyoB-1wqlB:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | ARG A 708VAL A1424PHE A 722GLU A 693 | None | 1.07A | 3tyoA-2b39A:undetectable3tyoB-2b39A:undetectable | 3tyoA-2b39A:13.583tyoB-2b39A:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | ARG A 586VAL A 578TRP A 579GLU A 555 | None | 1.29A | 3tyoA-2fjaA:undetectable3tyoB-2fjaA:undetectable | 3tyoA-2fjaA:22.293tyoB-2fjaA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT AADENYLYLSULFATEREDUCTASE, SUBUNIT B (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | ARG A 62VAL A 367TRP B 788GLU A 360 | None | 1.37A | 3tyoA-2fjaA:undetectable3tyoB-2fjaA:undetectable | 3tyoA-2fjaA:22.293tyoB-2fjaA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vda | TRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 4 | MET A 31ARG A 53VAL A 70GLU A 34 | None | 1.49A | 3tyoA-2vdaA:undetectable3tyoB-2vdaA:undetectable | 3tyoA-2vdaA:20.583tyoB-2vdaA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vy0 | ENDO-BETA-1,3-GLUCANASE (Pyrococcusfuriosus) |
PF00722(Glyco_hydro_16) | 4 | VAL A 245TRP A 252PHE A 254GLU A 251 | NoneNoneNoneMRD A1301 (-4.3A) | 1.44A | 3tyoA-2vy0A:undetectable3tyoB-2vy0A:undetectable | 3tyoA-2vy0A:20.003tyoB-2vy0A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IV (Homo sapiens) |
PF00069(Pkinase) | 4 | ARG A 278VAL A 269TRP A 266PHE A 261 | None | 1.43A | 3tyoA-2w4oA:undetectable3tyoB-2w4oA:undetectable | 3tyoA-2w4oA:20.263tyoB-2w4oA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 4 | ARG A 697VAL A 717PHE A 698GLU A 722 | None | 1.34A | 3tyoA-2xvgA:undetectable3tyoB-2xvgA:undetectable | 3tyoA-2xvgA:19.683tyoB-2xvgA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 4 | ARG A 211VAL A 239PHE A 309GLU A 305 | None | 1.34A | 3tyoA-2ywbA:undetectable3tyoB-2ywbA:undetectable | 3tyoA-2ywbA:21.543tyoB-2ywbA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z11 | RIBOSOMAL-PROTEIN-ALANINEACETYLTRANSFERASE (Thermusthermophilus) |
PF13302(Acetyltransf_3) | 4 | VAL A 64TRP A 66PHE A 4GLU A 6 | None | 1.41A | 3tyoA-2z11A:undetectable3tyoB-2z11A:undetectable | 3tyoA-2z11A:17.583tyoB-2z11A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zf8 | COMPONENT OFSODIUM-DRIVEN POLARFLAGELLAR MOTOR (Vibrioalginolyticus) |
PF00691(OmpA) | 4 | MET A 17TRP A 15PHE A 137GLU A 16 | None | 1.24A | 3tyoA-2zf8A:undetectable3tyoB-2zf8A:undetectable | 3tyoA-2zf8A:21.353tyoB-2zf8A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 4 | VAL A 314TRP A 293TRP A 374GLU A 372 | NoneNoneNoneEDO A 404 ( 3.8A) | 1.42A | 3tyoA-3b7fA:undetectable3tyoB-3b7fA:undetectable | 3tyoA-3b7fA:20.873tyoB-3b7fA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxz | PREPROTEINTRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF07517(SecA_DEAD) | 4 | MET A 31ARG A 53VAL A 70GLU A 34 | None | 1.49A | 3tyoA-3bxzA:undetectable3tyoB-3bxzA:undetectable | 3tyoA-3bxzA:20.853tyoB-3bxzA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2w | TAR DNA-BINDINGPROTEIN 43 (Mus musculus) |
PF00076(RRM_1) | 4 | MET A 202VAL A 220PHE A 211GLU A 206 | None | 1.02A | 3tyoA-3d2wA:undetectable3tyoB-3d2wA:undetectable | 3tyoA-3d2wA:12.223tyoB-3d2wA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddl | XANTHORHODOPSIN (Salinibacterruber) |
PF01036(Bac_rhodopsin) | 4 | VAL A 16TRP A 70PHE A 88GLU A 71 | None | 1.50A | 3tyoA-3ddlA:undetectable3tyoB-3ddlA:undetectable | 3tyoA-3ddlA:20.143tyoB-3ddlA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase) | 4 | ARG A 260TRP A 248PHE A 243GLU A 245 | None | 1.32A | 3tyoA-3f3zA:undetectable3tyoB-3f3zA:undetectable | 3tyoA-3f3zA:21.033tyoB-3f3zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs3 | SYMPLEKIN (Drosophilamelanogaster) |
PF11935(DUF3453) | 4 | ARG A 27VAL A 56PHE A 67GLU A 65 | None | 1.49A | 3tyoA-3gs3A:undetectable3tyoB-3gs3A:undetectable | 3tyoA-3gs3A:20.283tyoB-3gs3A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | ARG A 66VAL A 387TRP B 88GLU A 380 | None | 1.31A | 3tyoA-3gyxA:0.03tyoB-3gyxA:undetectable | 3tyoA-3gyxA:20.983tyoB-3gyxA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzp | NTF2-LIKE PROTEIN OFUNKNOWN FUNCTION (Prochlorococcusmarinus) |
PF12707(DUF3804) | 4 | MET A 20ARG A 118TRP A 51PHE A 34 | 1PE A 131 ( 3.8A)1PE A 131 (-3.7A)None1PE A 131 (-4.5A) | 1.34A | 3tyoA-3hzpA:undetectable3tyoB-3hzpA:undetectable | 3tyoA-3hzpA:14.183tyoB-3hzpA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ma6 | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | ARG A 269VAL A 260TRP A 257PHE A 252 | None | 1.43A | 3tyoA-3ma6A:undetectable3tyoB-3ma6A:undetectable | 3tyoA-3ma6A:21.553tyoB-3ma6A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3k | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Homo sapiens) |
PF00443(UCH) | 4 | ARG A 944TRP A1001PHE A 946GLU A 908 | None | 1.49A | 3tyoA-3n3kA:undetectable3tyoB-3n3kA:undetectable | 3tyoA-3n3kA:19.833tyoB-3n3kA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | ARG A 175VAL A 92PHE A 121GLU A 119 | None | 1.23A | 3tyoA-3owcA:undetectable3tyoB-3owcA:undetectable | 3tyoA-3owcA:16.473tyoB-3owcA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q63 | MLL2253 PROTEIN (Mesorhizobiumjaponicum) |
PF08327(AHSA1) | 4 | MET A 108TRP A 128PHE A 113GLU A 109 | None | 1.24A | 3tyoA-3q63A:undetectable3tyoB-3q63A:undetectable | 3tyoA-3q63A:13.713tyoB-3q63A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjy | ENDOGLUCANASEFNCEL5A (Fervidobacteriumnodosum) |
PF00150(Cellulase) | 4 | VAL A 149TRP A 146PHE A 162GLU A 187 | None | 1.28A | 3tyoA-3rjyA:0.83tyoB-3rjyA:undetectable | 3tyoA-3rjyA:21.273tyoB-3rjyA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxf | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | ARG A 286VAL A 277TRP A 274PHE A 269 | DMS A 711 (-4.1A)NoneNoneDMS A 711 (-3.9A) | 1.46A | 3tyoA-3sxfA:undetectable3tyoB-3sxfA:undetectable | 3tyoA-3sxfA:20.773tyoB-3sxfA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti8 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | VAL A 240TRP A 239PHE A 305GLU A 265 | None | 1.42A | 3tyoA-3ti8A:undetectable3tyoB-3ti8A:undetectable | 3tyoA-3ti8A:22.643tyoB-3ti8A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqu | NON-CANONICAL PURINENTP PYROPHOSPHATASE (Coxiellaburnetii) |
PF01725(Ham1p_like) | 4 | VAL A 162TRP A 140PHE A 118GLU A 141 | None | 1.28A | 3tyoA-3tquA:undetectable3tyoB-3tquA:undetectable | 3tyoA-3tquA:19.053tyoB-3tquA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uxm | THYMIDYLATE KINASE (Pseudomonasaeruginosa) |
PF02223(Thymidylate_kin) | 4 | ARG A 109VAL A 166PHE A 162GLU A 156 | NoneNoneNone MG A 213 (-3.2A) | 1.32A | 3tyoA-3uxmA:undetectable3tyoB-3uxmA:undetectable | 3tyoA-3uxmA:20.293tyoB-3uxmA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgd | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT) | 4 | VAL C2274TRP C2314PHE C2329GLU C2310 | None | 1.31A | 3tyoA-4bgdC:undetectable3tyoB-4bgdC:undetectable | 3tyoA-4bgdC:20.993tyoB-4bgdC:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | ARG A 373VAL A 412TRP A 383PHE A 370 | None | 1.48A | 3tyoA-4fnqA:undetectable3tyoB-4fnqA:undetectable | 3tyoA-4fnqA:20.733tyoB-4fnqA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g76 | PHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF14859(Colicin_M) | 4 | MET A 258VAL A 265TRP A 62PHE A 85 | None | 1.35A | 3tyoA-4g76A:undetectable3tyoB-4g76A:undetectable | 3tyoA-4g76A:19.863tyoB-4g76A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l37 | ARYLPHORIN (Bombyx mori) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | VAL B 351TRP B 355PHE B 327GLU B 424 | None | 1.07A | 3tyoA-4l37B:undetectable3tyoB-4l37B:undetectable | 3tyoA-4l37B:20.693tyoB-4l37B:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh1 | SORBOSEDEHYDROGENASE (Ketogulonicigeniumvulgare) |
PF13360(PQQ_2) | 4 | ARG A 385TRP A 387TRP A 218PHE A 286 | None | 1.41A | 3tyoA-4mh1A:undetectable3tyoB-4mh1A:undetectable | 3tyoA-4mh1A:21.163tyoB-4mh1A:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mln | PREDICTED HDPHOSPHOHYDROLASEPHNZ (unculturedbacteriumHF130_AEPn_1) |
PF01966(HD) | 4 | MET A 180VAL A 9PHE A 93GLU A 183 | None | 1.24A | 3tyoA-4mlnA:undetectable3tyoB-4mlnA:undetectable | 3tyoA-4mlnA:16.553tyoB-4mlnA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6w | PREDICTED HDPHOSPHOHYDROLASEPHNZ (unculturedbacteriumHF130_AEPn_1) |
PF01966(HD) | 4 | MET A 180VAL A 9PHE A 93GLU A 183 | None | 1.31A | 3tyoA-4n6wA:undetectable3tyoB-4n6wA:undetectable | 3tyoA-4n6wA:19.623tyoB-4n6wA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 4 | ARG A 75VAL A 79PHE A 141GLU A 162 | None | 1.36A | 3tyoA-4pneA:undetectable3tyoB-4pneA:undetectable | 3tyoA-4pneA:21.363tyoB-4pneA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | ARG A 276VAL A 305PHE A 264GLU A 266 | None | 1.14A | 3tyoA-4xj6A:1.63tyoB-4xj6A:1.7 | 3tyoA-4xj6A:21.063tyoB-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | VAL A 305TRP A 263PHE A 264GLU A 266 | None | 1.10A | 3tyoA-4xj6A:1.63tyoB-4xj6A:1.7 | 3tyoA-4xj6A:21.063tyoB-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylr | TUBULINPOLYGLUTAMYLASETTLL7 (Homo sapiens) |
PF03133(TTL) | 4 | VAL A 288TRP A 292PHE A 277GLU A 279 | None | 1.40A | 3tyoA-4ylrA:0.43tyoB-4ylrA:undetectable | 3tyoA-4ylrA:22.813tyoB-4ylrA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zva | DIGUANYLATE CYCLASEDOSC (Escherichiacoli) |
PF11563(Protoglobin) | 4 | MET A 8VAL A 84TRP A 12GLU A 11 | None | 1.35A | 3tyoA-4zvaA:1.43tyoB-4zvaA:undetectable | 3tyoA-4zvaA:18.863tyoB-4zvaA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zvb | DIGUANYLATE CYCLASEDOSC (Escherichiacoli) |
PF11563(Protoglobin) | 4 | MET A 8VAL A 84TRP A 12GLU A 11 | None | 1.45A | 3tyoA-4zvbA:undetectable3tyoB-4zvbA:undetectable | 3tyoA-4zvbA:17.063tyoB-4zvbA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 4 | ARG A 505VAL A 736TRP A 732GLU A 731 | None | 1.38A | 3tyoA-5by3A:undetectable3tyoB-5by3A:undetectable | 3tyoA-5by3A:19.823tyoB-5by3A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6g | AGR133CPSISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF10345(Cohesin_load)no annotation | 4 | VAL B 28TRP A 401PHE A 397GLU A 402 | None | 1.49A | 3tyoA-5c6gB:undetectable3tyoB-5c6gB:undetectable | 3tyoA-5c6gB:18.693tyoB-5c6gB:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjn | L-AMINO ACIDDEAMINASE (Cosenzaeamyxofaciens) |
PF01266(DAO) | 4 | ARG A 316VAL A 438TRP A 439GLU A 418 | BE2 A1476 (-4.0A)BE2 A1476 ( 4.3A)BE2 A1476 ( 3.7A)None | 1.32A | 3tyoA-5fjnA:undetectable3tyoB-5fjnA:undetectable | 3tyoA-5fjnA:23.273tyoB-5fjnA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kn8 | ADENINE DNAGLYCOSYLASE (Geobacillusstearothermophilus) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | VAL A 92TRP A 83PHE A 61GLU A 84 | None | 1.34A | 3tyoA-5kn8A:undetectable3tyoB-5kn8A:undetectable | 3tyoA-5kn8A:22.283tyoB-5kn8A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m7r | PROTEIN O-GLCNACASE (Homo sapiens) |
PF07555(NAGidase) | 4 | ARG A 84TRP A 73PHE A 318GLU A 317 | None | 1.42A | 3tyoA-5m7rA:undetectable3tyoB-5m7rA:0.5 | 3tyoA-5m7rA:18.133tyoB-5m7rA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | ARG A 225TRP A 414PHE A 411GLU A 413 | None | 1.08A | 3tyoA-5m8tA:undetectable3tyoB-5m8tA:undetectable | 3tyoA-5m8tA:20.003tyoB-5m8tA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x89 | ENDA-LIKEPROTEIN,TRNA-SPLICING ENDONUCLEASE (Methanopyruskandleri) |
no annotation | 4 | MET A 249VAL A 231PHE A 258GLU A 253 | None | 1.05A | 3tyoA-5x89A:undetectable3tyoB-5x89A:undetectable | 3tyoA-5x89A:12.703tyoB-5x89A:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xf7 | PROTEINDISULFIDE-ISOMERASE-LIKE PROTEIN OF THETESTIS (Homo sapiens) |
no annotation | 4 | ARG A 129VAL A 65PHE A 113GLU A 106 | None | 1.23A | 3tyoA-5xf7A:undetectable3tyoB-5xf7A:undetectable | 3tyoA-5xf7A:10.853tyoB-5xf7A:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwd | VH CHAIN OF 059-152VL CHAIN OF 059-152 (Homo sapiens) |
no annotation | 4 | MET H 105VAL D 98TRP D 91TRP H 49 | None | 1.04A | 3tyoA-5xwdH:undetectable3tyoB-5xwdH:undetectable | 3tyoA-5xwdH:9.593tyoB-5xwdH:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk1 | UDP-GLYCOSYLTRANSFERASE 79 (Oryza sativa) |
no annotation | 4 | ARG A 331VAL A 317TRP A 316GLU A 322 | NoneUDP A 501 ( 4.8A)NoneNone | 1.29A | 3tyoA-6bk1A:undetectable3tyoB-6bk1A:undetectable | 3tyoA-6bk1A:13.483tyoB-6bk1A:13.48 |