SIMILAR PATTERNS OF AMINO ACIDS FOR 3TWP_C_SALC404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvy PROTEIN (CYTOCHROME
P450 BM-3)

(Bacillus
megaterium) 		PF00258
(Flavodoxin_1) 		4 ASN F 543
ALA F 544
PRO F 541
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 1.12A 3twpC-1bvyF:
undetectable		 3twpC-1bvyF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A  36
PRO A 398
TYR A 402
ALA A 347
 None
 1.03A 3twpC-1cg2A:
undetectable		 3twpC-1cg2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 292
ALA A 326
PRO A 325
ALA A 367
 None
 1.10A 3twpC-1cg2A:
undetectable		 3twpC-1cg2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 398
TYR A 402
ARG A 400
ALA A 347
 None
 1.08A 3twpC-1cg2A:
undetectable		 3twpC-1cg2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		4 ASN A 226
TYR A 272
ARG A 273
ALA A 251
 None
 1.01A 3twpC-1dctA:
3.5		 3twpC-1dctA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ALA B 889
TYR B 927
ARG B 928
ALA B 929
 None
 1.11A 3twpC-1gl9B:
undetectable		 3twpC-1gl9B:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 ASN A 549
PRO A 514
ARG A 512
ALA A 555
 None
 0.95A 3twpC-1gxkA:
undetectable		 3twpC-1gxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 ASN A 417
ALA A 316
ARG A 421
ARG A 426
 None
 1.13A 3twpC-1hg4A:
undetectable		 3twpC-1hg4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF

(Homo sapiens) 		PF09128
(RGS-like) 		4 ALA A  57
PRO A  56
ARG A  54
ARG A 183
 None
 1.11A 3twpC-1iapA:
undetectable		 3twpC-1iapA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		4 ASN A 149
ALA A 192
ARG A 189
ALA A 180
 None
 0.98A 3twpC-1iy8A:
4.6		 3twpC-1iy8A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ALA A 386
PRO A 387
TYR A 298
ALA A 407
 None
 1.13A 3twpC-1j0nA:
undetectable		 3twpC-1j0nA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ALA A 226
PRO A 227
ARG A 235
ALA A 197
 None
 1.00A 3twpC-1nkvA:
2.3		 3twpC-1nkvA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ALA B 486
TYR B 483
ARG B 346
ARG B 238
 None
 1.03A 3twpC-1qh1B:
3.3		 3twpC-1qh1B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 ASN A 293
ALA A 290
ARG A 227
ALA A 228
 None
 0.98A 3twpC-1ru4A:
undetectable		 3twpC-1ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF09128
(RGS-like) 		4 ALA C  57
PRO C  56
ARG C  54
ARG C 183
 None
 1.03A 3twpC-1shzC:
undetectable		 3twpC-1shzC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ASN A 270
ALA A 273
PRO A 272
ALA A  64
 None
 1.06A 3twpC-1u08A:
undetectable		 3twpC-1u08A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		4 ASN A 239
ALA A  91
ARG A 111
ALA A  84
 None
 1.01A 3twpC-1vjoA:
2.1		 3twpC-1vjoA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6g MEGAKARYOCYTE-ASSOCI
ATED
TYROSINE-PROTEIN
KINASE

(Homo sapiens) 		PF00018
(SH3_1) 		4 ALA A  15
PRO A  16
TYR A  54
ARG A  55
 None
 1.01A 3twpC-1x6gA:
undetectable		 3twpC-1x6gA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 ASN 1   4
ALA 1  30
PRO 1  29
TYR 1  27
 None
 0.81A 3twpC-1y791:
2.1		 3twpC-1y791:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ALA A  57
PRO A  56
TYR A  54
ARG A  52
 None
 1.10A 3twpC-1yirA:
undetectable		 3twpC-1yirA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ALA B 490
TYR B 487
ARG B 350
ARG B 242
 None
 1.05A 3twpC-2afhB:
3.2		 3twpC-2afhB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus) 		PF01975
(SurE) 		4 ASN A   7
ALA A  33
PRO A  34
ALA A 113
 None
 1.13A 3twpC-2e6eA:
undetectable		 3twpC-2e6eA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 109
ALA A 150
ARG A 158
ALA A 161
 None
 0.94A 3twpC-2elcA:
46.1		 3twpC-2elcA:
39.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ASN A 218
ALA A 219
ALA A 322
ARG A 318
 NAD  A 450 (-4.1A)
JPA  A 500 (-4.0A)
None
None
 1.03A 3twpC-2foiA:
undetectable		 3twpC-2foiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE

(Shewanella
oneidensis) 		PF04261
(Dyp_perox) 		4 ASN A  68
ALA A  67
PRO A  84
ALA A  97
 None
 0.86A 3twpC-2iizA:
undetectable		 3twpC-2iizA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbf ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 ASN A 388
ALA A 338
PRO A 408
ALA A 411
 None
 0.94A 3twpC-2kbfA:
undetectable		 3twpC-2kbfA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyi SGTA PROTEIN

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		4 ALA A 157
PRO A 156
TYR A 158
ALA A 125
 None
 1.10A 3twpC-2vyiA:
undetectable		 3twpC-2vyiA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ALA A 552
TYR A 548
ARG A 485
ALA A 488
 None
 1.03A 3twpC-2xsgA:
undetectable		 3twpC-2xsgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwx GLCNAC-BINDING
PROTEIN A

(Vibrio cholerae) 		PF03067
(LPMO_10) 		4 ASN A 258
ALA A 257
PRO A 219
ARG A 100
 None
 0.97A 3twpC-2xwxA:
undetectable		 3twpC-2xwxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 111
ARG A  70
ALA A  73
ARG A  77
 None
 1.01A 3twpC-2z0mA:
undetectable		 3twpC-2z0mA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		4 ALA A 351
TYR A 308
ARG A 286
ALA A 306
 None
 1.13A 3twpC-2z61A:
undetectable		 3twpC-2z61A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 ASN A   2
ALA A  45
ARG A  27
ALA A  50
 None
 1.10A 3twpC-3f7wA:
undetectable		 3twpC-3f7wA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.05A 3twpC-3fk2A:
undetectable		 3twpC-3fk2A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqx NOP5P PROTEIN

(Pyrococcus
horikoshii) 		no annotation 4 ALA B 333
TYR B 316
ARG B 327
ALA B 318
 None
 1.06A 3twpC-3gqxB:
undetectable		 3twpC-3gqxB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ALA A 319
PRO A 318
TYR A 306
ARG A 325
 None
 0.96A 3twpC-3hwwA:
undetectable		 3twpC-3hwwA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 ALA A 340
TYR A 323
ARG A 334
ALA A 325
 None
 0.96A 3twpC-3icxA:
undetectable		 3twpC-3icxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ASN A 122
ALA A 121
ALA A  91
ARG A  93
 None
None
NDP  A 326 ( 4.9A)
None
 0.88A 3twpC-3ingA:
3.2		 3twpC-3ingA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		4 ASN A 227
ALA A 232
ARG A 269
ALA A 265
 None
 0.79A 3twpC-3ivuA:
undetectable		 3twpC-3ivuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 327
ALA A 325
TYR A 316
ALA A  79
 None
 0.98A 3twpC-3k5pA:
2.7		 3twpC-3k5pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfv TIGHT JUNCTION
PROTEIN ZO-3

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 ALA A 719
PRO A 718
TYR A 739
ARG A 736
 None
 0.95A 3twpC-3kfvA:
undetectable		 3twpC-3kfvA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 ASN A 195
ALA A 155
ALA A 112
ARG A 116
 None
 1.09A 3twpC-3ktcA:
undetectable		 3twpC-3ktcA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA

(Bos taurus) 		PF06957
(COPI_C) 		4 ALA B1147
ARG B1119
ALA B1122
ARG B1126
 None
 1.12A 3twpC-3mkrB:
undetectable		 3twpC-3mkrB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 PRO A 225
TYR A 219
ARG A 195
ALA A 194
 None
 1.09A 3twpC-3mz2A:
undetectable		 3twpC-3mz2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 256
ARG A 234
ALA A 237
ARG A 241
 None
 1.07A 3twpC-3n2cA:
undetectable		 3twpC-3n2cA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ASN A  86
ALA A  62
ARG A 231
ALA A 265
 None
 1.11A 3twpC-3njpA:
undetectable		 3twpC-3njpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)

(Mycolicibacterium
thermoresistibile) 		PF13561
(adh_short_C2) 		4 ASN A  62
PRO A  61
ARG A  58
ARG A  95
 None
 1.04A 3twpC-3oecA:
3.7		 3twpC-3oecA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 ASN A 585
ALA A 531
PRO A 530
ALA A 444
 None
 1.07A 3twpC-3phfA:
undetectable		 3twpC-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ALA A 382
ARG A 385
ALA A 358
ARG A 364
 None
 1.10A 3twpC-3pvcA:
undetectable		 3twpC-3pvcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2

(Arabidopsis
thaliana) 		no annotation 4 ALA C 182
PRO C 251
ARG C 178
ALA C 313
 None
 1.13A 3twpC-3r0qC:
undetectable		 3twpC-3r0qC:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 ASN A 255
PRO A 232
ARG A 234
ALA A 237
 None
 1.11A 3twpC-3sg1A:
undetectable		 3twpC-3sg1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A  29
PRO A  28
ARG A  25
ALA A 338
 None
 1.10A 3twpC-3tz6A:
3.2		 3twpC-3tz6A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 ALA A 239
TYR A 243
ARG A 244
ALA A 285
 None
 1.11A 3twpC-3wc3A:
undetectable		 3twpC-3wc3A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 ALA A 255
TYR A 243
ARG A 244
ALA A 285
 None
 0.86A 3twpC-3wc3A:
undetectable		 3twpC-3wc3A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		4 ALA A  22
TYR A  68
ARG A  67
ALA B  65
 None
None
None
I3C  A1205 (-3.5A)
 1.12A 3twpC-4bvxA:
undetectable		 3twpC-4bvxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		4 ASN A  93
ALA A  92
ARG A 154
ALA A 156
 ASN  A  93 ( 0.6A)
ALA  A  92 ( 0.0A)
ARG  A 154 ( 0.6A)
ALA  A 156 ( 0.0A)
 1.10A 3twpC-4c9gA:
undetectable		 3twpC-4c9gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ALA A 672
PRO A 669
ARG A 667
ALA A 680
 None
 1.10A 3twpC-4f7zA:
undetectable		 3twpC-4f7zA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		4 PRO A  19
TYR A  45
ALA A  27
ARG A  31
 None
 1.00A 3twpC-4ffcA:
undetectable		 3twpC-4ffcA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 ASN A 327
ALA A  57
TYR A  92
ARG A  93
 None
 1.11A 3twpC-4fixA:
3.4		 3twpC-4fixA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ALA A 466
TYR A  74
ARG A  75
ARG A 218
 None
 1.11A 3twpC-4fysA:
undetectable		 3twpC-4fysA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 ALA A 152
TYR A 311
ARG A 176
ALA A 179
 None
None
None
AI9  A 402 ( 4.7A)
 1.13A 3twpC-4g3mA:
undetectable		 3twpC-4g3mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		4 PRO A 205
ARG A 230
ALA A 178
ARG A 150
 None
 1.10A 3twpC-4glpA:
undetectable		 3twpC-4glpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASN A 361
ARG A 370
ALA A 118
ARG A 122
 None
 1.13A 3twpC-4gqaA:
3.3		 3twpC-4gqaA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 ALA A  35
PRO A  36
ARG A 174
ALA A 177
 None
 0.70A 3twpC-4hn8A:
undetectable		 3twpC-4hn8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 ASN A 249
ALA A 237
ALA A  97
ARG A 101
 ASN  A 249 ( 0.6A)
ALA  A 237 ( 0.0A)
ALA  A  97 ( 0.0A)
ARG  A 101 ( 0.6A)
 0.76A 3twpC-4hneA:
undetectable		 3twpC-4hneA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hs4 CHROMATE REDUCTASE

(Komagataeibacter
hansenii) 		PF03358
(FMN_red) 		4 ALA A  33
PRO A  34
ALA A 181
ARG A 185
 None
 1.05A 3twpC-4hs4A:
3.5		 3twpC-4hs4A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 ASN B 242
ALA B 241
ARG B 472
ALA B 454
 GLJ  B 601 (-3.0A)
None
None
None
 1.00A 3twpC-4hstB:
undetectable		 3twpC-4hstB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ALA B  62
TYR B  57
ALA B 102
ARG B 135
 None
 1.12A 3twpC-4l37B:
2.8		 3twpC-4l37B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ASN A 218
ALA A  66
ALA A  61
ARG A  29
 None
 1.01A 3twpC-4lihA:
3.7		 3twpC-4lihA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 ASN A 295
PRO A 292
TYR A 223
ALA A 226
 None
None
SO4  A 416 (-4.7A)
None
 0.92A 3twpC-4qb7A:
undetectable		 3twpC-4qb7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ALA A 478
PRO A 479
ARG A 465
ALA A 467
 None
 0.97A 3twpC-4qreA:
2.6		 3twpC-4qreA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 212
TYR A 204
ARG A 208
ALA A 206
 None
None
SO4  A 417 (-3.9A)
None
 1.08A 3twpC-4qtbA:
undetectable		 3twpC-4qtbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 ASN A 385
ALA A 383
TYR A 187
ARG A 166
 None
 0.93A 3twpC-4r40A:
3.3		 3twpC-4r40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASN A 106
ALA A 136
ARG A 277
ALA A 159
 None
 1.06A 3twpC-4ztcA:
undetectable		 3twpC-4ztcA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP58

(Xenopus laevis) 		PF15967
(Nucleoporin_FG2) 		4 ASN B 373
ALA B 375
PRO B 376
ALA B 359
 None
 0.97A 3twpC-5c3lB:
undetectable		 3twpC-5c3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASN A 597
ALA A 551
TYR A 569
ALA A 579
 None
 0.94A 3twpC-5e9aA:
2.1		 3twpC-5e9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		4 ASN A 113
ALA A  99
ARG A 109
ALA A  87
 None
 1.11A 3twpC-5egnA:
undetectable		 3twpC-5egnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 ASN A 399
PRO A 402
ALA A 411
ARG A 416
 None
 1.10A 3twpC-5ev7A:
undetectable		 3twpC-5ev7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		4 ALA A2137
PRO A2136
ARG A2102
ALA A2019
 None
 0.95A 3twpC-5fbyA:
undetectable		 3twpC-5fbyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC

(Escherichia
coli) 		PF09344
(Cas_CT1975) 		4 ALA D 291
TYR D 227
ARG D 226
ALA D 185
 None
 1.08A 3twpC-5h9fD:
undetectable		 3twpC-5h9fD:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ALA A 419
PRO A 418
TYR A 433
ARG A 431
 None
 1.08A 3twpC-5i2gA:
undetectable		 3twpC-5i2gA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		4 ASN A 870
PRO A 872
ARG B 873
ALA B 820
 None
 1.06A 3twpC-5ic9A:
2.4		 3twpC-5ic9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		4 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.01A 3twpC-5ircA:
undetectable		 3twpC-5ircA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 ASN A 128
ALA A 123
TYR A 120
ALA A 154
 None
 0.96A 3twpC-5jjoA:
undetectable		 3twpC-5jjoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ALA B 478
TYR B 475
ARG B 345
ARG B 238
 None
 1.00A 3twpC-5kohB:
2.5		 3twpC-5kohB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		4 ASN A   7
ALA A  34
PRO A  35
ALA A 109
 None
 1.11A 3twpC-5kssA:
4.1		 3twpC-5kssA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 ASN A  11
ALA A  37
PRO A  36
TYR A  34
 None
 0.93A 3twpC-5l44A:
undetectable		 3twpC-5l44A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		4 ASN A 120
ALA A 113
TYR A 149
ALA A 107
 None
None
None
FMN  A 201 (-3.3A)
 1.01A 3twpC-5lvaA:
undetectable		 3twpC-5lvaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1q PHAGE TERMINASE
LARGE SUBUNIT

(Thermus phage
G20c) 		PF17289
(Terminase_6C) 		4 ALA A 342
TYR A 339
ARG A 284
ALA A 315
 None
 1.12A 3twpC-5m1qA:
undetectable		 3twpC-5m1qA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		4 ASN A 217
PRO A 215
TYR A 176
ALA A 167
 None
 1.06A 3twpC-5ntfA:
2.2		 3twpC-5ntfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASN A 316
ALA A 313
ARG A 240
ALA A 241
 None
 1.01A 3twpC-5olsA:
undetectable		 3twpC-5olsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 ASN A 141
ALA A 149
PRO A 151
ALA A 321
 None
 1.11A 3twpC-5suoA:
undetectable		 3twpC-5suoA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		4 ASN A 127
ALA A 126
ALA A  54
ARG A 372
 None
 0.99A 3twpC-5txeA:
undetectable		 3twpC-5txeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 ASN A 307
ALA A 775
PRO A 774
ALA A 738
 None
 0.96A 3twpC-5u2gA:
undetectable		 3twpC-5u2gA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 ALA A 514
TYR A 511
ARG A 507
ALA A 368
 None
 1.10A 3twpC-5vmsA:
undetectable		 3twpC-5vmsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 4 ASN U 329
PRO U 332
TYR U 359
ALA U 363
 None
 1.07A 3twpC-5zvtU:
undetectable		 3twpC-5zvtU:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 ALA A 461
TYR A  70
ARG A  71
ARG A 213
 None
 1.13A 3twpC-6bv2A:
undetectable		 3twpC-6bv2A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY

(Thermobifida
fusca) 		no annotation 4 ALA B 297
PRO B 298
ALA M   9
ARG M   7
 None
 1.02A 3twpC-6c66B:
undetectable		 3twpC-6c66B:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 ALA A 183
TYR A 187
ALA A 112
ARG A 111
 None
 1.01A 3twpC-6cauA:
3.8		 3twpC-6cauA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 ASN D  69
ALA D  70
PRO D  67
TYR D  43
ALA A1143
 None
 1.40A 3twpC-6eojD:
undetectable		 3twpC-6eojD:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 ASN A 110
PRO A 113
ARG A 132
ALA A  70
 None
 1.13A 3twpC-6f79A:
undetectable		 3twpC-6f79A:
undetectable