SIMILAR PATTERNS OF AMINO ACIDS FOR 3TWP_B_SALB404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvy PROTEIN (CYTOCHROME
P450 BM-3)

(Bacillus
megaterium) 		PF00258
(Flavodoxin_1) 		4 ASN F 543
ALA F 544
PRO F 541
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 1.10A 3twpB-1bvyF:
undetectable		 3twpB-1bvyF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A  36
PRO A 398
TYR A 402
ARG A 400
ALA A 347
 None
 1.26A 3twpB-1cg2A:
undetectable		 3twpB-1cg2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 292
ALA A 326
PRO A 325
ALA A 367
 None
 1.10A 3twpB-1cg2A:
undetectable		 3twpB-1cg2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 ASN A 549
PRO A 514
ARG A 512
ALA A 555
 None
 1.01A 3twpB-1gxkA:
undetectable		 3twpB-1gxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 ASN A 417
ALA A 316
ARG A 421
ARG A 426
 None
 0.99A 3twpB-1hg4A:
undetectable		 3twpB-1hg4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF

(Homo sapiens) 		PF09128
(RGS-like) 		4 ALA A  57
PRO A  56
ARG A  54
ARG A 183
 None
 1.05A 3twpB-1iapA:
undetectable		 3twpB-1iapA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		4 ASN A 149
ALA A 192
ARG A 189
ALA A 180
 None
 0.92A 3twpB-1iy8A:
3.6		 3twpB-1iy8A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ALA A 386
PRO A 387
TYR A 298
ALA A 407
 None
 1.12A 3twpB-1j0nA:
undetectable		 3twpB-1j0nA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ALA A 226
PRO A 227
ARG A 235
ALA A 197
 None
 1.10A 3twpB-1nkvA:
3.1		 3twpB-1nkvA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1

(Bos taurus) 		PF00153
(Mito_carr) 		4 ASN A  76
ALA A  75
ARG A 139
ALA A 141
 None
 1.12A 3twpB-1okcA:
undetectable		 3twpB-1okcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 ASN A 293
ALA A 290
ARG A 227
ALA A 228
 None
 1.07A 3twpB-1ru4A:
undetectable		 3twpB-1ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ASN A 270
ALA A 273
PRO A 272
ALA A  64
 None
 1.07A 3twpB-1u08A:
undetectable		 3twpB-1u08A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 ALA A 492
TYR A 497
ARG A 406
ALA A 405
 None
 1.12A 3twpB-1uf2A:
undetectable		 3twpB-1uf2A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		4 ASN A 239
ALA A  91
ARG A 111
ALA A  84
 None
 1.11A 3twpB-1vjoA:
undetectable		 3twpB-1vjoA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		4 ALA A 204
ARG A 150
ALA A 151
ARG A 154
 None
 1.13A 3twpB-1w0mA:
undetectable		 3twpB-1w0mA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 ASN 1   4
ALA 1  30
PRO 1  29
TYR 1  27
 None
 0.81A 3twpB-1y791:
2.6		 3twpB-1y791:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 109
ALA A 150
ARG A 158
ALA A 161
 None
 0.84A 3twpB-2elcA:
46.2		 3twpB-2elcA:
39.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ALA A 344
PRO A 343
ARG A 451
ARG A 324
 None
None
NAD  A5555 (-4.1A)
None
 1.05A 3twpB-2fknA:
3.1		 3twpB-2fknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ASN A 218
ALA A 219
ALA A 322
ARG A 318
 NAD  A 450 (-4.1A)
JPA  A 500 (-4.0A)
None
None
 1.03A 3twpB-2foiA:
undetectable		 3twpB-2foiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		4 ALA A 114
TYR A  29
ARG A 106
ALA A  30
 None
 1.11A 3twpB-2hytA:
undetectable		 3twpB-2hytA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ALA A 385
TYR A 595
ARG A 382
ARG A 436
 None
 1.08A 3twpB-2hz7A:
2.2		 3twpB-2hz7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE

(Shewanella
oneidensis) 		PF04261
(Dyp_perox) 		4 ASN A  68
ALA A  67
PRO A  84
ALA A  97
 None
 0.86A 3twpB-2iizA:
undetectable		 3twpB-2iizA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbf ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 ASN A 388
ALA A 338
PRO A 408
ALA A 411
 None
 0.93A 3twpB-2kbfA:
undetectable		 3twpB-2kbfA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ALA A 558
TYR A 560
ARG A 616
ALA A 619
 None
 1.03A 3twpB-2p2mA:
undetectable		 3twpB-2p2mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ALA A 348
PRO A 347
ARG A 455
ARG A 328
 None
None
NAD  A3001 (-4.0A)
None
 1.08A 3twpB-2v7gA:
undetectable		 3twpB-2v7gA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyi SGTA PROTEIN

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		4 ALA A 157
PRO A 156
TYR A 158
ALA A 125
 None
 1.10A 3twpB-2vyiA:
undetectable		 3twpB-2vyiA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ALA A 552
TYR A 548
ARG A 485
ALA A 488
 None
 1.06A 3twpB-2xsgA:
2.7		 3twpB-2xsgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwx GLCNAC-BINDING
PROTEIN A

(Vibrio cholerae) 		PF03067
(LPMO_10) 		4 ASN A 258
ALA A 257
PRO A 219
ARG A 100
 None
 0.98A 3twpB-2xwxA:
undetectable		 3twpB-2xwxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 111
ARG A  70
ALA A  73
ARG A  77
 None
 1.09A 3twpB-2z0mA:
undetectable		 3twpB-2z0mA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvq PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5

(Trypanosoma
brucei) 		PF13432
(TPR_16) 		4 ALA A 542
ARG A 549
ALA A 520
ARG A 524
 None
 0.97A 3twpB-3cvqA:
undetectable		 3twpB-3cvqA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 ALA A 130
PRO A 131
ARG A 371
ALA A 361
 None
 0.98A 3twpB-3eleA:
undetectable		 3twpB-3eleA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Mus musculus;
Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 ALA A3396
TYR A3400
ARG A3362
ALA A3354
 None
 1.10A 3twpB-3errA:
undetectable		 3twpB-3errA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 ASN A   2
ALA A  45
ARG A  27
ALA A  50
 None
 0.99A 3twpB-3f7wA:
undetectable		 3twpB-3f7wA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.13A 3twpB-3fk2A:
undetectable		 3twpB-3fk2A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqx NOP5P PROTEIN

(Pyrococcus
horikoshii) 		no annotation 4 ALA B 333
TYR B 316
ARG B 327
ALA B 318
 None
 0.98A 3twpB-3gqxB:
undetectable		 3twpB-3gqxB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		4 ASN A  11
ALA A 177
ARG A 153
ALA A  14
 None
 1.12A 3twpB-3h7uA:
undetectable		 3twpB-3h7uA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ALA A 319
PRO A 318
TYR A 306
ARG A 325
 None
 1.12A 3twpB-3hwwA:
undetectable		 3twpB-3hwwA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 ALA A 340
TYR A 323
ARG A 334
ALA A 325
 None
 0.90A 3twpB-3icxA:
undetectable		 3twpB-3icxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ASN A 122
ALA A 121
ALA A  91
ARG A  93
 None
None
NDP  A 326 ( 4.9A)
None
 0.88A 3twpB-3ingA:
2.9		 3twpB-3ingA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		4 ASN A 227
ALA A 232
ARG A 269
ALA A 265
 None
 0.84A 3twpB-3ivuA:
undetectable		 3twpB-3ivuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1u CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1, SERYL
T-RNA SYNTHETASE
CHIMERA

(Mus musculus) 		PF12777
(MT) 		4 ALA A3396
TYR A3400
ARG A3362
ALA A3354
 None
 1.06A 3twpB-3j1uA:
undetectable		 3twpB-3j1uA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 ALA A 193
PRO A 192
ARG A  63
ALA A  54
 None
None
None
SO4  A 507 ( 4.6A)
 1.13A 3twpB-3ju8A:
3.0		 3twpB-3ju8A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 327
ALA A 325
TYR A 316
ALA A  79
 None
 0.98A 3twpB-3k5pA:
2.4		 3twpB-3k5pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfv TIGHT JUNCTION
PROTEIN ZO-3

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 ALA A 719
PRO A 718
TYR A 739
ARG A 736
 None
 0.96A 3twpB-3kfvA:
undetectable		 3twpB-3kfvA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 ASN A 195
ALA A 155
ALA A 112
ARG A 116
 None
 1.11A 3twpB-3ktcA:
undetectable		 3twpB-3ktcA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 PRO A 225
TYR A 219
ARG A 195
ALA A 194
 None
 1.08A 3twpB-3mz2A:
undetectable		 3twpB-3mz2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 256
ARG A 234
ALA A 237
ARG A 241
 None
 1.10A 3twpB-3n2cA:
undetectable		 3twpB-3n2cA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF02581
(TMP-TENI) 		4 ALA A 204
PRO A 207
ARG A 208
ALA A 211
 None
 1.09A 3twpB-3o63A:
undetectable		 3twpB-3o63A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 ASN A 585
ALA A 531
PRO A 530
ALA A 444
 None
 1.07A 3twpB-3phfA:
2.7		 3twpB-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 ASN A 255
PRO A 232
ARG A 234
ALA A 237
 None
 0.96A 3twpB-3sg1A:
undetectable		 3twpB-3sg1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 ALA A 255
TYR A 243
ARG A 244
ALA A 285
 None
 1.04A 3twpB-3wc3A:
undetectable		 3twpB-3wc3A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		4 ASN A 416
ALA A 412
ARG A 389
ALA A 404
 None
 1.14A 3twpB-3wmyA:
undetectable		 3twpB-3wmyA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 ASN A 255
PRO A 232
ARG A 234
ALA A 237
 None
 0.99A 3twpB-3zh4A:
undetectable		 3twpB-3zh4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		4 ASN A  93
ALA A  92
ARG A 154
ALA A 156
 ASN  A  93 ( 0.6A)
ALA  A  92 ( 0.0A)
ARG  A 154 ( 0.6A)
ALA  A 156 ( 0.0A)
 0.97A 3twpB-4c9gA:
undetectable		 3twpB-4c9gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		4 PRO A  19
TYR A  45
ALA A  27
ARG A  31
 None
 0.99A 3twpB-4ffcA:
undetectable		 3twpB-4ffcA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 ALA A 217
PRO A 216
TYR A 214
ARG A 212
 None
 1.07A 3twpB-4g25A:
2.6		 3twpB-4g25A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 ALA A 152
TYR A 311
ARG A 176
ALA A 179
 None
None
None
AI9  A 402 ( 4.7A)
 1.00A 3twpB-4g3mA:
undetectable		 3twpB-4g3mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		4 ASN A 257
ALA A 232
PRO A 233
ARG A  73
 None
 1.10A 3twpB-4hn3A:
undetectable		 3twpB-4hn3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 ALA A  35
PRO A  36
ARG A 174
ALA A 177
 None
 0.82A 3twpB-4hn8A:
undetectable		 3twpB-4hn8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 ASN A 249
ALA A 237
ALA A  97
ARG A 101
 ASN  A 249 ( 0.6A)
ALA  A 237 ( 0.0A)
ALA  A  97 ( 0.0A)
ARG  A 101 ( 0.6A)
 0.75A 3twpB-4hneA:
undetectable		 3twpB-4hneA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hs4 CHROMATE REDUCTASE

(Komagataeibacter
hansenii) 		PF03358
(FMN_red) 		4 ALA A  33
PRO A  34
ALA A 181
ARG A 185
 None
 1.04A 3twpB-4hs4A:
3.5		 3twpB-4hs4A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 ASN B 242
ALA B 241
ARG B 472
ALA B 454
 GLJ  B 601 (-3.0A)
None
None
None
 1.02A 3twpB-4hstB:
undetectable		 3twpB-4hstB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ALA A 192
PRO A 191
ARG A  62
ALA A  53
 None
 1.09A 3twpB-4knaA:
2.9		 3twpB-4knaA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ALA B  62
TYR B  57
ALA B 102
ARG B 135
 None
 1.13A 3twpB-4l37B:
undetectable		 3twpB-4l37B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ASN A 218
ALA A  66
ALA A  61
ARG A  29
 None
 1.02A 3twpB-4lihA:
0.0		 3twpB-4lihA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 ASN A 289
ALA A 285
ARG A 262
ALA A 277
 None
 1.13A 3twpB-4pviA:
undetectable		 3twpB-4pviA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 ASN A 295
PRO A 292
TYR A 223
ALA A 226
 None
None
SO4  A 416 (-4.7A)
None
 0.92A 3twpB-4qb7A:
undetectable		 3twpB-4qb7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		4 ALA A 202
TYR A 220
ARG A 210
ALA A 266
 None
 1.14A 3twpB-4qlbA:
5.1		 3twpB-4qlbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 212
TYR A 204
ARG A 208
ALA A 206
 None
None
SO4  A 417 (-3.9A)
None
 1.07A 3twpB-4qtbA:
undetectable		 3twpB-4qtbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 ASN A 385
ALA A 383
TYR A 187
ARG A 166
 None
 1.06A 3twpB-4r40A:
3.4		 3twpB-4r40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wny UNIVERSAL STRESS
PROTEIN

(Burkholderia
pseudomallei) 		PF00582
(Usp) 		4 ALA A   8
ARG A  85
ALA A 103
ARG A  99
 None
 0.97A 3twpB-4wnyA:
2.3		 3twpB-4wnyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 ALA A 375
PRO A 205
ARG A 599
ARG A 596
 None
 1.09A 3twpB-4xqkA:
undetectable		 3twpB-4xqkA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		4 ALA A 267
TYR A 264
ALA A 257
ARG A 359
 None
 0.95A 3twpB-4zmiA:
undetectable		 3twpB-4zmiA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP58

(Xenopus laevis) 		PF15967
(Nucleoporin_FG2) 		4 ASN B 373
ALA B 375
PRO B 376
ALA B 359
 None
 0.98A 3twpB-5c3lB:
undetectable		 3twpB-5c3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASN A 597
ALA A 551
TYR A 569
ALA A 579
 None
 0.93A 3twpB-5e9aA:
2.0		 3twpB-5e9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		4 ASN A 113
ALA A  99
ARG A 109
ALA A  87
 None
 0.89A 3twpB-5egnA:
undetectable		 3twpB-5egnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 ASN A 399
PRO A 402
ALA A 411
ARG A 416
 None
 1.09A 3twpB-5ev7A:
undetectable		 3twpB-5ev7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		4 ALA A2137
PRO A2136
ARG A2102
ALA A2019
 None
 1.02A 3twpB-5fbyA:
undetectable		 3twpB-5fbyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		4 ASN A 870
PRO A 872
ARG B 873
ALA B 820
 None
 1.08A 3twpB-5ic9A:
2.2		 3twpB-5ic9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ALA A  54
TYR A  51
ARG A  49
ALA A  46
 None
 1.06A 3twpB-5ikpA:
undetectable		 3twpB-5ikpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		4 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.04A 3twpB-5ircA:
2.1		 3twpB-5ircA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 ASN A 128
ALA A 123
TYR A 120
ALA A 154
 None
 0.94A 3twpB-5jjoA:
undetectable		 3twpB-5jjoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ALA A 642
ARG A 545
ALA A 683
ARG A 687
 None
 1.02A 3twpB-5kf7A:
2.4		 3twpB-5kf7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ALA B 478
TYR B 475
ARG B 345
ARG B 238
 None
 1.13A 3twpB-5kohB:
2.4		 3twpB-5kohB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		4 ASN A   7
ALA A  34
PRO A  35
ALA A 109
 None
 1.11A 3twpB-5kssA:
3.5		 3twpB-5kssA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 ASN A  11
ALA A  37
PRO A  36
TYR A  34
 None
 0.93A 3twpB-5l44A:
undetectable		 3twpB-5l44A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 ASN A 185
ALA A 269
ARG A 266
ALA A 259
 None
 1.10A 3twpB-5l51A:
3.5		 3twpB-5l51A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo9 CYTOCHROME C

(Marichromatium
purpuratum) 		PF00034
(Cytochrom_C)
PF13442
(Cytochrome_CBB3) 		4 ASN A 431
TYR A 500
ARG A 438
ARG A 480
 None
 1.11A 3twpB-5lo9A:
undetectable		 3twpB-5lo9A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		4 ASN A 120
ALA A 113
TYR A 149
ALA A 107
 None
None
None
FMN  A 201 (-3.3A)
 1.00A 3twpB-5lvaA:
undetectable		 3twpB-5lvaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		4 ASN A 217
PRO A 215
TYR A 176
ALA A 167
 None
 1.06A 3twpB-5ntfA:
2.1		 3twpB-5ntfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASN A 316
ALA A 313
ARG A 240
ALA A 241
 None
 1.11A 3twpB-5olsA:
undetectable		 3twpB-5olsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 ASN A 141
ALA A 149
PRO A 151
ALA A 321
 None
 1.10A 3twpB-5suoA:
undetectable		 3twpB-5suoA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		4 ASN A 127
ALA A 126
ALA A  54
ARG A 372
 None
 1.00A 3twpB-5txeA:
undetectable		 3twpB-5txeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 ASN A 307
ALA A 775
PRO A 774
ALA A 738
 None
 0.98A 3twpB-5u2gA:
undetectable		 3twpB-5u2gA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		4 ALA C 103
PRO C 102
ARG D  78
ALA C  94
 None
None
None
SF4  C 201 (-3.9A)
 1.00A 3twpB-5xfaC:
undetectable		 3twpB-5xfaC:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 4 ASN U 329
PRO U 332
TYR U 359
ALA U 363
 None
 1.08A 3twpB-5zvtU:
undetectable		 3twpB-5zvtU:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY

(Thermobifida
fusca) 		no annotation 4 ALA B 297
PRO B 298
ALA M   9
ARG M   7
 None
 1.02A 3twpB-6c66B:
undetectable		 3twpB-6c66B:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 ALA A 183
TYR A 187
ALA A 112
ARG A 111
 None
 1.01A 3twpB-6cauA:
3.6		 3twpB-6cauA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 ASN D  69
ALA D  70
PRO D  67
TYR D  43
ALA A1143
 None
 1.39A 3twpB-6eojD:
undetectable		 3twpB-6eojD:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 ASN A 110
PRO A 113
ARG A 132
ALA A  70
 None
 1.13A 3twpB-6f79A:
undetectable		 3twpB-6f79A:
undetectable