SIMILAR PATTERNS OF AMINO ACIDS FOR 3TVX_B_PNXB902_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		4 ASN A  72
ILE A  73
PHE A  34
GLN A  80
 None
 1.14A 3tvxB-1azzA:
undetectable		 3tvxB-1azzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ASN A 606
PHE A 367
MET A 378
PHE A 398
 None
 1.28A 3tvxB-1br2A:
undetectable		 3tvxB-1br2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens) 		PF00581
(Rhodanese) 		4 TYR A 463
ILE A 425
PHE A 379
PHE A 372
 None
 1.13A 3tvxB-1c25A:
undetectable		 3tvxB-1c25A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq2 ADP-L-GLYCERO-D-MANN
OHEPTOSE 6-EPIMERASE

(Escherichia
coli) 		PF01370
(Epimerase) 		4 TYR A 167
ASN A 221
ILE A  11
PHE A  10
 NAP  A2400 (-4.6A)
None
NAP  A2400 (-3.8A)
NAP  A2400 (-4.9A)
 1.15A 3tvxB-1eq2A:
undetectable		 3tvxB-1eq2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A 126
ILE A 113
PHE A 119
PHE A 208
 None
 0.94A 3tvxB-1gtuA:
undetectable		 3tvxB-1gtuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 ASN A  57
ILE A 408
PHE A 430
MET A 425
 None
 1.03A 3tvxB-1h4pA:
undetectable		 3tvxB-1h4pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E SMALL SUBUNIT

(Galdieria
partita) 		PF00101
(RuBisCO_small) 		4 ASN B  64
ILE B  48
MET B   8
GLN B  12
 None
 1.26A 3tvxB-1iwaB:
undetectable		 3tvxB-1iwaB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		4 ASN A 302
ILE A 291
PHE A 234
PHE A 262
 None
 1.25A 3tvxB-1j71A:
undetectable		 3tvxB-1j71A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ILE A 291
PHE A 236
GLN A 294
PHE A 335
 None
 1.26A 3tvxB-1jx2A:
undetectable		 3tvxB-1jx2A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ASN A 320
ILE A 330
GLN A 328
PHE A 323
 None
 1.03A 3tvxB-1ndfA:
undetectable		 3tvxB-1ndfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 TYR A 111
PHE A 187
MET A 311
GLN A 347
 EDO  A1020 (-3.6A)
None
None
None
 1.09A 3tvxB-1pffA:
undetectable		 3tvxB-1pffA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 736
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.59A 3tvxB-1sojA:
41.3		 3tvxB-1sojA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 ASN A 260
ILE A 264
PHE A 295
MET A 298
 None
 1.27A 3tvxB-1tp7A:
undetectable		 3tvxB-1tp7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 178
MET B  57
GLN B 175
PHE B 147
 None
 1.18A 3tvxB-1uliB:
undetectable		 3tvxB-1uliB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2u ENDOGLUCANASE

(Humicola grisea) 		PF01670
(Glyco_hydro_12) 		4 ASN A 196
ILE A  77
PHE A 181
GLN A 195
 None
 1.27A 3tvxB-1w2uA:
undetectable		 3tvxB-1w2uA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 211
ASN A 365
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.57A 3tvxB-1zklA:
45.1		 3tvxB-1zklA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE

(Archaeoglobus
fulgidus) 		PF01884
(PcrB) 		4 TYR A1219
ASN A1018
ILE A1218
PHE A1226
 None
 1.13A 3tvxB-2f6xA:
undetectable		 3tvxB-2f6xA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 ASN A 104
ILE A 102
PHE A  64
MET A  61
 None
 1.11A 3tvxB-2fq4A:
undetectable		 3tvxB-2fq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jp7 MRNA EXPORT FACTOR
MEX67

(Saccharomyces
cerevisiae) 		PF03943
(TAP_C) 		4 TYR A 577
ILE A 581
PHE A 584
MET A 588
 None
 0.84A 3tvxB-2jp7A:
undetectable		 3tvxB-2jp7A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 TYR A 545
ASN A 583
ILE A 584
PHE A 598
 None
 1.24A 3tvxB-2ktqA:
undetectable		 3tvxB-2ktqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ASN A 594
ILE A 593
PHE A 565
MET A 318
 None
 1.03A 3tvxB-2obeA:
undetectable		 3tvxB-2obeA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379

(Pseudomonas
syringae group
genomosp. 3) 		PF07286
(DUF1445) 		4 ASN A 208
ILE A 207
PHE A 229
MET A 171
 None
 1.17A 3tvxB-2pifA:
undetectable		 3tvxB-2pifA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 329
PHE A 330
GLN A 325
PHE A 321
 None
 1.18A 3tvxB-2pz1A:
undetectable		 3tvxB-2pz1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		4 ASN A  53
ILE A  59
PHE A  32
PHE A 173
 None
 1.19A 3tvxB-2qmxA:
undetectable		 3tvxB-2qmxA:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 371
ASN A 533
ILE A 548
PHE A 552
MET A 569
GLN A 581
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.4A)
NPV  A   3 (-3.8A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.24A 3tvxB-2qykA:
56.1		 3tvxB-2qykA:
98.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 281
ASN A 443
ILE A 458
PHE A 494
 None
 0.57A 3tvxB-2qymA:
45.2		 3tvxB-2qymA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
ASN A 838
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.77A 3tvxB-2r8qA:
39.6		 3tvxB-2r8qA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN B 254
ILE B 238
PHE B 242
MET B 246
 None
 0.95A 3tvxB-2w2kB:
undetectable		 3tvxB-2w2kB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb6 AFV1-102

(Acidianus
filamentous
virus 1) 		no annotation 4 TYR A  85
ILE A  70
PHE A  15
MET A  19
 None
 1.13A 3tvxB-2wb6A:
undetectable		 3tvxB-2wb6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		4 ASN A 170
ILE A 172
PHE A 174
GLN A  74
 None
 1.03A 3tvxB-2ygnA:
undetectable		 3tvxB-2ygnA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		4 ASN A 170
ILE A 172
PHE A 174
GLN A  74
 None
 1.13A 3tvxB-2ygoA:
undetectable		 3tvxB-2ygoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygq WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF)
PF12661
(hEGF) 		4 ASN A 170
ILE A 172
PHE A 174
GLN A  74
 None
 1.15A 3tvxB-2ygqA:
undetectable		 3tvxB-2ygqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ASN A 134
ILE A 156
PHE A 164
MET A 165
 None
 1.17A 3tvxB-2yxxA:
undetectable		 3tvxB-2yxxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 TYR A 740
PHE A 690
MET A 705
GLN A 752
 None
 1.28A 3tvxB-3a0fA:
undetectable		 3tvxB-3a0fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN

(Bacillus
subtilis) 		PF01019
(G_glu_transpept) 		4 ASN A 371
ILE A 365
PHE A 308
GLN A 322
 None
 1.27A 3tvxB-3a75A:
undetectable		 3tvxB-3a75A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ASN A 299
ILE B  61
PHE B  34
MET A 365
 None
 1.16A 3tvxB-3ab4A:
undetectable		 3tvxB-3ab4A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 612
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.53A 3tvxB-3b2rA:
31.6		 3tvxB-3b2rA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 612
PHE A 786
GLN A 817
PHE A 820
 None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.40A 3tvxB-3bjcA:
34.4		 3tvxB-3bjcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		4 ILE B  85
PHE B  56
MET B  54
PHE B 194
 None
 1.22A 3tvxB-3cjiB:
undetectable		 3tvxB-3cjiB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 TYR A 614
ILE A 390
PHE A 386
MET A 376
 None
 0.95A 3tvxB-3d3lA:
undetectable		 3tvxB-3d3lA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 555
ASN A 729
ILE A 744
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.38A 3tvxB-3ecnA:
44.5		 3tvxB-3ecnA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ASN A  24
ILE A  25
PHE A 428
PHE A  43
 None
 1.21A 3tvxB-3eqnA:
undetectable		 3tvxB-3eqnA:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 325
ASN A 487
ILE A 502
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.48A 3tvxB-3g4gA:
51.3		 3tvxB-3g4gA:
70.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 TYR A 131
ILE A 128
PHE A 188
MET A 184
 None
 1.20A 3tvxB-3hnrA:
undetectable		 3tvxB-3hnrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 TYR A 655
ILE A 826
GLN A 859
PHE A 862
 None
 0.59A 3tvxB-3ibjA:
33.0		 3tvxB-3ibjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ign DIGUANYLATE CYCLASE

(Marinobacter
hydrocarbonoclasticus) 		PF00990
(GGDEF) 		4 TYR A 275
ILE A 194
PHE A 197
PHE A 238
 None
 1.06A 3tvxB-3ignA:
undetectable		 3tvxB-3ignA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ILE A 341
PHE A 348
GLN A 339
PHE A 331
 None
 1.17A 3tvxB-3ldgA:
undetectable		 3tvxB-3ldgA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ASN A 612
ILE A 661
PHE A 760
MET A 757
 None
 1.10A 3tvxB-3lltA:
undetectable		 3tvxB-3lltA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 TYR B 411
ILE B 407
PHE B 209
MET B 369
 None
 1.17A 3tvxB-3n2zB:
undetectable		 3tvxB-3n2zB:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		4 ASN A  99
ILE A 101
PHE A  48
GLN A 102
 None
 1.26A 3tvxB-3nztA:
undetectable		 3tvxB-3nztA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ASN A 395
ILE A 410
MET A 431
GLN A 443
PHE A 446
 ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.88A 3tvxB-3o57A:
52.8		 3tvxB-3o57A:
86.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 233
ASN A 395
ILE A 410
PHE A 414
GLN A 443
PHE A 446
 None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.51A 3tvxB-3o57A:
52.8		 3tvxB-3o57A:
86.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 TYR A 276
ASN A 145
ILE A 290
GLN A 167
 None
 1.23A 3tvxB-3ohnA:
undetectable		 3tvxB-3ohnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyy ELONGATION FACTOR P

(Pseudomonas
aeruginosa) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		4 ASN A  14
ILE A  15
MET A  39
PHE A   7
 None
 1.21A 3tvxB-3oyyA:
undetectable		 3tvxB-3oyyA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 112
ILE A  59
PHE A  80
PHE A  62
 None
None
None
A2N  A1000 (-3.8A)
 1.20A 3tvxB-3pkjA:
undetectable		 3tvxB-3pkjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pna CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Bos taurus) 		PF00027
(cNMP_binding) 		4 ILE A 163
PHE A 198
MET A 180
PHE A 156
 CMP  A 250 ( 4.3A)
None
None
None
 1.14A 3tvxB-3pnaA:
undetectable		 3tvxB-3pnaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 TYR A 614
ILE A 391
PHE A 387
MET A 377
 None
 0.97A 3tvxB-3rdeA:
undetectable		 3tvxB-3rdeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 ASN A 422
ILE A 399
PHE A 410
MET A 384
 None
 1.24A 3tvxB-3rhdA:
undetectable		 3tvxB-3rhdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		4 ASN A 138
ILE A 136
PHE A 133
GLN A  51
 None
None
None
ACY  A 213 ( 4.5A)
 1.28A 3tvxB-3rnrA:
undetectable		 3tvxB-3rnrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		4 TYR A 237
ILE A 136
GLN A 134
PHE A  88
 GOL  A 364 (-4.2A)
GOL  A 363 ( 4.5A)
None
GOL  A 363 (-4.6A)
 1.26A 3tvxB-3rpwA:
undetectable		 3tvxB-3rpwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A 198
ILE A 115
PHE A 424
PHE A 432
 D7V  A1201 (-4.6A)
D7V  A1201 (-3.8A)
None
5EH  A1200 ( 4.3A)
 0.94A 3tvxB-3rzeA:
undetectable		 3tvxB-3rzeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 TYR A  86
ILE A  99
PHE A 304
GLN A  97
 None
 0.94A 3tvxB-3s5kA:
undetectable		 3tvxB-3s5kA:
14.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 159
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.52A 3tvxB-3sl5A:
51.6		 3tvxB-3sl5A:
85.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 632
PHE A 654
MET A 659
PHE A 616
 None
 1.22A 3tvxB-3sunA:
undetectable		 3tvxB-3sunA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
ILE A 692
PHE A 696
MET A 713
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 1.03A 3tvxB-3ui7A:
38.3		 3tvxB-3ui7A:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 TYR A 340
ASN A 338
ILE A 384
GLN A 408
 None
 1.17A 3tvxB-3ujzA:
undetectable		 3tvxB-3ujzA:
16.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		5 TYR A 367
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.55A 3tvxB-3v94A:
39.8		 3tvxB-3v94A:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
HEME SUBUNIT

(Thermochromatium
tepidum) 		no annotation 4 TYR A  72
ASN A   9
PHE A  37
MET A  41
 None
None
HEC  A 201 (-4.6A)
HEC  A 201 (-3.6A)
 1.27A 3tvxB-3vrdA:
undetectable		 3tvxB-3vrdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 112
ILE A  59
PHE A  80
PHE A  62
 None
None
None
APR  A1296 (-3.6A)
 1.27A 3tvxB-3zg6A:
undetectable		 3tvxB-3zg6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 TYR A 489
ASN A 251
ILE A 249
PHE A 492
 None
 1.26A 3tvxB-4be9A:
undetectable		 3tvxB-4be9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius) 		PF00588
(SpoU_methylase) 		4 ASN A  15
ILE A  19
PHE A  31
MET A  58
 None
 1.26A 3tvxB-4cngA:
undetectable		 3tvxB-4cngA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gom DNA ADENINE
METHYLASE

(Escherichia
coli) 		PF02086
(MethyltransfD12) 		4 TYR D 237
ASN D 227
ILE D 225
PHE D  35
 None
None
None
0Y0  D 301 (-4.4A)
 1.23A 3tvxB-4gomD:
undetectable		 3tvxB-4gomD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 655
ILE A 826
PHE A 830
MET A 847
GLN A 859
PHE A 862
 None
 0.82A 3tvxB-4htzA:
38.9		 3tvxB-4htzA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
ASN A 825
PHE A 844
GLN A 874
PHE A 877
 None
 0.86A 3tvxB-4i15A:
38.9		 3tvxB-4i15A:
31.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
ASN A 825
PHE A 844
MET A 861
PHE A 877
 None
 0.69A 3tvxB-4i15A:
38.9		 3tvxB-4i15A:
31.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		4 TYR A 240
ASN A 193
ILE A 321
PHE A 325
 NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
NDP  A 401 ( 4.8A)
None
 1.11A 3tvxB-4ijrA:
undetectable		 3tvxB-4ijrA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		PF00579
(tRNA-synt_1b) 		4 TYR A 425
PHE A 412
GLN A 456
PHE A 460
 None
None
TYM  A 701 (-3.4A)
TYM  A 701 (-4.7A)
 1.25A 3tvxB-4j75A:
undetectable		 3tvxB-4j75A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 TYR A 265
ILE A 234
GLN A 131
PHE A 162
 None
 1.12A 3tvxB-4nenA:
undetectable		 3tvxB-4nenA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzi TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF00017
(SH2) 		4 TYR A 193
ASN A 122
ILE A 204
PHE A 130
 None
 0.85A 3tvxB-4tziA:
undetectable		 3tvxB-4tziA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uow OBSCURIN
TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 ASN 0  93
ILE 0  14
PHE 1  92
GLN 1  47
 None
None
CL  0 201 (-4.8A)
None
 1.22A 3tvxB-4uow0:
undetectable		 3tvxB-4uow0:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		4 TYR A 311
ASN A 309
ILE A 328
MET A 285
 None
 1.12A 3tvxB-4uq9A:
undetectable		 3tvxB-4uq9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		4 TYR A 587
ASN A 625
ILE A 626
PHE A 640
 None
 1.19A 3tvxB-4uqgA:
undetectable		 3tvxB-4uqgA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ASN A 567
ILE A 582
PHE A 586
MET A 603
GLN A 615
 None
 1.01A 3tvxB-4wziA:
52.3		 3tvxB-4wziA:
50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 405
ASN A 567
ILE A 582
PHE A 586
GLN A 615
PHE A 618
 None
 0.62A 3tvxB-4wziA:
52.3		 3tvxB-4wziA:
50.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A  92
PHE A 301
GLN A  79
PHE A 458
 None
 1.24A 3tvxB-4z26A:
undetectable		 3tvxB-4z26A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ASN A 265
ILE A 266
PHE A 285
MET A 289
 None
 1.20A 3tvxB-4zviA:
undetectable		 3tvxB-4zviA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 TYR A 283
ASN A 338
PHE A 285
PHE A 252
 None
 1.28A 3tvxB-5axiA:
undetectable		 3tvxB-5axiA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 222
PHE A 392
GLN A 421
PHE A 424
 None
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.44A 3tvxB-5b25A:
43.4		 3tvxB-5b25A:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxo EPOXIDE HYDROLASE

(Streptomyces
albus) 		PF12680
(SnoaL_2) 		4 TYR A  54
ILE A  36
PHE A  30
PHE A 106
 P6G  A 202 (-4.9A)
None
None
None
 1.15A 3tvxB-5cxoA:
undetectable		 3tvxB-5cxoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		4 TYR A 416
ASN A 718
ILE A 413
PHE A 403
 None
 1.27A 3tvxB-5e1rA:
undetectable		 3tvxB-5e1rA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 4 ASN Y 475
ILE Y 454
PHE Y 442
MET Y 444
 None
 1.17A 3tvxB-5gaiY:
undetectable		 3tvxB-5gaiY:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
ASN A 826
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.4A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.67A 3tvxB-5h2rA:
39.5		 3tvxB-5h2rA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 4 ASN A  68
ILE A  64
PHE A 106
PHE A  59
 None
 1.21A 3tvxB-5h60A:
undetectable		 3tvxB-5h60A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		4 TYR A  39
ASN A  88
ILE A  41
MET A 297
 None
 1.27A 3tvxB-5i4kA:
undetectable		 3tvxB-5i4kA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC3

(Saccharomyces
cerevisiae) 		PF03870
(RNA_pol_Rpb8) 		4 TYR H  98
ASN H 139
PHE H 118
MET H 123
 None
 1.21A 3tvxB-5ip9H:
undetectable		 3tvxB-5ip9H:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 ASN A 239
ILE A 348
PHE A 327
GLN A 255
 None
 1.12A 3tvxB-5mrwA:
undetectable		 3tvxB-5mrwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 7 TYR A 405
ASN A 567
ILE A 582
PHE A 586
MET A 603
GLN A 615
PHE A 618
 None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 0.58A 3tvxB-5ohjA:
54.4		 3tvxB-5ohjA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 7 TYR A 159
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
 AKJ  A 601 ( 4.7A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 0.33A 3tvxB-5wh6A:
52.4		 3tvxB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wof DYNEIN LIGHT CHAIN
1, PUTATIVE

(Plasmodium
falciparum) 		PF01221
(Dynein_light) 		4 ASN A  66
ILE A  68
PHE A  70
PHE A  40
 None
 1.21A 3tvxB-5wofA:
undetectable		 3tvxB-5wofA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 ASN A  85
ILE A  66
PHE A  95
MET A 118
 None
 1.27A 3tvxB-5xnpA:
undetectable		 3tvxB-5xnpA:
11.99