SIMILAR PATTERNS OF AMINO ACIDS FOR 3TTR_A_LQZA90_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 PRO A 132
THR A 128
LEU A 124
 None
 0.73A 3ttrA-1a8sA:
0.7		 3ttrA-1a8sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		3 PRO A 121
THR A 122
LEU A 133
 None
 0.80A 3ttrA-1ag9A:
1.9		 3ttrA-1ag9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 240
 None
 0.53A 3ttrA-1bev2:
0.0		 3ttrA-1bev2:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 PRO A 429
THR A 430
LEU A 651
 None
 0.48A 3ttrA-1biyA:
41.0		 3ttrA-1biyA:
91.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		3 PRO A 520
THR A 519
LEU A 320
 None
 0.77A 3ttrA-1cu1A:
0.2		 3ttrA-1cu1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		3 PRO A 203
THR A 202
LEU A 265
 None
 0.68A 3ttrA-1dhsA:
0.0		 3ttrA-1dhsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		3 PRO A 510
THR A 509
LEU A 417
 None
 0.71A 3ttrA-1dpbA:
undetectable		 3ttrA-1dpbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 PRO A 375
THR A 376
LEU A 368
 None
 0.80A 3ttrA-1e1cA:
1.7		 3ttrA-1e1cA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		3 PRO A1404
THR A1402
LEU A1427
 None
 0.75A 3ttrA-1eqfA:
undetectable		 3ttrA-1eqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 255
 None
 0.52A 3ttrA-1ev12:
0.0		 3ttrA-1ev12:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exs BETA-LACTOGLOBULIN

(Sus scrofa) 		PF00061
(Lipocalin) 		3 PRO A  48
THR A  49
LEU A  72
 None
 0.66A 3ttrA-1exsA:
undetectable		 3ttrA-1exsA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		3 PRO A 185
THR A 224
LEU A 160
 None
 0.80A 3ttrA-1fi8A:
undetectable		 3ttrA-1fi8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		3 PRO A 444
THR A 443
LEU A 448
 TTP  A1589 ( 4.0A)
TTP  A1589 (-4.3A)
TTP  A1589 (-4.0A)
 0.77A 3ttrA-1h79A:
undetectable		 3ttrA-1h79A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 PRO C  37
THR C 140
LEU C  62
 None
 0.79A 3ttrA-1ixrC:
undetectable		 3ttrA-1ixrC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 PRO A2885
THR A2886
LEU A2800
 None
 0.75A 3ttrA-1js8A:
undetectable		 3ttrA-1js8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PRO A 962
THR A 961
LEU A 967
 None
 0.72A 3ttrA-1jx2A:
undetectable		 3ttrA-1jx2A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 PRO A 211
THR A 212
LEU A 208
 None
 0.62A 3ttrA-1mg5A:
undetectable		 3ttrA-1mg5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO B  53
THR B  54
LEU B 255
 None
 0.46A 3ttrA-1mqtB:
undetectable		 3ttrA-1mqtB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		3 PRO A  61
THR A  60
LEU A   3
 None
 0.78A 3ttrA-1nbwA:
undetectable		 3ttrA-1nbwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		3 PRO A 109
THR A 108
LEU A 213
 None
 0.70A 3ttrA-1ni6A:
undetectable		 3ttrA-1ni6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF09201
(SRX)
PF09439
(SRPRB) 		3 PRO A  10
THR A   9
LEU B  73
 None
 0.69A 3ttrA-1nrjA:
undetectable		 3ttrA-1nrjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyi PROTEIN (PYRIMIDINE
PATHWAY REGULATOR 1)

(Saccharomyces
cerevisiae) 		PF00172
(Zn_clus) 		3 PRO A  98
THR A  99
LEU A  91
 None
 0.56A 3ttrA-1pyiA:
undetectable		 3ttrA-1pyiA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 PRO A  55
THR A  56
LEU A  33
 GTS  A1004 (-4.2A)
None
None
 0.68A 3ttrA-1r5aA:
undetectable		 3ttrA-1r5aA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		3 PRO A  48
THR A  49
LEU A  70
 None
 0.79A 3ttrA-1tz7A:
undetectable		 3ttrA-1tz7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO B 309
THR B 310
LEU B 306
 None
 0.55A 3ttrA-1umbB:
undetectable		 3ttrA-1umbB:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		3 PRO A  24
THR A  25
LEU A 131
 None
 0.56A 3ttrA-1wdvA:
undetectable		 3ttrA-1wdvA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7u ACYL-COA HYDROLASE

(Bacillus cereus) 		PF03061
(4HBT) 		3 PRO A 130
THR A  91
LEU A 122
 None
COA  A 201 (-3.9A)
None
 0.78A 3ttrA-1y7uA:
undetectable		 3ttrA-1y7uA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoa PUTATIVE
FLAVOPROTEIN

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 PRO A  85
THR A  86
LEU A  56
 FAD  A 401 (-4.2A)
FAD  A 401 (-4.5A)
FAD  A 401 ( 4.5A)
 0.71A 3ttrA-1yoaA:
undetectable		 3ttrA-1yoaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz H2-T22 PROTEIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A 124
THR A 125
LEU A 116
 None
 0.68A 3ttrA-1ypzA:
undetectable		 3ttrA-1ypzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 PRO A  10
THR A 103
LEU A  54
 None
 0.73A 3ttrA-1yqqA:
undetectable		 3ttrA-1yqqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 PRO A 110
THR A 109
LEU A 498
 None
 0.72A 3ttrA-1z14A:
undetectable		 3ttrA-1z14A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 263
 None
 0.40A 3ttrA-1z7s2:
undetectable		 3ttrA-1z7s2:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		3 PRO A 135
THR A 131
LEU A 127
 None
 0.78A 3ttrA-1zoiA:
undetectable		 3ttrA-1zoiA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		3 PRO A  79
THR A  80
LEU A  94
 FMN  A 390 (-3.8A)
FMN  A 390 (-4.5A)
None
 0.76A 3ttrA-2a7nA:
undetectable		 3ttrA-2a7nA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		3 PRO A1141
THR A1140
LEU A1076
 None
 0.77A 3ttrA-2c0gA:
undetectable		 3ttrA-2c0gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		3 PRO A 215
THR A 239
LEU A 247
 None
 0.64A 3ttrA-2c2gA:
0.5		 3ttrA-2c2gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d86 VAV-3 PROTEIN

(Homo sapiens) 		PF11971
(CAMSAP_CH) 		3 PRO A 126
THR A 125
LEU A  57
 None
 0.74A 3ttrA-2d86A:
undetectable		 3ttrA-2d86A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 PRO A 362
THR A 348
LEU A 367
 None
 0.78A 3ttrA-2eezA:
undetectable		 3ttrA-2eezA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE

(Archaeoglobus
fulgidus) 		PF01884
(PcrB) 		3 PRO A1081
THR A1082
LEU A1161
 MPD  A4001 (-3.7A)
None
None
 0.63A 3ttrA-2f6xA:
undetectable		 3ttrA-2f6xA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		3 PRO A1461
THR A1462
LEU A1638
 None
 0.67A 3ttrA-2fr1A:
1.0		 3ttrA-2fr1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		3 PRO A1024
THR A1044
LEU A1027
 None
 0.74A 3ttrA-2iusA:
undetectable		 3ttrA-2iusA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9l CHLORIDE CHANNEL
PROTEIN 5

(Homo sapiens) 		PF00571
(CBS) 		3 PRO A 675
THR A 676
LEU A 669
 None
 0.72A 3ttrA-2j9lA:
undetectable		 3ttrA-2j9lA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4z DSRR

(Allochromatium
vinosum) 		PF01521
(Fe-S_biosyn) 		3 PRO A  96
THR A  97
LEU A  91
 None
 0.79A 3ttrA-2k4zA:
undetectable		 3ttrA-2k4zA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS) 		3 PRO A 152
THR A 151
LEU A 234
 None
 0.70A 3ttrA-2o3bA:
undetectable		 3ttrA-2o3bA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		3 PRO A 276
THR A 277
LEU A 252
 None
 0.63A 3ttrA-2r9yA:
undetectable		 3ttrA-2r9yA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 PRO A  38
THR A 126
LEU A  69
 BEZ  A1222 ( 4.6A)
None
None
 0.70A 3ttrA-2v41A:
undetectable		 3ttrA-2v41A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		3 PRO A 112
THR A 111
LEU A  99
 None
 0.63A 3ttrA-2wbpA:
undetectable		 3ttrA-2wbpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wse PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF02531
(PsaD) 		3 PRO D  25
THR D  24
LEU D  74
 None
 0.76A 3ttrA-2wseD:
undetectable		 3ttrA-2wseD:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		3 PRO A  13
THR A  12
LEU A  71
 None
 0.73A 3ttrA-2wu8A:
undetectable		 3ttrA-2wu8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		3 PRO A 272
THR A 273
LEU A 250
 None
 0.60A 3ttrA-2x7xA:
undetectable		 3ttrA-2x7xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 PRO A 181
THR A 180
LEU A 188
 None
 0.78A 3ttrA-2zyjA:
undetectable		 3ttrA-2zyjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 PRO A  43
THR A 124
LEU A  74
 None
 0.62A 3ttrA-3a5wA:
undetectable		 3ttrA-3a5wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		3 PRO C  53
THR C  54
LEU C 272
 None
 0.57A 3ttrA-3cjiC:
undetectable		 3ttrA-3cjiC:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 PRO A  66
THR A  67
LEU A  63
 None
 0.76A 3ttrA-3ct9A:
undetectable		 3ttrA-3ct9A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		3 PRO A  68
THR A  67
LEU A  76
 None
 0.64A 3ttrA-3d00A:
undetectable		 3ttrA-3d00A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dz1 DIHYDRODIPICOLINATE
SYNTHASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		3 PRO A  15
THR A  16
LEU A  47
 None
 0.77A 3ttrA-3dz1A:
undetectable		 3ttrA-3dz1A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		3 PRO A 591
THR A 592
LEU A 575
 None
 0.77A 3ttrA-3ebbA:
undetectable		 3ttrA-3ebbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ein GLUTATHIONE
S-TRANSFERASE 1-1

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 PRO A  54
THR A  55
LEU A  32
 GSH  A 210 (-4.3A)
None
None
 0.70A 3ttrA-3einA:
undetectable		 3ttrA-3einA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 263
 None
 0.58A 3ttrA-3epc2:
undetectable		 3ttrA-3epc2:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 262
 None
 0.49A 3ttrA-3epd2:
undetectable		 3ttrA-3epd2:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 262
 None
 0.40A 3ttrA-3epf2:
undetectable		 3ttrA-3epf2:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Novosphingobium
aromaticivorans) 		PF07883
(Cupin_2) 		3 PRO A  35
THR A  36
LEU A  10
 None
 0.79A 3ttrA-3es1A:
undetectable		 3ttrA-3es1A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE

(Azospirillum
brasilense) 		PF00701
(DHDPS) 		3 PRO A  28
THR A  29
LEU A  60
 None
 0.79A 3ttrA-3fkrA:
undetectable		 3ttrA-3fkrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvc GLYCOPROTEIN GP110

(Human
gammaherpesvirus
4) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		3 PRO A 170
THR A 171
LEU A 207
 None
 0.78A 3ttrA-3fvcA:
undetectable		 3ttrA-3fvcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3l PUTATIVE SUGAR
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 PRO A 135
THR A 134
LEU A 240
 None
 0.73A 3ttrA-3h3lA:
undetectable		 3ttrA-3h3lA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9u HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		3 PRO A 109
THR A 108
LEU A 213
 None
 0.73A 3ttrA-3i9uA:
undetectable		 3ttrA-3i9uA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		3 PRO A 214
THR A 215
LEU A 222
 None
 0.51A 3ttrA-3if2A:
undetectable		 3ttrA-3if2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO C  44
THR C  45
LEU C 246
 None
 0.45A 3ttrA-3j2jC:
undetectable		 3ttrA-3j2jC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		3 PRO A 133
THR A 134
LEU A 151
 None
 0.69A 3ttrA-3jx8A:
undetectable		 3ttrA-3jx8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 PRO A 189
THR A 188
LEU A 196
 None
 0.80A 3ttrA-3lduA:
undetectable		 3ttrA-3lduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		3 PRO A 269
THR A 268
LEU A 637
 None
 0.65A 3ttrA-3nttA:
undetectable		 3ttrA-3nttA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu1 HEMIN-BINDING
PERIPLASMIC PROTEIN

(Yersinia pestis) 		PF01497
(Peripla_BP_2) 		3 PRO A 242
THR A 241
LEU A 216
 None
 0.79A 3ttrA-3nu1A:
undetectable		 3ttrA-3nu1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 PRO A  36
THR A 483
LEU A  11
 None
 0.75A 3ttrA-3ojyA:
undetectable		 3ttrA-3ojyA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		3 PRO A 144
THR A 143
LEU A 147
 None
 0.74A 3ttrA-3othA:
undetectable		 3ttrA-3othA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 PRO A 162
THR A 165
LEU A 173
 None
 0.75A 3ttrA-3qreA:
undetectable		 3ttrA-3qreA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 PRO A 279
THR A 278
LEU A 648
 None
 0.63A 3ttrA-3shmA:
undetectable		 3ttrA-3shmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 PRO A  88
THR A 516
LEU A  63
 None
 0.67A 3ttrA-3t5oA:
undetectable		 3ttrA-3t5oA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 PRO A 187
THR A 188
LEU A 205
 EDO  A 492 ( 4.7A)
None
EDO  A 496 ( 4.7A)
 0.80A 3ttrA-3tc9A:
undetectable		 3ttrA-3tc9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		3 PRO B 215
THR B 214
LEU B 187
 None
 0.64A 3ttrA-3u44B:
undetectable		 3ttrA-3u44B:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 PRO A 415
THR A 416
LEU A 380
 None
 0.66A 3ttrA-3ufbA:
undetectable		 3ttrA-3ufbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 PRO A 416
THR A 373
LEU A 409
 None
 0.80A 3ttrA-3v39A:
undetectable		 3ttrA-3v39A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 PRO A 339
THR A 338
LEU A 316
 None
 0.75A 3ttrA-3va8A:
undetectable		 3ttrA-3va8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		3 PRO A 341
THR A 340
LEU A 318
 None
 0.78A 3ttrA-3vdgA:
undetectable		 3ttrA-3vdgA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE

(Staphylococcus
aureus) 		PF01884
(PcrB) 		3 PRO A  82
THR A  83
LEU A 155
 None
 0.54A 3ttrA-3w01A:
undetectable		 3ttrA-3w01A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 PRO A 424
THR A 423
LEU A 252
 None
 0.77A 3ttrA-4agsA:
undetectable		 3ttrA-4agsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		3 PRO A 558
THR A 557
LEU A 588
 None
 0.72A 3ttrA-4aysA:
undetectable		 3ttrA-4aysA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomyces
pombe) 		PF10075
(CSN8_PSD8_EIF3K) 		3 PRO A  40
THR A  41
LEU A  37
 None
 0.78A 3ttrA-4b0zA:
undetectable		 3ttrA-4b0zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7w HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 PRO A 163
THR A 164
LEU A 282
 None
 0.54A 3ttrA-4c7wA:
undetectable		 3ttrA-4c7wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 PRO A 173
THR A 172
LEU A 208
 None
 0.80A 3ttrA-4d28A:
undetectable		 3ttrA-4d28A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		3 PRO A 135
THR A 131
LEU A 127
 None
 0.76A 3ttrA-4dgqA:
undetectable		 3ttrA-4dgqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es6 UROPORPHYRINOGEN-III
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02602
(HEM4) 		3 PRO A  33
THR A   9
LEU A 174
 None
CL  A 301 (-4.4A)
None
 0.68A 3ttrA-4es6A:
undetectable		 3ttrA-4es6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		3 PRO A 336
THR A 334
LEU A 287
 None
SEY  A 401 ( 4.7A)
None
 0.75A 3ttrA-4ezdA:
undetectable		 3ttrA-4ezdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 PRO A 115
THR A 114
LEU A 126
 None
 0.69A 3ttrA-4f9oA:
undetectable		 3ttrA-4f9oA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 PRO A 429
THR A 430
LEU A 651
 None
 0.34A 3ttrA-4fimA:
58.5		 3ttrA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fml VSDC

(Aeromonas
hydrophila) 		PF03496
(ADPrib_exo_Tox) 		3 PRO A 245
THR A 246
LEU A 241
 None
 0.69A 3ttrA-4fmlA:
undetectable		 3ttrA-4fmlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO 2  53
THR 2  54
LEU 2 257
 None
 0.51A 3ttrA-4gb32:
undetectable		 3ttrA-4gb32:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0m C-PHYCOCYANIN ALPHA
CHAIN

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		3 PRO A 106
THR A 104
LEU A 112
 None
 0.78A 3ttrA-4h0mA:
undetectable		 3ttrA-4h0mA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE

(Scaptomyza
nigrita) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 PRO A  54
THR A  55
LEU A  32
 GSH  A 301 ( 4.6A)
None
None
 0.75A 3ttrA-4i97A:
undetectable		 3ttrA-4i97A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmf PROBABLE CHAPERONE

(Pseudomonas
aeruginosa) 		PF05932
(CesT) 		3 PRO B  19
THR B  20
LEU B  14
 None
 0.80A 3ttrA-4jmfB:
undetectable		 3ttrA-4jmfB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		3 PRO A  60
THR A  61
LEU A  70
 None
 0.77A 3ttrA-4k35A:
undetectable		 3ttrA-4k35A:
17.96