SIMILAR PATTERNS OF AMINO ACIDS FOR 3TPX_E_ACTE204

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1af5 I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		3 LYS A  82
PRO A  83
LEU A  84
 None
 0.82A 3tpxE-1af5A:
0.0		 3tpxE-1af5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)

(Bos taurus) 		PF00637
(Clathrin) 		3 LYS A1415
PRO A1416
LEU A1417
 None
 0.85A 3tpxE-1b89A:
0.0		 3tpxE-1b89A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo9 PROTEIN (ANNEXIN I)

(Homo sapiens) 		PF00191
(Annexin) 		3 LYS A  50
PRO A  51
LEU A  52
 None
 0.79A 3tpxE-1bo9A:
undetectable		 3tpxE-1bo9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 LYS A 359
PRO A 360
LEU A 361
 None
 0.87A 3tpxE-1cbgA:
0.0		 3tpxE-1cbgA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		3 LYS A 322
PRO A 323
LEU A 324
 None
 0.87A 3tpxE-1fbvA:
0.0		 3tpxE-1fbvA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h59 INSULIN-LIKE GROWTH
FACTOR BINDING
PROTEIN 5

(Homo sapiens) 		no annotation 3 LYS B  68
PRO B  69
LEU B  70
 None
 0.88A 3tpxE-1h59B:
undetectable		 3tpxE-1h59B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 LYS A  33
PRO A  34
LEU A  35
 None
 0.84A 3tpxE-1k0fA:
undetectable		 3tpxE-1k0fA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		3 LYS A 120
PRO A  94
LEU A  93
 None
 0.84A 3tpxE-1mqsA:
0.0		 3tpxE-1mqsA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvl PPC DECARBOXYLASE
ATHAL3A

(Arabidopsis
thaliana) 		PF02441
(Flavoprotein) 		3 LYS A 133
PRO A 134
LEU A 135
 None
 0.74A 3tpxE-1mvlA:
0.0		 3tpxE-1mvlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1f INTERLEUKIN-19

(Homo sapiens) 		PF00726
(IL10) 		3 LYS A  52
PRO A  53
LEU A  54
 None
 0.63A 3tpxE-1n1fA:
undetectable		 3tpxE-1n1fA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 LYS A 581
PRO A 582
LEU A 573
 None
 0.85A 3tpxE-1n76A:
0.0		 3tpxE-1n76A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p83 10 KDA CHAPERONIN

(Mycobacterium
tuberculosis) 		no annotation 3 LYS A   6
PRO A   7
LEU A   8
 None
 0.78A 3tpxE-1p83A:
undetectable		 3tpxE-1p83A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 LYS A 237
PRO A 238
LEU A 229
 None
 0.80A 3tpxE-1qjmA:
undetectable		 3tpxE-1qjmA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzu HYPOTHETICAL PROTEIN
MDS018

(Homo sapiens) 		PF02441
(Flavoprotein) 		3 LYS A 131
PRO A 132
LEU A 133
 None
 0.85A 3tpxE-1qzuA:
undetectable		 3tpxE-1qzuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		3 LYS A 181
PRO A 180
LEU A 173
 None
 0.71A 3tpxE-1rytA:
undetectable		 3tpxE-1rytA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 LYS A  33
PRO A  34
LEU A  35
 None
 0.74A 3tpxE-1toaA:
undetectable		 3tpxE-1toaA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		3 LYS A 485
PRO A 486
LEU A 487
 None
 0.71A 3tpxE-1uwiA:
undetectable		 3tpxE-1uwiA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9n MALATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF02615
(Ldh_2) 		3 LYS A 179
PRO A 180
LEU A 182
 None
 0.84A 3tpxE-1v9nA:
undetectable		 3tpxE-1v9nA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		3 LYS A   3
PRO A   4
LEU A   5
 None
 0.81A 3tpxE-1vgqA:
undetectable		 3tpxE-1vgqA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4m FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		3 LYS A  62
PRO A  63
LEU A  64
 None
 0.72A 3tpxE-1x4mA:
undetectable		 3tpxE-1x4mA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		3 LYS A 344
PRO A 345
LEU A 346
 None
 0.86A 3tpxE-1ytuA:
undetectable		 3tpxE-1ytuA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LYS A 583
PRO A 584
LEU A 585
 None
 0.82A 3tpxE-1zcjA:
undetectable		 3tpxE-1zcjA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		3 LYS C 116
PRO C 117
LEU C 118
 None
 0.74A 3tpxE-2advC:
undetectable		 3tpxE-2advC:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		3 LYS A 201
PRO A 202
LEU A 203
 None
 0.73A 3tpxE-2ah5A:
undetectable		 3tpxE-2ah5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch8 33 KDA EARLY PROTEIN

(Human
gammaherpesvirus
4) 		no annotation 3 LYS A 123
PRO A 124
LEU A 125
 None
 0.69A 3tpxE-2ch8A:
undetectable		 3tpxE-2ch8A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8c PHOSPHATIDYLCHOLINE:
CERAMIDE
CHOLINEPHOSPHOTRANSF
ERASE 1

(Mus musculus) 		PF00536
(SAM_1) 		3 LYS A  59
PRO A  60
LEU A  62
 None
 0.80A 3tpxE-2d8cA:
undetectable		 3tpxE-2d8cA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db2 KIAA0890 PROTEIN

(Homo sapiens) 		PF00035
(dsrm) 		3 LYS A  70
PRO A  69
LEU A  73
 None
 0.79A 3tpxE-2db2A:
undetectable		 3tpxE-2db2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		3 LYS A 262
PRO A 263
LEU A 266
 None
 0.66A 3tpxE-2e21A:
undetectable		 3tpxE-2e21A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqn HYPOTHETICAL PROTEIN
LOC92345

(Homo sapiens) 		PF04410
(Gar1) 		3 LYS A  26
PRO A  27
LEU A  28
 None
 0.88A 3tpxE-2eqnA:
undetectable		 3tpxE-2eqnA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		3 LYS A 136
PRO A 137
LEU A 138
 None
 0.82A 3tpxE-2favA:
undetectable		 3tpxE-2favA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd4 AVIRULENCE PROTEIN
AVRPTOB

(Pseudomonas
syringae) 		PF09046
(AvrPtoB-E3_ubiq) 		3 LYS A 529
PRO A 530
LEU A 526
 None
 0.86A 3tpxE-2fd4A:
undetectable		 3tpxE-2fd4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 LYS A 230
PRO A 231
LEU A 232
 None
 0.54A 3tpxE-2fknA:
undetectable		 3tpxE-2fknA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 LYS A 172
PRO A 173
LEU A 174
 None
 0.51A 3tpxE-2fwrA:
undetectable		 3tpxE-2fwrA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz4 DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII) 		3 LYS A 172
PRO A 173
LEU A 174
 None
 0.72A 3tpxE-2fz4A:
undetectable		 3tpxE-2fz4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 LYS A 267
PRO A 268
LEU A 269
 SO4  A 404 (-2.8A)
None
None
 0.74A 3tpxE-2g17A:
undetectable		 3tpxE-2g17A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 LYS A 569
PRO A 570
LEU A 561
 None
 0.84A 3tpxE-2hauA:
undetectable		 3tpxE-2hauA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 130
PRO A 131
LEU A 132
 None
 0.85A 3tpxE-2hneA:
undetectable		 3tpxE-2hneA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		3 LYS A 199
PRO A 200
LEU A 201
 None
 0.88A 3tpxE-2i7xA:
undetectable		 3tpxE-2i7xA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ido DNA POLYMERASE III
EPSILON SUBUNIT

(Escherichia
coli) 		PF00929
(RNase_T) 		3 LYS A  76
PRO A  77
LEU A  52
 None
 0.81A 3tpxE-2idoA:
undetectable		 3tpxE-2idoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvz FAR UPSTREAM
ELEMENT-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		3 LYS A  49
PRO A  50
LEU A  51
 None
 0.84A 3tpxE-2jvzA:
undetectable		 3tpxE-2jvzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jys PROTEASE/REVERSE
TRANSCRIPTASE

(Macaque simian
foamy virus) 		PF03539
(Spuma_A9PTase) 		3 LYS A  96
PRO A  97
LEU A  98
 None
 0.68A 3tpxE-2jysA:
undetectable		 3tpxE-2jysA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp MYOTROPHIN

(Mus musculus) 		PF12796
(Ank_2) 		3 LYS C 637
PRO C 638
LEU C 639
 None
 0.63A 3tpxE-2kxpC:
undetectable		 3tpxE-2kxpC:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2leq UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF08327
(AHSA1) 		3 LYS A  86
PRO A  87
LEU A  89
 None
 0.71A 3tpxE-2leqA:
undetectable		 3tpxE-2leqA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m86 E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		PF02201
(SWIB) 		3 LYS B  96
PRO B  97
LEU B  98
 None
 0.48A 3tpxE-2m86B:
13.1		 3tpxE-2m86B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9o KALATA-B7

(Oldenlandia
affinis) 		PF03784
(Cyclotide) 		3 LYS A  27
PRO A   3
LEU A   2
 None
 0.84A 3tpxE-2m9oA:
undetectable		 3tpxE-2m9oA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 LYS A 101
PRO A 102
LEU A 103
 None
 0.64A 3tpxE-2np0A:
undetectable		 3tpxE-2np0A:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		3 LYS A 110
PRO A 109
LEU A 112
 None
ACT  A 156 (-4.1A)
None
 0.87A 3tpxE-2otmA:
undetectable		 3tpxE-2otmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py2 ANTIFREEZE PROTEIN
TYPE II

(Clupea harengus) 		PF00059
(Lectin_C) 		3 LYS A 127
PRO A 128
LEU A 129
 None
 0.86A 3tpxE-2py2A:
undetectable		 3tpxE-2py2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyb MEMBRANE PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		3 LYS A  93
PRO A  94
LEU A  95
 None
 0.78A 3tpxE-2qybA:
undetectable		 3tpxE-2qybA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ruh E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		PF02201
(SWIB) 		3 LYS A  37
PRO A  38
LEU A  39
 None
 0.88A 3tpxE-2ruhA:
12.7		 3tpxE-2ruhA:
91.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		3 LYS A  33
PRO A  34
LEU A  35
 None
 0.75A 3tpxE-2wc1A:
undetectable		 3tpxE-2wc1A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4

(Caenorhabditis
elegans) 		no annotation 3 LYS A  16
PRO A  17
LEU A  18
 None
 0.81A 3tpxE-2yv9A:
undetectable		 3tpxE-2yv9A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		3 LYS A  10
PRO A  11
LEU A  12
 None
 0.72A 3tpxE-2zatA:
undetectable		 3tpxE-2zatA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 370
PRO A 371
LEU A 372
 None
 0.82A 3tpxE-3a62A:
undetectable		 3tpxE-3a62A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		3 LYS A 190
PRO A 191
LEU A 192
 None
 0.85A 3tpxE-3aczA:
undetectable		 3tpxE-3aczA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b64 MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN

(Leishmania
major) 		PF01187
(MIF) 		3 LYS A  33
PRO A  34
LEU A  37
 None
 0.77A 3tpxE-3b64A:
undetectable		 3tpxE-3b64A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bci DISULFIDE BOND
PROTEIN A

(Staphylococcus
aureus) 		PF13462
(Thioredoxin_4) 		3 LYS A  15
PRO A  16
LEU A  17
 None
 0.87A 3tpxE-3bciA:
undetectable		 3tpxE-3bciA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1

(Streptococcus
pneumoniae) 		PF01625
(PMSR)
PF01641
(SelR) 		3 LYS A 159
PRO A 160
LEU A 161
 None
 0.82A 3tpxE-3e0mA:
undetectable		 3tpxE-3e0mA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec8 PUTATIVE
UNCHARACTERIZED
PROTEIN FLJ10324

(Homo sapiens) 		PF00788
(RA) 		3 LYS A 139
PRO A 140
LEU A 141
 None
 0.69A 3tpxE-3ec8A:
undetectable		 3tpxE-3ec8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezh NITRATE/NITRITE
SENSOR PROTEIN NARX

(Escherichia
coli) 		PF13675
(PilJ) 		3 LYS A  71
PRO A  72
LEU A  73
 None
 0.60A 3tpxE-3ezhA:
undetectable		 3tpxE-3ezhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		3 LYS A 215
PRO A 216
LEU A 217
 IOD  A  16 (-4.5A)
IOD  A  16 ( 4.2A)
IOD  A  16 (-4.3A)
 0.66A 3tpxE-3fgwA:
undetectable		 3tpxE-3fgwA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5b NETRIN RECEPTOR
UNC5B

(Rattus
norvegicus) 		PF00531
(Death)
PF00791
(ZU5)
PF17217
(UPA) 		3 LYS A 743
PRO A 744
LEU A 745
 None
 0.81A 3tpxE-3g5bA:
undetectable		 3tpxE-3g5bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 LYS A  21
PRO A  22
LEU A  23
 None
 0.87A 3tpxE-3gb4A:
undetectable		 3tpxE-3gb4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LYS A  40
PRO A  41
LEU A  42
 None
 0.79A 3tpxE-3h9uA:
undetectable		 3tpxE-3h9uA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		3 LYS A 150
PRO A 151
LEU A 152
 None
 0.86A 3tpxE-3hlkA:
undetectable		 3tpxE-3hlkA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		3 LYS A 469
PRO A 470
LEU A 471
 None
 0.78A 3tpxE-3hq2A:
undetectable		 3tpxE-3hq2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 LYS A  92
PRO A  93
LEU A  94
 None
 0.85A 3tpxE-3hrxA:
undetectable		 3tpxE-3hrxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 LYS A 184
PRO A 185
LEU A 186
 None
 0.74A 3tpxE-3ialA:
undetectable		 3tpxE-3ialA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A 785
PRO A 786
LEU A 788
 None
 0.79A 3tpxE-3iu6A:
undetectable		 3tpxE-3iu6A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		3 LYS B 217
PRO B 218
LEU B 219
 None
 0.72A 3tpxE-3l4gB:
undetectable		 3tpxE-3l4gB:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		3 LYS A 243
PRO A 244
LEU A 245
 None
 0.86A 3tpxE-3m6cA:
undetectable		 3tpxE-3m6cA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 LYS A1208
PRO A1209
LEU A1211
 None
 0.86A 3tpxE-3mmpA:
undetectable		 3tpxE-3mmpA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nke PROTEIN YGBT

(Escherichia
coli) 		PF01867
(Cas_Cas1) 		3 LYS A 211
PRO A 212
LEU A 213
 None
 0.72A 3tpxE-3nkeA:
undetectable		 3tpxE-3nkeA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 LYS A 355
PRO A 356
LEU A 357
 None
 0.80A 3tpxE-3o9pA:
undetectable		 3tpxE-3o9pA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		3 LYS A 153
PRO A 154
LEU A 157
 None
 0.73A 3tpxE-3ohtA:
undetectable		 3tpxE-3ohtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A

(Escherichia
coli) 		PF00004
(AAA)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		3 LYS A  39
PRO A  40
LEU A  41
 None
 0.81A 3tpxE-3pvsA:
undetectable		 3tpxE-3pvsA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Shewanella
denitrificans) 		PF00465
(Fe-ADH) 		3 LYS A  48
PRO A  49
LEU A  50
 NAD  A 358 (-4.6A)
None
None
 0.66A 3tpxE-3rf7A:
undetectable		 3tpxE-3rf7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 LYS A 217
PRO A 218
LEU A 219
 None
 0.50A 3tpxE-3rlfA:
undetectable		 3tpxE-3rlfA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LYS A 301
PRO A 302
LEU A 300
 None
 0.83A 3tpxE-3rr5A:
undetectable		 3tpxE-3rr5A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		3 LYS A  52
PRO A  53
LEU A  46
 None
 0.87A 3tpxE-3s5tA:
undetectable		 3tpxE-3s5tA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		3 LYS A 165
PRO A 166
LEU A 198
 None
 0.85A 3tpxE-3skvA:
undetectable		 3tpxE-3skvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		3 LYS A   4
PRO A   5
LEU A   6
 None
 0.82A 3tpxE-3ta6A:
undetectable		 3tpxE-3ta6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		3 LYS A 188
PRO A 189
LEU A 190
 None
None
GOL  A 364 ( 4.2A)
 0.84A 3tpxE-3ty4A:
undetectable		 3tpxE-3ty4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		3 LYS A   9
PRO A  10
LEU A  11
 None
 0.75A 3tpxE-3ubmA:
undetectable		 3tpxE-3ubmA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		3 LYS A  13
PRO A  14
LEU A  15
 None
 0.69A 3tpxE-3ugkA:
undetectable		 3tpxE-3ugkA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 LYS A 127
PRO A 128
LEU A 129
 None
 0.56A 3tpxE-3uonA:
undetectable		 3tpxE-3uonA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcr PUTATIVE KDPG
(2-KETO-3-DEOXY-6-PH
OSPHOGLUCONATE)
ALDOLASE

(Oleispira
antarctica) 		PF01081
(Aldolase) 		3 LYS A  12
PRO A  13
LEU A  14
 None
 0.64A 3tpxE-3vcrA:
undetectable		 3tpxE-3vcrA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 LYS A 302
PRO A 303
LEU A 293
 None
 0.61A 3tpxE-3vuuA:
undetectable		 3tpxE-3vuuA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 LYS A 302
PRO A 303
LEU A 293
 None
 0.73A 3tpxE-3vuvA:
undetectable		 3tpxE-3vuvA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 LYS A 102
PRO A 103
LEU A 104
 None
 0.64A 3tpxE-3zuqA:
undetectable		 3tpxE-3zuqA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 LYS A 267
PRO A 268
LEU A 269
 None
 0.44A 3tpxE-4a27A:
undetectable		 3tpxE-4a27A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LYS A 695
PRO A 696
LEU A 697
 None
 0.82A 3tpxE-4aipA:
undetectable		 3tpxE-4aipA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		3 LYS B 435
PRO B 436
LEU B 437
 None
 0.71A 3tpxE-4az3B:
undetectable		 3tpxE-4az3B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqa UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735)
PF13385
(Laminin_G_3) 		3 LYS A 160
PRO A 161
LEU A 162
 None
 0.73A 3tpxE-4dqaA:
undetectable		 3tpxE-4dqaA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfs UNCHARACTERIZED
PROTEIN YNCM

(Bacillus
subtilis) 		PF15493
(YrpD) 		3 LYS A 115
PRO A 116
LEU A 117
 SO4  A 302 (-2.9A)
None
None
 0.71A 3tpxE-4hfsA:
undetectable		 3tpxE-4hfsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 3 LYS A 327
PRO A 328
LEU A 329
 None
 0.84A 3tpxE-4iruA:
undetectable		 3tpxE-4iruA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 3 LYS A 327
PRO A 328
LEU A 329
 None
 0.81A 3tpxE-4jw1A:
undetectable		 3tpxE-4jw1A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		3 LYS A 158
PRO A 159
LEU A 160
 None
 0.86A 3tpxE-4kfvA:
undetectable		 3tpxE-4kfvA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		3 LYS A 435
PRO A 436
LEU A 437
 LYS  A 435 ( 0.0A)
PRO  A 436 ( 1.1A)
LEU  A 437 ( 0.6A)
 0.68A 3tpxE-4mwtA:
undetectable		 3tpxE-4mwtA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt1 ACCELERATED-CELL-DEA
TH 11

(Arabidopsis
thaliana) 		PF08718
(GLTP) 		3 LYS A   8
PRO A   9
LEU A  10
 None
 0.45A 3tpxE-4nt1A:
undetectable		 3tpxE-4nt1A:
15.82