SIMILAR PATTERNS OF AMINO ACIDS FOR 3TPX_C_ACTC207

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 315
PRO A 316
LEU A 310
ASN A 313
 None
 1.11A 3tpxC-1jqiA:
undetectable		 3tpxC-1jqiA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 LYS A 109
PRO A 108
LEU A 112
ASN A 113
 None
 1.36A 3tpxC-3ppoA:
0.0		 3tpxC-3ppoA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00215
(OMPdecase) 		4 LYS A 137
PRO A 136
LEU A 108
ASN A 107
 None
 1.28A 3tpxC-4dbeA:
0.0		 3tpxC-4dbeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LYS A 772
PRO A 771
LEU A 809
ASN A 813
 None
CL  A 905 ( 4.9A)
CL  A 905 ( 4.8A)
None
 1.48A 3tpxC-5dllA:
0.0		 3tpxC-5dllA:
7.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		PF02201
(SWIB) 		4 LYS A  31
PRO A  32
LEU A  33
ASN A 106
 None
 0.94A 3tpxC-5lawA:
15.6		 3tpxC-5lawA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 LYS A 540
PRO A 539
LEU A 538
ASN A 423
 None
 1.45A 3tpxC-5nfhA:
0.4		 3tpxC-5nfhA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LYS A 548
PRO A 550
LEU A 552
ASN A 542
 None
 1.20A 3tpxC-5nz7A:
0.0		 3tpxC-5nz7A:
6.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		no annotation 4 LYS A  31
PRO A  32
LEU A  33
ASN A 106
 None
 0.86A 3tpxC-5swkA:
17.5		 3tpxC-5swkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s MEDIATOR COMPLEX
SUBUNIT 6

(Schizosaccharomyces
pombe) 		PF04934
(Med6) 		4 LYS F 103
PRO F 104
LEU F 105
ASN F  95
 None
 1.38A 3tpxC-5u0sF:
0.0		 3tpxC-5u0sF:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 4 LYS A 120
PRO A 121
LEU A 118
ASN A 119
 None
 1.50A 3tpxC-5xrfA:
undetectable		 3tpxC-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES26

(Toxoplasma
gondii) 		PF00318
(Ribosomal_S2) 		4 LYS a  66
PRO a  65
LEU a  64
ASN a  43
 None
 1.33A 3tpxC-5xxua:
undetectable		 3tpxC-5xxua:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S26

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2) 		4 LYS a  66
PRO a  65
LEU a  64
ASN a  43
 None
 1.49A 3tpxC-5xyia:
undetectable		 3tpxC-5xyia:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z02 E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		no annotation 4 LYS A  10
PRO A  11
LEU A  12
ASN A  85
 None
 1.03A 3tpxC-5z02A:
16.5		 3tpxC-5z02A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 LYS A 566
PRO A 567
LEU A 565
ASN A 560
 None
 1.47A 3tpxC-6aunA:
undetectable		 3tpxC-6aunA:
undetectable