SIMILAR PATTERNS OF AMINO ACIDS FOR 3TOU_B_ACTB228

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		4 ALA A  64
ARG I 249
TYR A  68
ARG A  67
 None
 1.29A 3touB-2gk1A:
undetectable		 3touB-2gk1A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj8 UREASE ACCESSORY
PROTEIN UREE

(Helicobacter
pylori) 		PF02814
(UreE_N)
PF05194
(UreE_C) 		4 ALA A 104
ARG A  31
TYR A 106
ARG A 145
 None
 1.44A 3touB-3tj8A:
0.0		 3touB-3tj8A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ALA A  10
ARG A 110
TYR A 168
ARG A 172
 ACT  A 227 (-3.5A)
ACT  A 227 (-4.7A)
ACT  A 227 (-4.5A)
ACT  A 227 (-3.9A)
 0.34A 3touB-3totA:
36.0		 3touB-3totA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF

(Pseudomonas
fluorescens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ALA A   8
ARG A 112
TYR A 167
ARG A 171
 ACT  A 303 ( 3.9A)
None
ACT  A 303 (-4.5A)
ACT  A 303 (-4.0A)
 0.50A 3touB-4id0A:
28.1		 3touB-4id0A:
42.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ALA A1390
ARG A 576
TYR A1356
ARG A1354
 None
 1.17A 3touB-5n8oA:
0.0		 3touB-5n8oA:
8.74