SIMILAR PATTERNS OF AMINO ACIDS FOR 3TNE_A_RITA401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 SER D 233
VAL D 181
THR D 197
THR D 148
 None
 1.16A 3tneA-1h4lD:
undetectable		 3tneA-1h4lD:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 SER A  35
TYR A  74
THR A 217
THR A 218
 None
 0.39A 3tneA-1ibqA:
35.6		 3tneA-1ibqA:
31.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 TYR A 229
VAL A 278
THR A 226
THR A 225
 None
 1.08A 3tneA-1io1A:
undetectable		 3tneA-1io1A:
24.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		4 SER A  36
TYR A  75
THR A 217
THR A 218
 None
 0.17A 3tneA-1izeA:
35.8		 3tneA-1izeA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		6 PRO A  12
SER A  35
TYR A  84
VAL A 119
THR A 221
THR A 222
 None
None
None
None
EOH  A 575 ( 4.4A)
None
 0.30A 3tneA-1j71A:
49.5		 3tneA-1j71A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A1296
VAL A1095
THR A1087
THR A1086
 None
 1.09A 3tneA-1jqbA:
undetectable		 3tneA-1jqbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 PRO A 105
TYR A  81
VAL A 124
THR A 102
 None
 1.05A 3tneA-1kb0A:
undetectable		 3tneA-1kb0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 PRO A 241
VAL A 274
THR A 221
THR A 260
 None
 0.99A 3tneA-1m22A:
undetectable		 3tneA-1m22A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 PRO A  13
SER A  80
THR A  85
THR A  86
 None
 0.91A 3tneA-1q2eA:
undetectable		 3tneA-1q2eA:
24.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 SER A  37
TYR A  77
THR A 217
THR A 218
 None
 0.36A 3tneA-1qs8A:
34.9		 3tneA-1qs8A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 PRO B  17
SER C 159
VAL B 171
THR B  57
 AGS  B 802 (-4.4A)
None
None
AGS  B 802 (-3.8A)
 1.16A 3tneA-1sxjB:
undetectable		 3tneA-1sxjB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1v SH3 DOMAIN-BINDING
GLUTAMIC ACID-RICH
PROTEIN-LIKE 3

(Mus musculus) 		PF04908
(SH3BGR) 		4 SER A  19
TYR A  74
VAL A  78
THR A  25
 None
 1.05A 3tneA-1t1vA:
undetectable		 3tneA-1t1vA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		4 SER A  38
TYR A  77
THR A 221
THR A 222
 None
 0.38A 3tneA-1uh9A:
38.9		 3tneA-1uh9A:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 PRO A  66
SER A  77
THR A  69
THR A  67
 None
None
PLP  A 513 (-3.5A)
PLP  A 513 (-4.1A)
 1.10A 3tneA-1v72A:
undetectable		 3tneA-1v72A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		4 TYR A 267
VAL A 231
THR A 254
THR A 251
 None
 1.03A 3tneA-1vkyA:
undetectable		 3tneA-1vkyA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		4 SER A  35
TYR A  63
THR A 215
THR A 216
 None
 0.40A 3tneA-1wkrA:
35.4		 3tneA-1wkrA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		4 SER A  35
VAL A 101
THR A 215
THR A 216
 None
 1.14A 3tneA-1wkrA:
35.4		 3tneA-1wkrA:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		4 PRO A 453
TYR A 503
VAL A 461
THR A 509
 None
 1.04A 3tneA-1xezA:
undetectable		 3tneA-1xezA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 PRO A1106
SER A1071
TYR A1074
THR A1098
 None
 1.03A 3tneA-1yguA:
undetectable		 3tneA-1yguA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		4 SER A  35
TYR A  84
THR A 221
THR A 222
 A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 (-3.6A)
A70  A 500 (-4.0A)
 0.31A 3tneA-1zapA:
47.9		 3tneA-1zapA:
51.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A  86
VAL A 287
THR A  90
THR A 103
 None
 1.07A 3tneA-2bc0A:
undetectable		 3tneA-2bc0A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 433
VAL A 485
THR A 455
THR A 514
 None
 1.07A 3tneA-2e6kA:
undetectable		 3tneA-2e6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edx PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, F

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A  18
VAL A  96
THR A  52
THR A 100
 None
 1.15A 3tneA-2edxA:
undetectable		 3tneA-2edxA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eig LECTIN

(Lotus
tetragonolobus) 		PF00139
(Lectin_legB) 		4 PRO A  34
VAL A  70
THR A 207
THR A  39
 None
 1.10A 3tneA-2eigA:
undetectable		 3tneA-2eigA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		4 SER A  51
TYR A  87
THR A 244
THR A 245
 DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.8A)
 0.35A 3tneA-2ewyA:
33.1		 3tneA-2ewyA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4s NEXT TO BRCA1 GENE 1
PROTEIN

(Homo sapiens) 		PF00564
(PB1) 		4 PRO A  23
SER A  60
THR A  27
THR A  26
 None
 1.06A 3tneA-2g4sA:
undetectable		 3tneA-2g4sA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		4 PRO A 131
SER A  58
TYR A 189
VAL A 202
 None
 1.00A 3tneA-2gk9A:
undetectable		 3tneA-2gk9A:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 SER A  35
TYR A  84
VAL A 119
THR A 221
THR A 222
 None
 0.24A 3tneA-2h6tA:
47.6		 3tneA-2h6tA:
53.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jex REGULATORY PROTEIN
E2

(Deltapapillomavirus
4) 		PF00508
(PPV_E2_N) 		4 SER A 199
TYR A 186
VAL A 119
THR A 183
 None
 1.05A 3tneA-2jexA:
undetectable		 3tneA-2jexA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 TYR A 413
VAL A 411
THR A 203
THR A 204
 None
 1.05A 3tneA-2jf7A:
undetectable		 3tneA-2jf7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9x HYPOTHETICAL PROTEIN
PH0832

(Pyrococcus
horikoshii) 		PF11537
(DUF3227) 		4 SER A   2
TYR A  43
VAL A  90
THR A  11
 ZN  A2001 ( 4.9A)
None
None
None
 1.14A 3tneA-2p9xA:
undetectable		 3tneA-2p9xA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Enterococcus
faecalis) 		PF09383
(NIL) 		4 SER A 313
TYR A 315
VAL A 258
THR A 339
 None
 1.08A 3tneA-2qswA:
undetectable		 3tneA-2qswA:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		4 SER A  35
TYR A  84
THR A 221
THR A 222
 None
 0.38A 3tneA-2qzwA:
48.3		 3tneA-2qzwA:
52.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		4 SER A  35
TYR A  84
THR A 221
THR A 222
 None
 0.24A 3tneA-2qzxA:
47.6		 3tneA-2qzxA:
46.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae) 		PF00089
(Trypsin) 		4 SER A 147
VAL A 132
THR A 174
THR A 173
 None
 0.99A 3tneA-2sfaA:
undetectable		 3tneA-2sfaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvd SPIKE PROTEIN P1

(Pseudoalteromonas
virus PM2) 		no annotation 4 PRO A 237
TYR A 175
VAL A 316
THR A 311
 None
 1.11A 3tneA-2vvdA:
undetectable		 3tneA-2vvdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vve SPIKE PROTEIN P1

(Pseudoalteromonas
virus PM2) 		no annotation 4 PRO A 236
TYR A 174
VAL A 315
THR A 310
 None
 1.12A 3tneA-2vveA:
undetectable		 3tneA-2vveA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzz RV0802C

(Mycobacterium
tuberculosis) 		PF13302
(Acetyltransf_3) 		4 TYR A 122
VAL A  91
THR A  14
THR A  13
 None
 1.09A 3tneA-2vzzA:
undetectable		 3tneA-2vzzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0c PROTEIN 2

(Pseudoalteromonas
virus PM2) 		no annotation 4 PRO L 236
TYR L 174
VAL L 315
THR L 310
 None
 1.10A 3tneA-2w0cL:
undetectable		 3tneA-2w0cL:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 SER A  36
TYR A  75
THR A 216
THR A 217
 PP6  A 327 ( 4.0A)
PP6  A 327 (-3.8A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.5A)
 0.25A 3tneA-2wedA:
35.7		 3tneA-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 PRO A 846
SER A 887
VAL A 724
THR A 891
 None
 1.09A 3tneA-2xyuA:
undetectable		 3tneA-2xyuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 TYR A 229
VAL A 278
THR A 226
THR A 225
 None
 0.94A 3tneA-3a5xA:
undetectable		 3tneA-3a5xA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 PRO H 282
VAL H 353
THR H 285
THR H 283
 None
 1.15A 3tneA-3c75H:
undetectable		 3tneA-3c75H:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 SER A1240
TYR A1264
THR A1074
THR A1073
 ANP  A1400 ( 4.2A)
ANP  A1400 (-4.6A)
ANP  A1400 (-3.7A)
MG  A1701 ( 3.0A)
 1.03A 3tneA-3cmvA:
undetectable		 3tneA-3cmvA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 SER A 114
VAL A 216
THR A  58
THR A  59
 None
None
None
UP3  A 944 (-4.2A)
 1.11A 3tneA-3d8nA:
undetectable		 3tneA-3d8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edp LIN2111 PROTEIN

(Listeria
innocua) 		PF00392
(GntR)
PF07702
(UTRA) 		4 PRO A  72
SER A 166
TYR A 147
THR A  26
 None
 0.98A 3tneA-3edpA:
undetectable		 3tneA-3edpA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 SER A  35
TYR A  75
THR A 218
THR A 219
 None
 0.28A 3tneA-3emyA:
35.7		 3tneA-3emyA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 296
VAL A  95
THR A  87
THR A  86
 None
 1.14A 3tneA-3fplA:
undetectable		 3tneA-3fplA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		6 PRO A  12
SER A  35
TYR A  78
VAL A 113
THR A 223
THR A 224
 None
 0.29A 3tneA-3fv3A:
55.9		 3tneA-3fv3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2

(Homo sapiens) 		PF16099
(RMI1_C)
PF16100
(RMI2) 		4 SER B  20
TYR A 540
VAL A 515
THR A 538
 None
 1.08A 3tneA-3nbhB:
undetectable		 3tneA-3nbhB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qve HMG BOX-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08517
(AXH) 		4 PRO A 314
SER A  -1
TYR A 303
THR A 317
 EDO  A 343 (-4.1A)
None
EDO  A  40 (-4.6A)
None
 1.07A 3tneA-3qveA:
undetectable		 3tneA-3qveA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		4 PRO A 202
VAL A 178
THR A 171
THR A 204
 None
 0.98A 3tneA-3qvoA:
undetectable		 3tneA-3qvoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 TYR A 429
VAL A 478
THR A 424
THR A 423
 None
 1.13A 3tneA-3rcnA:
undetectable		 3tneA-3rcnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 SER A 100
VAL A 170
THR A 103
THR A 104
 None
 1.02A 3tneA-3ri6A:
undetectable		 3tneA-3ri6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		4 PRO A 295
TYR A 257
THR A 301
THR A 300
 None
 1.02A 3tneA-3rosA:
undetectable		 3tneA-3rosA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 PRO A 245
SER A 235
VAL A 175
THR A 216
 None
 0.97A 3tneA-3s4dA:
undetectable		 3tneA-3s4dA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 PRO A 188
TYR A 143
VAL A 196
THR A 192
THR A 191
 None
COA  A 601 (-4.3A)
None
None
None
 1.15A 3tneA-3sqzA:
undetectable		 3tneA-3sqzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1e FLAGELLA BASAL-BODY
PROTEIN

(Vibrio
alginolyticus) 		PF16538
(FlgT_C)
PF16539
(FlgT_M)
PF16548
(FlgT_N) 		4 PRO A 156
TYR A 170
VAL A 212
THR A 159
 None
 1.07A 3tneA-3w1eA:
undetectable		 3tneA-3w1eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 258
TYR A 269
VAL A 227
THR A 262
 None
 1.10A 3tneA-4b6lA:
undetectable		 3tneA-4b6lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 PRO A   5
VAL A 380
THR A  15
THR A  14
 None
 1.11A 3tneA-4bkoA:
undetectable		 3tneA-4bkoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9o MEMBRANE-ASSOCIATED
PROTEIN VP24

(Reston
ebolavirus) 		PF06389
(Filo_VP24) 		4 SER A 123
VAL A 201
THR A 129
THR A 130
 None
 0.99A 3tneA-4d9oA:
undetectable		 3tneA-4d9oA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djh KAPPA-TYPE OPIOID
RECEPTOR, LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 TYR A 330
VAL A  80
THR A  94
THR A  92
 None
 1.15A 3tneA-4djhA:
undetectable		 3tneA-4djhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 SER A 219
TYR A 193
VAL A 200
THR A 189
 None
 1.15A 3tneA-4dqdA:
undetectable		 3tneA-4dqdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 PRO A 201
SER A 196
TYR A 227
VAL A 180
 None
 0.82A 3tneA-4gpgA:
undetectable		 3tneA-4gpgA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 SER A 271
TYR A 335
VAL A 346
THR A 295
 None
 1.03A 3tneA-4im4A:
undetectable		 3tneA-4im4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 189
TYR A 381
VAL A 395
THR A 213
 None
 1.15A 3tneA-4ip4A:
undetectable		 3tneA-4ip4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 PRO A 201
SER A 196
TYR A 227
VAL A 180
 None
 0.83A 3tneA-4nsyA:
undetectable		 3tneA-4nsyA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 PRO A 295
TYR A 257
THR A 301
THR A 300
 None
 0.92A 3tneA-4ohtA:
undetectable		 3tneA-4ohtA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PRO A 508
TYR A 502
VAL A 498
THR A 458
 None
 1.03A 3tneA-4okdA:
undetectable		 3tneA-4okdA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pph CONGLUTIN GAMMA

(Lupinus
angustifolius) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 PRO A 108
SER A  24
VAL A 160
THR A 281
 None
 1.08A 3tneA-4pphA:
25.4		 3tneA-4pphA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 PRO A 418
TYR A 752
VAL A 755
THR A 318
 None
 1.15A 3tneA-4qi4A:
undetectable		 3tneA-4qi4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 SER A 405
TYR A 109
VAL A 171
THR A 125
 None
 1.08A 3tneA-4s3jA:
undetectable		 3tneA-4s3jA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		4 PRO A 903
TYR A 931
THR A 899
THR A 900
 None
 1.07A 3tneA-4ts6A:
undetectable		 3tneA-4ts6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		4 PRO A 489
VAL A 542
THR A 493
THR A 492
 None
 1.11A 3tneA-4ut1A:
undetectable		 3tneA-4ut1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		4 SER A 263
TYR A 318
THR A 322
THR A 323
 None
 0.84A 3tneA-4v33A:
undetectable		 3tneA-4v33A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 PRO A  72
SER A 147
VAL A  82
THR A  75
 None
 1.06A 3tneA-4wy5A:
undetectable		 3tneA-4wy5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 4 PRO A 528
VAL A 524
THR A 531
THR A 530
 None
 1.09A 3tneA-4xn3A:
undetectable		 3tneA-4xn3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 4 SER C 169
VAL C 205
THR C 175
THR C 178
 None
 1.00A 3tneA-4xruC:
undetectable		 3tneA-4xruC:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		6 PRO A  12
SER A  35
TYR A  77
VAL A 112
THR A 214
THR A 215
 None
 0.47A 3tneA-4y9wA:
49.0		 3tneA-4y9wA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxz DTOR_9X31L

(synthetic
construct) 		no annotation 4 TYR A  93
VAL A 103
THR A  88
THR A  87
 None
 1.06A 3tneA-4yxzA:
undetectable		 3tneA-4yxzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		4 PRO A 270
SER A 210
VAL A 227
THR A 235
 None
 1.12A 3tneA-4zn2A:
undetectable		 3tneA-4zn2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
purpureum) 		PF00840
(Glyco_hydro_7) 		4 PRO A  13
SER A  79
THR A  84
THR A  85
 None
 0.82A 3tneA-4zzpA:
undetectable		 3tneA-4zzpA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 PRO A  13
SER A  79
THR A  84
THR A  85
 None
 1.05A 3tneA-4zzqA:
undetectable		 3tneA-4zzqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		4 SER A  33
VAL A 135
THR A  43
THR A  44
 B12  A 403 ( 4.0A)
B12  A 403 (-4.1A)
None
B12  A 403 (-3.8A)
 0.88A 3tneA-5d6sA:
undetectable		 3tneA-5d6sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foa DECAY ACCELERATING
FACTOR, CD55

(Homo sapiens) 		PF00084
(Sushi) 		4 PRO E 112
SER E  97
TYR E 118
THR E 115
 None
 1.14A 3tneA-5foaE:
undetectable		 3tneA-5foaE:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula) 		PF01328
(Peroxidase_2) 		4 SER A 125
VAL A 180
THR A 110
THR A 109
 None
 0.91A 3tneA-5fukA:
undetectable		 3tneA-5fukA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3p FORMAMIDASE

(Bacillus cereus) 		PF00795
(CN_hydrolase) 		4 SER A 216
VAL A 257
THR A 241
THR A 240
 None
None
EDO  A1331 (-2.9A)
None
 1.09A 3tneA-5g3pA:
undetectable		 3tneA-5g3pA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 TYR A 155
VAL A 226
THR A 147
THR A 146
 None
 0.78A 3tneA-5gj8A:
undetectable		 3tneA-5gj8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A  38
TYR A  79
THR A 222
THR A 223
 None
61P  A 406 (-4.3A)
61P  A 406 ( 3.5A)
PG4  A 408 (-3.8A)
 0.31A 3tneA-5hctA:
36.5		 3tneA-5hctA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN

(Homo sapiens) 		PF02586
(SRAP) 		4 SER A   6
TYR A 126
VAL A 252
THR A 248
 None
 1.03A 3tneA-5ko9A:
undetectable		 3tneA-5ko9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		4 SER A 126
TYR A 174
VAL A 210
THR A   6
 None
 1.15A 3tneA-5kzmA:
undetectable		 3tneA-5kzmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 PRO A 297
SER A 350
THR A 294
THR A 295
 None
 1.14A 3tneA-5lrbA:
undetectable		 3tneA-5lrbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdm GLYCOPROTEIN

(Chandipura
vesiculovirus) 		no annotation 4 PRO E 111
SER E 118
THR E  67
THR E  66
 None
 1.10A 3tneA-5mdmE:
undetectable		 3tneA-5mdmE:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 PRO A 503
SER A 536
TYR A 532
VAL A 516
 None
 0.85A 3tneA-5mzoA:
undetectable		 3tneA-5mzoA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		4 SER B  19
VAL B 105
THR B  22
THR B  23
 None
 1.00A 3tneA-5osnB:
undetectable		 3tneA-5osnB:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A  38
TYR A  79
THR A 222
THR A 223
 None
 0.26A 3tneA-5p60A:
36.7		 3tneA-5p60A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sga PROTEINASE A (SGPA)

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 SER E 195
VAL E 177
THR E 226
THR E 225
 None
 0.84A 3tneA-5sgaE:
undetectable		 3tneA-5sgaE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 TYR E  13
VAL E 187
THR E   5
THR E   4
 None
 1.15A 3tneA-5v8fE:
undetectable		 3tneA-5v8fE:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 4 PRO A   5
VAL A 380
THR A  15
THR A  14
 None
 1.03A 3tneA-5xi0A:
undetectable		 3tneA-5xi0A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 4 PRO A   5
VAL A 383
THR A  15
THR A  14
 None
 0.93A 3tneA-5xi0A:
undetectable		 3tneA-5xi0A:
14.71