SIMILAR PATTERNS OF AMINO ACIDS FOR 3TMZ_A_06XA504_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 LEU B 219
LEU A 111
GLN A 134
GLU A 124
VAL B 222
 None
 1.22A 3tmzA-1efpB:
0.0		 3tmzA-1efpB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 LEU A 444
ILE A 544
ILE A 546
PHE A 580
VAL A 581
 None
 1.50A 3tmzA-1j0hA:
0.0		 3tmzA-1j0hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162

(Helicobacter
pylori) 		PF01709
(Transcrip_reg) 		5 LEU A 185
ILE A 204
GLU A 165
PHE A 137
VAL A 136
 None
 1.14A 3tmzA-1mw7A:
0.1		 3tmzA-1mw7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qql FIBROBLAST GROWTH
FACTOR 7/1 CHIMERA

(Homo sapiens;
Rattus
norvegicus) 		PF00167
(FGF) 		5 LEU A  65
LEU A  23
ILE A  10
PHE A  85
VAL A  54
 None
 1.47A 3tmzA-1qqlA:
0.0		 3tmzA-1qqlA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 LEU A  95
LEU A 130
ILE A 378
ILE A 139
GLU A 233
 None
 1.42A 3tmzA-1vlpA:
0.0		 3tmzA-1vlpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		5 LEU A 486
LEU A 457
GLU A 455
PHE A 408
VAL A 425
 None
 1.15A 3tmzA-1w8oA:
0.0		 3tmzA-1w8oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		5 LEU A  26
LEU A   9
GLN A  24
GLU A  21
GLU A  65
 None
 1.05A 3tmzA-1yloA:
undetectable		 3tmzA-1yloA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmm PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF00085
(Thioredoxin) 		5 LEU A 131
LEU A  70
ILE A  40
PHE A 106
VAL A  48
 None
 1.45A 3tmzA-2dmmA:
undetectable		 3tmzA-2dmmA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		5 LEU A 177
LEU A 164
GLU A 192
PHE A 158
GLU A 162
 None
 1.30A 3tmzA-2e54A:
undetectable		 3tmzA-2e54A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2emq HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00571
(CBS) 		5 LEU A  17
LEU A  98
ILE A  93
GLU A 118
VAL A 115
 None
 1.45A 3tmzA-2emqA:
undetectable		 3tmzA-2emqA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 LEU A   6
ILE A 145
ILE A 147
PHE A 103
VAL A 104
 None
None
None
DND  A 998 (-4.9A)
None
 1.25A 3tmzA-2h29A:
undetectable		 3tmzA-2h29A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		5 LEU A 458
LEU A 427
ILE A 555
ILE A 553
PHE A 566
 None
 1.19A 3tmzA-2j04A:
undetectable		 3tmzA-2j04A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8a ENDOGLUCANASE

(Bacillus
subtilis) 		PF00942
(CBM_3) 		5 LEU A 374
ILE A 354
ILE A 493
PHE A 438
VAL A 389
 None
 1.36A 3tmzA-2l8aA:
undetectable		 3tmzA-2l8aA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 LEU A 233
ILE A 221
GLU A 239
PHE A 294
VAL A 247
 None
 1.32A 3tmzA-2nqnA:
undetectable		 3tmzA-2nqnA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 480
LEU A 350
ILE A 439
PHE A 427
VAL A 428
 None
 1.32A 3tmzA-2nrxA:
undetectable		 3tmzA-2nrxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 LEU A 245
LEU A 480
ILE A 428
ILE A 471
GLN A 473
 None
 1.23A 3tmzA-2nyfA:
1.9		 3tmzA-2nyfA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 383
LEU A 329
ILE A 244
ILE A 351
GLN A 352
 None
 1.09A 3tmzA-2o4jA:
undetectable		 3tmzA-2o4jA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 LEU A 542
LEU A 550
ILE A 123
ILE A 143
GLU A 554
 None
 1.44A 3tmzA-2qxlA:
undetectable		 3tmzA-2qxlA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 5 LEU A   7
ILE A  24
ILE A  53
PHE A  41
VAL A  40
 None
 1.32A 3tmzA-2rbgA:
undetectable		 3tmzA-2rbgA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B 157
LEU B 122
ILE B 119
ILE B  50
GLU B 124
 None
 1.31A 3tmzA-2rhqB:
undetectable		 3tmzA-2rhqB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 359
LEU A 526
ILE A 498
GLU A 523
PHE A 505
 LEU  A 359 ( 0.5A)
LEU  A 526 ( 0.5A)
ILE  A 498 ( 0.7A)
GLU  A 523 ( 0.5A)
PHE  A 505 ( 1.3A)
 1.28A 3tmzA-2vbfA:
undetectable		 3tmzA-2vbfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 441
LEU A 237
ILE A 335
ILE A 400
GLU A 239
 None
 1.19A 3tmzA-2vpqA:
undetectable		 3tmzA-2vpqA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 405
ILE A 311
ILE A 465
GLU A 379
VAL A 299
 None
 1.44A 3tmzA-2x58A:
undetectable		 3tmzA-2x58A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		5 LEU A 138
LEU A 148
ILE A 186
ILE A 184
GLU A 153
 None
 1.29A 3tmzA-2z02A:
undetectable		 3tmzA-2z02A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 194
LEU A 215
ILE A 362
ILE A 189
GLN A 208
 None
 1.49A 3tmzA-3af5A:
undetectable		 3tmzA-3af5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 LEU A 540
LEU A 529
ILE A 262
GLU A 556
PHE A 544
 None
 1.31A 3tmzA-3aqpA:
undetectable		 3tmzA-3aqpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 291
ILE A 281
ILE A 318
GLU A 283
VAL A 189
 None
 1.18A 3tmzA-3be7A:
undetectable		 3tmzA-3be7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		5 ILE A 113
ILE A 175
PHE A 294
GLU A  48
VAL A  44
 None
 1.41A 3tmzA-3d3aA:
undetectable		 3tmzA-3d3aA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		5 LEU A  52
LEU A  17
GLU A  36
PHE A  69
GLU A  30
 None
None
None
ACT  A 303 ( 4.3A)
None
 1.29A 3tmzA-3fmsA:
1.2		 3tmzA-3fmsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fza GLUTAREDOXIN

(Populus tremula
x Populus
tremuloides) 		PF00462
(Glutaredoxin) 		5 LEU A  65
LEU A  51
GLN A  71
GLU A  50
VAL A  77
 None
 1.48A 3tmzA-3fzaA:
undetectable		 3tmzA-3fzaA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides) 		PF00210
(Ferritin) 		5 LEU A  58
LEU A 123
ILE A  49
GLU A  50
GLU A  94
 None
None
None
None
FE  A 163 ( 4.5A)
 1.09A 3tmzA-3gvyA:
1.4		 3tmzA-3gvyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 LEU A 229
LEU A 276
ILE A 296
GLN A 269
PHE A 341
 None
 1.17A 3tmzA-3h55A:
undetectable		 3tmzA-3h55A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i10 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacteroides
thetaiotaomicron) 		PF03009
(GDPD)
PF16387
(DUF4996) 		5 LEU A 134
LEU A 145
ILE A  71
ILE A  29
GLN A 167
 None
None
None
EDO  A   6 ( 4.6A)
None
 1.35A 3tmzA-3i10A:
undetectable		 3tmzA-3i10A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 LEU A 103
ILE A 198
GLN A 182
PHE A 215
GLU A 228
 None
 1.36A 3tmzA-3i16A:
undetectable		 3tmzA-3i16A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		5 LEU A 139
LEU A 100
ILE A   7
PHE A 107
VAL A 113
 None
 1.26A 3tmzA-3ibyA:
undetectable		 3tmzA-3ibyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ied HEAT SHOCK PROTEIN

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 LEU A 198
LEU A 318
GLU A 311
GLU A 320
VAL A 254
 None
 1.28A 3tmzA-3iedA:
undetectable		 3tmzA-3iedA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 349
ILE A 143
GLN A 339
GLU A 329
VAL A 380
 None
 1.38A 3tmzA-3ijlA:
undetectable		 3tmzA-3ijlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		5 LEU A2290
LEU A2313
ILE A2323
ILE A2325
PHE A2294
 None
 1.48A 3tmzA-3javA:
undetectable		 3tmzA-3javA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		5 LEU A 240
LEU A 253
ILE A  64
ILE A  66
PHE A 233
 None
 1.31A 3tmzA-3k25A:
undetectable		 3tmzA-3k25A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd3 PHOSPHOSERINE
PHOSPHOHYDROLASE-LIK
E PROTEIN

(Francisella
tularensis) 		PF12710
(HAD) 		5 LEU A  54
LEU A 139
ILE A 123
GLU A 127
PHE A  50
 None
 1.34A 3tmzA-3kd3A:
undetectable		 3tmzA-3kd3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		5 LEU A 230
LEU A 360
ILE A 367
GLU A 227
VAL A  96
 None
 1.50A 3tmzA-3kk7A:
undetectable		 3tmzA-3kk7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		5 LEU A  80
ILE A 131
ILE A 133
PHE A  25
VAL A  24
 None
 1.49A 3tmzA-3kq5A:
undetectable		 3tmzA-3kq5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		5 LEU A 244
ILE A 131
ILE A 133
PHE A  25
VAL A  24
 None
 1.35A 3tmzA-3kq5A:
undetectable		 3tmzA-3kq5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		5 LEU A 191
LEU A 143
GLU A 149
PHE A 180
GLU A 134
 None
 1.48A 3tmzA-3kreA:
undetectable		 3tmzA-3kreA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 LEU A  60
LEU A  47
ILE A  10
ILE A   4
GLU A  51
 None
 1.22A 3tmzA-3m62A:
undetectable		 3tmzA-3m62A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 LEU A 281
ILE A  90
PHE A 206
GLU A 224
VAL A 209
 None
 1.46A 3tmzA-3me5A:
undetectable		 3tmzA-3me5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  63
ILE A  71
GLU A  68
PHE A  53
GLU A  57
 None
 1.41A 3tmzA-3mqtA:
undetectable		 3tmzA-3mqtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nea PEPTIDYL-TRNA
HYDROLASE

(Francisella
tularensis) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A 131
LEU A 181
ILE A 104
ILE A 166
VAL A  93
 None
 1.26A 3tmzA-3neaA:
undetectable		 3tmzA-3neaA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		5 LEU A 257
LEU A 238
PHE A 315
GLU A 297
VAL A 234
 None
 1.49A 3tmzA-3nsjA:
undetectable		 3tmzA-3nsjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 LEU B  63
LEU B  79
ILE B 119
PHE B  70
GLU B  77
 None
 1.16A 3tmzA-3r7wB:
undetectable		 3tmzA-3r7wB:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 LEU A  70
ILE A 101
ILE A 209
GLN A 215
GLU A 387
 None
CPZ  A 501 (-4.2A)
None
None
None
 1.07A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A 155
LEU A 182
ILE A 177
GLU A  90
VAL A 153
 None
 1.17A 3tmzA-3tkrA:
undetectable		 3tmzA-3tkrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A1021
LEU A1144
ILE A1088
ILE A1066
VAL A1042
 None
 1.22A 3tmzA-3u9wA:
undetectable		 3tmzA-3u9wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve9 OROTIDINE-5'-PHOSPHA
TE DECARBOXYLASE

(Metallosphaera
sedula) 		PF00215
(OMPdecase) 		5 LEU A  45
LEU A  33
ILE A   5
ILE A  52
VAL A  49
 None
 1.19A 3tmzA-3ve9A:
undetectable		 3tmzA-3ve9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 387
LEU A 333
ILE A 248
ILE A 355
GLN A 356
 None
 1.11A 3tmzA-3wgpA:
1.2		 3tmzA-3wgpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 587
LEU A 627
ILE A 599
PHE A 592
VAL A 685
 None
CL  A1751 (-4.6A)
None
None
None
 0.89A 3tmzA-3zzwA:
undetectable		 3tmzA-3zzwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 LEU A 541
LEU A 504
ILE A  39
ILE A  41
PHE A 646
 None
 1.15A 3tmzA-4a5wA:
undetectable		 3tmzA-4a5wA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A  96
LEU A  72
ILE A 107
PHE A 103
VAL A  94
 None
 1.21A 3tmzA-4aw2A:
undetectable		 3tmzA-4aw2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 NOP5/NOP56 RELATED
PROTEIN

(Pyrococcus
furiosus) 		PF01798
(Nop) 		5 LEU C  51
LEU C  47
ILE C  40
GLU C  45
PHE C  59
 None
 1.42A 3tmzA-4by9C:
undetectable		 3tmzA-4by9C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL21

(Sus scrofa) 		PF00829
(Ribosomal_L21p) 		5 LEU V 139
LEU V  99
ILE V 199
ILE V 118
VAL V 103
 None
 1.32A 3tmzA-4ce4V:
undetectable		 3tmzA-4ce4V:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		5 LEU A 260
LEU A 250
ILE A 273
GLU A 272
VAL A 283
 None
 1.22A 3tmzA-4dzhA:
undetectable		 3tmzA-4dzhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		5 LEU A 131
LEU A  75
ILE A 101
ILE A 212
PHE A 199
 None
None
0J9  A 302 (-4.3A)
None
None
 1.12A 3tmzA-4gkhA:
undetectable		 3tmzA-4gkhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 LEU M 831
LEU M 819
ILE M 840
GLU M 817
PHE M 733
 None
 1.42A 3tmzA-4gq2M:
undetectable		 3tmzA-4gq2M:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		5 LEU A  34
LEU A 146
ILE A 310
PHE A 135
VAL A 134
 None
 1.24A 3tmzA-4itmA:
undetectable		 3tmzA-4itmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpz FIBROBLAST GROWTH
FACTOR 13

(Homo sapiens) 		PF00167
(FGF) 		5 LEU A  70
LEU A  28
ILE A  16
PHE A  90
VAL A  59
 None
 1.47A 3tmzA-4jpzA:
undetectable		 3tmzA-4jpzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		5 LEU A1133
LEU A1121
ILE A1078
PHE A1114
VAL A1111
 None
None
None
SO4  A 504 (-4.9A)
None
 1.38A 3tmzA-4k5yA:
1.6		 3tmzA-4k5yA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		5 LEU A 144
LEU A 215
ILE A 235
ILE A 249
PHE A 207
 None
 1.26A 3tmzA-4m88A:
undetectable		 3tmzA-4m88A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4np9 RABPHILIN-3A

(Rattus
norvegicus) 		PF00168
(C2) 		5 LEU A 494
LEU A 399
ILE A 403
ILE A 404
PHE A 489
 None
 1.14A 3tmzA-4np9A:
undetectable		 3tmzA-4np9A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		5 LEU C 294
LEU C 314
ILE C 281
ILE C 323
GLU C 320
 None
None
None
None
MG  C 601 ( 2.5A)
 1.33A 3tmzA-4oogC:
undetectable		 3tmzA-4oogC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 173
LEU A 288
ILE A 194
ILE A 157
VAL A 182
 None
 1.28A 3tmzA-4q3nA:
undetectable		 3tmzA-4q3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 5 LEU A 252
LEU A 214
ILE A 175
PHE A 221
VAL A 220
 None
 1.45A 3tmzA-4rxxA:
undetectable		 3tmzA-4rxxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 132
ILE A 161
ILE A 166
GLN A 168
GLU A 165
 None
 1.22A 3tmzA-4tmcA:
undetectable		 3tmzA-4tmcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN

(Escherichia
coli) 		no annotation 5 LEU A 591
LEU A 610
ILE A 545
GLU A 594
GLU A 627
 None
 1.16A 3tmzA-4y25A:
undetectable		 3tmzA-4y25A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		5 LEU A 280
LEU A 228
ILE A 224
ILE A 116
PHE A 270
 None
 1.50A 3tmzA-4y63A:
undetectable		 3tmzA-4y63A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		5 LEU 6 263
LEU 6 108
ILE 6 174
GLN 6 123
GLU 6 125
 None
 1.32A 3tmzA-5ady6:
undetectable		 3tmzA-5ady6:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 LEU A 854
ILE A 677
ILE A 678
PHE A 711
GLU A 852
 None
 1.49A 3tmzA-5azaA:
undetectable		 3tmzA-5azaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 LEU A  84
ILE A  68
ILE A  72
GLU A  85
VAL A 220
 None
None
None
FAD  A 500 (-2.8A)
None
 1.10A 3tmzA-5fjnA:
undetectable		 3tmzA-5fjnA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU E  76
LEU E 149
ILE E 141
ILE E  95
VAL E  78
 None
 1.26A 3tmzA-5g06E:
undetectable		 3tmzA-5g06E:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		5 LEU A  91
GLU A  93
PHE A  81
GLU A 110
VAL A 101
 None
 1.23A 3tmzA-5ghsA:
undetectable		 3tmzA-5ghsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gus HELIX-TURN-HELIX
DOMAIN-CONTAINING
PROTEIN

(Zymomonas
mobilis) 		PF04266
(ASCH) 		5 LEU A 116
LEU A 140
ILE A  44
PHE A 123
GLU A   9
 None
 1.48A 3tmzA-5gusA:
undetectable		 3tmzA-5gusA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		5 LEU A  90
LEU A  78
ILE A  35
PHE A  71
VAL A  68
 None
 1.44A 3tmzA-5i14A:
undetectable		 3tmzA-5i14A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 LEU A 328
LEU A 313
ILE A  68
PHE A  35
GLU A  39
 None
 1.06A 3tmzA-5i77A:
undetectable		 3tmzA-5i77A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 LEU A 487
ILE A 183
GLN A 181
GLU A 182
PHE A 146
 None
 0.93A 3tmzA-5k04A:
undetectable		 3tmzA-5k04A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		5 LEU A1133
LEU A1121
ILE A1078
PHE A1114
VAL A1111
 None
 1.40A 3tmzA-5ndzA:
1.1		 3tmzA-5ndzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 5 LEU A 306
ILE A 429
ILE A 425
PHE A 277
VAL A 278
 None
 1.48A 3tmzA-5nlmA:
undetectable		 3tmzA-5nlmA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t38 EVDMO1

(Micromonospora
carbonacea) 		PF13847
(Methyltransf_31) 		5 LEU A 141
LEU A 131
ILE A  58
GLU A  60
GLU A  84
 None
SAH  A 301 (-4.3A)
None
None
SAH  A 301 (-1.8A)
 1.42A 3tmzA-5t38A:
undetectable		 3tmzA-5t38A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		5 LEU A 467
LEU A 405
ILE A 492
ILE A 488
GLN A 399
 None
 1.44A 3tmzA-5tgtA:
undetectable		 3tmzA-5tgtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tva 6-CARBOXYHEXANOATE--
COA LIGASE

(Aquifex
aeolicus) 		PF03744
(BioW) 		5 LEU A 152
LEU A 158
ILE A 238
GLU A  35
VAL A 147
 None
 1.21A 3tmzA-5tvaA:
undetectable		 3tmzA-5tvaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 LEU f 249
GLN f 213
GLU f 210
PHE f 256
VAL f 255
 None
 1.30A 3tmzA-5vhif:
undetectable		 3tmzA-5vhif:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
LEU A 270
GLU A 249
PHE A 195
VAL A 247
 None
 1.46A 3tmzA-5vl1A:
undetectable		 3tmzA-5vl1A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 ILE A 101
ILE A 209
GLN A 215
GLU A 218
GLU A 387
 9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 4.8A)
None
None
None
 0.90A 3tmzA-5wbgA:
55.7		 3tmzA-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 LEU A  52
ILE A 101
ILE A 209
GLN A 215
GLU A 218
 None
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 4.8A)
None
None
 1.17A 3tmzA-5wbgA:
55.7		 3tmzA-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 LEU A  70
ILE A 101
ILE A 209
GLN A 215
GLU A 387
 None
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 4.8A)
None
None
 0.86A 3tmzA-5wbgA:
55.7		 3tmzA-5wbgA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 LEU A 975
ILE A1158
GLN A 987
GLU A 986
GLU A1166
 None
 1.19A 3tmzA-5wnoA:
undetectable		 3tmzA-5wnoA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		5 LEU A 997
LEU A 962
ILE A 761
ILE A 759
GLU A 923
 None
 1.20A 3tmzA-5xblA:
undetectable		 3tmzA-5xblA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		no annotation 5 LEU A 133
LEU A 121
ILE A  78
PHE A 114
VAL A 111
 None
 1.39A 3tmzA-5yqrA:
undetectable		 3tmzA-5yqrA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 193
LEU A 273
GLU A 252
PHE A 198
VAL A 250
 None
 1.44A 3tmzA-6aqhA:
undetectable		 3tmzA-6aqhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 5 LEU A 123
ILE A 204
GLN A 206
GLU A 205
GLU A  93
 None
 1.07A 3tmzA-6bk1A:
undetectable		 3tmzA-6bk1A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 5 LEU A 721
LEU A 340
GLN A 322
GLU A 316
GLU A 707
 None
 1.09A 3tmzA-6bwmA:
1.9		 3tmzA-6bwmA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 LEU A 408
LEU A1104
ILE A1108
ILE A 412
VAL A 425
 None
 1.04A 3tmzA-6en4A:
undetectable		 3tmzA-6en4A:
11.16