SIMILAR PATTERNS OF AMINO ACIDS FOR 3TMZ_A_06XA503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi)
PF00544
(Pec_lyase_C)
5 ILE A 283
ILE A 252
THR A 312
VAL A 264
PRO A 263
None
0.87A 3tmzA-1airA:
undetectable
3tmzA-1airA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 290
PHE A 268
ILE A 248
VAL A 276
PRO A 277
None
1.10A 3tmzA-1bxzA:
undetectable
3tmzA-1bxzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
5 ILE A 280
ALA A 279
THR A 311
VAL A 421
PRO A 422
None
1.05A 3tmzA-1cptA:
28.7
3tmzA-1cptA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE


(Pyrococcus
horikoshii)
PF00155
(Aminotran_1_2)
5 PHE A 231
ILE A  90
ALA A 275
GLU A  70
PRO A 266
None
1.06A 3tmzA-1djuA:
0.0
3tmzA-1djuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanopyrus
kandleri)
PF00296
(Bac_luciferase)
5 ILE A 336
ALA A  26
GLU A  32
VAL A 324
VAL A 322
None
1.07A 3tmzA-1ezwA:
0.0
3tmzA-1ezwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
5 ILE A  42
ILE A  98
PHE A 194
ILE A 159
VAL A 234
None
1.01A 3tmzA-1f82A:
0.0
3tmzA-1f82A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
5 ILE A  98
PHE A 194
ILE A 159
ALA A 224
VAL A 234
None
1.04A 3tmzA-1f82A:
0.0
3tmzA-1f82A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE


(Magnaporthe
grisea)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 ILE A 129
ILE A 123
ILE A 442
ALA A 406
GLU A 435
None
0.79A 3tmzA-1ff9A:
0.0
3tmzA-1ff9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioa ARCELIN-5A

(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
5 ILE A 107
PHE A 108
ALA A  88
VAL A  92
PRO A  93
None
1.08A 3tmzA-1ioaA:
undetectable
3tmzA-1ioaA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN


(Oligotropha
carboxidovorans)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ILE B 513
ILE B 551
ILE B 587
ALA B 537
GLU B 543
None
0.97A 3tmzA-1n60B:
0.0
3tmzA-1n60B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Thermotoga
maritima)
PF00793
(DAHP_synth_1)
5 ILE A 233
ILE A 224
GLU A 164
PRO A 203
VAL A 162
None
None
PEP  A8002 ( 4.8A)
None
None
1.11A 3tmzA-1rzmA:
undetectable
3tmzA-1rzmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF03710
(GlnE)
PF08335
(GlnD_UR_UTase)
5 ILE A 177
ILE A 263
PHE A 239
ALA A 272
GLU A 274
None
0.88A 3tmzA-1v4aA:
undetectable
3tmzA-1v4aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
5 ILE A  43
ILE A  99
PHE A 195
ILE A 160
VAL A 235
None
1.04A 3tmzA-1zb7A:
undetectable
3tmzA-1zb7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
5 ILE A  99
PHE A 195
ILE A 160
ALA A 225
VAL A 235
None
1.07A 3tmzA-1zb7A:
undetectable
3tmzA-1zb7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A 166
ILE A 191
ILE A 150
VAL A 188
PRO A 286
None
0.97A 3tmzA-2a3kA:
undetectable
3tmzA-2a3kA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE


(Saccharomyces
cerevisiae)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 ILE A 128
ILE A 122
ILE A 438
ALA A 402
GLU A 431
None
0.89A 3tmzA-2axqA:
undetectable
3tmzA-2axqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE


(Chlorobaculum
tepidum)
PF00106
(adh_short)
5 ILE A 143
ILE A 213
ALA A  19
GLU A  21
VAL A  91
NAP  A 800 (-4.3A)
None
None
None
None
1.07A 3tmzA-2bd0A:
undetectable
3tmzA-2bd0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A 980
ILE A1005
ILE A 963
VAL A1002
PRO A1116
None
0.97A 3tmzA-2bzlA:
undetectable
3tmzA-2bzlA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00180
(Iso_dh)
5 ILE A 124
ILE A 289
ALA A 210
GLU A 212
PRO A 126
None
0.96A 3tmzA-2dhtA:
undetectable
3tmzA-2dhtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320


(Pyrococcus
horikoshii)
PF06858
(NOG1)
5 ILE A 172
ILE A 250
ILE A 218
THR A 333
VAL A 326
None
1.10A 3tmzA-2e87A:
undetectable
3tmzA-2e87A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A1773
ILE A1798
ILE A1758
VAL A1795
PRO A1899
None
0.99A 3tmzA-2h03A:
undetectable
3tmzA-2h03A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus)
PF09455
(Cas_DxTHG)
5 ILE A 113
ILE A 106
ILE A   4
ALA A 137
VAL A  86
None
None
None
None
MG  A 402 (-3.9A)
1.07A 3tmzA-2i71A:
undetectable
3tmzA-2i71A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx2 DEUBIQUITINATING
PROTEIN VCIP135


(Rattus
norvegicus)
no annotation 5 ILE A  79
ILE A  37
GLU A  35
VAL A  71
PRO A  72
None
1.10A 3tmzA-2mx2A:
undetectable
3tmzA-2mx2A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
5 ILE A  42
ILE A  98
PHE A 194
ILE A 159
VAL A 234
None
1.03A 3tmzA-2np0A:
2.0
3tmzA-2np0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
5 ILE A  98
PHE A 194
ILE A 159
ALA A 224
VAL A 234
None
1.02A 3tmzA-2np0A:
2.0
3tmzA-2np0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A 373
ILE A 398
ILE A 358
VAL A 395
PRO A 510
None
0.94A 3tmzA-2pa5A:
undetectable
3tmzA-2pa5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis)
PF06849
(DUF1246)
PF06973
(DUF1297)
5 ILE A 247
ILE A 294
PHE A 176
ALA A 295
GLU A 302
None
1.11A 3tmzA-2pbzA:
undetectable
3tmzA-2pbzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM


(Methylobacillus
flagellatus)
PF05050
(Methyltransf_21)
5 ILE A  98
PHE A 128
THR A 118
PRO A  96
VAL A  55
None
1.00A 3tmzA-2py6A:
undetectable
3tmzA-2py6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qie MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2


(Staphylococcus
aureus)
PF02391
(MoaE)
5 ILE A  78
ILE A  67
ILE A 115
GLU A 113
VAL A  96
None
1.06A 3tmzA-2qieA:
undetectable
3tmzA-2qieA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v72 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
5 ILE A  63
ILE A 112
PHE A 108
ILE A 119
VAL A  52
None
0.92A 3tmzA-2v72A:
undetectable
3tmzA-2v72A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd2 ATP
PHOSPHORIBOSYLTRANSF
ERASE


(Bacillus
subtilis)
PF01634
(HisG)
5 ILE A 114
ALA A 122
GLU A 128
VAL A 133
PRO A 112
None
1.10A 3tmzA-2vd2A:
undetectable
3tmzA-2vd2A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus)
PF00266
(Aminotran_5)
5 PHE A 248
ALA A 223
THR A 220
VAL A 231
VAL A 233
None
PLP  A 501 (-3.4A)
None
None
None
1.10A 3tmzA-3a9xA:
undetectable
3tmzA-3a9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF01256
(Carb_kinase)
5 ILE A 184
ILE A 125
ILE A 194
ALA A 220
VAL A 227
None
0.96A 3tmzA-3bgkA:
undetectable
3tmzA-3bgkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED


(Myxococcus
xanthus)
PF00204
(DNA_gyraseB)
5 ILE A 331
ILE A 324
THR A 261
VAL A 305
VAL A 303
None
0.97A 3tmzA-3cwvA:
undetectable
3tmzA-3cwvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica)
PF13614
(AAA_31)
5 ILE A  87
GLU A  37
THR A  36
VAL A 198
PRO A 199
None
1.04A 3tmzA-3ez9A:
undetectable
3tmzA-3ez9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 PHE A 239
ILE A 258
ALA A 244
VAL A 289
PRO A 290
None
1.08A 3tmzA-3fhtA:
undetectable
3tmzA-3fhtA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens)
PF00266
(Aminotran_5)
5 PHE C 260
ALA C 235
THR C 232
VAL C 243
VAL C 245
None
PLR  C 500 (-3.5A)
None
None
None
1.07A 3tmzA-3gzdC:
undetectable
3tmzA-3gzdC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A 100
ILE A 125
ILE A  85
VAL A 122
PRO A 222
None
0.97A 3tmzA-3h2xA:
undetectable
3tmzA-3h2xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
5 ILE A 380
ILE A 341
ALA A 383
VAL A 351
VAL A 279
None
0.86A 3tmzA-3i04A:
undetectable
3tmzA-3i04A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1


(Rattus
norvegicus)
PF00102
(Y_phosphatase)
5 ILE A 989
ILE A1014
ILE A 974
VAL A1011
PRO A1113
None
0.93A 3tmzA-3i36A:
undetectable
3tmzA-3i36A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Bacillus
anthracis)
PF00378
(ECH_1)
5 ILE A 103
PHE A 123
ALA A 194
GLU A 196
VAL A  53
None
1.04A 3tmzA-3kqfA:
undetectable
3tmzA-3kqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE


(Vibrio
parahaemolyticus)
PF02502
(LacAB_rpiB)
PF12408
(DUF3666)
5 ILE A 110
ILE A   3
ILE A 129
ALA A  26
GLU A 131
None
0.85A 3tmzA-3onoA:
undetectable
3tmzA-3onoA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis)
PF13354
(Beta-lactamase2)
5 ILE A 250
ILE A 223
ILE A 278
ALA A 214
PRO A 244
None
1.04A 3tmzA-3p09A:
undetectable
3tmzA-3p09A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE


(Paenibacillus
sp. JDR-2)
PF00331
(Glyco_hydro_10)
5 ILE A 119
ILE A 226
ALA A 174
GLU A 169
VAL A  84
None
1.11A 3tmzA-3ro8A:
undetectable
3tmzA-3ro8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rru TOM1L1 PROTEIN

(Homo sapiens)
PF00790
(VHS)
5 ILE A 119
ILE A  76
PHE A 122
ILE A 115
THR A  23
None
1.08A 3tmzA-3rruA:
undetectable
3tmzA-3rruA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s38 CYTOCHROME C OXIDASE
SUBUNIT 2


(Thermus
thermophilus)
PF00116
(COX2)
PF09125
(COX2-transmemb)
5 ILE B 107
PHE B 116
ILE B 103
PRO B  92
VAL B  71
None
1.10A 3tmzA-3s38B:
undetectable
3tmzA-3s38B:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Sinorhizobium
meliloti)
PF00106
(adh_short)
5 ILE A 138
ILE A   9
ILE A 214
ALA A  21
GLU A  23
None
1.10A 3tmzA-3tfoA:
undetectable
3tmzA-3tfoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Sinorhizobium
meliloti)
PF00106
(adh_short)
5 ILE A 138
ILE A 214
ALA A  21
GLU A  23
VAL A  86
None
1.08A 3tmzA-3tfoA:
undetectable
3tmzA-3tfoA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus)
PF00067
(p450)
7 ILE A 101
ILE A 114
ILE A 209
ALA A 298
THR A 302
VAL A 367
PRO A 368
CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
0.94A 3tmzA-3tk3A:
56.8
3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus)
PF00067
(p450)
6 ILE A 101
ILE A 114
PHE A 115
ILE A 209
ALA A 298
THR A 302
CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
1.12A 3tmzA-3tk3A:
56.8
3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus)
PF00067
(p450)
6 ILE A 101
ILE A 114
PHE A 206
ILE A 209
ALA A 298
THR A 302
CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
1.16A 3tmzA-3tk3A:
56.8
3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus)
PF00067
(p450)
6 ILE A 114
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
1.16A 3tmzA-3tk3A:
56.8
3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus)
PF00067
(p450)
6 ILE A 114
PHE A 108
PHE A 206
ILE A 209
ALA A 298
THR A 302
HEM  A 500 (-4.0A)
None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
1.39A 3tmzA-3tk3A:
56.8
3tmzA-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride)
PF01593
(Amino_oxidase)
5 PHE A 202
GLU A 193
THR A 194
VAL A 126
PRO A 127
None
1.11A 3tmzA-3x0vA:
undetectable
3tmzA-3x0vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 ILE A  43
ILE A  99
PHE A 195
ILE A 160
VAL A 235
None
1.01A 3tmzA-3zuqA:
1.0
3tmzA-3zuqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 ILE A  99
PHE A 195
ILE A 160
ALA A 225
VAL A 235
None
1.03A 3tmzA-3zuqA:
1.0
3tmzA-3zuqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxw RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN


(Thermosynechococcus
elongatus)
PF00101
(RuBisCO_small)
5 ILE B  24
ALA B  89
GLU B  41
VAL B  69
VAL B  73
None
1.06A 3tmzA-3zxwB:
undetectable
3tmzA-3zxwB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE


(Pyrococcus
furiosus)
PF00793
(DAHP_synth_1)
5 ILE A 162
ILE A 153
GLU A  93
PRO A 132
VAL A  91
None
1.09A 3tmzA-4c1lA:
undetectable
3tmzA-4c1lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1


(Caenorhabditis
elegans)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ILE A  99
ILE A 113
PHE A 114
ALA A 103
VAL A  89
None
0.97A 3tmzA-4j0eA:
undetectable
3tmzA-4j0eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1


(Caenorhabditis
elegans)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ILE A  99
ILE A 113
PHE A 114
ILE A 100
VAL A  89
None
0.96A 3tmzA-4j0eA:
undetectable
3tmzA-4j0eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani)
PF01742
(Peptidase_M27)
5 ILE A  43
ILE A  98
PHE A 198
ILE A 159
VAL A 238
None
0.91A 3tmzA-4j1lA:
1.5
3tmzA-4j1lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani)
PF01742
(Peptidase_M27)
5 ILE A  98
PHE A 198
ILE A 159
ALA A 228
VAL A 238
None
0.93A 3tmzA-4j1lA:
1.5
3tmzA-4j1lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A 102
ILE A 127
ILE A  87
VAL A 124
PRO A 224
None
1.00A 3tmzA-4nndA:
undetectable
3tmzA-4nndA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE


(Leptospira
biflexa)
PF00682
(HMGL-like)
5 ILE A 141
ILE A 134
ILE A 100
ALA A  84
GLU A  82
None
1.11A 3tmzA-4ov4A:
undetectable
3tmzA-4ov4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN


(Sulfurospirillum
deleyianum)
PF01497
(Peripla_BP_2)
5 ILE A 300
ALA A 192
GLU A 201
THR A 200
VAL A 189
None
1.02A 3tmzA-4pagA:
undetectable
3tmzA-4pagA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
5 ILE B  60
PHE B  75
ILE B 133
ALA B 124
PRO B  44
None
0.83A 3tmzA-4pswB:
undetectable
3tmzA-4pswB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE


(Bacteroides
uniformis)
PF10282
(Lactonase)
5 ILE A  45
ALA A  63
GLU A 104
VAL A  80
PRO A  73
None
0.96A 3tmzA-4qrjA:
undetectable
3tmzA-4qrjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167)
PF00232
(Glyco_hydro_1)
5 ILE A 289
ILE A 256
ALA A 330
GLU A 275
VAL A 273
None
0.96A 3tmzA-4r27A:
undetectable
3tmzA-4r27A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2


(Caenorhabditis
elegans)
PF00004
(AAA)
5 ILE A 284
ILE A 236
PHE A 233
ILE A 251
GLU A 211
None
1.07A 3tmzA-4xguA:
undetectable
3tmzA-4xguA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT


(Sulfurisphaera
tokodaii)
PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C)
5 ILE B 252
ILE B 153
PHE B 255
ILE B 250
THR B 131
None
1.01A 3tmzA-5b48B:
undetectable
3tmzA-5b48B:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7e TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 14


(Saccharomyces
cerevisiae)
PF03366
(YEATS)
5 ILE A   9
ILE A 120
ILE A 101
GLU A  98
VAL A  54
None
0.90A 3tmzA-5d7eA:
undetectable
3tmzA-5d7eA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes)
no annotation 5 ILE B 199
ILE B 277
ILE B 232
ALA B 263
VAL B 274
None
0.94A 3tmzA-5do8B:
undetectable
3tmzA-5do8B:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B


(Neotoma lepida)
PF00067
(p450)
7 ILE A 101
PHE A 108
PHE A 206
ILE A 209
ALA A 298
GLU A 301
THR A 302
CPZ  A 502 (-4.7A)
None
None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
1.24A 3tmzA-5e0eA:
55.8
3tmzA-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B


(Neotoma lepida)
PF00067
(p450)
8 ILE A 101
PHE A 206
ILE A 209
ALA A 298
GLU A 301
THR A 302
VAL A 367
PRO A 368
CPZ  A 502 (-4.7A)
None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
None
0.87A 3tmzA-5e0eA:
55.8
3tmzA-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B


(Neotoma lepida)
PF00067
(p450)
6 PHE A 115
ILE A 209
ALA A 298
GLU A 301
THR A 302
VAL A 367
None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
0.88A 3tmzA-5e0eA:
55.8
3tmzA-5e0eA:
79.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej0 ENVELOPE PROTEIN H3

(Vaccinia virus)
PF03213
(Pox_P35)
5 ILE A 130
ILE A 133
GLU A  27
VAL A  10
VAL A   8
None
1.10A 3tmzA-5ej0A:
undetectable
3tmzA-5ej0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE


(Thermococcus
kodakarensis)
PF02449
(Glyco_hydro_42)
5 ILE A 176
PHE A 157
ILE A 160
GLU A 270
VAL A 273
None
1.11A 3tmzA-5gsmA:
undetectable
3tmzA-5gsmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gx8 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Streptobacillus
moniliformis)
PF13416
(SBP_bac_8)
5 ILE A 245
PHE A 262
ILE A 261
ALA A 463
VAL A 216
None
1.04A 3tmzA-5gx8A:
undetectable
3tmzA-5gx8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A1798
ILE A1823
ILE A1783
VAL A1820
PRO A1928
None
0.92A 3tmzA-5h08A:
undetectable
3tmzA-5h08A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)


(Nostoc sp. PCC
7120)
PF02136
(NTF2)
PF09150
(Carot_N)
5 ILE A 195
PHE A  12
ALA A 259
VAL A 200
VAL A 303
None
0.96A 3tmzA-5hgrA:
undetectable
3tmzA-5hgrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE GAMMA
CHAIN


(Caldalkalibacillus
thermarum)
PF00231
(ATP-synt)
5 ILE G 115
ILE G 170
ALA G 117
THR G  82
VAL G  99
None
1.04A 3tmzA-5ik2G:
1.8
3tmzA-5ik2G:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00171
(Aldedh)
5 ILE A 433
PHE A 393
ALA A 419
PRO A 437
VAL A 400
None
1.08A 3tmzA-5j6bA:
undetectable
3tmzA-5j6bA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Mycobacterium
tuberculosis)
PF00535
(Glycos_transf_2)
5 ILE A  92
ILE A  62
ILE A  89
GLU A  55
VAL A  78
None
1.01A 3tmzA-5jqxA:
undetectable
3tmzA-5jqxA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL


(Bos taurus)
PF00329
(Complex1_30kDa)
5 ILE C 117
PHE C 142
GLU C  91
VAL C  57
VAL C 107
None
1.06A 3tmzA-5lc5C:
undetectable
3tmzA-5lc5C:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2


(Saccharomyces
cerevisiae)
PF01851
(PC_rep)
PF13646
(HEAT_2)
5 ILE N 874
ILE N 759
PHE N 884
ILE N 882
VAL N 868
None
1.07A 3tmzA-5mpdN:
undetectable
3tmzA-5mpdN:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
5 ILE A  43
ILE A  98
PHE A 198
ILE A 159
VAL A 238
None
0.94A 3tmzA-5n0cA:
1.2
3tmzA-5n0cA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
5 ILE A  98
PHE A 198
ILE A 159
ALA A 228
VAL A 238
None
0.97A 3tmzA-5n0cA:
1.2
3tmzA-5n0cA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE


(Fusobacterium
nucleatum)
PF00480
(ROK)
5 ILE A 222
ILE A 140
PHE A 226
ILE A 160
GLU A 156
None
1.09A 3tmzA-5nckA:
undetectable
3tmzA-5nckA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A


(Methanothermococcus
thermolithotrophicus)
PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
5 ILE A 423
PHE A 383
ILE A 359
GLU A 416
PRO A 378
None
1.05A 3tmzA-5odrA:
undetectable
3tmzA-5odrA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982)
5 ILE A 866
ILE A 857
ILE A 880
GLU A 796
VAL A 835
None
1.07A 3tmzA-5uj6A:
undetectable
3tmzA-5uj6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri)
PF16363
(GDP_Man_Dehyd)
5 ILE A 239
ILE A 232
ILE A 301
VAL A 326
VAL A 320
None
1.09A 3tmzA-5uzhA:
undetectable
3tmzA-5uzhA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens)
no annotation 6 ILE A 101
ILE A 114
ILE A 209
ALA A 298
VAL A 367
PRO A 368
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 4.2A)
None
0.92A 3tmzA-5wbgA:
55.7
3tmzA-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens)
no annotation 6 ILE A 101
ILE A 114
ILE A 209
THR A 302
VAL A 367
PRO A 368
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.99A 3tmzA-5wbgA:
55.7
3tmzA-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens)
no annotation 5 ILE A 114
ALA A 298
VAL A 367
PRO A 368
VAL A 477
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 4.2A)
None
None
0.86A 3tmzA-5wbgA:
55.7
3tmzA-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens)
no annotation 5 ILE A 114
THR A 302
VAL A 367
PRO A 368
VAL A 477
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
None
0.83A 3tmzA-5wbgA:
55.7
3tmzA-5wbgA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens)
no annotation 5 ILE A 144
PHE A 254
ALA A 153
GLU A 162
VAL A 188
None
1.04A 3tmzA-6b0tA:
undetectable
3tmzA-6b0tA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 5 ILE A2530
ILE A2510
ILE A1407
THR A2145
VAL A2155
None
0.92A 3tmzA-6bpzA:
undetectable
3tmzA-6bpzA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum)
no annotation 5 ILE A  98
PHE A 195
ILE A 155
ALA A 221
VAL A 231
None
0.98A 3tmzA-6bvdA:
undetectable
3tmzA-6bvdA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB)
no annotation 5 ILE A 307
PHE A 309
ALA A 294
GLU A 269
VAL A 248
None
1.02A 3tmzA-6etzA:
undetectable
3tmzA-6etzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1


(Homo sapiens)
no annotation 5 ILE A 233
ILE A 255
ILE A 222
ALA A 244
GLU A 246
None
1.05A 3tmzA-6gmbA:
undetectable
3tmzA-6gmbA:
10.81