SIMILAR PATTERNS OF AMINO ACIDS FOR 3TMZ_A_06XA503
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1air | PECTATE LYASE C (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 5 | ILE A 283ILE A 252THR A 312VAL A 264PRO A 263 | None | 0.87A | 3tmzA-1airA:undetectable | 3tmzA-1airA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 290PHE A 268ILE A 248VAL A 276PRO A 277 | None | 1.10A | 3tmzA-1bxzA:undetectable | 3tmzA-1bxzA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 5 | ILE A 280ALA A 279THR A 311VAL A 421PRO A 422 | None | 1.05A | 3tmzA-1cptA:28.7 | 3tmzA-1cptA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dju | AROMATICAMINOTRANSFERASE (Pyrococcushorikoshii) |
PF00155(Aminotran_1_2) | 5 | PHE A 231ILE A 90ALA A 275GLU A 70PRO A 266 | None | 1.06A | 3tmzA-1djuA:0.0 | 3tmzA-1djuA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezw | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanopyruskandleri) |
PF00296(Bac_luciferase) | 5 | ILE A 336ALA A 26GLU A 32VAL A 324VAL A 322 | None | 1.07A | 3tmzA-1ezwA:0.0 | 3tmzA-1ezwA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f82 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | ILE A 42ILE A 98PHE A 194ILE A 159VAL A 234 | None | 1.01A | 3tmzA-1f82A:0.0 | 3tmzA-1f82A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f82 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | ILE A 98PHE A 194ILE A 159ALA A 224VAL A 234 | None | 1.04A | 3tmzA-1f82A:0.0 | 3tmzA-1f82A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ff9 | SACCHAROPINEREDUCTASE (Magnaporthegrisea) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | ILE A 129ILE A 123ILE A 442ALA A 406GLU A 435 | None | 0.79A | 3tmzA-1ff9A:0.0 | 3tmzA-1ff9A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ioa | ARCELIN-5A (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 5 | ILE A 107PHE A 108ALA A 88VAL A 92PRO A 93 | None | 1.08A | 3tmzA-1ioaA:undetectable | 3tmzA-1ioaA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE LARGECHAIN (Oligotrophacarboxidovorans) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ILE B 513ILE B 551ILE B 587ALA B 537GLU B 543 | None | 0.97A | 3tmzA-1n60B:0.0 | 3tmzA-1n60B:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzm | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Thermotogamaritima) |
PF00793(DAHP_synth_1) | 5 | ILE A 233ILE A 224GLU A 164PRO A 203VAL A 162 | NoneNonePEP A8002 ( 4.8A)NoneNone | 1.11A | 3tmzA-1rzmA:undetectable | 3tmzA-1rzmA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4a | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 5 | ILE A 177ILE A 263PHE A 239ALA A 272GLU A 274 | None | 0.88A | 3tmzA-1v4aA:undetectable | 3tmzA-1v4aA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zb7 | NEUROTOXIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | ILE A 43ILE A 99PHE A 195ILE A 160VAL A 235 | None | 1.04A | 3tmzA-1zb7A:undetectable | 3tmzA-1zb7A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zb7 | NEUROTOXIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | ILE A 99PHE A 195ILE A 160ALA A 225VAL A 235 | None | 1.07A | 3tmzA-1zb7A:undetectable | 3tmzA-1zb7A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3k | PROTEIN TYROSINEPHOSPHATASE,NON-RECEPTOR TYPE 7,ISOFORM 1 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A 166ILE A 191ILE A 150VAL A 188PRO A 286 | None | 0.97A | 3tmzA-2a3kA:undetectable | 3tmzA-2a3kA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2axq | SACCHAROPINEDEHYDROGENASE (Saccharomycescerevisiae) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | ILE A 128ILE A 122ILE A 438ALA A 402GLU A 431 | None | 0.89A | 3tmzA-2axqA:undetectable | 3tmzA-2axqA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bd0 | SEPIAPTERINREDUCTASE (Chlorobaculumtepidum) |
PF00106(adh_short) | 5 | ILE A 143ILE A 213ALA A 19GLU A 21VAL A 91 | NAP A 800 (-4.3A)NoneNoneNoneNone | 1.07A | 3tmzA-2bd0A:undetectable | 3tmzA-2bd0A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzl | TYROSINE-PROTEINPHOSPHATASE,NON-RECEPTOR TYPE 14 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A 980ILE A1005ILE A 963VAL A1002PRO A1116 | None | 0.97A | 3tmzA-2bzlA:undetectable | 3tmzA-2bzlA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dht | 409AA LONGHYPOTHETICALNADP-DEPENDENTISOCITRATEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00180(Iso_dh) | 5 | ILE A 124ILE A 289ALA A 210GLU A 212PRO A 126 | None | 0.96A | 3tmzA-2dhtA:undetectable | 3tmzA-2dhtA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e87 | HYPOTHETICAL PROTEINPH1320 (Pyrococcushorikoshii) |
PF06858(NOG1) | 5 | ILE A 172ILE A 250ILE A 218THR A 333VAL A 326 | None | 1.10A | 3tmzA-2e87A:undetectable | 3tmzA-2e87A:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h03 | PROTEIN TYROSINEPHOSPHATASE,RECEPTOR TYPE, B, (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A1773ILE A1798ILE A1758VAL A1795PRO A1899 | None | 0.99A | 3tmzA-2h03A:undetectable | 3tmzA-2h03A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i71 | HYPOTHETICAL PROTEIN (Sulfolobussolfataricus) |
PF09455(Cas_DxTHG) | 5 | ILE A 113ILE A 106ILE A 4ALA A 137VAL A 86 | NoneNoneNoneNone MG A 402 (-3.9A) | 1.07A | 3tmzA-2i71A:undetectable | 3tmzA-2i71A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mx2 | DEUBIQUITINATINGPROTEIN VCIP135 (Rattusnorvegicus) |
no annotation | 5 | ILE A 79ILE A 37GLU A 35VAL A 71PRO A 72 | None | 1.10A | 3tmzA-2mx2A:undetectable | 3tmzA-2mx2A:11.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np0 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | ILE A 42ILE A 98PHE A 194ILE A 159VAL A 234 | None | 1.03A | 3tmzA-2np0A:2.0 | 3tmzA-2np0A:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np0 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | ILE A 98PHE A 194ILE A 159ALA A 224VAL A 234 | None | 1.02A | 3tmzA-2np0A:2.0 | 3tmzA-2np0A:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa5 | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 9 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A 373ILE A 398ILE A 358VAL A 395PRO A 510 | None | 0.94A | 3tmzA-2pa5A:undetectable | 3tmzA-2pa5A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbz | HYPOTHETICAL PROTEIN (Thermococcuskodakarensis) |
PF06849(DUF1246)PF06973(DUF1297) | 5 | ILE A 247ILE A 294PHE A 176ALA A 295GLU A 302 | None | 1.11A | 3tmzA-2pbzA:undetectable | 3tmzA-2pbzA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2py6 | METHYLTRANSFERASEFKBM (Methylobacillusflagellatus) |
PF05050(Methyltransf_21) | 5 | ILE A 98PHE A 128THR A 118PRO A 96VAL A 55 | None | 1.00A | 3tmzA-2py6A:undetectable | 3tmzA-2py6A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qie | MOLYBDOPTERIN-CONVERTING FACTOR SUBUNIT2 (Staphylococcusaureus) |
PF02391(MoaE) | 5 | ILE A 78ILE A 67ILE A 115GLU A 113VAL A 96 | None | 1.06A | 3tmzA-2qieA:undetectable | 3tmzA-2qieA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v72 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 5 | ILE A 63ILE A 112PHE A 108ILE A 119VAL A 52 | None | 0.92A | 3tmzA-2v72A:undetectable | 3tmzA-2v72A:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd2 | ATPPHOSPHORIBOSYLTRANSFERASE (Bacillussubtilis) |
PF01634(HisG) | 5 | ILE A 114ALA A 122GLU A 128VAL A 133PRO A 112 | None | 1.10A | 3tmzA-2vd2A:undetectable | 3tmzA-2vd2A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9x | SELENOCYSTEINE LYASE (Rattusnorvegicus) |
PF00266(Aminotran_5) | 5 | PHE A 248ALA A 223THR A 220VAL A 231VAL A 233 | NonePLP A 501 (-3.4A)NoneNoneNone | 1.10A | 3tmzA-3a9xA:undetectable | 3tmzA-3a9xA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgk | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
PF01256(Carb_kinase) | 5 | ILE A 184ILE A 125ILE A 194ALA A 220VAL A 227 | None | 0.96A | 3tmzA-3bgkA:undetectable | 3tmzA-3bgkA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwv | DNA GYRASE, BSUBUNIT, TRUNCATED (Myxococcusxanthus) |
PF00204(DNA_gyraseB) | 5 | ILE A 331ILE A 324THR A 261VAL A 305VAL A 303 | None | 0.97A | 3tmzA-3cwvA:undetectable | 3tmzA-3cwvA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ez9 | PARA (Salmonellaenterica) |
PF13614(AAA_31) | 5 | ILE A 87GLU A 37THR A 36VAL A 198PRO A 199 | None | 1.04A | 3tmzA-3ez9A:undetectable | 3tmzA-3ez9A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fht | ATP-DEPENDENT RNAHELICASE DDX19B (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | PHE A 239ILE A 258ALA A 244VAL A 289PRO A 290 | None | 1.08A | 3tmzA-3fhtA:undetectable | 3tmzA-3fhtA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzd | SELENOCYSTEINE LYASE (Homo sapiens) |
PF00266(Aminotran_5) | 5 | PHE C 260ALA C 235THR C 232VAL C 243VAL C 245 | NonePLR C 500 (-3.5A)NoneNoneNone | 1.07A | 3tmzA-3gzdC:undetectable | 3tmzA-3gzdC:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2x | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 22 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A 100ILE A 125ILE A 85VAL A 122PRO A 222 | None | 0.97A | 3tmzA-3h2xA:undetectable | 3tmzA-3h2xA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT BETA (Moorellathermoacetica) |
PF03063(Prismane) | 5 | ILE A 380ILE A 341ALA A 383VAL A 351VAL A 279 | None | 0.86A | 3tmzA-3i04A:undetectable | 3tmzA-3i04A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i36 | VASCULAR PROTEINTYROSINE PHOSPHATASE1 (Rattusnorvegicus) |
PF00102(Y_phosphatase) | 5 | ILE A 989ILE A1014ILE A 974VAL A1011PRO A1113 | None | 0.93A | 3tmzA-3i36A:undetectable | 3tmzA-3i36A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kqf | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Bacillusanthracis) |
PF00378(ECH_1) | 5 | ILE A 103PHE A 123ALA A 194GLU A 196VAL A 53 | None | 1.04A | 3tmzA-3kqfA:undetectable | 3tmzA-3kqfA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ono | RIBOSE/GALACTOSEISOMERASE (Vibrioparahaemolyticus) |
PF02502(LacAB_rpiB)PF12408(DUF3666) | 5 | ILE A 110ILE A 3ILE A 129ALA A 26GLU A 131 | None | 0.85A | 3tmzA-3onoA:undetectable | 3tmzA-3onoA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p09 | BETA-LACTAMASE (Francisellatularensis) |
PF13354(Beta-lactamase2) | 5 | ILE A 250ILE A 223ILE A 278ALA A 214PRO A 244 | None | 1.04A | 3tmzA-3p09A:undetectable | 3tmzA-3p09A:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro8 | ENDO-1,4-BETA-XYLANASE (Paenibacillussp. JDR-2) |
PF00331(Glyco_hydro_10) | 5 | ILE A 119ILE A 226ALA A 174GLU A 169VAL A 84 | None | 1.11A | 3tmzA-3ro8A:undetectable | 3tmzA-3ro8A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rru | TOM1L1 PROTEIN (Homo sapiens) |
PF00790(VHS) | 5 | ILE A 119ILE A 76PHE A 122ILE A 115THR A 23 | None | 1.08A | 3tmzA-3rruA:undetectable | 3tmzA-3rruA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s38 | CYTOCHROME C OXIDASESUBUNIT 2 (Thermusthermophilus) |
PF00116(COX2)PF09125(COX2-transmemb) | 5 | ILE B 107PHE B 116ILE B 103PRO B 92VAL B 71 | None | 1.10A | 3tmzA-3s38B:undetectable | 3tmzA-3s38B:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tfo | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Sinorhizobiummeliloti) |
PF00106(adh_short) | 5 | ILE A 138ILE A 9ILE A 214ALA A 21GLU A 23 | None | 1.10A | 3tmzA-3tfoA:undetectable | 3tmzA-3tfoA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tfo | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Sinorhizobiummeliloti) |
PF00106(adh_short) | 5 | ILE A 138ILE A 214ALA A 21GLU A 23VAL A 86 | None | 1.08A | 3tmzA-3tfoA:undetectable | 3tmzA-3tfoA:19.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 7 | ILE A 101ILE A 114ILE A 209ALA A 298THR A 302VAL A 367PRO A 368 | CPZ A 501 (-4.2A)HEM A 500 (-4.0A)NoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A)HEM A 500 ( 4.3A)None | 0.94A | 3tmzA-3tk3A:56.8 | 3tmzA-3tk3A:99.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 6 | ILE A 101ILE A 114PHE A 115ILE A 209ALA A 298THR A 302 | CPZ A 501 (-4.2A)HEM A 500 (-4.0A)NoneNoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A) | 1.12A | 3tmzA-3tk3A:56.8 | 3tmzA-3tk3A:99.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 6 | ILE A 101ILE A 114PHE A 206ILE A 209ALA A 298THR A 302 | CPZ A 501 (-4.2A)HEM A 500 (-4.0A)NoneNoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A) | 1.16A | 3tmzA-3tk3A:56.8 | 3tmzA-3tk3A:99.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 6 | ILE A 114PHE A 108ILE A 209ALA A 298THR A 302VAL A 367 | HEM A 500 (-4.0A)NoneNoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A)HEM A 500 ( 4.3A) | 1.16A | 3tmzA-3tk3A:56.8 | 3tmzA-3tk3A:99.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 6 | ILE A 114PHE A 108PHE A 206ILE A 209ALA A 298THR A 302 | HEM A 500 (-4.0A)NoneNoneNoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A) | 1.39A | 3tmzA-3tk3A:56.8 | 3tmzA-3tk3A:99.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0v | L-LYSINE OXIDASE (Trichodermaviride) |
PF01593(Amino_oxidase) | 5 | PHE A 202GLU A 193THR A 194VAL A 126PRO A 127 | None | 1.11A | 3tmzA-3x0vA:undetectable | 3tmzA-3x0vA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuq | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | ILE A 43ILE A 99PHE A 195ILE A 160VAL A 235 | None | 1.01A | 3tmzA-3zuqA:1.0 | 3tmzA-3zuqA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuq | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | ILE A 99PHE A 195ILE A 160ALA A 225VAL A 235 | None | 1.03A | 3tmzA-3zuqA:1.0 | 3tmzA-3zuqA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxw | RIBULOSEBISPHOSPHATECARBOXYLASE SMALLCHAIN (Thermosynechococcuselongatus) |
PF00101(RuBisCO_small) | 5 | ILE B 24ALA B 89GLU B 41VAL B 69VAL B 73 | None | 1.06A | 3tmzA-3zxwB:undetectable | 3tmzA-3zxwB:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1l | 2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATEALDOLASE (Pyrococcusfuriosus) |
PF00793(DAHP_synth_1) | 5 | ILE A 162ILE A 153GLU A 93PRO A 132VAL A 91 | None | 1.09A | 3tmzA-4c1lA:undetectable | 3tmzA-4c1lA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0e | PROBABLE3-HYDROXYACYL-COADEHYDROGENASEF54C8.1 (Caenorhabditiselegans) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 99ILE A 113PHE A 114ALA A 103VAL A 89 | None | 0.97A | 3tmzA-4j0eA:undetectable | 3tmzA-4j0eA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0e | PROBABLE3-HYDROXYACYL-COADEHYDROGENASEF54C8.1 (Caenorhabditiselegans) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 99ILE A 113PHE A 114ILE A 100VAL A 89 | None | 0.96A | 3tmzA-4j0eA:undetectable | 3tmzA-4j0eA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j1l | TETANUS TOXIN (Clostridiumtetani) |
PF01742(Peptidase_M27) | 5 | ILE A 43ILE A 98PHE A 198ILE A 159VAL A 238 | None | 0.91A | 3tmzA-4j1lA:1.5 | 3tmzA-4j1lA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j1l | TETANUS TOXIN (Clostridiumtetani) |
PF01742(Peptidase_M27) | 5 | ILE A 98PHE A 198ILE A 159ALA A 228VAL A 238 | None | 0.93A | 3tmzA-4j1lA:1.5 | 3tmzA-4j1lA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnd | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 18 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A 102ILE A 127ILE A 87VAL A 124PRO A 224 | None | 1.00A | 3tmzA-4nndA:undetectable | 3tmzA-4nndA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov4 | 2-ISOPROPYLMALATESYNTHASE (Leptospirabiflexa) |
PF00682(HMGL-like) | 5 | ILE A 141ILE A 134ILE A 100ALA A 84GLU A 82 | None | 1.11A | 3tmzA-4ov4A:undetectable | 3tmzA-4ov4A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pag | PERIPLASMIC BINDINGPROTEIN (Sulfurospirillumdeleyianum) |
PF01497(Peripla_BP_2) | 5 | ILE A 300ALA A 192GLU A 201THR A 200VAL A 189 | None | 1.02A | 3tmzA-4pagA:undetectable | 3tmzA-4pagA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psw | HISTONEACETYLTRANSFERASETYPE B SUBUNIT 2 (Saccharomycescerevisiae) |
PF00400(WD40)PF12265(CAF1C_H4-bd) | 5 | ILE B 60PHE B 75ILE B 133ALA B 124PRO B 44 | None | 0.83A | 3tmzA-4pswB:undetectable | 3tmzA-4pswB:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qrj | PUTATIVE6-PHOSPHOGLUCONOLACTONASE (Bacteroidesuniformis) |
PF10282(Lactonase) | 5 | ILE A 45ALA A 63GLU A 104VAL A 80PRO A 73 | None | 0.96A | 3tmzA-4qrjA:undetectable | 3tmzA-4qrjA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 5 | ILE A 289ILE A 256ALA A 330GLU A 275VAL A 273 | None | 0.96A | 3tmzA-4r27A:undetectable | 3tmzA-4r27A:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgu | PUTATIVE PACHYTENECHECKPOINT PROTEIN 2 (Caenorhabditiselegans) |
PF00004(AAA) | 5 | ILE A 284ILE A 236PHE A 233ILE A 251GLU A 211 | None | 1.07A | 3tmzA-4xguA:undetectable | 3tmzA-4xguA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b48 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEBETA SUBUNIT (Sulfurisphaeratokodaii) |
PF02775(TPP_enzyme_C)PF12367(PFO_beta_C) | 5 | ILE B 252ILE B 153PHE B 255ILE B 250THR B 131 | None | 1.01A | 3tmzA-5b48B:undetectable | 3tmzA-5b48B:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7e | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 14 (Saccharomycescerevisiae) |
PF03366(YEATS) | 5 | ILE A 9ILE A 120ILE A 101GLU A 98VAL A 54 | None | 0.90A | 3tmzA-5d7eA:undetectable | 3tmzA-5d7eA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5do8 | LMO0184 PROTEIN (Listeriamonocytogenes) |
no annotation | 5 | ILE B 199ILE B 277ILE B 232ALA B 263VAL B 274 | None | 0.94A | 3tmzA-5do8B:undetectable | 3tmzA-5do8B:23.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e0e | CYTOCHROME P450FAMILY 2 SUBFAMILY B (Neotoma lepida) |
PF00067(p450) | 7 | ILE A 101PHE A 108PHE A 206ILE A 209ALA A 298GLU A 301THR A 302 | CPZ A 502 (-4.7A)NoneNoneNoneHEM A 501 ( 3.1A)NoneCPZ A 502 ( 4.0A) | 1.24A | 3tmzA-5e0eA:55.8 | 3tmzA-5e0eA:79.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e0e | CYTOCHROME P450FAMILY 2 SUBFAMILY B (Neotoma lepida) |
PF00067(p450) | 8 | ILE A 101PHE A 206ILE A 209ALA A 298GLU A 301THR A 302VAL A 367PRO A 368 | CPZ A 502 (-4.7A)NoneNoneHEM A 501 ( 3.1A)NoneCPZ A 502 ( 4.0A)HEM A 501 ( 4.4A)None | 0.87A | 3tmzA-5e0eA:55.8 | 3tmzA-5e0eA:79.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e0e | CYTOCHROME P450FAMILY 2 SUBFAMILY B (Neotoma lepida) |
PF00067(p450) | 6 | PHE A 115ILE A 209ALA A 298GLU A 301THR A 302VAL A 367 | NoneNoneHEM A 501 ( 3.1A)NoneCPZ A 502 ( 4.0A)HEM A 501 ( 4.4A) | 0.88A | 3tmzA-5e0eA:55.8 | 3tmzA-5e0eA:79.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej0 | ENVELOPE PROTEIN H3 (Vaccinia virus) |
PF03213(Pox_P35) | 5 | ILE A 130ILE A 133GLU A 27VAL A 10VAL A 8 | None | 1.10A | 3tmzA-5ej0A:undetectable | 3tmzA-5ej0A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsm | EXO-BETA-D-GLUCOSAMINIDASE (Thermococcuskodakarensis) |
PF02449(Glyco_hydro_42) | 5 | ILE A 176PHE A 157ILE A 160GLU A 270VAL A 273 | None | 1.11A | 3tmzA-5gsmA:undetectable | 3tmzA-5gsmA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gx8 | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Streptobacillusmoniliformis) |
PF13416(SBP_bac_8) | 5 | ILE A 245PHE A 262ILE A 261ALA A 463VAL A 216 | None | 1.04A | 3tmzA-5gx8A:undetectable | 3tmzA-5gx8A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h08 | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE ZETA (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A1798ILE A1823ILE A1783VAL A1820PRO A1928 | None | 0.92A | 3tmzA-5h08A:undetectable | 3tmzA-5h08A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgr | ORANGE CAROTENOIDPROTEIN (OCP) (Nostoc sp. PCC7120) |
PF02136(NTF2)PF09150(Carot_N) | 5 | ILE A 195PHE A 12ALA A 259VAL A 200VAL A 303 | None | 0.96A | 3tmzA-5hgrA:undetectable | 3tmzA-5hgrA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ik2 | ATP SYNTHASE GAMMACHAIN (Caldalkalibacillusthermarum) |
PF00231(ATP-synt) | 5 | ILE G 115ILE G 170ALA G 117THR G 82VAL G 99 | None | 1.04A | 3tmzA-5ik2G:1.8 | 3tmzA-5ik2G:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6b | ALDEHYDEDEHYDROGENASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 5 | ILE A 433PHE A 393ALA A 419PRO A 437VAL A 400 | None | 1.08A | 3tmzA-5j6bA:undetectable | 3tmzA-5j6bA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jqx | GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00535(Glycos_transf_2) | 5 | ILE A 92ILE A 62ILE A 89GLU A 55VAL A 78 | None | 1.01A | 3tmzA-5jqxA:undetectable | 3tmzA-5jqxA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN3, MITOCHONDRIAL (Bos taurus) |
PF00329(Complex1_30kDa) | 5 | ILE C 117PHE C 142GLU C 91VAL C 57VAL C 107 | None | 1.06A | 3tmzA-5lc5C:undetectable | 3tmzA-5lc5C:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN2 (Saccharomycescerevisiae) |
PF01851(PC_rep)PF13646(HEAT_2) | 5 | ILE N 874ILE N 759PHE N 884ILE N 882VAL N 868 | None | 1.07A | 3tmzA-5mpdN:undetectable | 3tmzA-5mpdN:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0c | TETANUS TOXIN (Clostridiumtetani) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | ILE A 43ILE A 98PHE A 198ILE A 159VAL A 238 | None | 0.94A | 3tmzA-5n0cA:1.2 | 3tmzA-5n0cA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0c | TETANUS TOXIN (Clostridiumtetani) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | ILE A 98PHE A 198ILE A 159ALA A 228VAL A 238 | None | 0.97A | 3tmzA-5n0cA:1.2 | 3tmzA-5n0cA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nck | N-ACETYLMANNOSAMINEKINASE (Fusobacteriumnucleatum) |
PF00480(ROK) | 5 | ILE A 222ILE A 140PHE A 226ILE A 160GLU A 156 | None | 1.09A | 3tmzA-5nckA:undetectable | 3tmzA-5nckA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT A (Methanothermococcusthermolithotrophicus) |
PF07992(Pyr_redox_2)PF13187(Fer4_9) | 5 | ILE A 423PHE A 383ILE A 359GLU A 416PRO A 378 | None | 1.05A | 3tmzA-5odrA:undetectable | 3tmzA-5odrA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj6 | GLYCOSYL HYDROLASESFAMILY 2, SUGARBINDING DOMAINPROTEIN (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF11721(Malectin)PF16355(DUF4982) | 5 | ILE A 866ILE A 857ILE A 880GLU A 796VAL A 835 | None | 1.07A | 3tmzA-5uj6A:undetectable | 3tmzA-5uj6A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uzh | NAFOA.00085.B (Naegleriafowleri) |
PF16363(GDP_Man_Dehyd) | 5 | ILE A 239ILE A 232ILE A 301VAL A 326VAL A 320 | None | 1.09A | 3tmzA-5uzhA:undetectable | 3tmzA-5uzhA:22.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 6 | ILE A 101ILE A 114ILE A 209ALA A 298VAL A 367PRO A 368 | 9ZJ A 502 (-4.5A)9ZJ A 502 ( 3.6A)9ZJ A 502 ( 4.8A)9ZJ A 502 ( 3.5A)9ZJ A 502 ( 4.2A)None | 0.92A | 3tmzA-5wbgA:55.7 | 3tmzA-5wbgA:86.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 6 | ILE A 101ILE A 114ILE A 209THR A 302VAL A 367PRO A 368 | 9ZJ A 502 (-4.5A)9ZJ A 502 ( 3.6A)9ZJ A 502 ( 4.8A)9ZJ A 502 ( 3.9A)9ZJ A 502 ( 4.2A)None | 0.99A | 3tmzA-5wbgA:55.7 | 3tmzA-5wbgA:86.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 5 | ILE A 114ALA A 298VAL A 367PRO A 368VAL A 477 | 9ZJ A 502 ( 3.6A)9ZJ A 502 ( 3.5A)9ZJ A 502 ( 4.2A)NoneNone | 0.86A | 3tmzA-5wbgA:55.7 | 3tmzA-5wbgA:86.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 5 | ILE A 114THR A 302VAL A 367PRO A 368VAL A 477 | 9ZJ A 502 ( 3.6A)9ZJ A 502 ( 3.9A)9ZJ A 502 ( 4.2A)NoneNone | 0.83A | 3tmzA-5wbgA:55.7 | 3tmzA-5wbgA:86.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b0t | FASCIN (Homo sapiens) |
no annotation | 5 | ILE A 144PHE A 254ALA A 153GLU A 162VAL A 188 | None | 1.04A | 3tmzA-6b0tA:undetectable | 3tmzA-6b0tA:9.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bpz | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,MOUSEPIEZO1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 5 | ILE A2530ILE A2510ILE A1407THR A2145VAL A2155 | None | 0.92A | 3tmzA-6bpzA:undetectable | 3tmzA-6bpzA:12.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bvd | LIGHT CHAIN (Clostridiumbotulinum) |
no annotation | 5 | ILE A 98PHE A 195ILE A 155ALA A 221VAL A 231 | None | 0.98A | 3tmzA-6bvdA:undetectable | 3tmzA-6bvdA:11.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 5 | ILE A 307PHE A 309ALA A 294GLU A 269VAL A 248 | None | 1.02A | 3tmzA-6etzA:undetectable | 3tmzA-6etzA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gmb | HYDROXYACID OXIDASE1 (Homo sapiens) |
no annotation | 5 | ILE A 233ILE A 255ILE A 222ALA A 244GLU A 246 | None | 1.05A | 3tmzA-6gmbA:undetectable | 3tmzA-6gmbA:10.81 |