SIMILAR PATTERNS OF AMINO ACIDS FOR 3TM4_B_SAMB401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1crl | LIPASE (Diutina rugosa) |
PF00135(COesterase) | 5 | ALA A 175LEU A 164GLY A 178ALA A 210PRO A 308 | None | 1.14A | 3tm4B-1crlA:undetectable | 3tm4B-1crlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ehk | BA3-TYPECYTOCHROME-C OXIDASE (Thermusthermophilus) |
PF00115(COX1) | 5 | ALA A 367LEU A 371GLY A 362HIS A 384LEU A 310 | HAS A 801 (-3.4A)NoneNoneHAS A 801 (-4.4A)HAS A 801 (-4.0A) | 1.22A | 3tm4B-1ehkA:undetectable | 3tm4B-1ehkA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5b | SERINE/THREONINEPROTEIN PHOSPHATASE (Escherichiavirus Lambda) |
PF00149(Metallophos) | 5 | ALA A 205GLY A 23HIS A 22ASN A 27LEU A 44 | NoneNone MN A1006 (-3.4A)NoneNone | 1.17A | 3tm4B-1g5bA:undetectable | 3tm4B-1g5bA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ir6 | EXONUCLEASE RECJ (Thermusthermophilus) |
PF01368(DHH)PF02272(DHHA1) | 5 | ALA A 254LEU A 250GLY A 301HIS A 304ALA A 275 | None | 1.25A | 3tm4B-1ir6A:2.6 | 3tm4B-1ir6A:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itk | CATALASE-PEROXIDASE (Haloarculamarismortui) |
PF00141(peroxidase) | 5 | GLY A 583TYR A 628ALA A 469ASN A 603PRO A 579 | CL A2004 (-4.1A)NoneNone CL A2004 (-4.1A)None | 1.07A | 3tm4B-1itkA:undetectable | 3tm4B-1itkA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | ALA A1122LEU A1193GLY A1198HIS A1088LEU A 846 | None | 1.31A | 3tm4B-1ofeA:5.0 | 3tm4B-1ofeA:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfx | PROTEIN (PH 2.5 ACIDPHOSPHATASE) (Aspergillusniger) |
PF00328(His_Phos_2) | 5 | ALA A 250LEU A 248MET A 243TYR A 111LEU A 80 | None | 1.17A | 3tm4B-1qfxA:undetectable | 3tm4B-1qfxA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyr | HIGH LEVELKASUGAMYCINRESISTANCE PROTEIN (Escherichiacoli) |
PF00398(RrnaAD) | 5 | LEU A 20GLY A 47ALA A 92ASN A 113PRO A 115 | None | 0.90A | 3tm4B-1qyrA:14.2 | 3tm4B-1qyrA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6m | RIBONUCLEASE PH (Pseudomonasaeruginosa) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | ALA A 236LEU A 232GLY A 133ALA A 102LEU A 156 | None | 1.32A | 3tm4B-1r6mA:undetectable | 3tm4B-1r6mA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1scj | SUBTILISIN ESUBTILISIN E (Bacillussubtilis;Bacillussubtilis) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | ALA A 176GLY A 154ALA B 374PRO A 168LEU A 135 | CA A 382 (-3.8A)NoneNoneNoneNone | 1.32A | 3tm4B-1scjA:undetectable | 3tm4B-1scjA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szs | 4-AMINOBUTYRATEAMINOTRANSFERASE (Escherichiacoli) |
PF00202(Aminotran_3) | 5 | LEU A 403GLY A 56HIS A 57ALA A 307ASN A 54 | NoneNoneEDO A1223 (-3.9A)NoneNone | 1.01A | 3tm4B-1szsA:3.2 | 3tm4B-1szsA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwy | CARBOXYPEPTIDASE M (Homo sapiens) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 5 | ALA A 63LEU A 263GLY A 174TYR A 270LEU A 276 | None | 0.99A | 3tm4B-1uwyA:undetectable | 3tm4B-1uwyA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl5 | UNKNOWN CONSERVEDPROTEIN BH2331 (Bacillushalodurans) |
PF08241(Methyltransf_11) | 5 | ALA A 59HIS A 89GLY A 54HIS A 55ALA A 117 | None | 1.24A | 3tm4B-1vl5A:11.1 | 3tm4B-1vl5A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyd | HYPOTHETICALASPARTYL-TRNASYNTHETASE (Sulfurisphaeratokodaii) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | LEU A 261MET A 407GLY A 410PRO A 269LEU A 316 | None | 0.93A | 3tm4B-1wydA:undetectable | 3tm4B-1wydA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1q | TRYPTOPHAN SYNTHASEBETA CHAIN (Thermusthermophilus) |
PF00291(PALP) | 5 | ALA A 378HIS A 377GLY A 278ALA A 267ASN A 258 | None | 1.28A | 3tm4B-1x1qA:undetectable | 3tm4B-1x1qA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfm | FUMARASE (Saccharomycescerevisiae) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ALA A 256LEU A 261GLY A 254ALA A 81ASN A 262 | None | 1.32A | 3tm4B-1yfmA:undetectable | 3tm4B-1yfmA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zel | HYPOTHETICAL PROTEINRV2827C (Mycobacteriumtuberculosis) |
PF09407(AbiEi_1)PF13338(AbiEi_4) | 5 | ALA A 106HIS A 109GLY A 111ALA A 209PRO A 180 | NoneNoneNone NA A 401 ( 4.2A)None | 1.25A | 3tm4B-1zelA:undetectable | 3tm4B-1zelA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c3o | PYRUVATE-FERREDOXINOXIDOREDUCTASE (Desulfovibrioafricanus) |
PF01558(POR)PF01855(POR_N)PF02775(TPP_enzyme_C)PF10371(EKR)PF13484(Fer4_16)PF17147(PFOR_II) | 5 | ALA A1106MET A1030GLY A1033TYR A1036ALA A1026 | None | 1.19A | 3tm4B-2c3oA:3.0 | 3tm4B-2c3oA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ckh | SENTRIN-SPECIFICPROTEASE 1 (Homo sapiens) |
PF02902(Peptidase_C48) | 5 | MET A 475HIS A 491ASN A 472PRO A 527LEU A 536 | None | 1.23A | 3tm4B-2ckhA:undetectable | 3tm4B-2ckhA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3i | OVOTRANSFERRIN (Gallus gallus) |
PF00405(Transferrin) | 5 | ALA A 538HIS A 455GLY A 526ALA A 555LEU A 561 | None | 1.22A | 3tm4B-2d3iA:2.5 | 3tm4B-2d3iA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | 3-KETOACYL-COATHIOLASE (Pseudomonasfragi) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 277GLY C 381ALA C 314PRO C 288LEU C 311 | NoneNoneACO C1003 (-3.4A)NoneNone | 1.30A | 3tm4B-2d3tC:undetectable | 3tm4B-2d3tC:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dqw | DIHYDROPTEROATESYNTHASE (Thermusthermophilus) |
PF00809(Pterin_bind) | 5 | ALA A 124LEU A 19HIS A 145ALA A 186LEU A 133 | None | 1.09A | 3tm4B-2dqwA:undetectable | 3tm4B-2dqwA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dqw | DIHYDROPTEROATESYNTHASE (Thermusthermophilus) |
PF00809(Pterin_bind) | 5 | LEU A 19GLY A 146HIS A 145ALA A 186LEU A 133 | None | 1.14A | 3tm4B-2dqwA:undetectable | 3tm4B-2dqwA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1k | PREPHENATEDEHYDROGENASE (Synechocystissp. PCC 6803) |
PF02153(PDH) | 5 | LEU A 164GLY A 111HIS A 112ALA A 101PRO A 167 | NoneNoneOMT A 114 ( 3.9A)NoneNone | 1.32A | 3tm4B-2f1kA:6.7 | 3tm4B-2f1kA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hwt | PUTATIVEREPLICASE-ASSOCIATEDPROTEIN (Faba beannecroticyellows virus) |
PF02407(Viral_Rep) | 5 | ALA A 64HIS A 65TYR A 30ASN A 13PRO A 15 | None | 0.94A | 3tm4B-2hwtA:2.5 | 3tm4B-2hwtA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjp | CYTOCHROME P450113A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | ALA A 149LEU A 151GLY A 242HIS A 243LEU A 125 | None | 1.12A | 3tm4B-2jjpA:undetectable | 3tm4B-2jjpA:25.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0m | TRANSCRIPTIONALREGULATOR, SORCFAMILY (Enterococcusfaecalis) |
PF04198(Sugar-bind) | 5 | HIS A 170MET A 195GLY A 201ALA A 158LEU A 131 | None | 1.31A | 3tm4B-2o0mA:undetectable | 3tm4B-2o0mA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odp | COMPLEMENT C2 (Homo sapiens) |
PF00089(Trypsin)PF00092(VWA) | 5 | ALA A 475HIS A 461MET A 553LYS A 550PRO A 559 | None | 1.26A | 3tm4B-2odpA:undetectable | 3tm4B-2odpA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p50 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 5 | ALA A 178GLY A 210ALA A 214PRO A 173LEU A 231 | None | 1.17A | 3tm4B-2p50A:undetectable | 3tm4B-2p50A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q01 | URONATE ISOMERASE (Caulobactervibrioides) |
PF02614(UxaC) | 5 | LEU A 319GLY A 327TYR A 66ASN A 313LEU A 360 | None | 1.20A | 3tm4B-2q01A:undetectable | 3tm4B-2q01A:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q49 | PROBABLEN-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Arabidopsisthaliana) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | HIS A 41MET A 343GLY A 345ALA A 155ASN A 341 | None | 1.17A | 3tm4B-2q49A:3.1 | 3tm4B-2q49A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qdd | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 309HIS A 306LEU A 307GLY A 126PRO A 312 | None | 1.25A | 3tm4B-2qddA:2.2 | 3tm4B-2qddA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 5 | ALA A 674HIS A 675GLY A 682TYR A 335LEU A 328 | None | 1.30A | 3tm4B-2rdyA:undetectable | 3tm4B-2rdyA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkq | PEPTIDOGLYCAN-RECOGNITION PROTEIN-SD (Drosophilamelanogaster) |
PF01510(Amidase_2) | 5 | ALA A 41HIS A 42LEU A 163GLY A 149LEU A 141 | None | 1.24A | 3tm4B-2rkqA:undetectable | 3tm4B-2rkqA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 5 | ALA A 258HIS A 259LEU A 260GLY A 17HIS A 18 | NoneUFP A 529 (-4.1A)NoneNoneNone | 1.29A | 3tm4B-2tddA:undetectable | 3tm4B-2tddA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk1 | NOVP (Actinoalloteichuscyanogriseus) |
PF05711(TylF) | 5 | HIS A 144LEU A 143GLY A 126ALA A 121LEU A 182 | SO4 A 401 (-4.0A)NoneSAH A 301 (-3.0A)NoneNone | 1.14A | 3tm4B-2wk1A:12.0 | 3tm4B-2wk1A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x58 | PEROXISOMALBIFUNCTIONAL ENZYME (Rattusnorvegicus) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | LEU A 508TYR A 581HIS A 589ALA A 524LEU A 526 | None | 1.29A | 3tm4B-2x58A:4.3 | 3tm4B-2x58A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfh | GLUTAMATEDEHYDROGENASE,NAD-SPECIFICGLUTAMATEDEHYDROGENASE,GLUTAMATEDEHYDROGENASE (Escherichiacoli;[Clostridium]symbiosum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ALA A 343LEU A 425GLY A 368ALA A 377LEU A 401 | None | 1.20A | 3tm4B-2yfhA:4.8 | 3tm4B-2yfhA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | GLY A 209HIS A 206ASN A 214PRO A 239LEU A 163 | None | 1.30A | 3tm4B-2z8zA:undetectable | 3tm4B-2z8zA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gju | PUTATIVEAMINOTRANSFERASE (Mesorhizobiumjaponicum) |
PF00202(Aminotran_3) | 5 | ALA A 57LEU A 434GLY A 65ALA A 336ASN A 63 | None | 1.30A | 3tm4B-3gjuA:2.2 | 3tm4B-3gjuA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gry | DIMETHYLADENOSINETRANSFERASE (Methanocaldococcusjannaschii) |
PF00398(RrnaAD) | 5 | LEU A 13GLY A 40ALA A 85ASN A 101PRO A 103 | SAM A 300 (-4.0A)SAM A 300 (-3.3A)SAM A 300 (-3.6A)SAM A 300 (-3.6A)SAM A 300 (-3.8A) | 1.15A | 3tm4B-3gryA:15.7 | 3tm4B-3gryA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iha | SALT-TOLERANTGLUTAMINASE (Micrococcusluteus) |
PF04960(Glutaminase) | 5 | ALA A 73LEU A 75ALA A 268PRO A 68LEU A 266 | None | 1.18A | 3tm4B-3ihaA:undetectable | 3tm4B-3ihaA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ALA A 174GLY A 202ALA A 290ASN A 305LEU A 321 | GTP A 383 (-4.7A)GTP A 383 (-2.6A)GTP A 383 (-3.7A)GTP A 383 (-4.2A)None | 0.88A | 3tm4B-3lduA:33.3 | 3tm4B-3lduA:28.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 6 | MET A 200GLY A 202ALA A 290ASN A 305PRO A 307LEU A 321 | GTP A 383 (-4.5A)GTP A 383 (-2.6A)GTP A 383 (-3.7A)GTP A 383 (-4.2A)GTP A 383 (-3.7A)None | 0.62A | 3tm4B-3lduA:33.3 | 3tm4B-3lduA:28.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3msy | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (marineactinobacteriumPHSC20C1) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 329HIS A 326LEU A 327GLY A 146PRO A 332 | None | 1.32A | 3tm4B-3msyA:undetectable | 3tm4B-3msyA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muo | PROLYL ENDOPEPTIDASE (Aeromonascaviae) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | LEU A 686GLY A 481TYR A 483ALA A 533LEU A 559 | NoneNoneZPR A 702 (-4.8A)NoneNone | 1.24A | 3tm4B-3muoA:undetectable | 3tm4B-3muoA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nf4 | ACYL-COADEHYDROGENASE (Mycolicibacteriumthermoresistibile) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 210HIS A 209LEU A 208ALA A 27LEU A 52 | None | 1.07A | 3tm4B-3nf4A:undetectable | 3tm4B-3nf4A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ruy | ORNITHINEAMINOTRANSFERASE (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | HIS A 367GLY A 197ALA A 240PRO A 204LEU A 209 | None | 1.09A | 3tm4B-3ruyA:2.1 | 3tm4B-3ruyA:20.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tm5 | CRYSTAL STRUCTURE OFTRM14 (Pyrococcusfuriosus) |
PF01170(UPF0020)PF02926(THUMP) | 12 | ALA A 200HIS A 201LEU A 202MET A 225GLY A 227LYS A 249TYR A 250HIS A 253ALA A 277ASN A 293PRO A 295LEU A 309 | SFG A 401 (-3.9A)NoneSFG A 401 (-4.5A)SFG A 401 (-3.9A)SFG A 401 ( 3.7A)SFG A 401 (-4.9A)SFG A 401 (-4.5A)SFG A 401 (-3.9A)SFG A 401 (-3.1A)SFG A 401 (-4.4A)SFG A 401 ( 4.4A)None | 0.24A | 3tm4B-3tm5A:55.1 | 3tm4B-3tm5A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | LEU A 168GLY A 194ALA A 244PRO A 262LEU A 276 | None | 0.78A | 3tm4B-3tmaA:34.8 | 3tm4B-3tmaA:30.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | LEU A 168GLY A 194ASN A 260PRO A 262LEU A 276 | None | 0.89A | 3tm4B-3tmaA:34.8 | 3tm4B-3tmaA:30.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u3z | MICROCEPHALIN (Homo sapiens) |
PF00533(BRCT)PF16589(BRCT_2) | 5 | LEU A 695GLY A 700TYR A 751ALA A 736LEU A 755 | None | 1.32A | 3tm4B-3u3zA:undetectable | 3tm4B-3u3zA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8v | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE L (Escherichiacoli) |
PF01170(UPF0020)PF02926(THUMP)PF10672(Methyltrans_SAM) | 5 | MET A 197GLY A 199ASN A 309PRO A 311LEU A 325 | SAM A 801 (-4.5A)SAM A 801 (-3.2A)SAM A 801 (-4.5A)SAM A 801 ( 4.1A)SAM A 801 ( 4.8A) | 0.52A | 3tm4B-3v8vA:31.2 | 3tm4B-3v8vA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vss | BETA-FRUCTOFURANOSIDASE (Microbacteriumsaccharophilum) |
PF02435(Glyco_hydro_68) | 5 | HIS A 453GLY A 430ALA A 504ASN A 85PRO A 88 | None | 1.25A | 3tm4B-3vssA:undetectable | 3tm4B-3vssA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6u | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 186GLY A 195ALA A 217PRO A 181LEU A 253 | None | 1.03A | 3tm4B-4e6uA:undetectable | 3tm4B-4e6uA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exj | UNCHARACTERIZEDPROTEIN (Lodderomyceselongisporus) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | ALA A 165LEU A 167GLY A 10PRO A 15LEU A 4 | NoneNoneSO4 A 302 (-3.7A)NoneNone | 1.06A | 3tm4B-4exjA:undetectable | 3tm4B-4exjA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fsf | PENICILLIN-BINDINGPROTEIN 3 (Pseudomonasaeruginosa) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | LEU A 405GLY A 293ALA A 508PRO A 298LEU A 461 | None0W0 A 601 ( 3.7A)NoneNoneNone | 1.04A | 3tm4B-4fsfA:undetectable | 3tm4B-4fsfA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 5 | LEU A 38GLY A 65LYS A 86ASN A 141PRO A 143 | NoneNoneNoneNoneACT A 402 ( 4.9A) | 0.96A | 3tm4B-4gc5A:14.1 | 3tm4B-4gc5A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hrw | CYTIDINE ANDDEOXYCYTIDYLATEDEAMINASEZINC-BINDING REGION (Nitrosomonaseuropaea) |
PF00383(dCMP_cyt_deam_1) | 5 | HIS A 77ALA A 131ASN A 40PRO A 47LEU A 174 | ZN A 201 (-3.2A)NoneNoneNoneNone | 1.30A | 3tm4B-4hrwA:undetectable | 3tm4B-4hrwA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihe | THNT PROTEIN (Streptomycescattleya) |
PF03576(Peptidase_S58) | 5 | ALA A 278GLY A 192HIS A 389ALA A 375ASN A 281 | None | 1.16A | 3tm4B-4iheA:undetectable | 3tm4B-4iheA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jbh | ALCOHOLDEHYDROGENASE (ZINC) (Pyrobaculumaerophilum) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | ALA A 314LEU A 318GLY A 37LYS A 140TYR A 35ALA A 300 | None | 1.39A | 3tm4B-4jbhA:8.9 | 3tm4B-4jbhA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyk | HTH-TYPETRANSCRIPTIONALREGULATOR RUTR (Escherichiacoli) |
PF00440(TetR_N)PF08362(TetR_C_3) | 5 | ALA A 168HIS A 172MET A 119ALA A 123LEU A 130 | None | 1.27A | 3tm4B-4jykA:2.3 | 3tm4B-4jykA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlg | BETA-XYLOSIDASE (unculturedorganism) |
PF04616(Glyco_hydro_43) | 5 | LEU A 71GLY A 68HIS A 67PRO A 29LEU A 303 | None | 1.13A | 3tm4B-4mlgA:undetectable | 3tm4B-4mlgA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nle | ADENYLOSUCCINATELYASE (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | ALA A 263HIS A 265LEU A 261TYR A 139LEU A 349 | None | 1.30A | 3tm4B-4nleA:undetectable | 3tm4B-4nleA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o0e | ISOASPARTYLPEPTIDASE/L-ASPARAGINASE (Homo sapiens) |
PF01112(Asparaginase_2) | 5 | LEU A 166GLY A 9HIS A 8ALA A 54ASN A 62 | None | 1.24A | 3tm4B-4o0eA:undetectable | 3tm4B-4o0eA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oc9 | PUTATIVEO-ACETYLHOMOSERINE(THIOL)-LYASE (Campylobacterjejuni) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 159GLY A 395ALA A 379ASN A 316PRO A 156 | None | 1.27A | 3tm4B-4oc9A:3.3 | 3tm4B-4oc9A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pl0 | MICROCIN-J25 EXPORTATP-BINDING/PERMEASEPROTEIN MCJD (Escherichiacoli) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | GLY A 484TYR A 481ALA A 492ASN A 515LEU A 455 | None | 1.28A | 3tm4B-4pl0A:2.1 | 3tm4B-4pl0A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2b | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Ochrobactrumanthropi) |
PF01547(SBP_bac_1) | 5 | ALA A 379LEU A 95GLY A 376ALA A 368ASN A 303 | NoneGLC A 501 (-4.8A)NoneNoneGLC A 501 (-3.9A) | 1.19A | 3tm4B-4r2bA:undetectable | 3tm4B-4r2bA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rkr | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Arthrobactersp. FB24) |
PF13377(Peripla_BP_3) | 5 | ALA A 118HIS A 121GLY A 74ALA A 308LEU A 152 | None | 1.20A | 3tm4B-4rkrA:2.2 | 3tm4B-4rkrA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv4 | OROTATEPHOSPHORIBOSYLTRANSFERASE (Bacillusanthracis) |
PF00156(Pribosyltran) | 5 | ALA A 74HIS A 78GLY A 70LYS A 105ALA A 135 | PRP A 301 (-3.3A)NoneNoneNoneNone | 1.12A | 3tm4B-4rv4A:undetectable | 3tm4B-4rv4A:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rx4 | HIV-1 CLADE AQ842.D12 GP120 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | GLY G 250TYR G 217ALA G 70PRO G 253LEU G 111 | EDO G 510 ( 4.3A)NoneNoneNoneNone | 0.98A | 3tm4B-4rx4G:undetectable | 3tm4B-4rx4G:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v06 | TRYPTOPHAN5-HYDROXYLASE 2 (Homo sapiens) |
PF00351(Biopterin_H) | 5 | LEU A 148GLY A 345ALA A 292PRO A 155LEU A 161 | None | 0.99A | 3tm4B-4v06A:undetectable | 3tm4B-4v06A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ye4 | HT593.1 GP120 (Humanimmunodeficiencyvirus) |
PF00516(GP120) | 5 | GLY G 250TYR G 217ALA G 70PRO G 253LEU G 111 | None | 1.01A | 3tm4B-4ye4G:undetectable | 3tm4B-4ye4G:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zm6 | N-ACETYL-BETA-DGLUCOSAMINIDASE (Rhizomucormiehei) |
PF00583(Acetyltransf_1)PF00933(Glyco_hydro_3) | 5 | ALA A 115LEU A 122ASN A 130PRO A 133LEU A 135 | None | 1.20A | 3tm4B-4zm6A:undetectable | 3tm4B-4zm6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zm6 | N-ACETYL-BETA-DGLUCOSAMINIDASE (Rhizomucormiehei) |
PF00583(Acetyltransf_1)PF00933(Glyco_hydro_3) | 5 | GLY A 168ALA A 216ASN A 130PRO A 133LEU A 135 | None | 1.18A | 3tm4B-4zm6A:undetectable | 3tm4B-4zm6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aek | SENTRIN-SPECIFICPROTEASE 2 (Homo sapiens) |
PF02902(Peptidase_C48) | 5 | MET A 420HIS A 436ASN A 417PRO A 472LEU A 481 | None | 1.31A | 3tm4B-5aekA:undetectable | 3tm4B-5aekA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5alc | ANTI-TICAGRELOR FAB72, HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | HIS H 97LEU H 98GLY H 95HIS H 35PRO H 52 | None | 1.16A | 3tm4B-5alcH:undetectable | 3tm4B-5alcH:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bul | FLAVIN-DEPENDENTHALOGENASE TRIPLEMUTANT (Streptomyces) |
PF04820(Trp_halogenase) | 5 | ALA A 156MET A 308GLY A 311ALA A 53PRO A 16 | NoneNoneNoneNoneFAD A 501 (-3.3A) | 1.25A | 3tm4B-5bulA:4.1 | 3tm4B-5bulA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by8 | RPF2RRS1 (Aspergillusnidulans;Aspergillusnidulans) |
PF04427(Brix)PF04939(RRS1) | 5 | HIS A 218LEU A 220ALA A 188ASN B 69LEU A 147 | None | 1.29A | 3tm4B-5by8A:undetectable | 3tm4B-5by8A:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz4 | BETA-KETOTHIOLASE (Mycolicibacteriumsmegmatis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 290GLY A 394ALA A 327PRO A 301LEU A 324 | None | 1.19A | 3tm4B-5bz4A:2.2 | 3tm4B-5bz4A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwu | NUCLEOPORIN NUP188 (Chaetomiumthermophilum) |
no annotation | 5 | HIS A1649LEU A1650HIS A1640ALA A1633LEU A1555 | None | 1.29A | 3tm4B-5cwuA:undetectable | 3tm4B-5cwuA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9h | ISOCITRATE LYASE (Fusariumgraminearum) |
PF00463(ICL) | 5 | ALA A 142LEU A 144GLY A 137HIS A 138ALA A 176 | None | 1.23A | 3tm4B-5e9hA:undetectable | 3tm4B-5e9hA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7k | ELONGATION FACTOR 2 (Pyrococcushorikoshii) |
no annotation | 5 | ALA A 31HIS A 32GLY A 100ALA A 77LEU A 95 | GDP A 501 ( 4.2A)NoneNoneNoneNone | 1.18A | 3tm4B-5h7kA:2.8 | 3tm4B-5h7kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hnz | PROTEIN CLARETSEGREGATIONAL,PROTEIN CLARETSEGREGATIONAL,PLUS-END DIRECTEDKINESIN-1/KINESIN-14,PROTEIN CLARETSEGREGATIONAL,PROTEIN CLARETSEGREGATIONAL (Drosophilamelanogaster;Rattusnorvegicus) |
PF00225(Kinesin) | 5 | HIS K 116LEU K 115HIS K 129ALA K 82LEU K 243 | None | 1.17A | 3tm4B-5hnzK:undetectable | 3tm4B-5hnzK:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqw | PUTATIVE POLYKETIDESYNTHASE (Brevibacillusbrevis) |
PF14765(PS-DH) | 5 | ALA A2259LEU A2414TYR A2378HIS A2382ALA A2425 | None | 1.02A | 3tm4B-5hqwA:undetectable | 3tm4B-5hqwA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqw | 4-AMINOBUTYRATETRANSAMINASE (Pseudomonas) |
PF00202(Aminotran_3) | 5 | ALA A 56LEU A 433GLY A 64ALA A 335ASN A 62 | None | 1.23A | 3tm4B-5kqwA:undetectable | 3tm4B-5kqwA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kr6 | 4-AMINOBUTYRATETRANSAMINASE (Pseudomonas) |
PF00202(Aminotran_3) | 5 | ALA A 56LEU A 433GLY A 64ALA A 335ASN A 62 | None | 1.25A | 3tm4B-5kr6A:2.0 | 3tm4B-5kr6A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lh9 | OMEGA TRANSAMINASE (Pseudomonas sp.) |
PF00202(Aminotran_3) | 5 | LEU A 427GLY A 59HIS A 60ALA A 331ASN A 57 | None | 1.14A | 3tm4B-5lh9A:2.4 | 3tm4B-5lh9A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ly6 | PNEUMOLYSIN (Streptococcuspneumoniae) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 5 | ALA B 91LEU B 89GLY B 73ALA B 126PRO B 118 | None | 1.28A | 3tm4B-5ly6B:undetectable | 3tm4B-5ly6B:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5neu | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | ALA A 361LEU A 391GLY A 371TYR A 364ALA A 397 | None | 1.33A | 3tm4B-5neuA:undetectable | 3tm4B-5neuA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 5 | ALA A 206LEU A 176HIS A 211ALA A 236LEU A 221 | None | 1.32A | 3tm4B-5nnbA:undetectable | 3tm4B-5nnbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ofu | FBP PROTEIN (Leishmaniamajor) |
PF00316(FBPase) | 5 | ALA A 171LEU A 192GLY A 174ALA A 49LEU A 73 | None | 1.25A | 3tm4B-5ofuA:undetectable | 3tm4B-5ofuA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2g | PENICILLIN-BINDINGPROTEIN 1A (Haemophilusinfluenzae) |
PF00905(Transpeptidase)PF00912(Transgly)PF17092(PCB_OB) | 5 | LEU A 547GLY A 451ALA A 741PRO A 456LEU A 697 | None | 0.97A | 3tm4B-5u2gA:undetectable | 3tm4B-5u2gA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wya | ISOLEUCINE2-EPIMERASE (Lactobacillusbuchneri) |
PF00202(Aminotran_3) | 5 | ALA A 52LEU A 413GLY A 60ALA A 319ASN A 58 | None | 1.15A | 3tm4B-5wyaA:2.5 | 3tm4B-5wyaA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wya | ISOLEUCINE2-EPIMERASE (Lactobacillusbuchneri) |
PF00202(Aminotran_3) | 5 | LEU A 413GLY A 60HIS A 61ALA A 319ASN A 58 | None | 1.01A | 3tm4B-5wyaA:2.5 | 3tm4B-5wyaA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtc | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2 (Homo sapiens) |
no annotation | 5 | GLY i 107TYR i 59ALA i 66PRO i 138LEU i 33 | None | 1.27A | 3tm4B-5xtci:undetectable | 3tm4B-5xtci:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvi | GLUTAMATEDEHYDROGENASE (Aspergillusniger) |
no annotation | 5 | ALA A 342LEU A 437GLY A 375ALA A 384LEU A 408 | None | 1.21A | 3tm4B-5xviA:undetectable | 3tm4B-5xviA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 5 | HIS A 274LEU A 273GLY A 236HIS A 276LEU A 307 | SO4 A 917 (-3.9A)NoneNoneNoneNone | 1.15A | 3tm4B-5zlnA:undetectable | 3tm4B-5zlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw5 | RIBOKINASE (Cryptococcusneoformans) |
no annotation | 5 | ALA A 276MET A 310GLY A 270ALA A 40LEU A 75 | None | 1.24A | 3tm4B-6cw5A:4.0 | 3tm4B-6cw5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2 (Mus musculus) |
no annotation | 5 | LEU N 191GLY N 107ALA N 66PRO N 138LEU N 33 | None | 1.24A | 3tm4B-6g72N:undetectable | 3tm4B-6g72N:undetectable |