SIMILAR PATTERNS OF AMINO ACIDS FOR 3TL9_A_ROCA401_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1akm | ORNITHINETRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ARG A 246VAL A 255THR A 230 | None | 0.74A | 3tl9A-1akmA:0.0 | 3tl9A-1akmA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bco | BACTERIOPHAGE MUTRANSPOSASE (Escherichiavirus Mu) |
PF02914(DDE_2)PF09299(Mu-transpos_C) | 3 | ARG A 324VAL A 467THR A 297 | None | 0.81A | 3tl9A-1bcoA:0.0 | 3tl9A-1bcoA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cg4 | PROTEIN(ADENYLOSUCCINATESYNTHETASE) (Escherichiacoli) |
PF00709(Adenylsucc_synt) | 3 | ARG A 272VAL A 313THR A 358 | None | 0.85A | 3tl9A-1cg4A:0.0 | 3tl9A-1cg4A:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 3 | ARG A 185VAL A 303THR A 218 | None | 0.83A | 3tl9A-1flgA:0.0 | 3tl9A-1flgA:10.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fml | RETINOL DEHYDRATASE (Spodopterafrugiperda) |
PF00685(Sulfotransfer_1) | 3 | ARG A 185VAL A 68THR A 79 | A3P A 400 (-2.8A)NoneNone | 0.84A | 3tl9A-1fmlA:0.0 | 3tl9A-1fmlA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fml | RETINOL DEHYDRATASE (Spodopterafrugiperda) |
PF00685(Sulfotransfer_1) | 3 | ARG A 312VAL A 293THR A 77 | A3P A 400 (-3.7A)NoneA3P A 400 (-3.6A) | 0.79A | 3tl9A-1fmlA:0.0 | 3tl9A-1fmlA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 3 | ARG A 394VAL A 464THR A 399 | None | 0.68A | 3tl9A-1fohA:0.0 | 3tl9A-1fohA:9.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | A79 A 800 (-3.4A)A79 A 800 ( 4.4A)None | 0.41A | 3tl9A-1hvcA:14.0 | 3tl9A-1hvcA:47.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | A79 A 800 (-3.6A)A79 A 800 ( 4.3A)None | 0.40A | 3tl9A-1hvcA:14.0 | 3tl9A-1hvcA:47.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iu9 | ASPARTATE RACEMASE (Pyrococcushorikoshii) |
PF01177(Asp_Glu_race) | 3 | ARG A 172VAL A 155THR A 178 | None | 0.87A | 3tl9A-1iu9A:undetectable | 3tl9A-1iu9A:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lar | PROTEIN (LAR) (Homo sapiens) |
PF00102(Y_phosphatase) | 3 | ARG A1505VAL A1829THR A1844 | None | 0.85A | 3tl9A-1larA:0.0 | 3tl9A-1larA:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m4i | AMINOGLYCOSIDE2'-N-ACETYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF13527(Acetyltransf_9) | 3 | ARG A 176VAL A 147THR A 149 | None | 0.88A | 3tl9A-1m4iA:undetectable | 3tl9A-1m4iA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mb9 | BETA-LACTAMSYNTHETASE (Streptomycesclavuligerus) |
PF00733(Asn_synthase)PF13537(GATase_7) | 3 | ARG A 120VAL A 51THR A 30 | None | 0.85A | 3tl9A-1mb9A:undetectable | 3tl9A-1mb9A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mlz | 7,8-DIAMINO-PELARGONIC ACIDAMINOTRANSFERASE (Escherichiacoli) |
PF00202(Aminotran_3) | 3 | ARG A 221VAL A 154THR A 139 | None | 0.61A | 3tl9A-1mlzA:undetectable | 3tl9A-1mlzA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 3 | ARG A 266VAL A 247THR A 71 | None | 0.57A | 3tl9A-1n9bA:undetectable | 3tl9A-1n9bA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ort | ORNITHINETRANSCARBAMOYLASE (Pseudomonasaeruginosa) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ARG A 246VAL A 255THR A 230 | None | 0.65A | 3tl9A-1ortA:undetectable | 3tl9A-1ortA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ow0 | IG ALPHA-1 CHAIN CREGION (Homo sapiens) |
PF00047(ig)PF07654(C1-set) | 3 | ARG A 401VAL A 381THR A 397 | None | 0.80A | 3tl9A-1ow0A:undetectable | 3tl9A-1ow0A:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qge | PROTEIN(TRIACYLGLYCEROLHYDROLASE) (Burkholderiaglumae) |
PF00561(Abhydrolase_1)no annotation | 3 | ARG D 94VAL E 276THR D 192 | None | 0.88A | 3tl9A-1qgeD:undetectable | 3tl9A-1qgeD:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlb | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Wolinellasuccinogenes) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 3 | ARG A 139VAL A 105THR A 159 | None | 0.81A | 3tl9A-1qlbA:undetectable | 3tl9A-1qlbA:12.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8t | HEPARAN SULFATED-GLUCOSAMINYL3-O-SULFOTRANSFERASE3A1 (Homo sapiens) |
PF00685(Sulfotransfer_1) | 3 | ARG A 248VAL A 379THR A 270 | None | 0.64A | 3tl9A-1t8tA:undetectable | 3tl9A-1t8tA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkc | TRANSKETOLASE (Saccharomycescerevisiae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | ARG A 417VAL A 446THR A 441 | None | 0.79A | 3tl9A-1tkcA:undetectable | 3tl9A-1tkcA:9.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulv | GLUCODEXTRANASE (Arthrobacterglobiformis) |
PF00723(Glyco_hydro_15)PF09136(Glucodextran_B)PF09137(Glucodextran_N)PF09985(Glucodextran_C) | 3 | ARG A 768VAL A 418THR A 469 | None | 0.80A | 3tl9A-1ulvA:undetectable | 3tl9A-1ulvA:7.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9l | GLUTAMATEDEHYDROGENASE (Pyrobaculumislandicum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | ARG A 185VAL A 72THR A 148 | None | 0.85A | 3tl9A-1v9lA:undetectable | 3tl9A-1v9lA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vj7 | BIFUNCTIONALRELA/SPOT (Streptococcusdysgalactiae) |
PF04607(RelA_SpoT)PF13328(HD_4) | 3 | ARG A 290VAL A 282THR A 313 | None | 0.71A | 3tl9A-1vj7A:undetectable | 3tl9A-1vj7A:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkk | NUCLEOSIDEDIPHOSPHATE KINASE (Thermusthermophilus) |
PF00334(NDK) | 3 | ARG A 31VAL A 84THR A 4 | None | 0.84A | 3tl9A-1wkkA:undetectable | 3tl9A-1wkkA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wko | TERMINAL FLOWER 1PROTEIN (Arabidopsisthaliana) |
PF01161(PBP) | 3 | ARG A 122VAL A 71THR A 148 | None | 0.84A | 3tl9A-1wkoA:undetectable | 3tl9A-1wkoA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wox | HEME OXYGENASE 2 (Synechocystissp. PCC 6803) |
PF01126(Heme_oxygenase) | 3 | ARG A 39VAL A 205THR A 98 | None | 0.86A | 3tl9A-1woxA:undetectable | 3tl9A-1woxA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb5 | QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ARG A 12VAL A 73THR A 98 | None | 0.66A | 3tl9A-1yb5A:undetectable | 3tl9A-1yb5A:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykd | ADENYLATE CYCLASE (Anabaena sp.) |
PF01590(GAF) | 3 | ARG A 236VAL A 120THR A 92 | None | 0.86A | 3tl9A-1ykdA:undetectable | 3tl9A-1ykdA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yr2 | PROLYLOLIGOPEPTIDASE (Novosphingobiumcapsulatum) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 3 | ARG A 101VAL A 479THR A 429 | None | 0.87A | 3tl9A-1yr2A:undetectable | 3tl9A-1yr2A:8.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ywg | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Plasmodiumfalciparum) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ARG O 16VAL O 290THR O 242 | None | 0.70A | 3tl9A-1ywgO:undetectable | 3tl9A-1ywgO:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9s | TOPOISOMERASE I-LIKEPROTEIN (Leishmaniadonovani) |
PF01028(Topoisom_I)PF02919(Topoisom_I_N) | 3 | ARG A 310VAL A 447THR A 417 | None | 0.85A | 3tl9A-2b9sA:undetectable | 3tl9A-2b9sA:13.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bru | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Escherichiacoli) |
PF02233(PNTB) | 3 | ARG C 58VAL C 109THR C 106 | None | 0.76A | 3tl9A-2bruC:undetectable | 3tl9A-2bruC:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bu2 | PYRUVATEDEHYDROGENSAE KINASEISOENZYME 2 (Homo sapiens) |
PF02518(HATPase_c)PF10436(BCDHK_Adom3) | 3 | ARG A 149VAL A 138THR A 376 | None | 0.85A | 3tl9A-2bu2A:undetectable | 3tl9A-2bu2A:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5s | PROBABLE THIAMINEBIOSYNTHESIS PROTEINTHII (Bacillusanthracis) |
PF02568(ThiI)PF02926(THUMP) | 3 | ARG A 314VAL A 207THR A 272 | None | 0.67A | 3tl9A-2c5sA:undetectable | 3tl9A-2c5sA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2col | BIFUNCTIONALHEMOLYSIN-ADENYLATECYCLASE (Bordetellapertussis) |
PF03497(Anthrax_toxA) | 3 | ARG A 15VAL A 43THR A 48 | None | 0.66A | 3tl9A-2colA:undetectable | 3tl9A-2colA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpw | HYPOTHETICAL PROTEINTTHA0179 (Thermusthermophilus) |
PF12804(NTP_transf_3) | 3 | ARG A 226VAL A 222THR A 131 | None | 0.81A | 3tl9A-2dpwA:undetectable | 3tl9A-2dpwA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2egg | SHIKIMATE5-DEHYDROGENASE (Geobacilluskaustophilus) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 3 | ARG A 173VAL A 146THR A 211 | None | 0.84A | 3tl9A-2eggA:undetectable | 3tl9A-2eggA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ek8 | AMINOPEPTIDASE (Aneurinibacillussp. AM-1) |
PF02225(PA)PF04389(Peptidase_M28) | 3 | ARG A 42VAL A 245THR A 268 | None | 0.79A | 3tl9A-2ek8A:undetectable | 3tl9A-2ek8A:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5t | DIPEPTIDYL PEPTIDASE4 (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 3 | ARG A 184VAL A 155THR A 152 | None | 0.76A | 3tl9A-2g5tA:undetectable | 3tl9A-2g5tA:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 3 | ARG A 422VAL A 246THR A 435 | None | 0.79A | 3tl9A-2gahA:undetectable | 3tl9A-2gahA:7.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gh8 | CAPSID PROTEIN (Vesicularexanthema ofswine virus) |
PF00915(Calici_coat) | 3 | ARG A 385VAL A 612THR A 620 | None | 0.86A | 3tl9A-2gh8A:undetectable | 3tl9A-2gh8A:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h7g | DNA TOPOISOMERASE 1 (Variola virus) |
PF01028(Topoisom_I)PF09266(VirDNA-topo-I_N) | 3 | ARG X 86VAL X 304THR X 278 | None | 0.76A | 3tl9A-2h7gX:undetectable | 3tl9A-2h7gX:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | ARG A 229VAL A 62THR A 94 | None | 0.82A | 3tl9A-2ihtA:undetectable | 3tl9A-2ihtA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzd | REPLICASEPOLYPROTEIN 1AB (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF11633(SUD-M) | 3 | ARG A 625VAL A 635THR A 528 | None | 0.86A | 3tl9A-2jzdA:undetectable | 3tl9A-2jzdA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lc0 | PUTATIVEUNCHARACTERIZEDPROTEIN TB39.8 (Mycobacteriumtuberculosis) |
PF12401(DUF3662) | 3 | ARG A 10VAL A 125THR A 100 | None | 0.78A | 3tl9A-2lc0A:undetectable | 3tl9A-2lc0A:28.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ng1 | SIGNAL SEQUENCERECOGNITION PROTEINFFH (Thermusaquaticus) |
PF00448(SRP54)PF02881(SRP54_N) | 3 | ARG A 36VAL A 43THR A 48 | None | 0.86A | 3tl9A-2ng1A:undetectable | 3tl9A-2ng1A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwq | PROBABLE SHORT-CHAINDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00106(adh_short) | 3 | ARG A 80VAL A 52THR A 50 | None | 0.78A | 3tl9A-2nwqA:undetectable | 3tl9A-2nwqA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oap | TYPE II SECRETIONSYSTEM PROTEIN (Archaeoglobusfulgidus) |
PF00437(T2SSE) | 3 | ARG 1 409VAL 1 265THR 1 276 | None | 0.82A | 3tl9A-2oap1:undetectable | 3tl9A-2oap1:14.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owm | RELATED TOKINESIN-LIKE PROTEINKIF1C (Neurosporacrassa) |
PF00225(Kinesin) | 3 | ARG A 294VAL A 40THR A 415 | None | 0.64A | 3tl9A-2owmA:undetectable | 3tl9A-2owmA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0q | ARYL ESTERASE (Mycolicibacteriumsmegmatis) |
PF13472(Lipase_GDSL_2) | 3 | ARG A 33VAL A 19THR A 25 | GOL A1730 (-2.9A)NoneNone | 0.82A | 3tl9A-2q0qA:undetectable | 3tl9A-2q0qA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjg | PUTATIVE ALDOLASEMJ0400 (Methanocaldococcusjannaschii) |
PF01791(DeoC) | 3 | ARG A 132VAL A 105THR A 140 | None | 0.88A | 3tl9A-2qjgA:undetectable | 3tl9A-2qjgA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpq | PROTEIN BUG27 (Bordetellapertussis) |
PF03401(TctC) | 3 | ARG A 83VAL A 77THR A 293 | None | 0.75A | 3tl9A-2qpqA:undetectable | 3tl9A-2qpqA:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqk | NEUROPILIN-2 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 3 | ARG A 518VAL A 468THR A 367 | None | 0.85A | 3tl9A-2qqkA:undetectable | 3tl9A-2qqkA:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qxl | HEAT SHOCK PROTEINHOMOLOG SSE1 (Saccharomycescerevisiae) |
PF00012(HSP70) | 3 | ARG A 70VAL A 175THR A 210 | None | 0.85A | 3tl9A-2qxlA:undetectable | 3tl9A-2qxlA:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9g | AAA ATPASE, CENTRALREGION (Enterococcusfaecium) |
PF12002(MgsA_C) | 3 | ARG A 278VAL A 320THR A 298 | None | 0.70A | 3tl9A-2r9gA:undetectable | 3tl9A-2r9gA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc3 | CBS DOMAIN (Nitrosomonaseuropaea) |
PF00571(CBS) | 3 | ARG A 124VAL A 102THR A 99 | BR A 171 (-4.4A)None BR A 177 ( 4.2A) | 0.88A | 3tl9A-2rc3A:undetectable | 3tl9A-2rc3A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvd | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 3 | ARG A 60VAL A 92THR A 112 | None | 0.70A | 3tl9A-2uvdA:undetectable | 3tl9A-2uvdA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w45 | ALKALINE EXONUCLEASE (Humangammaherpesvirus4) |
PF01771(Herpes_alk_exo) | 3 | ARG A 45VAL A 32THR A 454 | None | 0.76A | 3tl9A-2w45A:undetectable | 3tl9A-2w45A:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xub | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC3 (Homo sapiens) |
PF05645(RNA_pol_Rpc82)PF08221(HTH_9) | 3 | ARG A 150VAL A 107THR A 95 | None | 0.79A | 3tl9A-2xubA:undetectable | 3tl9A-2xubA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycb | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR (Methanothermobacterthermautotrophicus) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 3 | ARG A 149VAL A 298THR A 274 | None | 0.88A | 3tl9A-2ycbA:undetectable | 3tl9A-2ycbA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfq | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Peptoniphilusasaccharolyticus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | ARG A 187VAL A 73THR A 149 | SO4 A1423 (-2.1A)NoneNone | 0.78A | 3tl9A-2yfqA:undetectable | 3tl9A-2yfqA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z61 | PROBABLE ASPARTATEAMINOTRANSFERASE 2 (Methanocaldococcusjannaschii) |
PF00155(Aminotran_1_2) | 3 | ARG A 230VAL A 48THR A 43 | LLP A 222 ( 2.8A)NoneNone | 0.73A | 3tl9A-2z61A:undetectable | 3tl9A-2z61A:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 3 | ARG A 138VAL A 181THR A 393 | None | 0.84A | 3tl9A-3a2qA:undetectable | 3tl9A-3a2qA:11.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a71 | EXO-ARABINANASE (Penicilliumchrysogenum) |
no annotation | 3 | ARG A 164VAL A 172THR A 137 | None | 0.82A | 3tl9A-3a71A:undetectable | 3tl9A-3a71A:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axs | PROBABLEN(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASETRM1 (Aquifexaeolicus) |
PF02005(TRM) | 3 | ARG A 192VAL A 358THR A 355 | None | 0.78A | 3tl9A-3axsA:undetectable | 3tl9A-3axsA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckb | SUSD (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB) | 3 | ARG A 294VAL A 303THR A 316 | None | 0.79A | 3tl9A-3ckbA:undetectable | 3tl9A-3ckbA:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cps | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Cryptosporidiumparvum) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ARG A 252VAL A 261THR A 169 | None | 0.81A | 3tl9A-3cpsA:undetectable | 3tl9A-3cpsA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3y | UNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF05193(Peptidase_M16_C) | 3 | ARG A 343VAL A 274THR A 350 | None | 0.84A | 3tl9A-3d3yA:undetectable | 3tl9A-3d3yA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff2 | UNCHARACTERIZEDCYSTATIN FOLDPROTEIN(YP_497570.1) FROMNTF2 SUPERFAMILY (Novosphingobiumaromaticivorans) |
PF12680(SnoaL_2) | 3 | ARG A 111VAL A 23THR A 47 | None | 0.80A | 3tl9A-3ff2A:undetectable | 3tl9A-3ff2A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkj | PUTATIVEPHOSPHOSUGARISOMERASES (Salmonellaenterica) |
PF01380(SIS) | 3 | ARG A 23VAL A 92THR A 64 | None | 0.86A | 3tl9A-3fkjA:undetectable | 3tl9A-3fkjA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grf | ORNITHINECARBAMOYLTRANSFERASE (Giardiaintestinalis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ARG A 255VAL A 264THR A 239 | None | 0.80A | 3tl9A-3grfA:undetectable | 3tl9A-3grfA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gt5 | N-ACETYLGLUCOSAMINE2-EPIMERASE (Xylellafastidiosa) |
PF07221(GlcNAc_2-epim) | 3 | ARG A 204VAL A 125THR A 147 | None | 0.71A | 3tl9A-3gt5A:undetectable | 3tl9A-3gt5A:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdx | SUSD SUPERFAMILYPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | ARG A 161VAL A 106THR A 68 | None | 0.83A | 3tl9A-3hdxA:undetectable | 3tl9A-3hdxA:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ARG A 15VAL A 338THR A 304 | GAE A 411 (-3.0A)NoneNone | 0.87A | 3tl9A-3hpfA:undetectable | 3tl9A-3hpfA:13.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2m | ORF59 (Humangammaherpesvirus8) |
PF04929(Herpes_DNAp_acc) | 3 | ARG X 21VAL X 48THR X 30 | None | 0.85A | 3tl9A-3i2mX:undetectable | 3tl9A-3i2mX:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in5 | DNA POLYMERASE KAPPA (Homo sapiens) |
PF00817(IMS)PF11798(IMS_HHH)PF11799(IMS_C) | 3 | ARG A 298VAL A 177THR A 305 | None | 0.87A | 3tl9A-3in5A:undetectable | 3tl9A-3in5A:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ism | CG4930CG8862 (Drosophilamelanogaster) |
PF01223(Endonuclease_NS)PF08785(Ku_PK_bind) | 3 | ARG A 153VAL C 50THR C 55 | None | 0.79A | 3tl9A-3ismA:undetectable | 3tl9A-3ismA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3it4 | ARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ ALPHA CHAIN (Mycobacteriumtuberculosis) |
PF01960(ArgJ) | 3 | ARG A 133VAL A 124THR A 102 | None | 0.87A | 3tl9A-3it4A:undetectable | 3tl9A-3it4A:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 3 | ARG A 94VAL A 519THR A 148 | None | 0.77A | 3tl9A-3jb9A:undetectable | 3tl9A-3jb9A:3.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksd | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE1 (Staphylococcusaureus) |
no annotation | 3 | ARG Q 15VAL Q 284THR Q 239 | None | 0.67A | 3tl9A-3ksdQ:undetectable | 3tl9A-3ksdQ:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kya | PUTATIVE PHOSPHATASE (Bacteroidesthetaiotaomicron) |
PF01833(TIG) | 3 | ARG A 466VAL A 462THR A 444 | None | 0.85A | 3tl9A-3kyaA:undetectable | 3tl9A-3kyaA:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6r | SERINE RACEMASE (Homo sapiens) |
PF00291(PALP) | 3 | ARG A 277VAL A 293THR A 38 | None | 0.83A | 3tl9A-3l6rA:undetectable | 3tl9A-3l6rA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll9 | ISOPENTENYLPHOSPHATE KINASE (Methanothermobacterthermautotrophicus) |
PF00696(AA_kinase) | 3 | ARG A 59VAL A 142THR A 80 | None | 0.88A | 3tl9A-3ll9A:undetectable | 3tl9A-3ll9A:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 3 | ARG A 295VAL A 284THR A 22 | None | 0.84A | 3tl9A-3lm6A:undetectable | 3tl9A-3lm6A:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mcu | DIPICOLINATESYNTHASE, B CHAIN (Bacillus cereus) |
PF02441(Flavoprotein) | 3 | ARG A 37VAL A 124THR A 117 | None | 0.65A | 3tl9A-3mcuA:undetectable | 3tl9A-3mcuA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mcu | DIPICOLINATESYNTHASE, B CHAIN (Bacillus cereus) |
PF02441(Flavoprotein) | 3 | ARG A 170VAL A 125THR A 177 | None | 0.87A | 3tl9A-3mcuA:undetectable | 3tl9A-3mcuA:21.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | None | 0.69A | 3tl9A-3mwsA:19.8 | 3tl9A-3mwsA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ol2 | SEMAPHORIN-4D (Homo sapiens) |
PF00047(ig)PF01403(Sema)PF01437(PSI) | 3 | ARG A 412VAL A 404THR A 332 | None | 0.84A | 3tl9A-3ol2A:undetectable | 3tl9A-3ol2A:9.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdw | UNCHARACTERIZEDHYDROLASE YUTF (Bacillussubtilis) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | ARG A 124VAL A 119THR A 147 | None | 0.82A | 3tl9A-3pdwA:undetectable | 3tl9A-3pdwA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r6o | 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATEISOMERASE (Mycobacteroidesabscessus) |
PF01557(FAA_hydrolase) | 3 | ARG A 129VAL A 125THR A 197 | None | 0.86A | 3tl9A-3r6oA:undetectable | 3tl9A-3r6oA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 3 | ARG A 504VAL A 473THR A 457 | None | 0.75A | 3tl9A-3r75A:undetectable | 3tl9A-3r75A:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhy | N(G),N(G)-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 3 | ARG A 85VAL A 160THR A 165 | HM3 A 255 ( 4.7A)NoneNone | 0.73A | 3tl9A-3rhyA:undetectable | 3tl9A-3rhyA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sr6 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | ARG C1279VAL C1310THR C1286 | None | 0.86A | 3tl9A-3sr6C:undetectable | 3tl9A-3sr6C:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 3 | ARG A 440VAL A 360THR A 34 | None | 0.43A | 3tl9A-3tsdA:undetectable | 3tl9A-3tsdA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u44 | ATP-DEPENDENTHELICASE/DEOXYRIBONUCLEASE SUBUNIT B (Bacillussubtilis) |
PF12705(PDDEXK_1) | 3 | ARG B 84VAL B 75THR B 79 | None | 0.86A | 3tl9A-3u44B:undetectable | 3tl9A-3u44B:6.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi3 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 3 | ARG A 423VAL A 369THR A 292 | None | 0.80A | 3tl9A-3vi3A:undetectable | 3tl9A-3vi3A:11.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vys | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPD (Thermococcuskodakarensis) |
PF01924(HypD) | 3 | ARG B 84VAL B 73THR B 106 | None | 0.70A | 3tl9A-3vysB:undetectable | 3tl9A-3vysB:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdj | TYPE I PULLULANASE (Anoxybacillussp. LM18-11) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 3 | ARG A 321VAL A 344THR A 301 | None | 0.84A | 3tl9A-3wdjA:undetectable | 3tl9A-3wdjA:9.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wst | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Caenorhabditiselegans) |
PF13649(Methyltransf_25) | 3 | ARG A 122VAL A 118THR A 73 | SAH A 701 (-4.0A)NoneNone | 0.85A | 3tl9A-3wstA:undetectable | 3tl9A-3wstA:10.82 |