SIMILAR PATTERNS OF AMINO ACIDS FOR 3TKD_A_CYZA266_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli)
PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3)
4 ILE A  54
PRO A  23
LYS A  52
GLY A  50
None
1.06A 3tkdB-1b63A:
undetectable
3tkdB-1b63A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa)
PF00135
(COesterase)
4 ILE A  26
PRO A  27
SER A  55
GLY A  25
None
1.04A 3tkdB-1crlA:
undetectable
3tkdB-1crlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN


(Escherichia
virus T4)
PF13597
(NRDD)
4 ILE A 402
PRO A 320
SER A 479
GLY A 403
None
1.04A 3tkdB-1h79A:
undetectable
3tkdB-1h79A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 PRO A 362
SER A  31
LYS A  30
GLY A  29
None
1.17A 3tkdB-1j3nA:
undetectable
3tkdB-1j3nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN


(Methanosarcina
mazei)
PF00801
(PKD)
PF10282
(Lactonase)
4 ILE A 295
PRO A 253
SER A   1
GLY A 296
None
0.96A 3tkdB-1l0qA:
undetectable
3tkdB-1l0qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A


(Escherichia
coli)
PF00248
(Aldo_ket_red)
4 ILE A 230
SER A 233
LYS A 232
GLY A  22
None
PO4  A 901 (-2.6A)
None
None
0.97A 3tkdB-1mzrA:
undetectable
3tkdB-1mzrA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1


(Bos taurus)
PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N)
4 ILE A 339
PRO A 335
LYS A 341
GLY A 340
None
1.07A 3tkdB-1pztA:
undetectable
3tkdB-1pztA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF01467
(CTP_transf_like)
4 ILE A  21
PRO A 120
SER A 128
GLY A  17
None
None
SO4  A1161 (-4.8A)
None
1.10A 3tkdB-1qjcA:
undetectable
3tkdB-1qjcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)


(Rhinovirus A)
PF00073
(Rhv)
4 ILE 2 225
PRO 2 226
SER 2 157
GLY 2  77
None
1.15A 3tkdB-1r1a2:
undetectable
3tkdB-1r1a2:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
4 ILE A 196
PRO A  54
SER A 199
GLY A 197
None
YSA  A3001 (-4.1A)
None
YSA  A3001 (-3.6A)
1.04A 3tkdB-1vbmA:
undetectable
3tkdB-1vbmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq7 HYPOTHETICAL PROTEIN
MM0484


(Methanosarcina
mazei)
PF01871
(AMMECR1)
4 ILE A 125
PRO A 147
LYS A 127
GLY A 126
None
0.86A 3tkdB-1zq7A:
undetectable
3tkdB-1zq7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
4 ILE B 152
PRO B 149
SER B 116
GLY B 114
None
0.98A 3tkdB-2akaB:
undetectable
3tkdB-2akaB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B


(Homo sapiens)
PF03416
(Peptidase_C54)
4 ILE A 256
PRO A 145
SER A 262
GLY A 257
None
1.02A 3tkdB-2cy7A:
undetectable
3tkdB-2cy7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmh MYOFERLIN

(Homo sapiens)
PF00168
(C2)
4 ILE A  64
PRO A  65
SER A 139
GLY A  63
None
1.00A 3tkdB-2dmhA:
undetectable
3tkdB-2dmhA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6n STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00567
(TUDOR)
4 ILE A  41
PRO A  27
SER A  78
GLY A  82
None
1.07A 3tkdB-2e6nA:
undetectable
3tkdB-2e6nA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eoq ZINC FINGER PROTEIN
224


(Homo sapiens)
no annotation 4 ILE A  17
SER A  21
LYS A  20
GLY A  19
ZN  A 201 ( 4.2A)
None
None
None
1.15A 3tkdB-2eoqA:
undetectable
3tkdB-2eoqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B


(Methanosarcina
mazei)
PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans)
4 ILE B 320
PRO B 319
SER B 341
GLY B 321
None
1.11A 3tkdB-2q2eB:
undetectable
3tkdB-2q2eB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE


(Mycobacterium
tuberculosis)
PF00692
(dUTPase)
4 ILE A 146
SER A 102
LYS A 101
GLY A 147
None
0.97A 3tkdB-2qlpA:
undetectable
3tkdB-2qlpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
4 ILE A 184
PRO A 193
SER A 180
GLY A 183
FAD  A1535 (-4.2A)
None
FAD  A1535 (-3.2A)
FAD  A1535 (-3.3A)
1.13A 3tkdB-2qpmA:
undetectable
3tkdB-2qpmA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 124
PRO A 137
SER A 121
GLY A 251
None
1.14A 3tkdB-2rcbA:
30.3
3tkdB-2rcbA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdm RESPONSE REGULATOR
RECEIVER PROTEIN


(Sinorhizobium
medicae)
PF00072
(Response_reg)
4 ILE A  40
PRO A  62
SER A  34
GLY A  36
None
1.18A 3tkdB-2rdmA:
undetectable
3tkdB-2rdmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE


(Trypanosoma
brucei)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
4 ILE A 419
SER A 526
LYS A 527
GLY A 528
None
1.15A 3tkdB-2x0sA:
undetectable
3tkdB-2x0sA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00155
(Aminotran_1_2)
4 ILE A  76
PRO A  77
SER A  73
GLY A  75
None
1.18A 3tkdB-2x5dA:
undetectable
3tkdB-2x5dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE


(Paracoccus
pantotrophus)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
4 ILE A 413
PRO A 393
LYS A 395
GLY A 412
GOL  A1432 (-4.0A)
None
None
None
1.17A 3tkdB-2xtsA:
undetectable
3tkdB-2xtsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE


(Flavobacterium
frigidimaris)
PF01370
(Epimerase)
4 ILE A 145
PRO A 139
SER A  80
GLY A 144
None
None
GOL  A1001 (-3.6A)
None
1.14A 3tkdB-2yy7A:
undetectable
3tkdB-2yy7A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1


(Homo sapiens)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 504
PRO A 517
LYS A 747
GLY A 748
None
0.18A 3tkdB-2znsA:
37.7
3tkdB-2znsA:
53.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION


(Ruegeria
pomeroyi)
no annotation 4 ILE A  88
PRO A  97
LYS A 102
GLY A  89
None
1.13A 3tkdB-3cvoA:
undetectable
3tkdB-3cvoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum)
PF00128
(Alpha-amylase)
4 ILE A  54
SER A 112
LYS A  70
GLY A  55
None
1.17A 3tkdB-3dhuA:
undetectable
3tkdB-3dhuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum)
PF00082
(Peptidase_S8)
4 ILE A 268
PRO A 269
SER A 194
GLY A 267
None
1.11A 3tkdB-3f7oA:
undetectable
3tkdB-3f7oA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN


(Bacteroides
vulgatus)
PF12715
(Abhydrolase_7)
4 ILE A 143
PRO A 261
SER A 146
GLY A 258
None
0.74A 3tkdB-3g8yA:
undetectable
3tkdB-3g8yA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
5 ILE A  92
PRO A 105
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
GOL  A 270 ( 3.0A)
None
None
0.18A 3tkdB-3h6tA:
42.7
3tkdB-3h6tA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)


(Borreliella
burgdorferi)
PF00072
(Response_reg)
4 ILE A  18
PRO A  25
SER A  47
GLY A  17
None
1.17A 3tkdB-3hzhA:
undetectable
3tkdB-3hzhA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2


(Thermus
thermophilus)
PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S)
4 ILE 1 254
PRO 1 261
SER 2 127
GLY 1 262
None
None
FES  2 182 (-4.4A)
None
1.14A 3tkdB-3i9v1:
undetectable
3tkdB-3i9v1:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ILE A  82
SER A  97
LYS A 115
GLY A 116
None
1.01A 3tkdB-3k8zA:
undetectable
3tkdB-3k8zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei)
PF01593
(Amino_oxidase)
4 ILE A 198
PRO A 191
LYS A 196
GLY A 197
None
1.17A 3tkdB-3ka7A:
undetectable
3tkdB-3ka7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
4 ILE A 481
SER A 471
LYS A 469
GLY A 468
None
KCX  A 490 ( 4.2A)
None
None
1.17A 3tkdB-3la4A:
undetectable
3tkdB-3la4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lft UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF04392
(ABC_sub_bind)
5 ILE A 282
PRO A 166
SER A 317
LYS A 316
GLY A 315
None
1.32A 3tkdB-3lftA:
undetectable
3tkdB-3lftA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9g PROTEIN KINASE

(Staphylococcus
aureus)
PF03793
(PASTA)
4 ILE A 383
SER A 386
LYS A 385
GLY A 384
None
1.10A 3tkdB-3m9gA:
undetectable
3tkdB-3m9gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM


(Rhodopseudomonas
palustris)
no annotation 4 ILE B 147
PRO B 249
LYS B 149
GLY B 148
None
0.76A 3tkdB-3nndB:
undetectable
3tkdB-3nndB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuz PUTATIVE ACETYL
XYLAN ESTERASE


(Bacteroides
fragilis)
PF12715
(Abhydrolase_7)
4 ILE A 143
PRO A 261
SER A 146
GLY A 258
None
0.76A 3tkdB-3nuzA:
undetectable
3tkdB-3nuzA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica)
PF00390
(malic)
PF03949
(Malic_M)
4 ILE A 130
PRO A 364
LYS A 125
GLY A 128
None
1.07A 3tkdB-3nv9A:
undetectable
3tkdB-3nv9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus)
PF00248
(Aldo_ket_red)
4 ILE A 247
SER A 250
LYS A 249
GLY A  39
None
1.15A 3tkdB-3o0kA:
undetectable
3tkdB-3o0kA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE


(Mus musculus)
PF00155
(Aminotran_1_2)
4 ILE A 113
PRO A 111
SER A 117
GLY A 114
None
1.01A 3tkdB-3pdxA:
undetectable
3tkdB-3pdxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py9 PROTEIN KINASE

(Staphylococcus
aureus)
PF03793
(PASTA)
4 ILE A  13
SER A  16
LYS A  15
GLY A  14
None
1.01A 3tkdB-3py9A:
undetectable
3tkdB-3py9A:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2


(Homo sapiens)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 488
PRO A 501
LYS A 731
GLY A 732
None
0.28A 3tkdB-3qxmA:
37.7
3tkdB-3qxmA:
52.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
4 ILE A  91
PRO A 104
LYS A 213
GLY A 214
None
0.31A 3tkdB-3u92A:
37.6
3tkdB-3u92A:
52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE


(Aspergillus
fumigatus)
PF13450
(NAD_binding_8)
4 ILE A 221
PRO A 213
SER A  48
GLY A 220
None
1.14A 3tkdB-3ukfA:
undetectable
3tkdB-3ukfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF04850
(Baculo_E66)
4 ILE A 473
SER A 370
LYS A 371
GLY A 386
None
0.80A 3tkdB-3vsmA:
undetectable
3tkdB-3vsmA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525)
no annotation 4 ILE A 303
PRO A 380
SER A 487
GLY A 492
None
1.05A 3tkdB-3w36A:
undetectable
3tkdB-3w36A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE


(Gluconobacter
oxydans)
PF00248
(Aldo_ket_red)
4 ILE A 205
PRO A 216
LYS A 207
GLY A 206
None
1.16A 3tkdB-3wbxA:
undetectable
3tkdB-3wbxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE


(Gluconobacter
oxydans)
PF00248
(Aldo_ket_red)
4 ILE A 232
SER A 235
LYS A 234
GLY A  28
None
None
SO4  A 301 (-4.2A)
None
1.09A 3tkdB-3wbxA:
undetectable
3tkdB-3wbxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Cupriavidus
necator)
PF01370
(Epimerase)
4 ILE A 146
PRO A 140
SER A  81
GLY A 145
None
None
THR  A 402 (-2.8A)
None
1.08A 3tkdB-3wmxA:
undetectable
3tkdB-3wmxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE


(Bacteroides
thetaiotaomicron)
PF03663
(Glyco_hydro_76)
4 ILE A 414
PRO A 391
SER A 385
GLY A 389
None
1.15A 3tkdB-4c1sA:
undetectable
3tkdB-4c1sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus)
PF03446
(NAD_binding_2)
4 ILE A 145
SER A 148
LYS A 147
GLY A 146
None
1.17A 3tkdB-4d3dA:
undetectable
3tkdB-4d3dA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE


(Trypanosoma
cruzi)
PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8)
4 ILE A 214
PRO A 207
SER A  46
GLY A 211
None
None
FDA  A 502 (-3.1A)
None
1.12A 3tkdB-4dshA:
undetectable
3tkdB-4dshA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E


(Burkholderia
thailandensis)
PF01370
(Epimerase)
4 ILE A 119
PRO A 135
LYS A 143
GLY A 140
None
None
NAP  A 401 (-3.0A)
None
1.15A 3tkdB-4ej0A:
undetectable
3tkdB-4ej0A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE


(Trypanosoma
cruzi)
PF00248
(Aldo_ket_red)
4 ILE A 232
SER A 235
LYS A 234
GLY A  22
None
0.85A 3tkdB-4fziA:
undetectable
3tkdB-4fziA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Burkholderia
thailandensis)
PF00171
(Aldedh)
4 ILE A  95
PRO A 116
SER A  20
GLY A 142
None
1.19A 3tkdB-4ghkA:
undetectable
3tkdB-4ghkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
4 ILE A1255
PRO A1253
SER A1345
GLY A1254
None
1.14A 3tkdB-4iglA:
undetectable
3tkdB-4iglA:
11.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 126
PRO A 139
SER A 123
GLY A 253
None
1.11A 3tkdB-4kcdA:
29.7
3tkdB-4kcdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 126
PRO A 139
SER A 144
GLY A 251
None
1.02A 3tkdB-4kcdA:
29.7
3tkdB-4kcdA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA


(Shewanella
oneidensis)
no annotation 4 ILE A 299
PRO A 129
LYS A 304
GLY A 303
None
None
HEC  A 802 ( 4.4A)
None
1.11A 3tkdB-4lmhA:
undetectable
3tkdB-4lmhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
4 ILE A 185
PRO A 194
SER A 181
GLY A 184
FAD  A 601 (-4.3A)
None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.3A)
1.13A 3tkdB-4oalA:
undetectable
3tkdB-4oalA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis)
PF07737
(ATLF)
PF09156
(Anthrax-tox_M)
4 ILE A 525
SER A 553
LYS A 552
GLY A 526
None
0.91A 3tkdB-4pkvA:
undetectable
3tkdB-4pkvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE


(Homo sapiens)
PF00365
(PFK)
4 ILE A 689
PRO A 536
SER A 723
GLY A 721
None
0.98A 3tkdB-4u1rA:
undetectable
3tkdB-4u1rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE


(Pectobacterium
atrosepticum)
PF02275
(CBAH)
4 ILE A 134
PRO A  98
SER A 106
GLY A 104
None
0.87A 3tkdB-4wl2A:
undetectable
3tkdB-4wl2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE


(Vibrio cholerae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 PRO A 354
SER A  31
LYS A  30
GLY A  29
None
1.17A 3tkdB-4xoxA:
undetectable
3tkdB-4xoxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
4 ILE A  16
PRO A  80
SER A  26
GLY A  78
None
1.11A 3tkdB-4yjiA:
2.4
3tkdB-4yjiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 ILE A 209
PRO A 293
SER A 224
GLY A 222
None
1.00A 3tkdB-4zfmA:
undetectable
3tkdB-4zfmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE


(Thermotoga
maritima)
PF01370
(Epimerase)
4 ILE A 121
PRO A 139
LYS A 147
GLY A 144
None
None
NAD  A 401 (-2.8A)
None
0.96A 3tkdB-4zrmA:
undetectable
3tkdB-4zrmA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B


(Bacillus
subtilis)
PF02386
(TrkH)
4 ILE I 418
PRO I 420
SER I 312
GLY I 416
None
1.16A 3tkdB-5butI:
undetectable
3tkdB-5butI:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN


(Leishmania
donovani)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 ILE A 128
PRO A 129
SER A 125
GLY A 127
None
1.06A 3tkdB-5cfkA:
undetectable
3tkdB-5cfkA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera)
PF07899
(Frigida)
4 ILE A 246
PRO A 247
SER A 243
GLY A 245
None
1.13A 3tkdB-5ch6A:
undetectable
3tkdB-5ch6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN


(Influenza C
virus)
PF00603
(Flu_PA)
4 ILE A 238
PRO A 667
SER A 662
GLY A 664
None
0.98A 3tkdB-5d9aA:
undetectable
3tkdB-5d9aA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT


(Homo sapiens)
PF12851
(Tet_JBP)
4 ILE A1859
SER A1189
LYS A1188
GLY A1187
None
1.08A 3tkdB-5deuA:
undetectable
3tkdB-5deuA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE


(Neurospora
crassa)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
4 ILE A 777
SER A 784
LYS A 782
GLY A 781
None
1.18A 3tkdB-5e02A:
undetectable
3tkdB-5e02A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e05 NUCLEOCAPSID PROTEIN

(Sin Nombre
orthohantavirus)
PF00846
(Hanta_nucleocap)
4 ILE A 280
PRO A 316
SER A 121
LYS A 120
None
0.71A 3tkdB-5e05A:
undetectable
3tkdB-5e05A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum)
PF03568
(Peptidase_C50)
4 ILE A2077
PRO A2076
SER A2054
GLY A2024
None
0.94A 3tkdB-5fbyA:
undetectable
3tkdB-5fbyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN


(Enterococcus
faecalis)
no annotation 4 ILE A 446
PRO A 447
SER A 428
GLY A 445
None
1.13A 3tkdB-5h29A:
undetectable
3tkdB-5h29A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2)
PF01425
(Amidase)
4 ILE A  13
PRO A  76
SER A  23
GLY A  74
None
1.18A 3tkdB-5h6sA:
undetectable
3tkdB-5h6sA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
4 ILE A1928
PRO A1929
SER A1862
GLY A1927
None
1.08A 3tkdB-5i6gA:
undetectable
3tkdB-5i6gA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
4 ILE A1928
PRO A1929
SER A1862
GLY A1927
None
1.09A 3tkdB-5i6hA:
undetectable
3tkdB-5i6hA:
10.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster)
PF10613
(Lig_chan-Glu_bd)
4 ILE A  98
PRO A 111
LYS A 223
GLY A 224
None
0.22A 3tkdB-5ictA:
38.6
3tkdB-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
4 ILE A  91
PRO A 104
LYS A 214
GLY A 215
None
0.39A 3tkdB-5ikbA:
36.7
3tkdB-5ikbA:
55.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im4 PHOSPHOTRANSFERASE
SYSTEM,
MANNOSE/FRUCTOSE-SPE
CIFIC COMPONENT IIA


(Caldanaerobacter
subterraneus)
PF03610
(EIIA-man)
4 ILE F 121
PRO F  97
LYS F 123
GLY F 122
None
1.17A 3tkdB-5im4F:
2.5
3tkdB-5im4F:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 MEDI578 SCFV, HEAVY
CHAIN


(Homo sapiens)
PF07686
(V-set)
4 ILE C  52
PRO C  52
SER C  96
GLY C  33
None
1.17A 3tkdB-5jz7C:
undetectable
3tkdB-5jz7C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
4 ILE A 394
PRO A 395
SER A  38
GLY A 393
None
None
6TO  A 800 ( 4.3A)
None
0.88A 3tkdB-5kjuA:
undetectable
3tkdB-5kjuA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2


(Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 488
PRO A 501
LYS A 731
GLY A 732
None
0.70A 3tkdB-5kufA:
35.0
3tkdB-5kufA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2


(Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
4 ILE A 481
PRO A 494
LYS A 730
GLY A 731
None
0.53A 3tkdB-5l1bA:
21.7
3tkdB-5l1bA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5low RABPHILIN-3A

(Rattus
norvegicus)
PF00168
(C2)
4 ILE A 634
SER A 637
LYS A 636
GLY A 635
None
None
CA  A 703 ( 3.8A)
None
1.02A 3tkdB-5lowA:
undetectable
3tkdB-5lowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN


(Psathyrella)
PF13517
(VCBS)
4 ILE A  15
PRO A  16
SER A 291
GLY A 348
None
1.19A 3tkdB-5mb4A:
undetectable
3tkdB-5mb4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III


(Bacteroides
thetaiotaomicron)
no annotation 4 ILE A  36
PRO A 378
LYS A 628
GLY A 629
None
1.10A 3tkdB-5na7A:
undetectable
3tkdB-5na7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1


(Arabidopsis
thaliana)
no annotation 4 ILE A 137
SER A  54
LYS A  52
GLY A 138
None
1.17A 3tkdB-5tosA:
undetectable
3tkdB-5tosA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus)
no annotation 4 ILE A  47
PRO A  48
SER A  24
GLY A  46
None
1.18A 3tkdB-5uffA:
undetectable
3tkdB-5uffA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd)
5 ILE A 481
PRO A 494
SER A 729
LYS A 730
GLY A 731
None
0.85A 3tkdB-5welA:
31.6
3tkdB-5welA:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 ILE A 481
PRO A 494
SER A 729
LYS A 730
GLY A 731
None
CYZ  A1302 (-4.5A)
None
GLU  A1301 ( 3.7A)
None
0.61A 3tkdB-5weoA:
24.5
3tkdB-5weoA:
33.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 4 ILE C 229
SER C 232
LYS C 231
GLY C 470
None
1.07A 3tkdB-5x6xC:
undetectable
3tkdB-5x6xC:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE


(Pseudomonas sp.
MC1)
PF13561
(adh_short_C2)
4 ILE B  16
PRO B 224
SER B 188
GLY B  15
NAD  B 301 (-3.7A)
None
BPY  B 303 ( 4.9A)
NAD  B 301 (-3.2A)
1.12A 3tkdB-5xtgB:
undetectable
3tkdB-5xtgB:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5


(Homo sapiens)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
4 ILE B 482
PRO B 483
SER B 230
LYS B 233
None
1.19A 3tkdB-5y3rB:
undetectable
3tkdB-5y3rB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G


(Pyrococcus
furiosus)
no annotation 4 PRO C  67
SER A  27
LYS A  22
GLY A  23
None
1.14A 3tkdB-6cfwC:
undetectable
3tkdB-6cfwC:
15.85