SIMILAR PATTERNS OF AMINO ACIDS FOR 3TJ7_C_ACTC610_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		3 ASN A 180
ALA A 244
ARG A 178
 None
 0.80A 3tj7C-1bdbA:
0.0
3tj7D-1bdbA:
0.0		 3tj7C-1bdbA:
19.78
3tj7D-1bdbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		3 ASN A 211
ALA A 209
ARG A 192
 None
 0.83A 3tj7C-1dq3A:
0.0
3tj7D-1dq3A:
0.0		 3tj7C-1dq3A:
18.40
3tj7D-1dq3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA

(Pariacoto virus) 		PF01829
(Peptidase_A6) 		3 ASN A 195
ALA A 193
ARG A 215
 None
 0.56A 3tj7C-1f8vA:
0.0
3tj7D-1f8vA:
0.0		 3tj7C-1f8vA:
17.32
3tj7D-1f8vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		3 ASN A  54
ALA A 129
ARG A 143
 None
 0.88A 3tj7C-1harA:
0.0
3tj7D-1harA:
0.0		 3tj7C-1harA:
19.57
3tj7D-1harA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhs MOG1 PROTEIN

(Saccharomyces
cerevisiae) 		PF04603
(Mog1) 		3 ASN A  84
ALA A  82
ARG A 194
 None
 0.80A 3tj7C-1jhsA:
3.0
3tj7D-1jhsA:
4.3		 3tj7C-1jhsA:
21.46
3tj7D-1jhsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 ASN A 276
ALA A 280
ARG A 328
 None
 0.89A 3tj7C-1jhzA:
0.0
3tj7D-1jhzA:
0.0		 3tj7C-1jhzA:
21.45
3tj7D-1jhzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ASN A 492
ALA A 226
ARG A 230
 None
 0.90A 3tj7C-1knrA:
0.0
3tj7D-1knrA:
0.0		 3tj7C-1knrA:
17.22
3tj7D-1knrA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		3 ASN A 446
ALA A 440
ARG A 386
 None
 0.65A 3tj7C-1lrtA:
0.0
3tj7D-1lrtA:
0.0		 3tj7C-1lrtA:
20.00
3tj7D-1lrtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ASN A 446
ALA A 440
ARG A 386
 None
 0.74A 3tj7C-1mewA:
0.0
3tj7D-1mewA:
0.0		 3tj7C-1mewA:
18.53
3tj7D-1mewA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A  40
ALA A 127
ARG A 318
 None
NDP  A1325 ( 4.0A)
None
 0.84A 3tj7C-1o8cA:
undetectable
3tj7D-1o8cA:
1.0		 3tj7C-1o8cA:
20.06
3tj7D-1o8cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ASN A1330
ALA A 368
ARG A 353
 None
 0.65A 3tj7C-1ofeA:
undetectable
3tj7D-1ofeA:
undetectable		 3tj7C-1ofeA:
9.39
3tj7D-1ofeA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Escherichia
coli) 		PF02962
(CHMI) 		3 ASN A  11
ALA A  60
ARG A  99
 None
 0.70A 3tj7C-1otgA:
undetectable
3tj7D-1otgA:
undetectable		 3tj7C-1otgA:
22.39
3tj7D-1otgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		3 ASN A 175
ALA A 141
ARG A 103
 CNB  A 400 (-3.9A)
CNB  A 400 ( 4.7A)
None
 0.90A 3tj7C-1r1nA:
undetectable
3tj7D-1r1nA:
undetectable		 3tj7C-1r1nA:
18.91
3tj7D-1r1nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		3 ASN A 193
ALA A 141
ARG A 103
 CNB  A 400 (-4.6A)
CNB  A 400 ( 4.7A)
None
 0.74A 3tj7C-1r1nA:
undetectable
3tj7D-1r1nA:
undetectable		 3tj7C-1r1nA:
18.91
3tj7D-1r1nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1reg T4 REGA

(Escherichia
virus T4) 		PF01818
(Translat_reg) 		3 ASN X  27
ALA X  25
ARG X 102
 None
 0.84A 3tj7C-1regX:
undetectable
3tj7D-1regX:
undetectable		 3tj7C-1regX:
21.13
3tj7D-1regX:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A  44
ALA A 131
ARG A 325
 None
 0.86A 3tj7C-1tt7A:
undetectable
3tj7D-1tt7A:
undetectable		 3tj7C-1tt7A:
23.74
3tj7D-1tt7A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		3 ASN A  43
ALA A 130
ARG A 322
 SO4  A 329 (-4.7A)
SO4  A 329 ( 4.2A)
None
 0.75A 3tj7C-1xa0A:
undetectable
3tj7D-1xa0A:
undetectable		 3tj7C-1xa0A:
21.19
3tj7D-1xa0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		3 ASN A 183
ALA A 237
ARG A 181
 None
 0.77A 3tj7C-1zjyA:
undetectable
3tj7D-1zjyA:
undetectable		 3tj7C-1zjyA:
19.61
3tj7D-1zjyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 3 ASN P 269
ALA P 317
ARG P 274
 None
 0.74A 3tj7C-2btvP:
undetectable
3tj7D-2btvP:
undetectable		 3tj7C-2btvP:
20.86
3tj7D-2btvP:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 ASN A 153
ALA A 150
ARG A 144
 None
 0.81A 3tj7C-2cl2A:
1.3
3tj7D-2cl2A:
1.3		 3tj7C-2cl2A:
20.46
3tj7D-2cl2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cov BETA-1,3-XYLANASE

(Alcaligenes sp.
XY-234) 		PF11606
(AlcCBM31) 		3 ASN D 469
ALA D 427
ARG D 429
 None
 0.83A 3tj7C-2covD:
undetectable
3tj7D-2covD:
undetectable		 3tj7C-2covD:
17.09
3tj7D-2covD:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp3 CASPASE NC

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		3 ASN A 202
ALA A 216
ARG A 213
 None
 0.79A 3tj7C-2fp3A:
undetectable
3tj7D-2fp3A:
undetectable		 3tj7C-2fp3A:
19.94
3tj7D-2fp3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		3 ASN B 228
ALA A 260
ARG A 256
 None
 0.86A 3tj7C-2fpgB:
undetectable
3tj7D-2fpgB:
1.9		 3tj7C-2fpgB:
18.99
3tj7D-2fpgB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 ASN A 184
ALA A 270
ARG A 233
 FMN  A4401 (-4.6A)
FMN  A4401 ( 4.5A)
FMN  A4401 (-2.8A)
 0.83A 3tj7C-2gouA:
undetectable
3tj7D-2gouA:
undetectable		 3tj7C-2gouA:
17.68
3tj7D-2gouA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 ASN A 228
ALA A 230
ARG A 303
 None
 0.88A 3tj7C-2iopA:
undetectable
3tj7D-2iopA:
undetectable		 3tj7C-2iopA:
14.94
3tj7D-2iopA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		3 ASN A 501
ALA A 508
ARG A 397
 None
 0.86A 3tj7C-2j7nA:
undetectable
3tj7D-2j7nA:
undetectable		 3tj7C-2j7nA:
11.22
3tj7D-2j7nA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		3 ASN A  52
ALA A 120
ARG A 144
 SO4  A 223 (-3.3A)
SO4  A 223 (-3.6A)
SO4  A 223 (-3.1A)
 0.59A 3tj7C-2o2gA:
undetectable
3tj7D-2o2gA:
undetectable		 3tj7C-2o2gA:
21.22
3tj7D-2o2gA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE

(Bacillus
anthracis) 		PF01678
(DAP_epimerase) 		3 ASN A 149
ALA A 158
ARG A 147
 None
 0.89A 3tj7C-2otnA:
undetectable
3tj7D-2otnA:
undetectable		 3tj7C-2otnA:
20.95
3tj7D-2otnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 ASN A 211
ALA A 213
ARG A 215
 None
 0.75A 3tj7C-2pncA:
undetectable
3tj7D-2pncA:
undetectable		 3tj7C-2pncA:
14.27
3tj7D-2pncA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		3 ASN A  81
ALA A  91
ARG A  98
 None
None
NLG  A2001 (-4.0A)
 0.87A 3tj7C-2rd5A:
undetectable
3tj7D-2rd5A:
undetectable		 3tj7C-2rd5A:
23.47
3tj7D-2rd5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ASN A 876
ALA A 906
ARG A 926
 None
 0.85A 3tj7C-2vdcA:
undetectable
3tj7D-2vdcA:
undetectable		 3tj7C-2vdcA:
9.07
3tj7D-2vdcA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		3 ASN A 103
ALA A 105
ARG A 125
 None
 0.62A 3tj7C-2w7zA:
undetectable
3tj7D-2w7zA:
undetectable		 3tj7C-2w7zA:
18.47
3tj7D-2w7zA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 ASN A 296
ALA A 257
ARG A 240
 None
 0.90A 3tj7C-3aquA:
undetectable
3tj7D-3aquA:
undetectable		 3tj7C-3aquA:
19.37
3tj7D-3aquA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c30 AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio cholerae) 		PF09308
(LuxQ-periplasm) 		3 ASN A 110
ALA A  70
ARG A  67
 None
 0.60A 3tj7C-3c30A:
undetectable
3tj7D-3c30A:
undetectable		 3tj7C-3c30A:
21.03
3tj7D-3c30A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		3 ASN A 197
ALA A 297
ARG A  81
 None
 0.74A 3tj7C-3c3vA:
undetectable
3tj7D-3c3vA:
undetectable		 3tj7C-3c3vA:
17.39
3tj7D-3c3vA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634

(Shewanella
baltica) 		PF13640
(2OG-FeII_Oxy_3) 		3 ASN A  85
ALA A 169
ARG A 167
 None
 0.78A 3tj7C-3dkqA:
undetectable
3tj7D-3dkqA:
undetectable		 3tj7C-3dkqA:
22.18
3tj7D-3dkqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 ASN A 148
ALA A 132
ARG A 151
 None
 0.88A 3tj7C-3eqnA:
undetectable
3tj7D-3eqnA:
undetectable		 3tj7C-3eqnA:
12.15
3tj7D-3eqnA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		3 ASN A 402
ALA A 277
ARG A 409
 NIE  A 600 ( 4.1A)
None
GOL  A 700 ( 3.9A)
 0.89A 3tj7C-3fcjA:
undetectable
3tj7D-3fcjA:
undetectable		 3tj7C-3fcjA:
18.04
3tj7D-3fcjA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8i 30KLP

(Treponema
pallidum) 		no annotation 3 ASN A 223
ALA A 270
ARG A  61
 None
 0.84A 3tj7C-3k8iA:
undetectable
3tj7D-3k8iA:
undetectable		 3tj7C-3k8iA:
20.22
3tj7D-3k8iA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 ASN A 228
ALA A 200
ARG A 208
 None
 0.91A 3tj7C-3l0oA:
undetectable
3tj7D-3l0oA:
undetectable		 3tj7C-3l0oA:
20.42
3tj7D-3l0oA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ASN A 289
ALA A 283
ARG A 356
 None
 0.54A 3tj7C-3lmlA:
undetectable
3tj7D-3lmlA:
undetectable		 3tj7C-3lmlA:
17.47
3tj7D-3lmlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A  40
ALA A 127
ARG A 318
 None
NAP  A 330 ( 4.2A)
None
 0.82A 3tj7C-3nx4A:
undetectable
3tj7D-3nx4A:
undetectable		 3tj7C-3nx4A:
19.51
3tj7D-3nx4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		3 ASN A 539
ALA A 239
ARG A 244
 None
 0.79A 3tj7C-3tw0A:
undetectable
3tj7D-3tw0A:
undetectable		 3tj7C-3tw0A:
19.50
3tj7D-3tw0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ASN A 431
ALA A 414
ARG A 416
 None
 0.87A 3tj7C-3uk1A:
undetectable
3tj7D-3uk1A:
undetectable		 3tj7C-3uk1A:
12.38
3tj7D-3uk1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 ASN A 552
ALA A 522
ARG A 637
 None
 0.87A 3tj7C-3ut2A:
undetectable
3tj7D-3ut2A:
undetectable		 3tj7C-3ut2A:
14.15
3tj7D-3ut2A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		3 ASN A  79
ALA A  75
ARG A 413
 None
 0.69A 3tj7C-4d7eA:
undetectable
3tj7D-4d7eA:
undetectable		 3tj7C-4d7eA:
18.18
3tj7D-4d7eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		3 ASN A 199
ALA A 258
ARG A 197
 None
 0.79A 3tj7C-4dqxA:
undetectable
3tj7D-4dqxA:
undetectable		 3tj7C-4dqxA:
21.66
3tj7D-4dqxA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		3 ASN A 206
ALA A 458
ARG A 529
 None
 0.76A 3tj7C-4f9dA:
undetectable
3tj7D-4f9dA:
undetectable		 3tj7C-4f9dA:
15.05
3tj7D-4f9dA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 ASN A 428
ALA A 431
ARG A 456
 None
 0.81A 3tj7C-4ftdA:
undetectable
3tj7D-4ftdA:
undetectable		 3tj7C-4ftdA:
17.67
3tj7D-4ftdA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi7 GI20122

(Drosophila
mojavensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 ASN A 110
ALA A 134
ARG A 131
 None
 0.83A 3tj7C-4hi7A:
undetectable
3tj7D-4hi7A:
undetectable		 3tj7C-4hi7A:
20.94
3tj7D-4hi7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoj REGF PROTEIN

(Neisseria
gonorrhoeae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN A  64
ALA A 153
ARG A  15
 None
 0.90A 3tj7C-4hojA:
undetectable
3tj7D-4hojA:
undetectable		 3tj7C-4hojA:
19.21
3tj7D-4hojA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz4 GLUTATHIONE-S-TRANSF
ERASE

(Actinobacillus
pleuropneumoniae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN A  69
ALA A 161
ARG A  16
 None
 0.87A 3tj7C-4hz4A:
undetectable
3tj7D-4hz4A:
undetectable		 3tj7C-4hz4A:
22.98
3tj7D-4hz4A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 ASN B 420
ALA B 418
ARG B  59
 None
 0.87A 3tj7C-4iglB:
undetectable
3tj7D-4iglB:
undetectable		 3tj7C-4iglB:
14.74
3tj7D-4iglB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 ASN B 446
ALA B 418
ARG B  59
 None
 0.91A 3tj7C-4iglB:
undetectable
3tj7D-4iglB:
undetectable		 3tj7C-4iglB:
14.74
3tj7D-4iglB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		3 ASN A 170
ALA A 241
ARG A  25
 None
 0.90A 3tj7C-4jkxA:
undetectable
3tj7D-4jkxA:
undetectable		 3tj7C-4jkxA:
19.76
3tj7D-4jkxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4png LD04004P

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 ASN A 110
ALA A 134
ARG A 131
 None
 0.77A 3tj7C-4pngA:
undetectable
3tj7D-4pngA:
undetectable		 3tj7C-4pngA:
23.08
3tj7D-4pngA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		3 ASN A 223
ALA A 221
ARG A 236
 None
 0.76A 3tj7C-4q7aA:
undetectable
3tj7D-4q7aA:
undetectable		 3tj7C-4q7aA:
18.93
3tj7D-4q7aA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		3 ASN B 731
ALA B 733
ARG B 738
 None
 0.86A 3tj7C-4qlpB:
undetectable
3tj7D-4qlpB:
undetectable		 3tj7C-4qlpB:
18.69
3tj7D-4qlpB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 190
ALA A 192
ARG A 250
 None
 0.72A 3tj7C-4qorA:
undetectable
3tj7D-4qorA:
0.3		 3tj7C-4qorA:
16.92
3tj7D-4qorA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		3 ASN A 184
ALA A 238
ARG A 182
 None
 0.76A 3tj7C-4rf3A:
undetectable
3tj7D-4rf3A:
undetectable		 3tj7C-4rf3A:
18.08
3tj7D-4rf3A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpd CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 ASN A 441
ALA A 443
ARG A 430
 None
 0.81A 3tj7C-4rpdA:
undetectable
3tj7D-4rpdA:
undetectable		 3tj7C-4rpdA:
20.98
3tj7D-4rpdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ASN A 188
ALA A 199
ARG A 159
 None
 0.72A 3tj7C-4udrA:
undetectable
3tj7D-4udrA:
undetectable		 3tj7C-4udrA:
16.67
3tj7D-4udrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		3 ASN A 241
ALA A 205
ARG A 244
 None
None
SO4  A1456 (-4.0A)
 0.85A 3tj7C-4uz1A:
undetectable
3tj7D-4uz1A:
undetectable		 3tj7C-4uz1A:
21.26
3tj7D-4uz1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4q SORTASE, SRTB FAMILY

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		3 ASN A 247
ALA A 194
ARG A 249
 None
 0.80A 3tj7C-4y4qA:
undetectable
3tj7D-4y4qA:
undetectable		 3tj7C-4y4qA:
21.48
3tj7D-4y4qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh2 GLUTATHIONE S
TRANSFERASE E6

(Drosophila
melanogaster) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		3 ASN A 110
ALA A 134
ARG A 131
 None
 0.82A 3tj7C-4yh2A:
undetectable
3tj7D-4yh2A:
undetectable		 3tj7C-4yh2A:
20.83
3tj7D-4yh2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 ASN A 314
ALA A 306
ARG A 117
 None
 0.90A 3tj7C-4ymkA:
undetectable
3tj7D-4ymkA:
undetectable		 3tj7C-4ymkA:
20.81
3tj7D-4ymkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASN A2901
ALA A2823
ARG A2827
 None
 0.87A 3tj7C-4z37A:
undetectable
3tj7D-4z37A:
undetectable		 3tj7C-4z37A:
15.63
3tj7D-4z37A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		3 ASN A 361
ALA A 318
ARG A 243
 None
 0.80A 3tj7C-4zelA:
undetectable
3tj7D-4zelA:
1.3		 3tj7C-4zelA:
16.02
3tj7D-4zelA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 ASN A 318
ALA A 310
ARG A 121
 None
 0.88A 3tj7C-4zyoA:
undetectable
3tj7D-4zyoA:
undetectable		 3tj7C-4zyoA:
19.30
3tj7D-4zyoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN ALPHA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		3 ASN A  30
ALA A  34
ARG A  37
 None
 0.89A 3tj7C-5b13A:
undetectable
3tj7D-5b13A:
undetectable		 3tj7C-5b13A:
18.93
3tj7D-5b13A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 ASN A 413
ALA A 445
ARG A 329
 None
 0.73A 3tj7C-5c70A:
undetectable
3tj7D-5c70A:
undetectable		 3tj7C-5c70A:
14.65
3tj7D-5c70A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 ASN A  36
ALA A  48
ARG A  83
 None
 0.82A 3tj7C-5cuyA:
undetectable
3tj7D-5cuyA:
undetectable		 3tj7C-5cuyA:
18.60
3tj7D-5cuyA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1

(Homo sapiens) 		PF15005
(IZUMO)
PF16706
(Izumo-Ig) 		3 ASN A 239
ALA A 158
ARG A 160
 None
 0.74A 3tj7C-5f4eA:
undetectable
3tj7D-5f4eA:
undetectable		 3tj7C-5f4eA:
21.29
3tj7D-5f4eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 ASN A 365
ALA A 353
ARG A 149
 None
 0.79A 3tj7C-5fbzA:
undetectable
3tj7D-5fbzA:
undetectable		 3tj7C-5fbzA:
17.97
3tj7D-5fbzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		3 ASN A  43
ALA A 130
ARG A 323
 None
 0.79A 3tj7C-5gxfA:
undetectable
3tj7D-5gxfA:
undetectable		 3tj7C-5gxfA:
19.57
3tj7D-5gxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 3 ASN A 226
ALA A 231
ARG A 235
 None
 0.72A 3tj7C-5h6oA:
undetectable
3tj7D-5h6oA:
1.2		 3tj7C-5h6oA:
18.65
3tj7D-5h6oA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		3 ASN A 532
ALA A 433
ARG A 503
 None
None
SO4  A 702 (-3.9A)
 0.62A 3tj7C-5j6qA:
undetectable
3tj7D-5j6qA:
undetectable		 3tj7C-5j6qA:
15.29
3tj7D-5j6qA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ASN A 128
ALA A 126
ARG A 129
 None
 0.66A 3tj7C-5ja1A:
1.6
3tj7D-5ja1A:
undetectable		 3tj7C-5ja1A:
9.37
3tj7D-5ja1A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		3 ASN A 245
ALA A 300
ARG A 243
 None
 0.73A 3tj7C-5jydA:
undetectable
3tj7D-5jydA:
undetectable		 3tj7C-5jydA:
17.92
3tj7D-5jydA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 3 ASN B 420
ALA B 418
ARG B  59
 None
 0.86A 3tj7C-5kisB:
undetectable
3tj7D-5kisB:
undetectable		 3tj7C-5kisB:
11.24
3tj7D-5kisB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, B14.5B
SUBUNIT

(Ovis aries) 		no annotation 3 ASN o  46
ALA o  56
ARG o  51
 None
 0.60A 3tj7C-5lnko:
undetectable
3tj7D-5lnko:
undetectable		 3tj7C-5lnko:
18.78
3tj7D-5lnko:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		3 ASN A 435
ALA A 472
ARG A 474
 None
 0.91A 3tj7C-5n97A:
undetectable
3tj7D-5n97A:
undetectable		 3tj7C-5n97A:
11.15
3tj7D-5n97A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuq PROBABLE
PHOSPHOLIPID-BINDING
LIPOPROTEIN MLAA

(Serratia
marcescens) 		no annotation 3 ASN G  90
ALA G 102
ARG G  86
 None
 0.81A 3tj7C-5nuqG:
undetectable
3tj7D-5nuqG:
undetectable		 3tj7C-5nuqG:
20.16
3tj7D-5nuqG:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nur ABC TRANSPORTER
PERMEASE

(Klebsiella
pneumoniae) 		no annotation 3 ASN D  91
ALA D 103
ARG D  87
 None
 0.80A 3tj7C-5nurD:
undetectable
3tj7D-5nurD:
undetectable		 3tj7C-5nurD:
21.07
3tj7D-5nurD:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L10
50S RIBOSOMAL
PROTEIN L11

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF00466
(Ribosomal_L10)
PF00298
(Ribosomal_L11)
PF03946
(Ribosomal_L11_N) 		3 ASN J 119
ALA I  37
ARG I  41
 G  A1176 ( 3.4A)
U  A1200 ( 3.4A)
None
 0.84A 3tj7C-5o60J:
undetectable
3tj7D-5o60J:
undetectable		 3tj7C-5o60J:
21.46
3tj7D-5o60J:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upb ACETOACETATE
DECARBOXYLASE

(Sphingomonas
wittichii) 		PF06314
(ADC) 		3 ASN A 204
ALA A 180
ARG A  96
 None
 0.75A 3tj7C-5upbA:
2.0
3tj7D-5upbA:
2.0		 3tj7C-5upbA:
17.56
3tj7D-5upbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD

(Escherichia
coli) 		PF02470
(MlaD) 		3 ASN A 115
ALA A 113
ARG A 102
 None
 0.68A 3tj7C-5uw2A:
undetectable
3tj7D-5uw2A:
undetectable		 3tj7C-5uw2A:
18.69
3tj7D-5uw2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uw8 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD

(Escherichia
coli) 		PF02470
(MlaD) 		3 ASN A 115
ALA A 113
ARG A 102
 None
 0.77A 3tj7C-5uw8A:
undetectable
3tj7D-5uw8A:
undetectable		 3tj7C-5uw8A:
19.49
3tj7D-5uw8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		3 ASN C 281
ALA C 300
ARG C 284
 C  M  38 ( 3.8A)
None
C  M  38 ( 3.2A)
 0.78A 3tj7C-5uz9C:
undetectable
3tj7D-5uz9C:
undetectable		 3tj7C-5uz9C:
19.06
3tj7D-5uz9C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6l HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A37

(Oryctolagus
cuniculus) 		no annotation 3 ASN H 101
ALA H  96
ARG H  94
 None
 0.83A 3tj7C-5v6lH:
undetectable
3tj7D-5v6lH:
undetectable		 3tj7C-5v6lH:
undetectable
3tj7D-5v6lH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES

(Drosophila
melanogaster) 		no annotation 3 ASN A1228
ALA A1189
ARG A1157
 None
 0.78A 3tj7C-5vjcA:
undetectable
3tj7D-5vjcA:
undetectable		 3tj7C-5vjcA:
24.44
3tj7D-5vjcA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 ASN A 315
ALA A 300
ARG A 319
 None
 0.88A 3tj7C-5vocA:
undetectable
3tj7D-5vocA:
undetectable		 3tj7C-5vocA:
14.67
3tj7D-5vocA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 3 ASN A 862
ALA A 127
ARG A 131
 None
 0.89A 3tj7C-6bogA:
undetectable
3tj7D-6bogA:
undetectable		 3tj7C-6bogA:
undetectable
3tj7D-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 ASN A1117
ALA A1130
ARG A1128
 None
 0.66A 3tj7C-6bq1A:
undetectable
3tj7D-6bq1A:
undetectable		 3tj7C-6bq1A:
undetectable
3tj7D-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D

(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		no annotation
no annotation 		3 ASN D 133
ALA D 131
ARG C 191
 None
 0.83A 3tj7C-6btmD:
undetectable
3tj7D-6btmD:
undetectable		 3tj7C-6btmD:
undetectable
3tj7D-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 3 ASN A 497
ALA A 501
ARG A 500
 None
 0.86A 3tj7C-6dk2A:
undetectable
3tj7D-6dk2A:
undetectable		 3tj7C-6dk2A:
undetectable
3tj7D-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa;
Sus scrofa) 		no annotation
no annotation 		3 ASN C 177
ALA C 174
ARG B 803
 None
 0.87A 3tj7C-6exvC:
undetectable
3tj7D-6exvC:
undetectable		 3tj7C-6exvC:
undetectable
3tj7D-6exvC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 3 ASN B 716
ALA B 714
ARG B 720
 None
 0.85A 3tj7C-6f42B:
undetectable
3tj7D-6f42B:
undetectable		 3tj7C-6f42B:
undetectable
3tj7D-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 3 ASN D 270
ALA D 235
ARG D 236
 None
 0.89A 3tj7C-6f5dD:
undetectable
3tj7D-6f5dD:
undetectable		 3tj7C-6f5dD:
undetectable
3tj7D-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 3 ASN A2314
ALA A2409
ARG A2131
 None
 0.88A 3tj7C-6fayA:
undetectable
3tj7D-6fayA:
undetectable		 3tj7C-6fayA:
undetectable
3tj7D-6fayA:
undetectable