SIMILAR PATTERNS OF AMINO ACIDS FOR 3TJ7_C_ACTC608

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci0 PROTEIN (PNP
OXIDASE)

(Saccharomyces
cerevisiae) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		4 GLU A 195
ARG A 209
ARG A 120
GLU A 122
 None
 1.42A 3tj7C-1ci0A:
undetectable		 3tj7C-1ci0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 GLU A 135
LYS A  21
ARG A  51
GLU A  87
 None
 1.25A 3tj7C-1i9aA:
undetectable		 3tj7C-1i9aA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001

(Pyrococcus
furiosus) 		PF01928
(CYTH) 		4 GLU A  72
ARG A 102
ARG A  47
GLU A  74
 UNX  A 205 ( 4.0A)
UNX  A 204 (-3.6A)
UNX  A 205 ( 3.8A)
UNX  A 205 ( 4.9A)
 0.96A 3tj7C-1yemA:
13.5		 3tj7C-1yemA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aca PUTATIVE ADENYLATE
CYCLASE

(Vibrio
parahaemolyticus) 		PF01928
(CYTH) 		5 GLU A  14
ARG A  65
LYS A  78
ARG A 115
GLU A 138
 PO4  A 304 (-2.8A)
PO4  A 304 (-2.7A)
PO4  A 304 (-3.8A)
PO4  A 304 (-2.8A)
PO4  A 304 ( 3.4A)
 1.06A 3tj7C-2acaA:
13.7		 3tj7C-2acaA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 GLU A  72
ARG A 102
ARG A  47
GLU A  74
 None
CL  A 502 ( 3.3A)
CL  A 502 (-3.6A)
None
 1.00A 3tj7C-2dc4A:
13.2		 3tj7C-2dc4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 GLU A 127
ARG A  47
LYS A  60
ARG A 102
 None
CL  A 502 (-3.6A)
CL  A 502 ( 3.8A)
CL  A 502 ( 3.3A)
 0.95A 3tj7C-2dc4A:
13.2		 3tj7C-2dc4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 GLU A 127
ARG A  47
LYS A  60
GLU A 113
 None
CL  A 502 (-3.6A)
CL  A 502 ( 3.8A)
CL  A 502 ( 4.4A)
 1.34A 3tj7C-2dc4A:
13.2		 3tj7C-2dc4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2een HYPOTHETICAL PROTEIN
PH1819

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 GLU A   3
ARG A  52
LYS A  67
GLU A 137
 None
 1.09A 3tj7C-2eenA:
14.2		 3tj7C-2eenA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2een HYPOTHETICAL PROTEIN
PH1819

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		5 GLU A   5
ARG A  52
LYS A  67
ARG A 111
GLU A 135
 None
 0.89A 3tj7C-2eenA:
14.2		 3tj7C-2eenA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2een HYPOTHETICAL PROTEIN
PH1819

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 GLU A 135
ARG A  50
LYS A 109
GLU A   5
 None
 1.28A 3tj7C-2eenA:
14.2		 3tj7C-2eenA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gfg BH2851

(Bacillus
halodurans) 		PF01928
(CYTH) 		5 GLU A   8
ARG A  57
LYS A  68
ARG A 125
GLU A 151
 EDO  A 503 ( 3.9A)
UNL  A 500 ( 3.4A)
UNL  A 500 ( 3.7A)
UNL  A 500 (-3.6A)
UNL  A 500 ( 2.8A)
 0.83A 3tj7C-2gfgA:
25.8		 3tj7C-2gfgA:
45.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p06 HYPOTHETICAL PROTEIN
AF_0060

(Archaeoglobus
fulgidus) 		PF03819
(MazG) 		4 GLU A  47
ARG A  24
LYS A  17
GLU A  50
 MG  A 101 (-3.0A)
None
None
MG  A 101 (-3.2A)
 0.98A 3tj7C-2p06A:
undetectable		 3tj7C-2p06A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p06 HYPOTHETICAL PROTEIN
AF_0060

(Archaeoglobus
fulgidus) 		PF03819
(MazG) 		4 GLU A  50
ARG A  24
ARG A  21
GLU A  47
 MG  A 101 (-3.2A)
None
None
MG  A 101 (-3.0A)
 1.26A 3tj7C-2p06A:
undetectable		 3tj7C-2p06A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dup MUTT/NUDIX FAMILY
PROTEIN

(Rhodospirillum
rubrum) 		PF15916
(DUF4743) 		4 GLU A 174
ARG A 106
LYS A 142
GLU A 170
 None
PO4  A 299 ( 3.3A)
PO4  A 299 (-3.1A)
None
 1.42A 3tj7C-3dupA:
undetectable		 3tj7C-3dupA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF02940
(mRNA_triPase) 		4 GLU A 307
LYS A 409
ARG A 458
GLU A 494
 None
 1.31A 3tj7C-3kyhA:
8.9		 3tj7C-3kyhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0z ADENYLATE CYCLASE 2

(Yersinia pestis) 		PF01928
(CYTH) 		5 GLU A  12
ARG A  63
LYS A  76
ARG A 113
GLU A 136
 MN  A 182 ( 3.4A)
3AT  A 181 (-3.0A)
3AT  A 181 (-3.4A)
3AT  A 181 (-3.1A)
MN  A 182 ( 2.1A)
 1.19A 3tj7C-3n0zA:
13.3		 3tj7C-3n0zA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tj7 GBAA_1210 PROTEIN

(Bacillus
anthracis) 		PF01928
(CYTH) 		4 GLU A   8
LYS A  66
ARG A 123
GLU A 149
 None
 0.91A 3tj7C-3tj7A:
29.8		 3tj7C-3tj7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tvl THIAMINE-TRIPHOSPHAT
ASE

(Homo sapiens) 		PF01928
(CYTH) 		4 GLU A 159
ARG A  57
LYS A  65
ARG A 125
 3PO  A 231 ( 4.3A)
3PO  A 231 (-3.0A)
3PO  A 231 (-2.7A)
3PO  A 231 (-2.9A)
 1.08A 3tj7C-3tvlA:
12.6		 3tj7C-3tvlA:
30.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 ARG A  54
LYS A  76
ARG A 143
GLU A   4
 CIT  A 301 (-2.8A)
CIT  A 301 (-2.8A)
CIT  A 301 (-3.0A)
CIT  A 301 ( 3.9A)
 1.39A 3tj7C-3v85A:
18.5		 3tj7C-3v85A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 GLU A   2
ARG A  54
ARG A 143
GLU A   4
 CIT  A 301 ( 4.2A)
CIT  A 301 (-2.8A)
CIT  A 301 (-3.0A)
CIT  A 301 ( 3.9A)
 1.15A 3tj7C-3v85A:
18.5		 3tj7C-3v85A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		5 GLU A   4
ARG A  54
LYS A  76
ARG A 143
GLU A 169
 CIT  A 301 ( 3.9A)
CIT  A 301 (-2.8A)
CIT  A 301 (-2.8A)
CIT  A 301 (-3.0A)
CIT  A 301 (-2.6A)
 0.81A 3tj7C-3v85A:
18.5		 3tj7C-3v85A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 GLU A 168
ARG A  33
LYS A  10
GLU A 167
 None
 1.49A 3tj7C-3w08A:
undetectable		 3tj7C-3w08A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 GLU A  39
ARG A  77
LYS A 161
GLU A 194
 None
 1.36A 3tj7C-4ckbA:
7.7		 3tj7C-4ckbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ARG A 324
LYS A 261
ARG A 297
GLU A 312
 SO4  A 402 ( 4.9A)
ADP  A 401 (-2.5A)
SO4  A 402 (-3.7A)
ADP  A 401 (-3.3A)
 1.50A 3tj7C-4fu0A:
undetectable		 3tj7C-4fu0A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		5 GLU A   6
ARG A  58
LYS A  69
ARG A 126
GLU A 160
 MG  A 501 (-2.6A)
3PO  A1000 (-2.9A)
3PO  A1000 (-2.8A)
3PO  A1000 (-2.8A)
MG  A 500 ( 2.0A)
 0.89A 3tj7C-5a60A:
15.6		 3tj7C-5a60A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		4 GLU A 162
ARG A  58
LYS A  69
ARG A 126
 MG  A 501 (-3.0A)
3PO  A1000 (-2.9A)
3PO  A1000 (-2.8A)
3PO  A1000 (-2.8A)
 1.17A 3tj7C-5a60A:
15.6		 3tj7C-5a60A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a65 THIAMINE
TRIPHOSPHATASE

(Mus musculus) 		PF01928
(CYTH) 		4 GLU A 157
ARG A  55
LYS A 193
GLU A 159
 MG  A 500 (-2.7A)
TPP  A1000 (-3.2A)
TPP  A1000 (-2.8A)
MG  A 501 (-1.9A)
 1.11A 3tj7C-5a65A:
11.1		 3tj7C-5a65A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a65 THIAMINE
TRIPHOSPHATASE

(Mus musculus) 		PF01928
(CYTH) 		4 GLU A 157
ARG A  57
LYS A 193
GLU A 159
 MG  A 500 (-2.7A)
TPP  A1000 ( 3.2A)
TPP  A1000 (-2.8A)
MG  A 501 (-1.9A)
 1.10A 3tj7C-5a65A:
11.1		 3tj7C-5a65A:
26.11