SIMILAR PATTERNS OF AMINO ACIDS FOR 3TIC_A_ZMRA1002_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2) 		PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin) 		4 LEU A  40
ARG A  52
ILE A  79
ARG A  82
 None
 1.48A 3ticA-1bu2A:
undetectable		 3ticA-1bu2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU C 310
ARG C 507
ILE C 290
ARG C 294
 None
 0.99A 3ticA-1d7wC:
undetectable		 3ticA-1d7wC:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 LEU C 229
ARG C 166
ARG C 206
ARG C 165
 None
 1.04A 3ticA-1h2tC:
undetectable		 3ticA-1h2tC:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 4 LEU A 350
ARG A 357
ILE A 327
ARG A 360
 None
 1.27A 3ticA-1hz4A:
undetectable		 3ticA-1hz4A:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU N 134
ARG N 152
ARG N 156
ILE N 222
ARG N 224
 None
 0.35A 3ticA-1nmbN:
63.9		 3ticA-1nmbN:
47.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 140
ARG A 158
ARG A 162
ILE A 229
ARG A 231
 None
 0.21A 3ticA-1v0zA:
64.9		 3ticA-1v0zA:
43.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 LEU A 132
ARG A 150
ARG A 154
ILE A 221
ARG A 223
 None
IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
IBA  A   1 ( 4.3A)
IBA  A   1 ( 4.5A)
 0.47A 3ticA-1vcjA:
54.2		 3ticA-1vcjA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 135
ARG A 153
ARG A 157
ILE A 224
ARG A 226
 None
ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
ABW  A1000 ( 4.7A)
None
 0.49A 3ticA-1xogA:
63.9		 3ticA-1xogA:
41.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xty PEPTIDYL-TRNA
HYDROLASE

(Sulfolobus
solfataricus) 		PF01981
(PTH2) 		4 LEU A 117
ARG A  70
ILE A  97
ARG A   9
 None
None
None
SO4  A 807 (-2.7A)
 1.46A 3ticA-1xtyA:
undetectable		 3ticA-1xtyA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE

(Methanothermobacter
thermautotrophicus) 		PF01502
(PRA-CH) 		4 LEU A  66
ARG A  48
ARG A  49
ARG A  44
 None
 1.37A 3ticA-1zpsA:
undetectable		 3ticA-1zpsA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 297
ARG A 295
ILE A 276
ARG A 292
 None
 1.41A 3ticA-2c47A:
undetectable		 3ticA-2c47A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE

(Variovorax sp.
Pal2) 		PF13714
(PEP_mutase) 		4 LEU A 159
ARG A 171
ILE A 131
ARG A 170
 None
 1.28A 3ticA-2duaA:
undetectable		 3ticA-2duaA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
 0.55A 3ticA-2htvA:
62.6		 3ticA-2htvA:
41.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 383
ARG A 393
ILE A 376
ARG A 221
 None
 1.27A 3ticA-2ibuA:
undetectable		 3ticA-2ibuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK

(Escherichia
coli) 		PF02586
(SRAP) 		4 LEU A  61
ARG A 184
ARG A 180
ILE A 187
 None
 1.49A 3ticA-2icuA:
undetectable		 3ticA-2icuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		4 ARG A 368
ARG A 369
ILE A 377
ARG A 374
 None
HEM  A 401 (-2.2A)
None
None
 1.45A 3ticA-2nwbA:
undetectable		 3ticA-2nwbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 ARG A  15
ARG A 364
ILE A  19
ARG A  17
 None
 1.23A 3ticA-2oz8A:
undetectable		 3ticA-2oz8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppy ENOYL-COA HYDRATASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 LEU A 121
ARG A 126
ILE A 181
ARG A 162
 None
 1.37A 3ticA-2ppyA:
undetectable		 3ticA-2ppyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		4 LEU A 192
ARG A 227
ARG A 230
ARG A 202
 None
 1.41A 3ticA-2zieA:
undetectable		 3ticA-2zieA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bby UNCHARACTERIZED
GST-LIKE PROTEIN
YFCF

(Escherichia
coli) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 LEU A 134
ARG A 177
ARG A 120
ARG A 117
 None
 1.40A 3ticA-3bbyA:
undetectable		 3ticA-3bbyA:
16.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
ZMR  A 469 (-4.4A)
 0.66A 3ticA-3ckzA:
64.0		 3ticA-3ckzA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr8 YNCA

(Salmonella
enterica) 		PF13420
(Acetyltransf_4) 		4 LEU A 134
ARG A  98
ILE A   3
ARG A 103
 None
 1.14A 3ticA-3dr8A:
undetectable		 3ticA-3dr8A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 LEU A3430
ARG A3428
ILE A3391
ARG A3425
 None
 1.23A 3ticA-3hwcA:
undetectable		 3ticA-3hwcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		4 LEU A 269
ARG A 266
ILE A 484
ARG A 492
 None
 1.22A 3ticA-3nztA:
undetectable		 3ticA-3nztA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 LEU A 113
ARG A 118
ILE A 172
ARG A 153
 None
 1.41A 3ticA-3qkaA:
undetectable		 3ticA-3qkaA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 LEU A 117
ARG A 122
ILE A 176
ARG A 157
 None
 1.40A 3ticA-3r9qA:
undetectable		 3ticA-3r9qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 LEU A 122
ARG A 127
ILE A 182
ARG A 163
 GOL  A 270 (-4.6A)
GOL  A 270 (-3.0A)
None
None
 1.37A 3ticA-3sllA:
undetectable		 3ticA-3sllA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
LNV  A 901 (-4.1A)
 0.11A 3ticA-3ti8A:
65.2		 3ticA-3ti8A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
LNV  A 801 (-4.2A)
 0.06A 3ticA-3tiaA:
76.6		 3ticA-3tiaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.19A 3ticA-3u7vA:
undetectable		 3ticA-3u7vA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
ARG A 225
 None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
 0.26A 3ticA-4b7jA:
64.0		 3ticA-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 LEU A 131
ARG A 149
ARG A 153
ILE A 220
ARG A 222
 None
ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
ZMR  A 700 (-3.8A)
 0.22A 3ticA-4cpnA:
55.2		 3ticA-4cpnA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 LEU A 115
ARG A 124
ARG A 119
ILE A 198
 None
 1.22A 3ticA-4d1iA:
undetectable		 3ticA-4d1iA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
SLB  A 512 (-3.8A)
None
None
SLB  A 512 (-4.2A)
 0.08A 3ticA-4h53A:
76.4		 3ticA-4h53A:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
 0.18A 3ticA-4hzzA:
64.7		 3ticA-4hzzA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 LEU A 157
ARG A 114
ILE A 262
ARG A 266
 None
 1.25A 3ticA-4ineA:
undetectable		 3ticA-4ineA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbb PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Klebsiella
pneumoniae) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 LEU A 134
ARG A 177
ARG A 120
ARG A 117
 None
FMT  A 302 (-2.9A)
None
None
 1.19A 3ticA-4jbbA:
undetectable		 3ticA-4jbbA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
27S  A 501 (-4.2A)
None
27S  A 501 ( 4.6A)
27S  A 501 (-4.3A)
 0.57A 3ticA-4mjuA:
62.7		 3ticA-4mjuA:
42.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp4 GLUTATHIONE
S-TRANSFERASE

(Acinetobacter
baumannii) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 LEU A 132
ARG A 175
ARG A 118
ARG A 115
 None
 1.49A 3ticA-4mp4A:
undetectable		 3ticA-4mp4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt4 GILGAMESH, ISOFORM I

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 LEU A 300
ARG A 298
ILE A 279
ARG A 295
 None
 1.23A 3ticA-4nt4A:
undetectable		 3ticA-4nt4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 224
ARG A 221
ILE A 175
ARG A 233
 None
 1.16A 3ticA-4oc9A:
undetectable		 3ticA-4oc9A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 177
ARG A 172
ILE A 100
ARG A 105
 None
 1.31A 3ticA-4oqjA:
undetectable		 3ticA-4oqjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 320
ARG A 326
ILE A 306
ARG A 333
 None
 1.34A 3ticA-4px9A:
undetectable		 3ticA-4px9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU A 113
ARG A 118
ILE A 172
ARG A 153
 None
 1.41A 3ticA-4qfeA:
undetectable		 3ticA-4qfeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 427
ARG B 429
ILE B 652
ARG B 440
 None
 1.16A 3ticA-4qiwB:
undetectable		 3ticA-4qiwB:
17.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A  52
ARG A  70
ARG A  74
ILE A 141
ARG A 143
 None
 0.22A 3ticA-4qn3A:
64.4		 3ticA-4qn3A:
43.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 LEU A 519
ARG A 738
ARG A 496
ILE A 742
 None
 1.49A 3ticA-5by3A:
undetectable		 3ticA-5by3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0n ENOYL-COA
HYDRATASE/ISOMERASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU X 126
ARG X 131
ILE X 186
ARG X 167
 None
 1.27A 3ticA-5e0nX:
undetectable		 3ticA-5e0nX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 320
ARG A 326
ILE A 306
ARG A 333
 None
 1.36A 3ticA-5e7jA:
undetectable		 3ticA-5e7jA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 LEU A 442
ARG A 361
ILE A 337
ARG A 339
 None
 1.36A 3ticA-5fkrA:
4.2		 3ticA-5fkrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 LEU A 457
ARG A 485
ARG A 488
ARG A 480
 None
 1.32A 3ticA-5gggA:
undetectable		 3ticA-5gggA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 4 LEU A 368
ARG A 456
ILE A 441
ARG A 429
 None
 1.04A 3ticA-5h4vA:
undetectable		 3ticA-5h4vA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		4 LEU A 381
ARG A 285
ILE A 287
ARG A 298
 None
 1.37A 3ticA-5hkjA:
undetectable		 3ticA-5hkjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		4 LEU A 412
ARG A 329
ILE A 417
ARG A 301
 None
 1.35A 3ticA-5j39A:
undetectable		 3ticA-5j39A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU A 476
ARG A 673
ILE A 456
ARG A 460
 None
 1.04A 3ticA-5mfaA:
undetectable		 3ticA-5mfaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S19, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LEU o 116
ARG o  73
ILE o 108
ARG o 111
 None
U  E2028 ( 3.0A)
None
A  E2031 ( 3.4A)
 1.43A 3ticA-5opto:
undetectable		 3ticA-5opto:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 4 LEU A 182
ARG A 217
ARG A 184
ILE A 244
 None
 1.43A 3ticA-5w0xA:
undetectable		 3ticA-5w0xA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 4 LEU A 441
ARG A 494
ILE A 323
ARG A 319
 None
 1.43A 3ticA-5yv5A:
undetectable		 3ticA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 LEU A 476
ARG A 673
ILE A 456
ARG A 460
 None
 1.00A 3ticA-6azpA:
undetectable		 3ticA-6azpA:
12.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
E3M  A 511 (-3.8A)
None
E3M  A 511 ( 4.3A)
E3M  A 511 (-3.8A)
 0.13A 3ticA-6br6A:
74.5		 3ticA-6br6A:
90.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzh PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Mus musculus) 		no annotation 4 LEU A 124
ARG A 143
ARG A 140
ARG A 148
 None
 1.29A 3ticA-6bzhA:
undetectable		 3ticA-6bzhA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4

(Homo sapiens) 		no annotation 4 LEU A  61
ARG B  35
ARG B  36
ILE B  46
 LEU  A  61 ( 0.6A)
ARG  B  35 ( 0.6A)
ARG  B  36 ( 0.6A)
ILE  B  46 ( 0.7A)
 1.43A 3ticA-6c0wA:
undetectable		 3ticA-6c0wA:
9.89