SIMILAR PATTERNS OF AMINO ACIDS FOR 3THR_D_C2FD1200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 246
HIS A 247
SER A 342
LEU A 383
HIS A 348
 None
None
None
None
CU  A 666 (-3.8A)
 1.42A 3thrA-1hcyA:
0.0
3thrB-1hcyA:
0.0
3thrC-1hcyA:
0.7
3thrD-1hcyA:
0.9		 3thrA-1hcyA:
18.06
3thrB-1hcyA:
18.06
3thrC-1hcyA:
18.06
3thrD-1hcyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 LEU B  27
HIS B 233
SER B 173
TYR B 175
LEU B  28
 None
 1.46A 3thrA-1jk0B:
undetectable
3thrB-1jk0B:
undetectable
3thrC-1jk0B:
undetectable
3thrD-1jk0B:
undetectable		 3thrA-1jk0B:
21.13
3thrB-1jk0B:
21.13
3thrC-1jk0B:
21.13
3thrD-1jk0B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  80
HIS A  79
SER A 247
TYR A 249
LEU A  13
 NAD  A1200 (-4.4A)
None
None
None
NAD  A1200 (-3.7A)
 1.50A 3thrA-1orrA:
6.1
3thrB-1orrA:
6.0
3thrC-1orrA:
6.8
3thrD-1orrA:
6.7		 3thrA-1orrA:
23.05
3thrB-1orrA:
23.05
3thrC-1orrA:
23.05
3thrD-1orrA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		5 LEU A 207
HIS A 214
MET A 215
THR A 217
ARG A 239
 None
 0.20A 3thrA-1r8yA:
43.2
3thrB-1r8yA:
43.0
3thrC-1r8yA:
43.1
3thrD-1r8yA:
43.2		 3thrA-1r8yA:
95.55
3thrB-1r8yA:
95.55
3thrC-1r8yA:
95.55
3thrD-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4p ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		no annotation 5 HIS A 147
LEU A  12
HIS A  13
THR A   8
TYR A  34
 None
None
ZN  A1001 (-3.2A)
None
None
 1.37A 3thrA-1v4pA:
0.0
3thrB-1v4pA:
0.0
3thrC-1v4pA:
undetectable
3thrD-1v4pA:
0.0		 3thrA-1v4pA:
18.31
3thrB-1v4pA:
18.31
3thrC-1v4pA:
18.31
3thrD-1v4pA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 496
HIS A 494
TYR A 471
LEU A 455
THR A 469
 None
FAD  A 801 ( 4.7A)
None
None
None
 1.37A 3thrA-2ipiA:
0.0
3thrB-2ipiA:
0.3
3thrC-2ipiA:
0.0
3thrD-2ipiA:
0.0		 3thrA-2ipiA:
19.89
3thrB-2ipiA:
19.89
3thrC-2ipiA:
19.89
3thrD-2ipiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl2 AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF06094
(GGACT) 		5 LEU A  53
HIS A  61
THR A  36
TYR A   7
THR A  64
 None
 1.01A 3thrA-2kl2A:
0.0
3thrB-2kl2A:
0.0
3thrC-2kl2A:
0.0
3thrD-2kl2A:
0.0		 3thrA-2kl2A:
19.33
3thrB-2kl2A:
19.33
3thrC-2kl2A:
19.33
3thrD-2kl2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF02758
(PYRIN) 		5 LEU A  77
MET A  80
LEU A  85
MET A  88
THR A  14
 None
 1.32A 3thrA-2km6A:
undetectable
3thrB-2km6A:
undetectable
3thrC-2km6A:
undetectable
3thrD-2km6A:
undetectable		 3thrA-2km6A:
18.25
3thrB-2km6A:
18.25
3thrC-2km6A:
18.25
3thrD-2km6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpf POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		5 LEU A 633
MET A 581
LEU A 560
THR A 558
THR A 554
 None
 1.47A 3thrA-2mpfA:
0.0
3thrB-2mpfA:
undetectable
3thrC-2mpfA:
0.0
3thrD-2mpfA:
undetectable		 3thrA-2mpfA:
19.23
3thrB-2mpfA:
19.23
3thrC-2mpfA:
19.23
3thrD-2mpfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbj CHROMOSOMAL PROTEIN
MC1

(Methanosarcina
thermophila) 		PF05854
(MC1) 		5 LEU A  47
HIS A  56
SER A  36
LEU A   8
HIS A  16
 None
 1.40A 3thrA-2nbjA:
0.0
3thrB-2nbjA:
0.0
3thrC-2nbjA:
0.0
3thrD-2nbjA:
0.0		 3thrA-2nbjA:
13.70
3thrB-2nbjA:
13.70
3thrC-2nbjA:
13.70
3thrD-2nbjA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p12 HYPOTHETICAL PROTEIN
DUF402

(Rhodococcus
jostii) 		PF04167
(DUF402) 		5 LEU A 123
HIS A 127
MET A 124
LEU A 105
THR A 143
 None
 1.46A 3thrA-2p12A:
undetectable
3thrB-2p12A:
undetectable
3thrC-2p12A:
undetectable
3thrD-2p12A:
0.0		 3thrA-2p12A:
21.85
3thrB-2p12A:
21.85
3thrC-2p12A:
21.85
3thrD-2p12A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		5 LEU A 118
SER A 111
LEU A  61
HIS A  60
THR A  67
 None
 1.43A 3thrA-2wamA:
undetectable
3thrB-2wamA:
undetectable
3thrC-2wamA:
undetectable
3thrD-2wamA:
undetectable		 3thrA-2wamA:
23.24
3thrB-2wamA:
23.24
3thrC-2wamA:
23.24
3thrD-2wamA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 LEU A 535
SER A 492
MET A 508
TYR A 486
THR A 488
 None
 1.50A 3thrA-3hjeA:
undetectable
3thrB-3hjeA:
undetectable
3thrC-3hjeA:
undetectable
3thrD-3hjeA:
undetectable		 3thrA-3hjeA:
17.40
3thrB-3hjeA:
17.40
3thrC-3hjeA:
17.40
3thrD-3hjeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 SER A1730
TYR A1232
HIS A1703
TYR A1235
THR A1732
 None
 1.34A 3thrA-3hmjA:
4.8
3thrB-3hmjA:
5.7
3thrC-3hmjA:
5.6
3thrD-3hmjA:
5.8		 3thrA-3hmjA:
9.65
3thrB-3hmjA:
9.65
3thrC-3hmjA:
9.65
3thrD-3hmjA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C

(Homo sapiens) 		PF02828
(L27)
PF09058
(L27_1) 		5 LEU A 103
SER A  20
TYR A  18
LEU A  14
HIS A  13
 None
 1.13A 3thrA-3lraA:
undetectable
3thrB-3lraA:
undetectable
3thrC-3lraA:
undetectable
3thrD-3lraA:
undetectable		 3thrA-3lraA:
22.26
3thrB-3lraA:
22.26
3thrC-3lraA:
22.26
3thrD-3lraA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		5 LEU A  43
HIS A  47
SER A 239
LEU A  40
HIS A  64
 None
None
None
None
SAH  A 263 (-4.3A)
 1.44A 3thrA-3px2A:
19.9
3thrB-3px2A:
20.7
3thrC-3px2A:
20.8
3thrD-3px2A:
20.2		 3thrA-3px2A:
25.75
3thrB-3px2A:
25.75
3thrC-3px2A:
25.75
3thrD-3px2A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcm TATD FAMILY
HYDROLASE

(Pseudomonas
putida) 		PF01026
(TatD_DNase) 		5 LEU A 232
SER A 246
LEU A   3
THR A 254
THR A 250
 None
 1.44A 3thrA-3rcmA:
undetectable
3thrB-3rcmA:
undetectable
3thrC-3rcmA:
undetectable
3thrD-3rcmA:
1.2		 3thrA-3rcmA:
22.36
3thrB-3rcmA:
22.36
3thrC-3rcmA:
22.36
3thrD-3rcmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfn BB_1WNU_001

(Pyrococcus
horikoshii) 		no annotation 5 HIS A 147
LEU A  12
HIS A  13
THR A   8
TYR A  34
 None
None
ZN  A   1 (-3.3A)
None
None
 1.24A 3thrA-3rfnA:
undetectable
3thrB-3rfnA:
undetectable
3thrC-3rfnA:
undetectable
3thrD-3rfnA:
undetectable		 3thrA-3rfnA:
20.97
3thrB-3rfnA:
20.97
3thrC-3rfnA:
20.97
3thrD-3rfnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 712
HIS A 717
SER A 699
TYR A 701
LEU A 709
 None
None
SO4  A   2 (-3.1A)
None
None
 1.30A 3thrA-3tt0A:
undetectable
3thrB-3tt0A:
undetectable
3thrC-3tt0A:
undetectable
3thrD-3tt0A:
undetectable		 3thrA-3tt0A:
22.39
3thrB-3tt0A:
22.39
3thrC-3tt0A:
22.39
3thrD-3tt0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A 354
SER A  93
TYR A  95
THR A 102
THR A  97
 None
 1.42A 3thrA-3vw7A:
undetectable
3thrB-3vw7A:
undetectable
3thrC-3vw7A:
undetectable
3thrD-3vw7A:
undetectable		 3thrA-3vw7A:
20.93
3thrB-3vw7A:
20.93
3thrC-3vw7A:
20.93
3thrD-3vw7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A 395
TYR A 501
LEU A 398
MET A 402
THR A 503
 None
 1.46A 3thrA-4ehiA:
undetectable
3thrB-4ehiA:
undetectable
3thrC-4ehiA:
1.7
3thrD-4ehiA:
undetectable		 3thrA-4ehiA:
20.86
3thrB-4ehiA:
20.86
3thrC-4ehiA:
20.86
3thrD-4ehiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
leprae) 		PF00300
(His_Phos_1) 		5 LEU A 192
HIS A 195
TYR A 217
LEU A  11
THR A   8
 None
 1.19A 3thrA-4eo9A:
undetectable
3thrB-4eo9A:
undetectable
3thrC-4eo9A:
undetectable
3thrD-4eo9A:
undetectable		 3thrA-4eo9A:
24.05
3thrB-4eo9A:
24.05
3thrC-4eo9A:
24.05
3thrD-4eo9A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 LEU A 254
HIS A 277
SER A 227
LEU A 239
HIS A 222
 None
None
None
None
ZN  A 501 (-3.3A)
 1.34A 3thrA-4fvlA:
undetectable
3thrB-4fvlA:
undetectable
3thrC-4fvlA:
undetectable
3thrD-4fvlA:
undetectable		 3thrA-4fvlA:
20.41
3thrB-4fvlA:
20.41
3thrC-4fvlA:
20.41
3thrD-4fvlA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 LEU A 254
HIS A 277
SER A 227
LEU A 239
MET A 240
 None
 1.11A 3thrA-4fvlA:
undetectable
3thrB-4fvlA:
undetectable
3thrC-4fvlA:
undetectable
3thrD-4fvlA:
undetectable		 3thrA-4fvlA:
20.41
3thrB-4fvlA:
20.41
3thrC-4fvlA:
20.41
3thrD-4fvlA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9o CREB-BINDING PROTEIN

(Mus musculus) 		PF02172
(KIX) 		5 LEU A 599
HIS A 602
TYR A 649
HIS A 592
TYR A 650
 None
 1.32A 3thrA-4i9oA:
undetectable
3thrB-4i9oA:
undetectable
3thrC-4i9oA:
undetectable
3thrD-4i9oA:
undetectable		 3thrA-4i9oA:
16.79
3thrB-4i9oA:
16.79
3thrC-4i9oA:
16.79
3thrD-4i9oA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		5 LEU A 273
SER A 290
LEU A 277
TYR A 329
THR A 294
 None
 1.39A 3thrA-4xjnA:
undetectable
3thrB-4xjnA:
undetectable
3thrC-4xjnA:
undetectable
3thrD-4xjnA:
undetectable		 3thrA-4xjnA:
20.49
3thrB-4xjnA:
20.49
3thrC-4xjnA:
20.49
3thrD-4xjnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 107
SER A 315
TYR A 119
LEU A 174
THR A 318
 None
 1.42A 3thrA-4zk3A:
undetectable
3thrB-4zk3A:
0.5
3thrC-4zk3A:
undetectable
3thrD-4zk3A:
0.8		 3thrA-4zk3A:
20.60
3thrB-4zk3A:
20.60
3thrC-4zk3A:
20.60
3thrD-4zk3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 LEU A 278
HIS A 365
LEU A 371
THR A 329
THR A 334
 None
None
ACT  A 701 ( 4.2A)
None
None
 1.30A 3thrA-5nv6A:
undetectable
3thrB-5nv6A:
undetectable
3thrC-5nv6A:
undetectable
3thrD-5nv6A:
undetectable		 3thrA-5nv6A:
20.09
3thrB-5nv6A:
20.09
3thrC-5nv6A:
20.09
3thrD-5nv6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 LEU f 582
MET f 585
SER f 539
LEU f 609
THR f 577
 None
 1.27A 3thrA-5t0hf:
undetectable
3thrB-5t0hf:
undetectable
3thrC-5t0hf:
undetectable
3thrD-5t0hf:
undetectable		 3thrA-5t0hf:
16.64
3thrB-5t0hf:
16.64
3thrC-5t0hf:
16.64
3thrD-5t0hf:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 MET A  59
SER A  47
LEU A 298
HIS A 266
ARG A 156
 None
 1.25A 3thrA-5wgcA:
undetectable
3thrB-5wgcA:
undetectable
3thrC-5wgcA:
undetectable
3thrD-5wgcA:
undetectable		 3thrA-5wgcA:
undetectable
3thrB-5wgcA:
undetectable
3thrC-5wgcA:
undetectable
3thrD-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 5 LEU A 273
SER A 290
LEU A 277
TYR A 329
THR A 294
 None
 1.34A 3thrA-5wknA:
undetectable
3thrB-5wknA:
undetectable
3thrC-5wknA:
undetectable
3thrD-5wknA:
undetectable		 3thrA-5wknA:
undetectable
3thrB-5wknA:
undetectable
3thrC-5wknA:
undetectable
3thrD-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 MET A  73
SER A 208
LEU A 132
HIS A 133
MET A 129
 None
 1.47A 3thrA-5wnmA:
undetectable
3thrB-5wnmA:
undetectable
3thrC-5wnmA:
undetectable
3thrD-5wnmA:
undetectable		 3thrA-5wnmA:
undetectable
3thrB-5wnmA:
undetectable
3thrC-5wnmA:
undetectable
3thrD-5wnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 5 LEU A 372
HIS A 371
SER A 246
THR A 561
THR A 250
 None
 1.27A 3thrA-5zh5A:
undetectable
3thrB-5zh5A:
0.1
3thrC-5zh5A:
1.2
3thrD-5zh5A:
0.4		 3thrA-5zh5A:
undetectable
3thrB-5zh5A:
undetectable
3thrC-5zh5A:
undetectable
3thrD-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 5 LEU A 415
TYR A 366
LEU A 204
THR A 155
THR A 207
 None
 1.47A 3thrA-6b9rA:
undetectable
3thrB-6b9rA:
0.8
3thrC-6b9rA:
1.1
3thrD-6b9rA:
1.5		 3thrA-6b9rA:
undetectable
3thrB-6b9rA:
undetectable
3thrC-6b9rA:
undetectable
3thrD-6b9rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 5 LEU A 415
TYR A 368
LEU A 205
THR A 154
THR A 208
 None
 1.43A 3thrA-6b9sA:
undetectable
3thrB-6b9sA:
1.7
3thrC-6b9sA:
0.0
3thrD-6b9sA:
undetectable		 3thrA-6b9sA:
undetectable
3thrB-6b9sA:
undetectable
3thrC-6b9sA:
undetectable
3thrD-6b9sA:
undetectable