SIMILAR PATTERNS OF AMINO ACIDS FOR 3TGY_A_ASCA800_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d7w MYELOPEROXIDASE
MYELOPEROXIDASE

(Homo sapiens;
Homo sapiens) 		PF03098
(An_peroxidase)
PF03098
(An_peroxidase) 		4 HIS A  95
ARG C 239
GLU C 242
PHE C 366
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.31A 3tgyA-1d7wA:
undetectable		 3tgyA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d7w MYELOPEROXIDASE
MYELOPEROXIDASE

(Homo sapiens;
Homo sapiens) 		PF03098
(An_peroxidase)
PF03098
(An_peroxidase) 		4 HIS A  95
ARG C 239
GLU C 242
PHE C 407
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.10A 3tgyA-1d7wA:
undetectable		 3tgyA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		4 HIS A  95
ARG A 239
GLU A 242
PHE A 366
 SCN  A1502 ( 4.8A)
HEM  A 605 (-4.7A)
HEM  A 605 ( 2.2A)
None
 0.50A 3tgyA-2gjmA:
60.1		 3tgyA-2gjmA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 4 HIS A 101
ARG A 233
GLU A 236
PHE A 352
 None
HEM  A 604 (-3.1A)
HEM  A 604 (-2.2A)
None
 0.76A 3tgyA-6ercA:
39.6		 3tgyA-6ercA:
undetectable