SIMILAR PATTERNS OF AMINO ACIDS FOR 3TGV_B_BEZB1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aep APOLIPOPHORIN III

(Locusta
migratoria) 		no annotation 4 LEU A  31
GLY A  30
LEU A  29
GLU A  27
 None
 0.93A 3tgvB-1aepA:
undetectable		 3tgvB-1aepA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)

(Saccharomyces
cerevisiae) 		PF01088
(Peptidase_C12) 		4 LEU A  27
GLY A  26
LEU A 106
GLU A 107
 None
 1.03A 3tgvB-1cmxA:
0.0		 3tgvB-1cmxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffw CHEMOTAXIS PROTEIN
CHEA

(Escherichia
coli) 		PF09078
(CheY-binding) 		4 LEU B 182
GLY B 180
LEU B 179
GLU B 178
 None
 1.10A 3tgvB-1ffwB:
undetectable		 3tgvB-1ffwB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 ECOTIN
ECOTIN

(Escherichia
coli;
Escherichia
coli) 		PF03974
(Ecotin)
PF03974
(Ecotin) 		4 LEU D 101
GLY D 105
LEU C  40
GLU C  39
 None
 1.03A 3tgvB-1fi8D:
undetectable		 3tgvB-1fi8D:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 LEU A 360
GLY A 361
LEU A 363
GLU A 364
 None
 1.12A 3tgvB-1g7rA:
0.0		 3tgvB-1g7rA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A  41
GLY A  38
LEU A  37
GLU A  40
 None
 1.10A 3tgvB-1ggmA:
0.2		 3tgvB-1ggmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 LEU A 336
GLY A 337
LEU A 338
GLU A 339
 None
 0.93A 3tgvB-1gkrA:
undetectable		 3tgvB-1gkrA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ifg ECOTIN

(Escherichia
coli) 		PF03974
(Ecotin) 		4 LEU A 101
GLY A 105
LEU A  40
GLU A  39
 None
 1.01A 3tgvB-1ifgA:
0.0		 3tgvB-1ifgA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 LEU A 255
GLY A 213
LEU A 210
GLU A 209
 None
 1.03A 3tgvB-1iwpA:
0.0		 3tgvB-1iwpA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 LEU A 195
GLY A 213
LEU A 248
GLU A 247
 None
 1.00A 3tgvB-1j0aA:
undetectable		 3tgvB-1j0aA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY

(Mus musculus) 		PF07686
(V-set) 		4 LEU A 288
GLY A 289
LEU A 309
GLU A 310
 None
 1.12A 3tgvB-1lmkA:
undetectable		 3tgvB-1lmkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 465
GLY A 444
LEU A 443
GLU A 442
 None
None
None
ANP  A 504 (-2.8A)
 0.85A 3tgvB-1m0wA:
undetectable		 3tgvB-1m0wA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5d CARBONYL
REDUCTASE/20BETA-HYD
ROXYSTEROID
DEHYDROGENASE

(Sus scrofa) 		PF00106
(adh_short) 		4 LEU A 170
GLY A 169
LEU A 167
GLU A 166
 None
 1.13A 3tgvB-1n5dA:
undetectable		 3tgvB-1n5dA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 LEU A  48
GLY A  73
LEU A  72
GLU A  71
 None
 0.95A 3tgvB-1qmhA:
undetectable		 3tgvB-1qmhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryj UNKNOWN

(Methanothermococcus
thermolithotrophicus) 		PF02597
(ThiS) 		4 LEU A  33
GLY A  34
LEU A  36
GLU A  37
 None
 1.12A 3tgvB-1ryjA:
undetectable		 3tgvB-1ryjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		4 LEU B 277
GLY B 278
LEU B 280
GLU B 281
 None
 0.88A 3tgvB-1s70B:
undetectable		 3tgvB-1s70B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 286
GLY A 285
LEU A 314
GLU A 320
 None
 1.03A 3tgvB-1smkA:
undetectable		 3tgvB-1smkA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf8 NEURABIN-I

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A   8
GLY A  97
LEU A  10
GLU A   9
 None
 0.99A 3tgvB-1wf8A:
undetectable		 3tgvB-1wf8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wie RIM BINDING PROTEIN
2

(Homo sapiens) 		PF14604
(SH3_9) 		4 LEU A  40
GLY A  62
LEU A  48
GLU A  63
 None
 1.01A 3tgvB-1wieA:
undetectable		 3tgvB-1wieA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		4 LEU A 155
GLY A 159
LEU A 163
GLU A 160
 None
 1.07A 3tgvB-1ysqA:
undetectable		 3tgvB-1ysqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 LEU I 467
GLY I 466
LEU I 454
GLU I 455
 None
 0.96A 3tgvB-1zo1I:
undetectable		 3tgvB-1zo1I:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 1.02A 3tgvB-2adfL:
undetectable		 3tgvB-2adfL:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU B 665
GLY B 677
LEU B 675
GLU B 676
 None
 1.08A 3tgvB-2asuB:
3.1		 3tgvB-2asuB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 LEU A 396
GLY A 426
LEU A 429
GLU A 430
 None
 0.98A 3tgvB-2dc0A:
undetectable		 3tgvB-2dc0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 243
GLY A 244
LEU A 249
GLU A  89
 None
 1.11A 3tgvB-2douA:
undetectable		 3tgvB-2douA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 448
GLY A 427
LEU A 426
GLU A 425
 None
None
None
ADP  A 500 (-2.6A)
 0.88A 3tgvB-2hgsA:
undetectable		 3tgvB-2hgsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jo6 NITRITE REDUCTASE
[NAD(P)H] SMALL
SUBUNIT

(Escherichia
coli) 		PF13806
(Rieske_2) 		4 LEU A  22
GLY A  24
LEU A  23
GLU A  26
 None
 1.07A 3tgvB-2jo6A:
undetectable		 3tgvB-2jo6A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kg4 GROWTH ARREST AND
DNA-DAMAGE-INDUCIBLE
PROTEIN GADD45 ALPHA

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		4 LEU A 162
GLY A  20
LEU A  23
GLU A  24
 None
 0.88A 3tgvB-2kg4A:
undetectable		 3tgvB-2kg4A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF08712
(Nfu_N) 		4 LEU A  80
GLY A  60
LEU A  85
GLU A  59
 None
 1.12A 3tgvB-2ltmA:
undetectable		 3tgvB-2ltmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n29 PROTEIN VPU

(Human
immunodeficiency
virus 1) 		PF00558
(Vpu) 		4 LEU A  43
GLY A  40
LEU A  39
GLU A  42
 None
 1.09A 3tgvB-2n29A:
undetectable		 3tgvB-2n29A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nms CMRF35-LIKE-MOLECULE
1

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A  31
GLY A  34
LEU A  98
GLU A  32
 None
 1.12A 3tgvB-2nmsA:
undetectable		 3tgvB-2nmsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		4 LEU A 186
GLY A 185
LEU A 181
GLU A 182
 None
 1.07A 3tgvB-2p1gA:
undetectable		 3tgvB-2p1gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		4 LEU B 152
GLY B 243
LEU B 247
GLU B 244
 None
 1.01A 3tgvB-2p5tB:
undetectable		 3tgvB-2p5tB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9r ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF01835
(A2M_N) 		4 LEU A 164
GLY A 163
LEU A 160
GLU A 161
 None
 0.98A 3tgvB-2p9rA:
undetectable		 3tgvB-2p9rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa) 		PF00089
(Trypsin) 		4 LEU B 162
GLY B 133
LEU B 132
GLU B 130
 None
 1.06A 3tgvB-2pkaB:
undetectable		 3tgvB-2pkaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU B 604
GLY B 606
LEU B 605
GLU B 608
 None
 1.01A 3tgvB-2uzxB:
undetectable		 3tgvB-2uzxB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 LEU D 307
GLY D 303
LEU D 286
GLU D 287
 None
 1.04A 3tgvB-2vnuD:
undetectable		 3tgvB-2vnuD:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 LEU A 169
GLY A 171
LEU A 166
GLU A 167
 None
None
None
SO4  A2007 ( 4.4A)
 1.12A 3tgvB-2zr2A:
undetectable		 3tgvB-2zr2A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ad9 SARCOSINE OXIDASE
GAMMA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04268
(SoxG) 		4 LEU C 115
GLY C  42
LEU C  88
GLU C  86
 None
 0.97A 3tgvB-3ad9C:
undetectable		 3tgvB-3ad9C:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB

(Mus musculus) 		no annotation 4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 1.03A 3tgvB-3bgfL:
undetectable		 3tgvB-3bgfL:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 260
GLY A 258
LEU A 257
GLU A 233
 None
 1.09A 3tgvB-3dfhA:
undetectable		 3tgvB-3dfhA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		4 LEU A 134
GLY A 138
LEU A 135
GLU A 139
 None
 1.06A 3tgvB-3ffhA:
undetectable		 3tgvB-3ffhA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fru NEONATAL FC RECEPTOR

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A 166
GLY A 167
LEU A 169
GLU A 170
 None
 1.12A 3tgvB-3fruA:
undetectable		 3tgvB-3fruA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 260
GLY A 232
LEU A 236
GLU A 233
 None
 1.01A 3tgvB-3nqpA:
undetectable		 3tgvB-3nqpA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		4 LEU A  48
GLY A  47
LEU A  84
GLU A  85
 None
 1.06A 3tgvB-3ocjA:
undetectable		 3tgvB-3ocjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 1.02A 3tgvB-3r08L:
undetectable		 3tgvB-3r08L:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rco TUDOR
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF12872
(OST-HTH) 		4 LEU A  19
GLY A  21
LEU A  23
GLU A  20
 None
 1.11A 3tgvB-3rcoA:
undetectable		 3tgvB-3rcoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		4 LEU A 244
GLY A 248
LEU A 251
GLU A 252
 None
 0.94A 3tgvB-3rk6A:
undetectable		 3tgvB-3rk6A:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tgv HEME-BINDING PROTEIN
HUTZ

(Vibrio cholerae) 		PF01243
(Putative_PNPOx) 		4 LEU A  14
GLY A 150
LEU A 151
GLU A 152
 None
 0.26A 3tgvB-3tgvA:
27.3		 3tgvB-3tgvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 258
GLY A 256
LEU A 255
GLU A 231
 None
None
None
MG  A 601 (-2.8A)
 0.98A 3tgvB-3tjiA:
undetectable		 3tgvB-3tjiA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		4 LEU A 598
GLY A 599
LEU A 541
GLU A 539
 None
 1.04A 3tgvB-3u6nA:
undetectable		 3tgvB-3u6nA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubl GLUTATHIONE
TRANSFERASE

(Leptospira
interrogans) 		PF13417
(GST_N_3) 		4 LEU A  18
GLY A  19
LEU A  21
GLU A  22
 None
None
None
SO4  A 242 ( 4.0A)
 1.10A 3tgvB-3ublA:
undetectable		 3tgvB-3ublA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		4 LEU A 274
GLY A 258
LEU A 262
GLU A 259
 None
 1.02A 3tgvB-3um1A:
undetectable		 3tgvB-3um1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU A 152
GLY A 153
LEU A 215
GLU A 216
 None
 1.04A 3tgvB-3umtA:
undetectable		 3tgvB-3umtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 LEU A 127
GLY A 175
LEU A 178
GLU A 130
 None
 1.12A 3tgvB-3wajA:
undetectable		 3tgvB-3wajA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccl 50S RIBOSOMAL
PROTEIN L16 ARGININE
HYDROXYLASE

(Escherichia
coli) 		PF08007
(Cupin_4) 		4 LEU A  43
GLY A  42
LEU A  40
GLU A  39
 None
 1.06A 3tgvB-4cclA:
undetectable		 3tgvB-4cclA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 199
GLY A 211
LEU A 209
GLU A 210
 None
 1.09A 3tgvB-4d9rA:
2.8		 3tgvB-4d9rA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 LEU A 461
GLY A 462
LEU A 509
GLU A 510
 None
 0.92A 3tgvB-4e2iA:
undetectable		 3tgvB-4e2iA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba RNA15

(Kluyveromyces
lactis) 		PF14327
(CSTF2_hinge) 		4 LEU G 138
GLY G 136
LEU G 135
GLU G 134
 None
 1.05A 3tgvB-4ebaG:
undetectable		 3tgvB-4ebaG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 LEU A 178
GLY A 182
LEU A 187
GLU A 183
 None
 1.09A 3tgvB-4eyoA:
undetectable		 3tgvB-4eyoA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fle ESTERASE

(Yersinia
enterocolitica) 		PF05728
(UPF0227) 		4 LEU A 104
GLY A 105
LEU A 118
GLU A 119
 None
 1.12A 3tgvB-4fleA:
undetectable		 3tgvB-4fleA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		4 LEU A 165
GLY A 166
LEU A 167
GLU A 168
 None
 1.02A 3tgvB-4g3hA:
undetectable		 3tgvB-4g3hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		4 LEU A 461
GLY A 462
LEU A 509
GLU A 510
 None
 1.06A 3tgvB-4gdfA:
undetectable		 3tgvB-4gdfA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 LEU A 386
GLY A 404
LEU A 405
GLU A 406
 None
 0.95A 3tgvB-4ghkA:
undetectable		 3tgvB-4ghkA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 258
GLY A 256
LEU A 255
GLU A 231
 None
None
None
MG  A 405 (-2.7A)
 0.94A 3tgvB-4gisA:
undetectable		 3tgvB-4gisA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 4 LEU A 115
GLY A  92
LEU A  93
GLU A  91
 None
 1.10A 3tgvB-4h5yA:
undetectable		 3tgvB-4h5yA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyz UNCHARACTERIZED
PROTEIN

([Ruminococcus]
gnavus) 		PF13026
(DUF3887) 		4 LEU A 109
GLY A 110
LEU A  42
GLU A  41
 None
 0.89A 3tgvB-4hyzA:
undetectable		 3tgvB-4hyzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 121
GLY A  47
LEU A  39
GLU A  46
 None
 1.08A 3tgvB-4ip4A:
undetectable		 3tgvB-4ip4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iul EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02854
(MIF4G) 		4 LEU A 220
GLY A 218
LEU A 217
GLU A 216
 None
 1.10A 3tgvB-4iulA:
undetectable		 3tgvB-4iulA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 LEU A 282
GLY A  81
LEU A  80
GLU A  83
 None
 1.00A 3tgvB-4iuwA:
undetectable		 3tgvB-4iuwA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B

(Danio rerio) 		PF02854
(MIF4G) 		4 LEU A 155
GLY A 159
LEU A 162
GLU A 163
 None
 0.86A 3tgvB-4jhjA:
undetectable		 3tgvB-4jhjA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 0.88A 3tgvB-4k2uL:
undetectable		 3tgvB-4k2uL:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU A 288
GLY A 318
LEU A 289
GLU A 319
 None
 1.09A 3tgvB-4p72A:
undetectable		 3tgvB-4p72A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 LEU B 348
GLY B 349
LEU B 377
GLU B 376
 None
 1.11A 3tgvB-4peqB:
undetectable		 3tgvB-4peqB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 120
GLY A 121
LEU A 149
GLU A 148
 None
 1.03A 3tgvB-4perA:
undetectable		 3tgvB-4perA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU C  15
GLY C  16
LEU C  78
GLU C  79
 None
 1.03A 3tgvB-4pp1C:
undetectable		 3tgvB-4pp1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)

(Escherichia
coli) 		PF02223
(Thymidylate_kin) 		4 LEU A 147
GLY A 146
LEU A  11
GLU A  12
 None
None
None
T5A  A 214 (-3.7A)
 1.04A 3tgvB-4tmkA:
undetectable		 3tgvB-4tmkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5j ADENYLATE KINASE

(Streptococcus
pneumoniae) 		PF00406
(ADK) 		4 LEU A   3
GLY A 110
LEU A 108
GLU A 109
 None
 1.03A 3tgvB-4w5jA:
undetectable		 3tgvB-4w5jA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02686
(Glu-tRNAGln) 		4 LEU C  87
GLY B 141
LEU B 132
GLU B 134
 None
 1.08A 3tgvB-4wj3C:
undetectable		 3tgvB-4wj3C:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp LIGHT CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 0.93A 3tgvB-4xmpL:
undetectable		 3tgvB-4xmpL:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU B 131
GLY B 132
LEU B 133
GLU B 134
 None
 1.10A 3tgvB-4y61B:
undetectable		 3tgvB-4y61B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 LEU A 178
GLY A 152
LEU A 156
GLU A 157
 None
 1.08A 3tgvB-5cj5A:
undetectable		 3tgvB-5cj5A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4y PROTEIN SHROOM2

(Homo sapiens) 		PF08687
(ASD2) 		4 LEU A1447
GLY A1598
LEU A1602
GLU A1599
 None
 0.88A 3tgvB-5f4yA:
undetectable		 3tgvB-5f4yA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LEU A 304
GLY A 306
LEU A 280
GLU A 307
 None
 1.10A 3tgvB-5fqdA:
undetectable		 3tgvB-5fqdA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN

(Homo sapiens) 		PF07686
(V-set) 		4 LEU H 149
GLY H 150
LEU H 212
GLU H 213
 LEU  H 149 ( 0.6A)
GLY  H 150 ( 0.0A)
LEU  H 212 ( 0.6A)
GLU  H 213 ( 0.6A)
 0.95A 3tgvB-5gruH:
undetectable		 3tgvB-5gruH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		4 LEU A 462
GLY A 463
LEU A 510
GLU A 511
 None
 1.04A 3tgvB-5j47A:
undetectable		 3tgvB-5j47A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyl SCFV TSP7

(Mus musculus) 		PF07686
(V-set) 		4 LEU B 153
GLY B 154
LEU B 216
GLU B 217
 None
 0.95A 3tgvB-5jylB:
undetectable		 3tgvB-5jylB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU C1015
GLY C1016
LEU C1078
GLU C1079
 None
 1.08A 3tgvB-5kovC:
undetectable		 3tgvB-5kovC:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 4 LEU A 207
GLY A 209
LEU A 208
GLU A 223
 None
 1.00A 3tgvB-5lf9A:
undetectable		 3tgvB-5lf9A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 604
GLY A 606
LEU A 605
GLU A 608
 None
 0.92A 3tgvB-5lspA:
undetectable		 3tgvB-5lspA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 313
GLY A 314
LEU A 331
GLU A 330
 None
 1.09A 3tgvB-5nccA:
undetectable		 3tgvB-5nccA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 4 LEU A 457
GLY A 436
LEU A 435
GLU A 434
 None
None
None
ADP  A 501 ( 2.7A)
 0.87A 3tgvB-5oesA:
undetectable		 3tgvB-5oesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG

(Methanothermobacter
wolfeii) 		PF12838
(Fer4_7) 		4 LEU G   5
GLY G   4
LEU G  78
GLU G  79
 SF4  G 102 ( 4.6A)
None
None
None
 1.09A 3tgvB-5t5iG:
undetectable		 3tgvB-5t5iG:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		4 LEU A 156
GLY A 104
LEU A 101
GLU A 100
 None
 1.10A 3tgvB-5tjrA:
undetectable		 3tgvB-5tjrA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		no annotation 4 LEU A 164
GLY A 129
LEU A 165
GLU A 166
 None
 1.05A 3tgvB-5v76A:
undetectable		 3tgvB-5v76A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 144
GLY A 141
LEU A 140
GLU A 143
 None
 1.06A 3tgvB-5wroA:
undetectable		 3tgvB-5wroA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqw FAB FRAGMENT OF
CATALYTIC ANTIBODY
7B9, LIGHT CHAIN

(Mus musculus) 		no annotation 4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 0.93A 3tgvB-5xqwL:
undetectable		 3tgvB-5xqwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 LEU C1484
GLY C1480
LEU C1483
GLU C1482
 None
 1.10A 3tgvB-5y3rC:
undetectable		 3tgvB-5y3rC:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus) 		no annotation 4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 1.05A 3tgvB-6bb4L:
undetectable		 3tgvB-6bb4L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 LEU B 369
GLY B 368
LEU B 365
GLU B 366
 None
 0.98A 3tgvB-6fd2B:
undetectable		 3tgvB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		4 TYR A 321
PHE A 232
PRO A 325
LEU A 301
 None
 1.29A 3tgvB-1a59A:
0.0		 3tgvB-1a59A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLN A 276
PHE A  29
PRO A  28
LEU A  26
 None
 0.93A 3tgvB-1bdgA:
0.0		 3tgvB-1bdgA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3u TRANSCRIPTION
INITIATION FACTOR
IIF, BETA SUBUNIT
TRANSCRIPTION
INITIATION FACTOR
IIF, ALPHA SUBUNIT

(Homo sapiens;
Homo sapiens) 		PF02270
(TFIIF_beta)
PF05793
(TFIIF_alpha) 		4 ARG B  49
TYR B 144
PHE A  96
LEU A 104
 None
 1.25A 3tgvB-1f3uB:
0.6		 3tgvB-1f3uB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLN A 262
TYR A 309
PHE A 332
LEU A 300
 None
 1.39A 3tgvB-1f4hA:
0.0		 3tgvB-1f4hA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt0 HEMOLYSIN SECRETION
ATP-BINDING PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 TYR A 519
PHE A 475
PRO A 521
LEU A 485
 None
 1.37A 3tgvB-1mt0A:
0.0		 3tgvB-1mt0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 GLN B 372
PHE B 388
PRO B 411
LEU B 390
 None
 1.11A 3tgvB-1mu2B:
0.0		 3tgvB-1mu2B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLN A  69
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 301 (-4.4A)
None
 1.21A 3tgvB-1pn9A:
undetectable		 3tgvB-1pn9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLN A 150
TYR A 159
PHE A 111
PRO A 168
 None
 1.28A 3tgvB-1uokA:
0.0		 3tgvB-1uokA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG L  39
PHE L  62
PRO L  59
LEU L  47
 None
 1.43A 3tgvB-1xgyL:
undetectable		 3tgvB-1xgyL:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 GLN B 249
PHE B 246
PRO B 247
LEU B 265
 None
 1.03A 3tgvB-1zunB:
1.4		 3tgvB-1zunB:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT

(Homo sapiens) 		PF00676
(E1_dh) 		4 GLN A 326
TYR A 322
PHE A 259
LEU A  52
 None
 1.33A 3tgvB-2bfeA:
undetectable		 3tgvB-2bfeA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		4 GLN A 120
TYR A 121
PHE A  45
LEU A 105
 None
 1.26A 3tgvB-2bghA:
undetectable		 3tgvB-2bghA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLN A 115
TYR A 308
PHE A 217
LEU A 216
 None
 1.36A 3tgvB-2f9gA:
undetectable		 3tgvB-2f9gA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		4 TYR A  58
PHE A 106
PRO A 105
LEU A 103
 None
 1.15A 3tgvB-2fv2A:
undetectable		 3tgvB-2fv2A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huo INOSITOL OXYGENASE

(Mus musculus) 		PF05153
(MIOX) 		4 GLN A 151
PHE A 222
PRO A 145
LEU A 185
 None
 1.26A 3tgvB-2huoA:
undetectable		 3tgvB-2huoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibn INOSITOL OXYGENASE

(Homo sapiens) 		PF05153
(MIOX) 		4 GLN A 151
PHE A 222
PRO A 145
LEU A 185
 None
 1.24A 3tgvB-2ibnA:
undetectable		 3tgvB-2ibnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 ARG B  24
PHE B 163
PRO B 161
LEU B   8
 None
 1.28A 3tgvB-2iwgB:
undetectable		 3tgvB-2iwgB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksi STEROL CARRIER
PROTEIN 2

(Aedes aegypti) 		PF02036
(SCP2) 		4 GLN A  25
PHE A 105
PRO A 104
LEU A 102
 None
PLM  A 200 (-3.0A)
None
PLM  A 200 (-2.8A)
 1.09A 3tgvB-2ksiA:
undetectable		 3tgvB-2ksiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ly9 ZINC FINGERS AND
HOMEOBOXES PROTEIN 1

(Homo sapiens) 		PF00046
(Homeobox) 		4 ARG A  58
GLN A  29
TYR A  25
PRO A  31
 None
 1.41A 3tgvB-2ly9A:
undetectable		 3tgvB-2ly9A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mk5 ENDOLYSIN

(Staphylococcus
virus G15) 		PF08460
(SH3_5) 		4 GLN A  41
TYR A  42
PHE A  68
PRO A  67
 None
 1.29A 3tgvB-2mk5A:
undetectable		 3tgvB-2mk5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8i HYPOTHETICAL PROTEIN
ATU2327

(Agrobacterium
fabrum) 		PF09349
(OHCU_decarbox) 		4 TYR A 107
PHE A 113
PRO A 114
LEU A  60
 None
 1.44A 3tgvB-2o8iA:
undetectable		 3tgvB-2o8iA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv PROTEIN SIP2

(Saccharomyces
cerevisiae) 		PF04739
(AMPKBI)
PF16561
(AMPK1_CBM) 		4 ARG B 169
GLN B 171
PHE B 217
LEU B 192
 None
 1.27A 3tgvB-2qlvB:
undetectable		 3tgvB-2qlvB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		4 ARG A 210
PHE A 240
PRO A 230
LEU A 241
 PG4  A 358 (-3.7A)
PG4  A 358 (-4.5A)
PG4  A 358 (-4.3A)
None
 1.39A 3tgvB-2rauA:
undetectable		 3tgvB-2rauA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5f PROLYL 4-HYDROXYLASE
SUBUNIT ALPHA-1

(Homo sapiens) 		PF07719
(TPR_2) 		4 GLN A 200
TYR A 196
PHE A 231
LEU A 204
 None
 1.37A 3tgvB-2v5fA:
undetectable		 3tgvB-2v5fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2van DNA POLYMERSE BETA

(Rattus
norvegicus) 		PF10391
(DNA_pol_lambd_f)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 GLN A 317
TYR A 327
PRO A 330
LEU A 270
 None
 1.37A 3tgvB-2vanA:
undetectable		 3tgvB-2vanA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ARG A 407
PHE A 397
PRO A 403
LEU A 394
 SO4  A1517 (-4.4A)
None
None
None
 1.41A 3tgvB-2w8sA:
undetectable		 3tgvB-2w8sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wz9 GLUTAREDOXIN-3

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 GLN A  48
PHE A  88
PRO A  86
LEU A 100
 None
 1.03A 3tgvB-2wz9A:
undetectable		 3tgvB-2wz9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 TYR A 231
PHE A 387
PRO A 235
LEU A 417
 None
 1.44A 3tgvB-2xd4A:
undetectable		 3tgvB-2xd4A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 GLN A 266
TYR A 244
PHE A 290
PRO A 197
 None
 0.99A 3tgvB-2xdqA:
undetectable		 3tgvB-2xdqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb6 UBIQUITIN-CONJUGATIN
G ENZYME E2 B

(Homo sapiens) 		PF00179
(UQ_con) 		4 TYR A 137
PHE A  48
PRO A  47
LEU A 113
 None
 1.29A 3tgvB-2yb6A:
undetectable		 3tgvB-2yb6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 ARG A 583
GLN A 517
PHE A 585
LEU A 612
 None
 1.37A 3tgvB-2z87A:
undetectable		 3tgvB-2z87A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 TYR A 231
PHE A  81
PRO A 232
LEU A  85
 None
 1.29A 3tgvB-2zktA:
undetectable		 3tgvB-2zktA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A 129
GLN A 126
PRO A 123
LEU A  95
 None
 1.40A 3tgvB-3abgA:
undetectable		 3tgvB-3abgA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adk ADENYLATE KINASE

(Sus scrofa) 		PF00406
(ADK) 		4 ARG A 167
GLN A 111
PHE A  12
LEU A 115
 None
 1.15A 3tgvB-3adkA:
undetectable		 3tgvB-3adkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7j GLUTATHIONE
TRANSFERASE GST1-4

(Anopheles dirus) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLN A  70
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 220 (-4.3A)
None
 1.24A 3tgvB-3g7jA:
undetectable		 3tgvB-3g7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLN A 322
PHE A 527
PRO A 382
LEU A 425
 None
 1.39A 3tgvB-3gg4A:
undetectable		 3tgvB-3gg4A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ARG X 308
TYR X 273
PHE X  23
LEU X  20
 None
 1.29A 3tgvB-3h1vX:
undetectable		 3tgvB-3h1vX:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjg PUTATIVE
ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
COBC

(Vibrio
parahaemolyticus) 		PF00300
(His_Phos_1) 		4 ARG A 126
GLN A  23
PRO A  54
LEU A  79
 None
 1.41A 3tgvB-3hjgA:
undetectable		 3tgvB-3hjgA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 249
PHE A 213
PRO A 163
LEU A 211
 None
 1.36A 3tgvB-3iayA:
undetectable		 3tgvB-3iayA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 GLN A 229
TYR A 261
PHE A 268
LEU A 171
 None
 1.05A 3tgvB-3ie1A:
undetectable		 3tgvB-3ie1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 ARG D 557
PHE D 449
PRO D 448
LEU D 444
 None
 0.98A 3tgvB-3k70D:
undetectable		 3tgvB-3k70D:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 ARG A 257
TYR A 356
PHE A 249
LEU A 250
 None
 1.34A 3tgvB-3kx6A:
undetectable		 3tgvB-3kx6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 ARG A 197
GLN A 160
TYR A 152
LEU A 136
 None
 1.37A 3tgvB-3m8yA:
undetectable		 3tgvB-3m8yA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 ARG A 146
TYR B  31
PHE B  50
PRO B  49
 None
 1.37A 3tgvB-3ml0A:
undetectable		 3tgvB-3ml0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 GLN A  79
TYR A 138
PHE A 210
PRO A  93
 None
 1.07A 3tgvB-3mn8A:
undetectable		 3tgvB-3mn8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE

(Bacillus
anthracis) 		PF07071
(KDGP_aldolase) 		4 ARG A 205
GLN A 249
TYR A 250
LEU A 204
 None
 1.37A 3tgvB-3muxA:
undetectable		 3tgvB-3muxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 TYR A 272
PHE A 315
PRO A 479
LEU A 471
 None
 1.39A 3tgvB-3o9pA:
undetectable		 3tgvB-3o9pA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLN A 947
TYR A 942
PHE A 867
LEU A 865
 None
 1.43A 3tgvB-3ogrA:
undetectable		 3tgvB-3ogrA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovk AMINOPEPTIDASE P,
XAA-PRO DIPEPTIDASE

(Streptococcus
pyogenes) 		PF01321
(Creatinase_N) 		4 GLN A 110
TYR A 106
PHE A  97
LEU A 119
 None
 1.42A 3tgvB-3ovkA:
undetectable		 3tgvB-3ovkA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0y RESPONSE REGULATOR
NEPR

(Caulobacter
vibrioides;
Caulobacter
vibrioides) 		no annotation
no annotation 		4 GLN A  39
PHE B  54
PRO B  51
LEU A  25
 None
 1.19A 3tgvB-3t0yA:
undetectable		 3tgvB-3t0yA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tgv HEME-BINDING PROTEIN
HUTZ

(Vibrio cholerae) 		PF01243
(Putative_PNPOx) 		6 ARG A  22
GLN A  48
TYR A  53
PHE A  95
PRO A 140
LEU A 144
 None
 0.67A 3tgvB-3tgvA:
27.3		 3tgvB-3tgvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tgv HEME-BINDING PROTEIN
HUTZ

(Vibrio cholerae) 		PF01243
(Putative_PNPOx) 		4 GLN A  48
TYR A  53
PHE A  95
LEU A  93
 None
 1.45A 3tgvB-3tgvA:
27.3		 3tgvB-3tgvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt6 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Bacillus
subtilis) 		PF00574
(CLP_protease) 		4 GLN A  81
TYR A  77
PHE A 101
LEU A 153
 None
 1.36A 3tgvB-3tt6A:
undetectable		 3tgvB-3tt6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		4 GLN A  67
PHE A  21
PRO A  71
LEU A  30
 None
 1.36A 3tgvB-3u4yA:
undetectable		 3tgvB-3u4yA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win 17 KD HEMAGGLUTININ
COMPONENT

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17) 		4 ARG C  54
PHE C  88
PRO C  89
LEU C 102
 None
 1.29A 3tgvB-3winC:
undetectable		 3tgvB-3winC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		4 ARG B  29
PHE B 167
PRO B 165
LEU B  13
 None
 1.29A 3tgvB-3zo0B:
undetectable		 3tgvB-3zo0B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 GLN A  96
PHE A 196
PRO A 202
LEU A 195
 None
 1.31A 3tgvB-4bqnA:
undetectable		 3tgvB-4bqnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		4 GLN A 243
TYR A 489
PRO A 494
LEU A 237
 None
 1.32A 3tgvB-4bx9A:
undetectable		 3tgvB-4bx9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 TYR A 169
PHE A 300
PRO A 301
LEU A 273
 None
 1.34A 3tgvB-4c1tA:
undetectable		 3tgvB-4c1tA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 GLN A 382
PHE A 441
PRO A 419
LEU A 442
 None
 1.42A 3tgvB-4cgyA:
undetectable		 3tgvB-4cgyA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		4 TYR B 160
PHE B 208
PRO B 207
LEU B 205
 None
 1.21A 3tgvB-4cv5B:
undetectable		 3tgvB-4cv5B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 GLN A 219
PHE A 120
PRO A 150
LEU A 152
 None
 1.44A 3tgvB-4cvuA:
undetectable		 3tgvB-4cvuA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etz PELD

(Pseudomonas
aeruginosa) 		PF13492
(GAF_3)
PF16963
(PelD_GGDEF) 		4 ARG A 168
TYR A 327
PRO A 389
LEU A 164
 None
 1.22A 3tgvB-4etzA:
undetectable		 3tgvB-4etzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 GLN A 111
TYR A  99
PRO A 160
LEU A 154
 None
None
CL  A 609 (-3.6A)
None
 1.39A 3tgvB-4f2aA:
undetectable		 3tgvB-4f2aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 ARG A 605
GLN A 496
PRO A 450
LEU A 499
 None
 1.19A 3tgvB-4fzhA:
undetectable		 3tgvB-4fzhA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		4 ARG A  68
GLN A  84
TYR A  49
PHE A  71
 None
 1.44A 3tgvB-4in9A:
undetectable		 3tgvB-4in9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2g KLTH0A00704P

(Lachancea
thermotolerans) 		PF10033
(ATG13) 		4 ARG A 232
TYR A 250
PRO A 166
LEU A 164
 None
 1.19A 3tgvB-4j2gA:
undetectable		 3tgvB-4j2gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 GLN A 559
PHE A 565
PRO A 566
LEU A 590
 None
 1.40A 3tgvB-4n3nA:
undetectable		 3tgvB-4n3nA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 GLN A 441
PHE A 447
PRO A 448
LEU A 472
 None
 1.39A 3tgvB-4n3sA:
undetectable		 3tgvB-4n3sA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 GLN A 100
PHE A 291
PRO A 290
LEU A 288
 None
 1.03A 3tgvB-4o89A:
undetectable		 3tgvB-4o89A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 287
PHE A 360
PRO A 372
LEU A 358
 None
 1.13A 3tgvB-4pfwA:
undetectable		 3tgvB-4pfwA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 287
PHE A 360
PRO A 372
LEU A 358
 None
 1.18A 3tgvB-4pfyA:
undetectable		 3tgvB-4pfyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLN A 326
TYR A 167
PHE A 299
LEU A 160
 None
 1.39A 3tgvB-4qq1A:
undetectable		 3tgvB-4qq1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 GLN A  40
TYR A  36
PRO A 473
LEU A 470
 None
 1.37A 3tgvB-4qreA:
undetectable		 3tgvB-4qreA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN

(Escherichia
coli) 		PF13508
(Acetyltransf_7) 		4 ARG A  35
TYR A  56
PRO A  76
LEU A  34
 None
 1.33A 3tgvB-4rs2A:
undetectable		 3tgvB-4rs2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ARG A 411
PHE A 401
PRO A 407
LEU A 398
 None
 1.35A 3tgvB-4uphA:
undetectable		 3tgvB-4uphA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ARG A 399
PHE A 389
PRO A 395
LEU A 386
 None
 1.38A 3tgvB-4upkA:
undetectable		 3tgvB-4upkA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 TYR A 100
PHE A  73
PRO A  87
LEU A  20
 None
 1.30A 3tgvB-4w8yA:
undetectable		 3tgvB-4w8yA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		4 TYR A   4
PHE A 198
PRO A   5
LEU A 199
 None
 1.42A 3tgvB-4zwnA:
undetectable		 3tgvB-4zwnA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A  51
TYR A  53
PHE A  92
PRO A  88
 None
 1.11A 3tgvB-5bswA:
undetectable		 3tgvB-5bswA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		4 ARG A 366
GLN A 208
PHE A 211
LEU A  36
 None
 1.40A 3tgvB-5c2iA:
undetectable		 3tgvB-5c2iA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Staphylococcus
aureus) 		PF00574
(CLP_protease) 		4 GLN A  82
TYR A  78
PHE A 102
LEU A 154
 None
None
None
MPD  A2001 ( 4.8A)
 1.44A 3tgvB-5c90A:
undetectable		 3tgvB-5c90A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		4 ARG A 144
GLN A 203
PHE A 185
LEU A 175
 None
 1.37A 3tgvB-5d4kA:
undetectable		 3tgvB-5d4kA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 ARG A 194
GLN A 136
PHE A 273
PRO A 274
 None
 1.43A 3tgvB-5ddsA:
undetectable		 3tgvB-5ddsA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 TYR A 411
PHE A 463
PRO A 465
LEU A 460
 None
None
CL  A 705 ( 4.2A)
CL  A 705 (-3.7A)
 1.37A 3tgvB-5gy0A:
undetectable		 3tgvB-5gy0A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 TYR A 365
PHE A 354
PRO A 362
LEU A 438
 None
 1.12A 3tgvB-5inrA:
undetectable		 3tgvB-5inrA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1f PLECTIN,PLECTIN

(Homo sapiens) 		no annotation 4 GLN A 993
TYR A 992
PHE A 941
LEU A 999
 None
 1.42A 3tgvB-5j1fA:
undetectable		 3tgvB-5j1fA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A 482
TYR A 291
PHE A 354
PRO A 284
 None
 1.32A 3tgvB-5lm8A:
undetectable		 3tgvB-5lm8A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLN A 222
TYR A 223
PHE A 310
PRO A  46
 None
 1.39A 3tgvB-5mmsA:
undetectable		 3tgvB-5mmsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Ogataea angusta) 		no annotation 4 TYR A 169
PHE A  56
PRO A  55
LEU A 144
 None
 1.27A 3tgvB-5nkzA:
undetectable		 3tgvB-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLN A1960
PHE A2086
PRO A2082
LEU A2247
 None
 1.11A 3tgvB-5nnnA:
undetectable		 3tgvB-5nnnA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN

(Mus musculus) 		no annotation 4 ARG F  44
PHE F  67
PRO F  64
LEU F  52
 None
 1.11A 3tgvB-5tbdF:
undetectable		 3tgvB-5tbdF:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		4 GLN A 469
TYR A 465
PHE A 263
PRO A 258
 None
 1.23A 3tgvB-5tgtA:
undetectable		 3tgvB-5tgtA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 4 GLN G 200
TYR G 162
PHE G 235
PRO G  73
 None
 1.18A 3tgvB-5uz5G:
undetectable		 3tgvB-5uz5G:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 ARG A 507
TYR A 541
PHE A 621
LEU A 605
 None
 1.39A 3tgvB-5wzrA:
undetectable		 3tgvB-5wzrA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG

(Klebsiella
pneumoniae) 		no annotation 4 ARG A  63
GLN A  36
PRO A   7
LEU A  91
 None
 1.19A 3tgvB-5xktA:
undetectable		 3tgvB-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Mus musculus) 		no annotation 4 ARG B 610
PHE B 614
PRO B 613
LEU B 611
 None
 1.31A 3tgvB-5y3tB:
undetectable		 3tgvB-5y3tB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 4 ARG A 231
TYR A 169
PHE A  56
PRO A 162
 None
 1.35A 3tgvB-6b4mA:
undetectable		 3tgvB-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1
MRNA
3'-END-PROCESSING
PROTEIN YTH1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 GLN A1210
PHE B  18
PRO A1201
LEU B  19
 None
 1.39A 3tgvB-6eojA:
undetectable		 3tgvB-6eojA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh8 -

(-) 		no annotation 4 GLN A 131
TYR A  49
PHE A 124
PRO A  43
 None
 1.27A 3tgvB-6gh8A:
undetectable		 3tgvB-6gh8A:
undetectable