SIMILAR PATTERNS OF AMINO ACIDS FOR 3TF1_A_ACTA191

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csm CHORISMATE MUTASE

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A 181
THR A 177
ILE A 180
PHE A 169
 None
 1.29A 3tf1A-1csmA:
0.0		 3tf1A-1csmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfr HEMOGLOBIN

(Paramphistomum
epiclitum) 		PF00042
(Globin) 		4 THR A  71
ILE A  74
PHE A 119
LEU A  14
 None
 1.18A 3tf1A-1kfrA:
undetectable		 3tf1A-1kfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjn MTH0777

(Methanothermobacter
thermautotrophicus) 		PF09001
(DUF1890) 		4 THR A  28
ILE A 149
PHE A  85
LEU A 107
 None
 1.17A 3tf1A-1kjnA:
0.0		 3tf1A-1kjnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		4 THR A  69
ILE A  73
PHE A  53
LEU A  22
 None
 1.37A 3tf1A-1lbuA:
1.6		 3tf1A-1lbuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		4 THR A 178
ILE A 154
PHE A 248
LEU A 152
 None
 1.43A 3tf1A-1t71A:
undetectable		 3tf1A-1t71A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 THR A 145
ILE A  62
PHE A 507
LEU A 455
 None
 1.05A 3tf1A-1ufaA:
0.0		 3tf1A-1ufaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 LYS A 869
ILE A 868
PHE A 827
LEU A 847
 None
 1.48A 3tf1A-1urjA:
0.0		 3tf1A-1urjA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3o ACYL CARRIER PROTEIN

(Thermus
thermophilus) 		PF00550
(PP-binding) 		4 LYS A   1
ILE A   6
PHE A  53
LEU A  79
 None
 1.22A 3tf1A-1x3oA:
2.6		 3tf1A-1x3oA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x66 FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF02198
(SAM_PNT) 		4 THR A  73
ILE A  48
PHE A  53
LEU A  81
 None
 1.25A 3tf1A-1x66A:
undetectable		 3tf1A-1x66A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		4 LYS C  20
THR C  23
ILE C 182
PHE C 147
 None
 0.99A 3tf1A-2bruC:
0.0		 3tf1A-2bruC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 THR A 327
ILE A 331
PHE A 405
LEU A 322
 None
 1.19A 3tf1A-2d5wA:
undetectable		 3tf1A-2d5wA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erc RRNA METHYL
TRANSFERASE

(Bacillus
subtilis) 		PF00398
(RrnaAD) 		4 THR A 108
ILE A 111
PHE A 131
LEU A 142
 None
 1.42A 3tf1A-2ercA:
2.2		 3tf1A-2ercA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B

(Homo sapiens) 		PF00378
(ECH_1) 		4 LYS A 315
THR A 311
ILE A 314
PHE A 350
 None
 1.34A 3tf1A-2fbmA:
undetectable		 3tf1A-2fbmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy1 RNA-BINDING MOTIF
PROTEIN, Y
CHROMOSOME, FAMILY 1
MEMBER A1

(Homo sapiens) 		PF00076
(RRM_1) 		4 LYS A   9
THR A  54
ILE A  53
LEU A  38
 A  B 121 ( 4.1A)
None
None
A  B 121 ( 3.8A)
 1.38A 3tf1A-2fy1A:
undetectable		 3tf1A-2fy1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		4 LYS A  26
THR A  23
ILE A 161
PHE A 217
 None
 1.37A 3tf1A-2ixdA:
undetectable		 3tf1A-2ixdA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 THR A 295
ILE A 206
PHE A 284
LEU A 221
 None
 1.49A 3tf1A-2jcjA:
undetectable		 3tf1A-2jcjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx7 SYNERGIN GAMMA

(Homo sapiens) 		no annotation 4 LYS A 305
THR A 309
ILE A 306
LEU A 388
 None
 1.14A 3tf1A-2mx7A:
2.0		 3tf1A-2mx7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbu UV EXCISION REPAIR
PROTEIN RAD23

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin) 		4 THR A  27
ILE A  24
PHE A   6
LEU A  62
 None
 1.32A 3tf1A-2nbuA:
undetectable		 3tf1A-2nbuA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 THR A 209
ILE A 228
PHE A 183
LEU A 246
 None
 1.25A 3tf1A-2pncA:
0.5		 3tf1A-2pncA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  51
ILE A  42
PHE A  64
 None
 1.44A 3tf1A-2rcqA:
undetectable		 3tf1A-2rcqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		4 THR A 306
ILE A   6
PHE A  94
LEU A 300
 None
 1.15A 3tf1A-2vvgA:
0.4		 3tf1A-2vvgA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18
SYNTAXIN1

(Monosiga
brevicollis;
Monosiga
brevicollis) 		PF00995
(Sec1)
PF00804
(Syntaxin)
PF05739
(SNARE) 		4 THR A  52
ILE B 135
PHE B  47
LEU A  64
 None
 1.44A 3tf1A-2xheA:
undetectable		 3tf1A-2xheA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bro TRANSCRIPTIONAL
REGULATOR

(Oenococcus oeni) 		PF12802
(MarR_2) 		4 THR A  35
ILE A  36
PHE A  57
LEU A  67
 None
 1.47A 3tf1A-3broA:
undetectable		 3tf1A-3broA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 THR A  47
ILE A  70
PHE A  53
LEU A  36
 None
 1.36A 3tf1A-3cnyA:
undetectable		 3tf1A-3cnyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 144
ILE A 148
PHE A 218
LEU A 207
 None
 1.02A 3tf1A-3glqA:
undetectable		 3tf1A-3glqA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4q PUTATIVE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00583
(Acetyltransf_1) 		4 THR A 123
ILE A  89
PHE A 141
LEU A 128
 None
None
None
UNL  A 170 ( 4.1A)
 1.21A 3tf1A-3h4qA:
undetectable		 3tf1A-3h4qA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix9 DIHYDROFOLATE
REDUCTASE

(Streptococcus
pneumoniae) 		PF00186
(DHFR_1) 		4 THR A  38
ILE A  43
PHE A  34
LEU A  58
 None
None
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
 1.47A 3tf1A-3ix9A:
undetectable		 3tf1A-3ix9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 THR A1926
ILE A1927
PHE A1874
LEU A1882
 None
 1.34A 3tf1A-3kg6A:
undetectable		 3tf1A-3kg6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		4 LYS A 200
THR A 172
ILE A 170
PHE A 180
 None
None
None
CL  A 310 ( 4.1A)
 0.96A 3tf1A-3psqA:
undetectable		 3tf1A-3psqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry6 LOW AFFINITY
IMMUNOGLOBULIN GAMMA
FC REGION RECEPTOR
II-A

(Homo sapiens) 		PF13895
(Ig_2) 		4 THR C  95
ILE C  17
PHE C 100
LEU C  98
 None
 1.24A 3tf1A-3ry6C:
undetectable		 3tf1A-3ry6C:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 THR A 444
ILE A 340
PHE A 346
LEU A 417
 None
 1.39A 3tf1A-3vtaA:
undetectable		 3tf1A-3vtaA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		4 THR A 170
ILE A   7
PHE A 196
LEU A  20
 None
 1.45A 3tf1A-4bofA:
undetectable		 3tf1A-4bofA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 4 THR A 150
ILE A 149
PHE A  89
LEU A 202
 None
 1.40A 3tf1A-4btgA:
undetectable		 3tf1A-4btgA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 THR A 596
ILE A 565
PHE A 485
LEU A 567
 None
 1.45A 3tf1A-4cakA:
undetectable		 3tf1A-4cakA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 THR A 341
ILE A 346
PHE A 198
LEU A 359
 None
 1.47A 3tf1A-4hwiA:
undetectable		 3tf1A-4hwiA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1
SYNTAXIN-1A

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00995
(Sec1)
PF00804
(Syntaxin) 		4 THR A  56
ILE B 115
PHE B  34
LEU A  71
 None
 1.33A 3tf1A-4jeuA:
undetectable		 3tf1A-4jeuA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqz TRANSCRIPTIONAL
PROTEIN SWT1

(Saccharomyces
cerevisiae) 		no annotation 4 THR A 348
ILE A 345
PHE A 385
LEU A 430
 None
 1.41A 3tf1A-4pqzA:
undetectable		 3tf1A-4pqzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwy ANTIBODY 8ANC131
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H 112
ILE H 110
PHE H 146
LEU H 170
 None
 1.20A 3tf1A-4rwyH:
3.2		 3tf1A-4rwyH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 THR A 330
ILE A 331
PHE A 338
LEU A 322
 None
 1.36A 3tf1A-4u7lA:
undetectable		 3tf1A-4u7lA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xav GLIOMEDIN

(Mus musculus) 		PF02191
(OLF) 		4 THR A 462
ILE A 444
PHE A 491
LEU A 479
 None
 1.31A 3tf1A-4xavA:
undetectable		 3tf1A-4xavA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 THR A 249
ILE A 259
PHE A 286
LEU A 257
 None
 1.31A 3tf1A-4xyiA:
undetectable		 3tf1A-4xyiA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 THR A 113
ILE A 116
PHE A  55
LEU A  88
 None
 1.26A 3tf1A-5amqA:
3.7		 3tf1A-5amqA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 THR A  87
ILE A  32
PHE A  89
LEU A  50
 None
 1.40A 3tf1A-5cioA:
0.8		 3tf1A-5cioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 THR A 488
ILE A 467
PHE A 371
LEU A 469
 None
 1.39A 3tf1A-5ereA:
undetectable		 3tf1A-5ereA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		4 THR A 198
ILE A 167
PHE A 221
LEU A 149
 None
 1.46A 3tf1A-5eyfA:
undetectable		 3tf1A-5eyfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4a ARGONAUTE PROTEIN

(Marinitoga
piezophila) 		no annotation 4 LYS A 236
THR A 240
PHE A 101
LEU A 128
 None
 1.37A 3tf1A-5i4aA:
undetectable		 3tf1A-5i4aA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 THR A 333
ILE A 338
PHE A 382
LEU A 363
 None
 1.27A 3tf1A-5t67A:
undetectable		 3tf1A-5t67A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		4 THR A1155
ILE A1160
PHE A1304
LEU A1168
 None
 1.22A 3tf1A-5w0mA:
1.0		 3tf1A-5w0mA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi2 CDNA FLJ56409,
HIGHLY SIMILAR TO
SERINE/THREONINE-PRO
TEIN KINASE CHK1 (EC
2.7.11.1)

(Homo sapiens) 		no annotation 4 THR A 382
ILE A 465
PHE A 380
LEU A 393
 None
 1.38A 3tf1A-5wi2A:
1.7		 3tf1A-5wi2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wva SHORT-CHAIN
DEHYDROGENASE

(Serratia
marcescens) 		no annotation 4 THR A  39
ILE A  64
PHE A  13
LEU A  74
 None
 1.39A 3tf1A-5wvaA:
undetectable		 3tf1A-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq NEUROLIGIN-2

(Homo sapiens) 		PF00135
(COesterase) 		4 THR A 430
ILE A 431
PHE A 600
LEU A 608
 None
 1.28A 3tf1A-5xeqA:
1.2		 3tf1A-5xeqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC

(Zea mays;
Zea mays) 		no annotation
no annotation 		4 THR H  64
ILE H  61
PHE D  89
LEU H  58
 None
 1.30A 3tf1A-5zjiH:
undetectable		 3tf1A-5zjiH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 THR B 146
ILE B 147
PHE B 166
LEU B 122
 None
 1.44A 3tf1A-6f5oB:
3.5		 3tf1A-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 4 LYS A  60
THR A  39
ILE A  61
PHE A  22
 None
SF4  A 403 (-4.6A)
None
None
 1.03A 3tf1A-6fahA:
undetectable		 3tf1A-6fahA:
undetectable