SIMILAR PATTERNS OF AMINO ACIDS FOR 3TEH_B_DAHB786

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 LEU A 332
GLY A 394
ALA A 396
PHE A 397
 None
 0.81A 3tehB-1cjyA:
0.0		 3tehB-1cjyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Escherichia
coli) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		4 HIS A  29
LEU A  16
GLY A  62
PHE A  63
 None
 0.96A 3tehB-1d8lA:
2.5		 3tehB-1d8lA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		4 PRO A 391
LEU A  13
ALA A  20
PHE A  24
 None
 0.92A 3tehB-1de6A:
0.0		 3tehB-1de6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 LEU A 321
GLY A 257
ALA A 259
PHE A 260
 None
 1.00A 3tehB-1dmwA:
0.0		 3tehB-1dmwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 PRO A 125
LEU A 118
GLY A 122
ALA A 157
 None
 0.82A 3tehB-1ee8A:
0.0		 3tehB-1ee8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 LEU A 124
GLY A 432
ALA A 520
PHE A 433
 None
 1.01A 3tehB-1l5jA:
undetectable		 3tehB-1l5jA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 PRO A 198
LEU A 106
ALA A  45
PHE A 209
 None
 0.98A 3tehB-1orfA:
undetectable		 3tehB-1orfA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1d GLUTAMATE RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 PRO A  65
LEU A  98
GLY A  36
GLU A  61
 None
 0.93A 3tehB-1p1dA:
0.0		 3tehB-1p1dA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 PRO A  54
LEU A 107
ALA A  32
PHE A  30
 None
 1.01A 3tehB-1qfjA:
2.4		 3tehB-1qfjA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ql0 NUCLEASE

(Serratia
marcescens) 		PF01223
(Endonuclease_NS) 		4 HIS A 184
LEU A 240
GLY A 235
ALA A 186
 None
 0.99A 3tehB-1ql0A:
undetectable		 3tehB-1ql0A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans) 		PF00115
(COX1)
PF00510
(COX3) 		4 LEU A 266
GLY A 240
ALA C 103
PHE C 100
 None
 1.01A 3tehB-1qleA:
undetectable		 3tehB-1qleA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  52
GLY A  64
GLU A  62
ALA A  68
 None
 1.00A 3tehB-1rtrA:
undetectable		 3tehB-1rtrA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		4 PRO A 223
HIS A 208
GLY A 205
ALA A   7
 None
MN  A 402 (-3.6A)
None
None
 0.97A 3tehB-1s8eA:
undetectable		 3tehB-1s8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 228
GLY A 219
ALA A 309
PHE A 297
 None
 0.98A 3tehB-1smkA:
undetectable		 3tehB-1smkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2

(Bos taurus) 		PF00022
(Actin) 		4 PRO B 262
LEU B 317
GLY B 224
GLU B 263
 None
 0.91A 3tehB-1u2vB:
undetectable		 3tehB-1u2vB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 153
GLY A  65
ALA A 127
PHE A  20
 None
 0.83A 3tehB-1wuuA:
3.1		 3tehB-1wuuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF03306
(AAL_decarboxy) 		4 HIS A 175
GLY A 184
ALA A  56
PHE A  62
 ZN  A 801 (-3.4A)
None
None
None
 0.86A 3tehB-1xv2A:
undetectable		 3tehB-1xv2A:
15.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		7 PRO B 259
HIS B 261
LEU B 286
GLY B 315
GLU B 334
ALA B 356
PHE B 360
 None
TYR  B 999 (-3.6A)
TYR  B 999 (-4.1A)
TYR  B 999 (-3.2A)
TYR  B 999 (-3.5A)
TYR  B 999 (-3.1A)
TYR  B 999 ( 4.8A)
 0.39A 3tehB-2amcB:
60.1		 3tehB-2amcB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 LEU A 194
GLY A 241
ALA A 191
PHE A 239
 None
 0.99A 3tehB-2aqwA:
undetectable		 3tehB-2aqwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 202
LEU A  67
GLY A  82
ALA A  85
 None
None
PLP  A 600 (-3.2A)
None
 1.00A 3tehB-2ctzA:
2.0		 3tehB-2ctzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LEU A 147
GLY A 129
ALA A 154
PHE A 153
 None
 1.01A 3tehB-2ecfA:
undetectable		 3tehB-2ecfA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		4 LEU A 275
GLY A 222
GLU A  40
ALA A 234
 None
None
EDO  A 317 (-3.9A)
None
 0.89A 3tehB-2ghsA:
undetectable		 3tehB-2ghsA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiq HYPOTHETICAL PROTEIN
YDHR

(Escherichia
coli) 		PF08803
(ydhR) 		4 PRO A  21
GLY A  23
GLU A  52
ALA A  25
 None
 0.98A 3tehB-2hiqA:
5.0		 3tehB-2hiqA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 190
GLY A 280
GLU A 218
ALA A 214
 None
 1.00A 3tehB-2i4nA:
11.7		 3tehB-2i4nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 LEU A 199
GLY A 256
ALA A 162
PHE A 163
 None
 0.89A 3tehB-2kdyA:
undetectable		 3tehB-2kdyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lu2 MICRONEME TGMIC5
PROTEIN

(Toxoplasma
gondii) 		no annotation 4 HIS A 120
GLY A 127
ALA A 125
PHE A  73
 None
 0.98A 3tehB-2lu2A:
3.1		 3tehB-2lu2A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 PRO A   6
LEU A 186
GLY A 177
ALA A 194
 None
 0.89A 3tehB-2nuxA:
undetectable		 3tehB-2nuxA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvn HYPOTHETICAL PROTEIN

(Synechococcus
elongatus) 		PF08848
(DUF1818) 		4 PRO A 104
LEU A  13
GLY A  10
ALA A 107
 GOL  A 122 ( 4.9A)
None
None
None
 1.00A 3tehB-2nvnA:
undetectable		 3tehB-2nvnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		4 HIS A 354
GLY A 352
GLU A 326
ALA A 356
 None
 0.94A 3tehB-2o78A:
undetectable		 3tehB-2o78A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 HIS A 349
GLY A 351
GLU A 348
PHE A  76
 None
 1.01A 3tehB-2q6zA:
undetectable		 3tehB-2q6zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 HIS A 345
LEU A 314
GLY A 348
ALA A 347
PHE A 361
 EDO  A 478 (-4.7A)
None
None
None
None
 1.41A 3tehB-2qneA:
undetectable		 3tehB-2qneA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 LEU A 160
GLY A 200
GLU A 166
ALA A 198
 None
 0.90A 3tehB-2qqpA:
undetectable		 3tehB-2qqpA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 HIS B 272
LEU B 298
GLY B 323
GLU B 342
PHE B 368
 None
 0.97A 3tehB-2rhqB:
45.8		 3tehB-2rhqB:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		6 PRO B 270
HIS B 272
GLY B 323
GLU B 342
ALA B 364
PHE B 368
 None
 0.95A 3tehB-2rhqB:
45.8		 3tehB-2rhqB:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LEU G 800
GLY G 772
ALA G1059
PHE G1062
 None
None
FMN  G3051 (-3.5A)
None
 0.99A 3tehB-2uv8G:
undetectable		 3tehB-2uv8G:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 HIS A 443
LEU A 232
GLY A 412
ALA A 415
 AD0  A1617 (-3.8A)
AD0  A1617 (-4.7A)
None
None
 0.94A 3tehB-2uvfA:
undetectable		 3tehB-2uvfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		4 HIS A 244
LEU A  99
GLY A 214
ALA A 242
 None
 0.99A 3tehB-2xuaA:
undetectable		 3tehB-2xuaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		4 LEU A 139
GLY A  77
ALA A  75
PHE A  58
 None
 1.00A 3tehB-2xziA:
undetectable		 3tehB-2xziA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 GLY A 293
GLU A 319
ALA A 253
PHE A 294
 None
None
HEX  A1016 ( 3.7A)
None
 0.87A 3tehB-2ynkA:
undetectable		 3tehB-2ynkA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 LEU A 191
GLY A 238
ALA A 188
PHE A 236
 None
 0.97A 3tehB-2za1A:
undetectable		 3tehB-2za1A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 LEU A 380
GLY A 219
ALA A 484
PHE A 215
 None
 0.97A 3tehB-3ahmA:
undetectable		 3tehB-3ahmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 19
PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3)
no annotation 		4 PRO A 327
LEU B  18
ALA B  25
PHE B  29
 None
 0.96A 3tehB-3ajbA:
undetectable		 3tehB-3ajbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		4 PRO X  31
HIS X  37
GLY X  35
GLU X  40
 None
 0.91A 3tehB-3eatX:
undetectable		 3tehB-3eatX:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  69
GLY A 107
ALA A  76
PHE A  80
 None
 0.81A 3tehB-3etcA:
undetectable		 3tehB-3etcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		4 LEU A 125
GLY A 117
GLU A  97
ALA A 113
 None
 0.88A 3tehB-3fijA:
undetectable		 3tehB-3fijA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A 115
GLY A 145
ALA A 149
PHE A 150
 None
 0.93A 3tehB-3g0oA:
undetectable		 3tehB-3g0oA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfh TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		4 LEU A 671
GLU A 717
ALA A 677
PHE A 678
 MLY  A 667 ( 4.4A)
MLY  A 721 ( 4.2A)
None
None
 0.96A 3tehB-3hfhA:
undetectable		 3tehB-3hfhA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		4 LEU A 170
GLY A 176
ALA A 138
PHE A 135
 None
 1.01A 3tehB-3kh1A:
undetectable		 3tehB-3kh1A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 HIS A 272
GLY A 321
ALA A 279
PHE A 333
 None
 1.01A 3tehB-3my7A:
undetectable		 3tehB-3my7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		4 PRO A 150
LEU A 141
GLY A 168
ALA A 170
 None
 0.99A 3tehB-3nvqA:
undetectable		 3tehB-3nvqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 HIS A 244
LEU A  98
GLY A 214
ALA A 242
 None
 0.95A 3tehB-3om8A:
undetectable		 3tehB-3om8A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME

(Vibrio cholerae) 		PF01965
(DJ-1_PfpI) 		4 HIS B  15
GLY B  80
ALA B  83
PHE B  84
 None
 0.92A 3tehB-3ot1B:
undetectable		 3tehB-3ot1B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  67
GLY A 107
GLU A  57
ALA A 105
 None
 0.95A 3tehB-3owaA:
undetectable		 3tehB-3owaA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 HIS B 265
LEU B 290
GLY B 314
GLU B 334
 None
 1.00A 3tehB-3pcoB:
undetectable		 3tehB-3pcoB:
38.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		6 PRO B 263
HIS B 265
LEU B 290
GLY B 315
GLU B 334
ALA B 356
 None
 0.84A 3tehB-3pcoB:
undetectable		 3tehB-3pcoB:
38.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 LEU A 318
GLY A 302
GLU A 127
ALA A 304
 None
 0.83A 3tehB-3phfA:
undetectable		 3tehB-3phfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Yersinia pestis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 PRO A  84
LEU A  17
GLU A  91
PHE A 422
 ANP  A 601 (-4.5A)
None
None
ANP  A 601 (-4.4A)
 1.00A 3tehB-3pyzA:
undetectable		 3tehB-3pyzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 PRO C 301
LEU C 314
GLY C 278
GLU C 275
 None
 0.96A 3tehB-3qgkC:
undetectable		 3tehB-3qgkC:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Sphaerobacter
thermophilus) 		PF12697
(Abhydrolase_6) 		4 PRO A  22
LEU A  75
GLY A  84
ALA A  82
 None
 0.94A 3tehB-3r0vA:
undetectable		 3tehB-3r0vA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 HIS A 112
LEU A 109
GLY A 142
PHE A 186
 None
 0.96A 3tehB-3r7kA:
undetectable		 3tehB-3r7kA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 LEU A  32
GLY A  40
GLU A  88
ALA A  42
 None
 1.01A 3tehB-3s51A:
undetectable		 3tehB-3s51A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE

(Mycolicibacterium
thermoresistibile) 		PF03308
(ArgK) 		4 HIS A 204
LEU A 174
GLY A 178
ALA A 211
 None
 0.94A 3tehB-3tk1A:
undetectable		 3tehB-3tk1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B 908
GLY B 872
GLU B1048
ALA B 877
 None
 0.98A 3tehB-3v0aB:
undetectable		 3tehB-3v0aB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 PRO B 387
LEU B 463
GLY B 401
ALA B 398
PHE B 359
 None
 1.28A 3tehB-3x17B:
undetectable		 3tehB-3x17B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzf ACETYLGLUTAMATE
KINASE

(Saccharomyces
cerevisiae) 		PF00696
(AA_kinase) 		4 PRO A 138
LEU A 113
GLY A 105
ALA A 107
 None
None
EDO  A1355 ( 4.5A)
None
 0.98A 3tehB-3zzfA:
undetectable		 3tehB-3zzfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 LEU A 206
GLY A 149
ALA A 299
PHE A 297
 None
 1.01A 3tehB-4c1tA:
undetectable		 3tehB-4c1tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 HIS A 274
LEU A 129
GLY A 242
ALA A 272
 VKC  A1294 ( 4.9A)
None
None
None
 0.95A 3tehB-4ccwA:
undetectable		 3tehB-4ccwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		4 LEU A 456
GLY A 368
ALA A 344
PHE A 367
 None
 1.00A 3tehB-4doeA:
undetectable		 3tehB-4doeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 LEU A  27
GLY A  33
ALA A  48
PHE A   8
 None
 0.99A 3tehB-4dykA:
undetectable		 3tehB-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		4 PRO A 291
LEU A 330
GLY A 303
ALA A 293
 None
 0.99A 3tehB-4fcgA:
undetectable		 3tehB-4fcgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		4 PRO A 157
LEU A 178
GLY A  80
GLU A  92
 None
None
None
MG  A 403 (-3.0A)
 1.01A 3tehB-4gedA:
undetectable		 3tehB-4gedA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Campylobacter
jejuni) 		PF00977
(His_biosynth) 		4 LEU A  50
GLY A  83
GLU A  89
ALA A  56
 None
 0.91A 3tehB-4gj1A:
undetectable		 3tehB-4gj1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 PRO A1021
HIS A 551
GLY A 983
PHE A 982
 None
 0.99A 3tehB-4hpfA:
undetectable		 3tehB-4hpfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 HIS A 549
LEU A 582
GLY A 575
PHE A 456
 None
 0.91A 3tehB-4iigA:
undetectable		 3tehB-4iigA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PRO A 576
GLY A 639
ALA A 637
PHE A 635
 None
 0.93A 3tehB-4j0mA:
undetectable		 3tehB-4j0mA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		4 PRO A 192
LEU A  10
GLY A 188
GLU A 123
 None
 1.00A 3tehB-4kf6A:
undetectable		 3tehB-4kf6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG

(Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		4 PRO A  67
GLY A 143
GLU A 139
ALA A 145
 None
 0.98A 3tehB-4kmhA:
undetectable		 3tehB-4kmhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		4 LEU A 152
GLY A 120
ALA A  69
PHE A  68
 None
None
None
EDO  A 817 (-4.8A)
 0.91A 3tehB-4lm8A:
undetectable		 3tehB-4lm8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		4 HIS A 147
GLU A 191
ALA A 125
PHE A 130
 None
 0.78A 3tehB-4ly4A:
undetectable		 3tehB-4ly4A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 295
GLY A  33
GLU A  36
ALA A  30
 None
 0.94A 3tehB-4mivA:
undetectable		 3tehB-4mivA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		4 HIS A 367
GLY A 321
GLU A 372
PHE A 340
 None
 0.97A 3tehB-4mpsA:
undetectable		 3tehB-4mpsA:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		6 PRO A 262
HIS A 264
LEU A 289
GLY A 314
GLU A 333
PHE A 359
 None
 0.72A 3tehB-4p72A:
undetectable		 3tehB-4p72A:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		4 LEU A 606
GLY A 594
GLU A 562
ALA A 596
 None
 0.82A 3tehB-4qmkA:
undetectable		 3tehB-4qmkA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		4 LEU A  31
GLY A 104
ALA A 107
PHE A 108
 None
 0.79A 3tehB-4uhhA:
undetectable		 3tehB-4uhhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 PRO A 107
HIS A 215
LEU A  71
ALA A  97
 None
 0.63A 3tehB-4uphA:
undetectable		 3tehB-4uphA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PRO A  63
LEU A 188
GLY A  87
ALA A  82
 None
 0.81A 3tehB-4xaeA:
undetectable		 3tehB-4xaeA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		4 LEU A  81
GLY A  88
ALA A  44
PHE A  49
 None
 1.01A 3tehB-4xzbA:
undetectable		 3tehB-4xzbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		4 PRO A 101
GLY A 143
ALA A 102
PHE A 104
 None
 0.95A 3tehB-4yn5A:
undetectable		 3tehB-4yn5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B 873
GLY B 837
GLU B1013
ALA B 842
 None
 0.90A 3tehB-4zktB:
undetectable		 3tehB-4zktB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 LEU A 253
GLY A 129
GLU A  96
ALA A 133
 None
None
K  A1562 (-4.0A)
None
 0.85A 3tehB-5a5gA:
undetectable		 3tehB-5a5gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 HIS C 159
LEU C 163
GLY C 122
ALA C  91
 None
 1.00A 3tehB-5a8rC:
undetectable		 3tehB-5a8rC:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 104
GLY A 326
ALA A 330
PHE A 790
 None
 1.01A 3tehB-5aw4A:
undetectable		 3tehB-5aw4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 358
GLY A 367
GLU A 387
ALA A 371
 None
 0.92A 3tehB-5bz4A:
undetectable		 3tehB-5bz4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		4 PRO B 240
GLY B 207
GLU B 630
ALA B 204
 None
 1.00A 3tehB-5ej1B:
undetectable		 3tehB-5ej1B:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 HIS A 550
LEU A 583
GLY A 576
PHE A 457
 None
 0.91A 3tehB-5fjiA:
undetectable		 3tehB-5fjiA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PRO A   8
LEU A 131
GLY A  35
ALA A  30
 None
 0.94A 3tehB-5gjaA:
undetectable		 3tehB-5gjaA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A  15
GLY A  71
ALA A 136
PHE A 286
 None
None
LAQ  A 401 ( 4.3A)
None
 0.81A 3tehB-5iclA:
undetectable		 3tehB-5iclA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifs TETHER CONTAINING
UBX DOMAIN FOR GLUT4

(Homo sapiens) 		PF00789
(UBX) 		4 LEU A 459
GLY A 405
ALA A 392
PHE A 406
 None
 0.97A 3tehB-5ifsA:
undetectable		 3tehB-5ifsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifw TETHER CONTAINING
UBX DOMAIN FOR GLUT4

(Homo sapiens) 		PF00789
(UBX) 		4 LEU A 459
GLY A 405
ALA A 392
PHE A 406
 None
 0.99A 3tehB-5ifwA:
undetectable		 3tehB-5ifwA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A  15
GLY A  71
ALA A 136
PHE A 288
 None
None
LPA  A 401 ( 3.8A)
None
 0.99A 3tehB-5ij6A:
undetectable		 3tehB-5ij6A:
17.88