SIMILAR PATTERNS OF AMINO ACIDS FOR 3TEG_A_DAHA416_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2o | CHEB METHYLESTERASE (Salmonellaenterica) |
PF00072(Response_reg)PF01339(CheB_methylest) | 5 | THR A 301GLY A 290GLY A 323ALA A 318GLY A 287 | None | 1.05A | 3tegA-1a2oA:undetectable | 3tegA-1a2oA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d2k | CHITINASE 1 (Coccidioidesimmitis) |
PF00704(Glyco_hydro_18) | 5 | PHE A 297PHE A 307THR A 300GLY A 250GLY A 302 | None | 1.09A | 3tegA-1d2kA:undetectable | 3tegA-1d2kA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1drk | D-RIBOSE-BINDINGPROTEIN (Escherichiacoli) |
PF13407(Peripla_BP_4) | 5 | PHE A 187GLY A 109GLY A 113ALA A 148GLY A 144 | None | 0.97A | 3tegA-1drkA:undetectable | 3tegA-1drkA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dys | ENDOGLUCANASE (Humicolainsolens) |
PF01341(Glyco_hydro_6) | 5 | SER A 218GLU A 243PHE A 263GLY A 188GLY A 184 | None | 1.18A | 3tegA-1dysA:undetectable | 3tegA-1dysA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I ALPHASUBUNIT (Methanopyruskandleri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | GLN A 434PHE A 446GLY A 401ALA A 405GLY A 486 | NoneTP7 A1554 (-4.2A)NoneNoneNone | 1.17A | 3tegA-1e6vA:4.1 | 3tegA-1e6vA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1erz | N-CARBAMYL-D-AMINOACID AMIDOHYDROLASE (Agrobacteriumsp. KNK712) |
PF00795(CN_hydrolase) | 5 | GLN A 11PHE A 91PHE A 44GLY A 94ALA A 48 | None | 1.12A | 3tegA-1erzA:undetectable | 3tegA-1erzA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gll | GLYCEROL KINASE (Escherichiacoli) |
no annotation | 5 | SER Y 383GLN Y 387PHE Y 348GLY Y 362GLY Y 350 | None | 1.14A | 3tegA-1gllY:undetectable | 3tegA-1gllY:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jft | PURINE NUCLEOTIDESYNTHESIS REPRESSOR (Escherichiacoli) |
PF00356(LacI)PF13377(Peripla_BP_3) | 5 | PHE A 244GLY A 166GLY A 170ALA A 203GLY A 199 | None | 1.11A | 3tegA-1jftA:undetectable | 3tegA-1jftA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jhz | PURINE NUCLEOTIDESYNTHESIS REPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 5 | PHE A 244GLY A 166GLY A 170ALA A 203GLY A 199 | None | 1.08A | 3tegA-1jhzA:undetectable | 3tegA-1jhzA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfi | PHOSPHOGLUCOMUTASE 1 (Parameciumtetraurelia) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | THR A 205GLY A 65GLY A 93ALA A 95GLY A 67 | None | 0.96A | 3tegA-1kfiA:3.6 | 3tegA-1kfiA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pox | PYRUVATE OXIDASE (Lactobacillusplantarum) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLN A 122GLY A 81GLY A 109ALA A 83GLY A 86 | None | 1.16A | 3tegA-1poxA:undetectable | 3tegA-1poxA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ta9 | GLYCEROLDEHYDROGENASE (Schizosaccharomycespombe) |
PF00465(Fe-ADH) | 5 | SER A 257PHE A 66THR A 67ALA A 252GLY A 309 | None | 1.08A | 3tegA-1ta9A:undetectable | 3tegA-1ta9A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wpq | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD+], CYTOPLASMIC (Homo sapiens) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | PHE A 219THR A 223GLY A 218GLY A 220GLY A 216 | None | 1.17A | 3tegA-1wpqA:undetectable | 3tegA-1wpqA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8a | HYPOTHETICAL PROTEINAF1437 (Archaeoglobusfulgidus) |
no annotation | 5 | SER A 208ARG A 301GLY A 182ALA A 51GLY A 309 | MG A 501 ( 4.1A) MG A 501 ( 4.7A)NoneNoneNone | 1.09A | 3tegA-1y8aA:undetectable | 3tegA-1y8aA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amc | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 5 | ARG A 204GLN A 218PHE A 258GLY A 281GLY A 316 | TYR A 888 (-3.9A)TYR A 888 (-3.3A)TYR A 888 (-3.0A)NoneTYR A 888 (-3.6A) | 0.95A | 3tegA-2amcA:23.2 | 3tegA-2amcA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amc | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 10 | SER A 180ARG A 204GLN A 218GLU A 220PHE A 258PHE A 260GLY A 282GLY A 284ALA A 314GLY A 316 | TYR A 888 (-2.7A)TYR A 888 (-3.9A)TYR A 888 (-3.3A)TYR A 888 (-3.5A)TYR A 888 (-3.0A)TYR A 888 (-4.5A)TYR A 888 ( 4.0A)NoneTYR A 888 (-3.4A)TYR A 888 (-3.6A) | 0.60A | 3tegA-2amcA:23.2 | 3tegA-2amcA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amc | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 10 | SER A 180GLN A 183ARG A 204GLN A 218PHE A 258PHE A 260GLY A 282GLY A 284ALA A 314GLY A 316 | TYR A 888 (-2.7A)NoneTYR A 888 (-3.9A)TYR A 888 (-3.3A)TYR A 888 (-3.0A)TYR A 888 (-4.5A)TYR A 888 ( 4.0A)NoneTYR A 888 (-3.4A)TYR A 888 (-3.6A) | 0.54A | 3tegA-2amcA:23.2 | 3tegA-2amcA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c11 | MEMBRANE COPPERAMINE OXIDASE (Homo sapiens) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | GLN A 650GLU A 367GLY A 390GLY A 346GLY A 387 | None | 1.07A | 3tegA-2c11A:undetectable | 3tegA-2c11A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ckr | ENDOGLUCANASE E-5 (Thermobifidafusca) |
PF00150(Cellulase) | 5 | GLN A 422PHE A 401THR A 405GLY A 410GLY A 414 | None | 1.18A | 3tegA-2ckrA:undetectable | 3tegA-2ckrA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czq | CUTINASE-LIKEPROTEIN (Cryptococcussp. S-2) |
PF01083(Cutinase) | 6 | SER A 24GLU A 19PHE A 27GLY A 87GLY A 115GLY A 16 | NoneNoneNoneNoneNoneEDO A 602 (-3.4A) | 1.29A | 3tegA-2czqA:undetectable | 3tegA-2czqA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gh9 | MALTOSE/MALTODEXTRIN-BINDING PROTEIN (Thermusthermophilus) |
PF13416(SBP_bac_8) | 5 | PHE A 247GLY A 304GLY A 233ALA A 236GLY A 303 | None | 1.02A | 3tegA-2gh9A:undetectable | 3tegA-2gh9A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o61 | TRANSCRIPTION FACTORP65/INTERFERONREGULATORY FACTOR7/INTERFERONREGULATORY FACTOR 3FUSION PROTEIN (Homo sapiens) |
PF00554(RHD_DNA_bind)PF00605(IRF)PF16179(RHD_dimer) | 5 | GLN A 119GLN A 132GLU A 89GLY A 92GLY A 98 | None | 0.79A | 3tegA-2o61A:undetectable | 3tegA-2o61A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqm | NEUROPILIN-1 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 5 | GLU A 579THR A 466GLY A 440GLY A 221GLY A 436 | None | 0.96A | 3tegA-2qqmA:undetectable | 3tegA-2qqmA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Staphylococcushaemolyticus) |
PF01409(tRNA-synt_2d) | 8 | GLN A 214PHE A 254PHE A 256THR A 257GLY A 288GLY A 290ALA A 311GLY A 313 | GAX A 352 (-4.2A)GAX A 352 (-3.8A)GAX A 352 (-4.6A)GAX A 352 (-3.9A)GAX A 352 (-3.2A)NoneGAX A 352 (-3.4A)GAX A 352 (-3.2A) | 0.69A | 3tegA-2rhqA:24.6 | 3tegA-2rhqA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Staphylococcushaemolyticus) |
PF01409(tRNA-synt_2d) | 8 | GLU A 216PHE A 254PHE A 256THR A 257GLY A 288GLY A 290ALA A 311GLY A 313 | GAX A 352 (-3.7A)GAX A 352 (-3.8A)GAX A 352 (-4.6A)GAX A 352 (-3.9A)GAX A 352 (-3.2A)NoneGAX A 352 (-3.4A)GAX A 352 (-3.2A) | 0.62A | 3tegA-2rhqA:24.6 | 3tegA-2rhqA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Staphylococcushaemolyticus) |
PF01409(tRNA-synt_2d) | 7 | SER A 174GLN A 214PHE A 256THR A 257GLY A 290ALA A 311GLY A 313 | GAX A 352 (-2.8A)GAX A 352 (-4.2A)GAX A 352 (-4.6A)GAX A 352 (-3.9A)NoneGAX A 352 (-3.4A)GAX A 352 (-3.2A) | 0.81A | 3tegA-2rhqA:24.6 | 3tegA-2rhqA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Staphylococcushaemolyticus) |
PF01409(tRNA-synt_2d) | 7 | SER A 174GLU A 216PHE A 256THR A 257GLY A 290ALA A 311GLY A 313 | GAX A 352 (-2.8A)GAX A 352 (-3.7A)GAX A 352 (-4.6A)GAX A 352 (-3.9A)NoneGAX A 352 (-3.4A)GAX A 352 (-3.2A) | 0.99A | 3tegA-2rhqA:24.6 | 3tegA-2rhqA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w2k | D-MANDELATEDEHYDROGENASE (Rhodotorulagraminis) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | PHE B 313THR B 312GLY B 113ALA B 116GLY B 306 | None | 1.11A | 3tegA-2w2kB:undetectable | 3tegA-2w2kB:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z9v | ASPARTATEAMINOTRANSFERASE (Mesorhizobiumloti) |
PF00266(Aminotran_5) | 5 | GLU A 112GLY A 98GLY A 93ALA A 91GLY A 100 | NoneGOL A 955 (-3.6A)NoneNoneNone | 1.06A | 3tegA-2z9vA:2.4 | 3tegA-2z9vA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anx | SPERMIDINE SYNTHASE (Thermusthermophilus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLN A 54GLU A 88THR A 160GLY A 85GLY A 87 | MTA A 315 (-2.4A)NoneMTA A 315 (-3.6A)MTA A 315 (-3.2A)MTA A 315 (-4.0A) | 1.12A | 3tegA-3anxA:undetectable | 3tegA-3anxA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg2 | DGTPTRIPHOSPHOHYDROLASE (Leeuwenhoekiellablandensis) |
PF01966(HD) | 5 | SER A 215GLN A 170GLU A 216GLY A 160ALA A 162 | None | 1.11A | 3tegA-3bg2A:undetectable | 3tegA-3bg2A:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmg | PUTATIVEBETA-GALACTOSIDASE (Bacteroidesfragilis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | GLN A 414GLU A 410GLY A 128GLY A 108ALA A 131 | None | 1.15A | 3tegA-3cmgA:undetectable | 3tegA-3cmgA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fse | TWO-DOMAIN PROTEINCONTAININGDJ-1/THIJ/PFPI-LIKEAND FERRITIN-LIKEDOMAINS (Trichormusvariabilis) |
PF01965(DJ-1_PfpI)PF09537(DUF2383) | 5 | GLU A 24PHE A 168GLY A 113GLY A 130GLY A 80 | CSX A 111 ( 3.0A)NoneCSX A 111 ( 4.5A)CSX A 111 ( 3.5A)CSX A 111 ( 3.6A) | 1.08A | 3tegA-3fseA:undetectable | 3tegA-3fseA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gg4 | GLYCEROL KINASE (Yersiniapseudotuberculosis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | GLN A 322PHE A 456THR A 451GLY A 284ALA A 446 | None | 1.00A | 3tegA-3gg4A:undetectable | 3tegA-3gg4A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gut | TRANSCRIPTION FACTORP65 (Homo sapiens) |
PF00554(RHD_DNA_bind)PF16179(RHD_dimer) | 5 | GLN A 119GLN A 132GLU A 89GLY A 92GLY A 98 | None | 0.95A | 3tegA-3gutA:undetectable | 3tegA-3gutA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hl0 | MALEYLACETATEREDUCTASE (Agrobacteriumfabrum) |
PF00465(Fe-ADH) | 5 | GLU A 269GLY A 290GLY A 284ALA A 280GLY A 288 | None | 0.81A | 3tegA-3hl0A:undetectable | 3tegA-3hl0A:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNITNICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | GLN A 396THR B 166GLY B 16GLY B 19GLY B 14 | None | 0.97A | 3tegA-3hrdA:undetectable | 3tegA-3hrdA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4g | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Homo sapiens) |
PF01409(tRNA-synt_2d) | 7 | ARG A 358GLN A 372GLU A 374THR A 413GLY A 436ALA A 456GLY A 458 | NonePHE A 509 (-3.4A)PHE A 509 (-3.6A)PHE A 509 (-3.7A)PHE A 509 (-4.0A)PHE A 509 ( 4.1A)PHE A 509 (-3.6A) | 0.93A | 3tegA-3l4gA:20.8 | 3tegA-3l4gA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l91 | ACYL-HOMOSERINELACTONE ACYLASE PVDQSUBUNIT BETA (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 5 | ARG B 591GLN B 590GLY B 694ALA B 679GLY B 670 | EDO B 917 (-3.9A)NoneNoneNoneNone | 1.08A | 3tegA-3l91B:undetectable | 3tegA-3l91B:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lot | UNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF05853(BKACE) | 7 | GLU A 261PHE A 149PHE A 120THR A 91GLY A 87GLY A 89ALA A 16 | ZN A 501 (-2.7A)UNL A 504 ( 4.6A)UNL A 504 ( 4.8A)UNL A 504 ( 4.7A)UNL A 502 ( 3.2A)NoneUNL A 504 ( 3.6A) | 1.30A | 3tegA-3lotA:undetectable | 3tegA-3lotA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob8 | BETA-GALACTOSIDASE (Kluyveromyceslactis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N) | 5 | ARG A 790GLY A 561GLY A 553ALA A 555GLY A 559 | None | 1.17A | 3tegA-3ob8A:undetectable | 3tegA-3ob8A:17.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pco | PHENYLALANYL-TRNASYNTHETASE, ALPHASUBUNIT (Escherichiacoli) |
PF01409(tRNA-synt_2d)PF02912(Phe_tRNA-synt_N) | 11 | SER A 171ARG A 195GLN A 208GLU A 210PHE A 248PHE A 250THR A 251GLY A 271GLY A 273ALA A 294GLY A 296 | PHE A 980 (-3.5A)AMP A 992 (-4.0A)PHE A 980 ( 3.6A)PHE A 980 (-3.0A)PHE A 980 (-3.6A)PHE A 980 (-4.5A)PHE A 980 ( 4.1A)PHE A 980 (-4.0A)NonePHE A 980 ( 4.0A)PHE A 980 (-3.6A) | 0.61A | 3tegA-3pcoA:25.1 | 3tegA-3pcoA:30.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pco | PHENYLALANYL-TRNASYNTHETASE, ALPHASUBUNIT (Escherichiacoli) |
PF01409(tRNA-synt_2d)PF02912(Phe_tRNA-synt_N) | 11 | SER A 171GLN A 174ARG A 195GLN A 208PHE A 248PHE A 250THR A 251GLY A 271GLY A 273ALA A 294GLY A 296 | PHE A 980 (-3.5A)PHE A 980 ( 4.5A)AMP A 992 (-4.0A)PHE A 980 ( 3.6A)PHE A 980 (-3.6A)PHE A 980 (-4.5A)PHE A 980 ( 4.1A)PHE A 980 (-4.0A)NonePHE A 980 ( 4.0A)PHE A 980 (-3.6A) | 0.65A | 3tegA-3pcoA:25.1 | 3tegA-3pcoA:30.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pwx | PUTATIVE FLAGELLARHOOK-ASSOCIATEDPROTEIN (Vibrioparahaemolyticus) |
PF00669(Flagellin_N) | 5 | ARG A 236GLN A 76GLY A 138GLY A 157ALA A 145 | None | 1.18A | 3tegA-3pwxA:undetectable | 3tegA-3pwxA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2u | UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE)PYROPHOSPHORYL-UNDECAPRENOLN-ACETYLGLUCOSAMINETRANSFERASE (Pseudomonasaeruginosa) |
PF03033(Glyco_transf_28)PF04101(Glyco_tran_28_C) | 5 | GLU A 43THR A 104GLY A 100ALA A 9GLY A 11 | None | 1.05A | 3tegA-3s2uA:undetectable | 3tegA-3s2uA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3teh | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 5 | ARG A 204GLN A 218PHE A 258GLY A 281GLY A 316 | DAH A 351 (-3.7A)DAH A 351 (-2.8A)DAH A 351 ( 3.8A)NoneDAH A 351 (-2.9A) | 0.93A | 3tegA-3tehA:23.2 | 3tegA-3tehA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3teh | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 6 | ARG A 204GLN A 218PHE A 258PHE A 260GLY A 282GLY A 264 | DAH A 351 (-3.7A)DAH A 351 (-2.8A)DAH A 351 ( 3.8A)DAH A 351 (-4.8A)DAH A 351 (-4.0A)None | 1.38A | 3tegA-3tehA:23.2 | 3tegA-3tehA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3teh | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 10 | SER A 180ARG A 204GLN A 218GLU A 220PHE A 258PHE A 260GLY A 282GLY A 284ALA A 314GLY A 316 | DAH A 351 (-2.9A)DAH A 351 (-3.7A)DAH A 351 (-2.8A)DAH A 351 (-3.3A)DAH A 351 ( 3.8A)DAH A 351 (-4.8A)DAH A 351 (-4.0A)DAH A 351 (-4.6A)DAH A 351 (-3.0A)DAH A 351 (-2.9A) | 0.50A | 3tegA-3tehA:23.2 | 3tegA-3tehA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3teh | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 10 | SER A 180GLN A 183ARG A 204GLN A 218PHE A 258PHE A 260GLY A 282GLY A 284ALA A 314GLY A 316 | DAH A 351 (-2.9A)DAH A 351 ( 4.3A)DAH A 351 (-3.7A)DAH A 351 (-2.8A)DAH A 351 ( 3.8A)DAH A 351 (-4.8A)DAH A 351 (-4.0A)DAH A 351 (-4.6A)DAH A 351 (-3.0A)DAH A 351 (-2.9A) | 0.46A | 3tegA-3tehA:23.2 | 3tegA-3tehA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | GLN A 81GLY A 70GLY A 50ALA A 226GLY A 224 | None | 1.18A | 3tegA-3tsdA:undetectable | 3tegA-3tsdA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4c | ALDEHYDEDEHYDROGENASE(NADP+) (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 5 | SER A 163THR A 90GLY A 189GLY A 86GLY A 191 | None | 1.16A | 3tegA-3v4cA:undetectable | 3tegA-3v4cA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w15 | PEROXISOMALTARGETING SIGNAL 2RECEPTOR (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | PHE A 64GLY A 29GLY A 11ALA A 27GLY A 38 | None | 1.05A | 3tegA-3w15A:undetectable | 3tegA-3w15A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmt | PROBABLE FERULOYLESTERASE B-1 (Aspergillusoryzae) |
PF07519(Tannase) | 5 | PHE A 170PHE A 160GLY A 127GLY A 151GLY A 154 | NoneNoneNoneNAG A 602 (-4.0A)None | 1.18A | 3tegA-3wmtA:undetectable | 3tegA-3wmtA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wzf | ASPARTATEAMINOTRANSFERASE,CYTOPLASMIC (Homo sapiens) |
PF00155(Aminotran_1_2) | 5 | ARG A 241GLN A 226PHE A 316GLY A 321GLY A 227 | None | 1.17A | 3tegA-3wzfA:2.4 | 3tegA-3wzfA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eip | PUTATIVEFAD-MONOOXYGENASE (Lechevalieriaaerocolonigenes) |
PF01494(FAD_binding_3) | 5 | SER A 54GLY A 312GLY A 18ALA A 20GLY A 314 | None | 1.17A | 3tegA-4eipA:undetectable | 3tegA-4eipA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ge0 | UNCHARACTERIZEDPROTEIN C22E12.03C (Schizosaccharomycespombe) |
PF01965(DJ-1_PfpI) | 5 | GLU A 16PHE A 167GLY A 113GLY A 129GLY A 78 | None | 1.12A | 3tegA-4ge0A:undetectable | 3tegA-4ge0A:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpv | S-ADENOSYLMETHIONINESYNTHASE (Sulfolobussolfataricus) |
PF01941(AdoMet_Synthase) | 5 | GLU A 181PHE A 123GLY A 28GLY A 197GLY A 26 | None | 1.12A | 3tegA-4hpvA:2.4 | 3tegA-4hpvA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | PREDICTED MEMBRANEPROTEIN (Lactobacillusbrevis) |
PF07155(ECF-ribofla_trS) | 5 | GLN S 143THR S 124GLY S 133ALA S 135GLY S 139 | None | 0.97A | 3tegA-4hzuS:undetectable | 3tegA-4hzuS:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0k | TANNASE (Lactobacillusplantarum) |
no annotation | 5 | GLN A 43THR A 118GLY A 81GLY A 115GLY A 112 | None | 1.13A | 3tegA-4j0kA:undetectable | 3tegA-4j0kA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyl | ENOYL-COA HYDRATASE (Thermoplasmavolcanium) |
PF00378(ECH_1) | 5 | GLN A 127GLU A 129GLY A 107ALA A 61GLY A 105 | None CL A 301 ( 4.2A)None CL A 301 (-3.8A) CL A 301 (-3.6A) | 0.98A | 3tegA-4jylA:undetectable | 3tegA-4jylA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mpt | PUTATIVELEU/ILE/VAL-BINDINGPROTEIN (Bordetellapertussis) |
PF13458(Peripla_BP_6) | 5 | GLN A 186GLU A 154PHE A 19GLY A 236GLY A 212 | None | 1.10A | 3tegA-4mptA:undetectable | 3tegA-4mptA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 9 | ARG C 116GLN C 129PHE C 169PHE C 171THR C 172GLY C 203GLY C 205ALA C 226GLY C 228 | 2U9 C 301 ( 4.2A)2U9 C 301 (-3.6A)2U9 C 301 (-3.9A)2U9 C 301 (-4.2A)2U9 C 301 ( 4.2A)2U9 C 301 (-3.2A)None2U9 C 301 (-3.3A)2U9 C 301 (-3.6A) | 0.64A | 3tegA-4p74C:25.0 | 3tegA-4p74C:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 8 | GLU C 131PHE C 169PHE C 171THR C 172GLY C 203GLY C 205ALA C 226GLY C 228 | 2U9 C 301 (-3.4A)2U9 C 301 (-3.9A)2U9 C 301 (-4.2A)2U9 C 301 ( 4.2A)2U9 C 301 (-3.2A)None2U9 C 301 (-3.3A)2U9 C 301 (-3.6A) | 0.73A | 3tegA-4p74C:25.0 | 3tegA-4p74C:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 9 | SER C 92ARG C 116GLN C 129PHE C 169PHE C 171THR C 172GLY C 205ALA C 226GLY C 228 | 2U9 C 301 (-3.6A)2U9 C 301 ( 4.2A)2U9 C 301 (-3.6A)2U9 C 301 (-3.9A)2U9 C 301 (-4.2A)2U9 C 301 ( 4.2A)None2U9 C 301 (-3.3A)2U9 C 301 (-3.6A) | 0.70A | 3tegA-4p74C:25.0 | 3tegA-4p74C:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 6 | SER C 92GLN C 95ARG C 116GLN C 129ALA C 226GLY C 228 | 2U9 C 301 (-3.6A)2U9 C 301 (-3.9A)2U9 C 301 ( 4.2A)2U9 C 301 (-3.6A)2U9 C 301 (-3.3A)2U9 C 301 (-3.6A) | 1.37A | 3tegA-4p74C:25.0 | 3tegA-4p74C:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 8 | SER C 92GLU C 131PHE C 169PHE C 171THR C 172GLY C 205ALA C 226GLY C 228 | 2U9 C 301 (-3.6A)2U9 C 301 (-3.4A)2U9 C 301 (-3.9A)2U9 C 301 (-4.2A)2U9 C 301 ( 4.2A)None2U9 C 301 (-3.3A)2U9 C 301 (-3.6A) | 0.96A | 3tegA-4p74C:25.0 | 3tegA-4p74C:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p79 | CLAUDIN-15 (Mus musculus) |
PF00822(PMP22_Claudin) | 5 | THR A 23GLY A 131GLY A 165ALA A 168GLY A 128 | None | 0.88A | 3tegA-4p79A:undetectable | 3tegA-4p79A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r72 | ABC-TYPE FE3+TRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Actinobacilluspleuropneumoniae) |
PF13343(SBP_bac_6) | 5 | PHE A 158THR A 157GLY A 108GLY A 227GLY A 202 | None | 0.87A | 3tegA-4r72A:undetectable | 3tegA-4r72A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ras | OXIDOREDUCTASE,NAD-BINDING/IRON-SULFUR CLUSTER-BINDINGPROTEIN (Nitratireductorpacificus) |
PF12838(Fer4_7)PF13486(Dehalogenase) | 5 | SER A 422GLY A 413GLY A 558ALA A 560GLY A 562 | B12 A 803 (-3.4A)NoneNoneNoneB12 A 803 (-3.5A) | 1.05A | 3tegA-4rasA:undetectable | 3tegA-4rasA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | SER A 274GLY A 143GLY A 203ALA A 202GLY A 74 | None | 1.13A | 3tegA-4rf7A:2.1 | 3tegA-4rf7A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk1 | RIBOSETRANSCRIPTIONALREGULATOR (Enterococcusfaecium) |
PF13377(Peripla_BP_3) | 5 | PHE A 248GLY A 172GLY A 176ALA A 209GLY A 205 | None | 1.15A | 3tegA-4rk1A:undetectable | 3tegA-4rk1A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4utg | SUGAR KINASE (Burkholderiapseudomallei) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | SER A 271GLY A 19GLY A 299ALA A 300GLY A 20 | None CL A 401 (-3.5A)ANP A 399 (-3.7A)ANP A 399 (-4.0A)None | 1.17A | 3tegA-4utgA:2.1 | 3tegA-4utgA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzj | NOTUM (Drosophilamelanogaster) |
PF03283(PAE) | 5 | SER A 186PHE A 273GLY A 271GLY A 319GLY A 240 | None | 1.03A | 3tegA-4uzjA:undetectable | 3tegA-4uzjA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wky | BETA-KETOACYLSYNTHASE (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLN A 187PHE A 107GLY A 215GLY A 258ALA A 370 | None | 1.15A | 3tegA-4wkyA:undetectable | 3tegA-4wkyA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zi6 | CYTOSOLAMINOPEPTIDASE (Helicobacterpylori) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | SER A 381THR A 367GLY A 283ALA A 464GLY A 481 | None | 1.14A | 3tegA-4zi6A:undetectable | 3tegA-4zi6A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zjp | MONOSACCHARIDE-TRANSPORTING ATPASE (Actinobacillussuccinogenes) |
PF13407(Peripla_BP_4) | 5 | PHE A 210GLY A 132GLY A 136ALA A 171GLY A 167 | None | 1.00A | 3tegA-4zjpA:undetectable | 3tegA-4zjpA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHA (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | GLN A 433PHE A 445GLY A 400ALA A 404GLY A 485 | DYA A 452 ( 3.9A)GL3 A 447 (-3.9A)MGN A 402 ( 4.2A)NoneNone | 1.17A | 3tegA-5a8rA:3.9 | 3tegA-5a8rA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa6 | VANADIUM-DEPENDENTBROMOPEROXIDASE 2 (Ascophyllumnodosum) |
no annotation | 5 | PHE A 312GLY A 440GLY A 534ALA A 436GLY A 438 | None | 1.13A | 3tegA-5aa6A:undetectable | 3tegA-5aa6A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5abm | RETINALDEHYDROGENASE 1 (Ovis aries) |
PF00171(Aldedh) | 5 | SER A 428PHE A 465GLY A 270GLY A 472GLY A 271 | NoneNoneTXE A 501 (-3.7A)NoneNone | 1.16A | 3tegA-5abmA:undetectable | 3tegA-5abmA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | PROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT GAMMA (Schizosaccharomycespombe) |
PF00483(NTP_transferase) | 5 | SER E 147ARG E 263GLY E 48ALA E 63GLY E 46 | None | 0.99A | 3tegA-5b04E:undetectable | 3tegA-5b04E:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bov | PUTATIVE EPOXIDEHYDROLASE PROTEIN (Klebsiellapneumoniae) |
PF00561(Abhydrolase_1) | 5 | SER A 168GLU A 285GLY A 317GLY A 290GLY A 286 | None | 0.96A | 3tegA-5bovA:undetectable | 3tegA-5bovA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4v | NUCLEOPROTEIN,PHOSPHOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap)PF13825(Paramyxo_PNT) | 5 | ARG A 389THR A 260GLY A 321GLY A 257GLY A 319 | None | 1.09A | 3tegA-5e4vA:undetectable | 3tegA-5e4vA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fuc | VHH6 (Camelusdromedarius) |
PF07686(V-set) | 5 | GLN E 117GLU E 6PHE E 37GLY E 35GLY E 116 | None | 1.15A | 3tegA-5fucE:undetectable | 3tegA-5fucE:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5glg | FUMARATE REDUCTASE 2 (Saccharomycescerevisiae) |
PF00890(FAD_binding_2) | 5 | GLN A 262PHE A 436GLY A 470GLY A 474GLY A 440 | None | 1.14A | 3tegA-5glgA:undetectable | 3tegA-5glgA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | SER A 10GLN A 6PHE A 250GLY A 33ALA A 35 | None | 1.14A | 3tegA-5i51A:undetectable | 3tegA-5i51A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i84 | PHOSPHATE-BINDINGPROTEIN PSTS (Xanthomonascitri) |
PF12849(PBP_like_2) | 5 | GLN A 68THR A 188GLY A 61GLY A 164GLY A 32 | NonePO4 A 403 ( 4.6A)NoneNoneNone | 1.16A | 3tegA-5i84A:undetectable | 3tegA-5i84A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iaa | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME 5 (Homo sapiens) |
PF00899(ThiF) | 5 | SER A 205GLY A 83GLY A 259ALA A 262GLY A 85 | None | 1.14A | 3tegA-5iaaA:undetectable | 3tegA-5iaaA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ly3 | ACTIN/ACTIN FAMILYPROTEIN (Pyrobaculumcalidifontis) |
PF00022(Actin) | 5 | GLN A 164GLU A 181THR A 20GLY A 185GLY A 182 | NoneADP A 501 ( 4.8A)ADP A 501 (-3.1A)NoneNone | 1.16A | 3tegA-5ly3A:undetectable | 3tegA-5ly3A:22.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mgv | PHENYLALANINE--TRNALIGASE,MITOCHONDRIAL (Homo sapiens) |
PF01409(tRNA-synt_2d)PF03147(FDX-ACB) | 12 | SER A 121GLN A 124ARG A 143GLN A 157GLU A 159PHE A 232PHE A 234THR A 235GLY A 254GLY A 256ALA A 275GLY A 277 | None | 0.23A | 3tegA-5mgvA:62.1 | 3tegA-5mgvA:99.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanotorrisformicicus) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | GLN A 433PHE A 445GLY A 400ALA A 404GLY A 485 | TRX A 429 ( 4.3A)GL3 A 447 (-4.1A)MGN A 402 ( 4.4A)NoneTRX A 429 ( 4.5A) | 1.14A | 3tegA-5n28A:4.0 | 3tegA-5n28A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4c | PROLYLOLIGOPEPTIDASE (Galerinamarginata) |
no annotation | 5 | GLU A 532GLY A 497GLY A 495ALA A 503GLY A 530 | None | 1.12A | 3tegA-5n4cA:undetectable | 3tegA-5n4cA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nof | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermococcuskodakarensis) |
no annotation | 5 | GLN A 310GLY A 270GLY A 272ALA A 266GLY A 269 | None | 1.10A | 3tegA-5nofA:undetectable | 3tegA-5nofA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nva | PUTATIVESODIUM:SOLUTESYMPORTER (Proteusmirabilis) |
no annotation | 5 | SER A 127PHE A 123GLY A 416GLY A 420GLY A 415 | None | 1.14A | 3tegA-5nvaA:undetectable | 3tegA-5nvaA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tch | TRYPTOPHAN SYNTHASEBETA CHAIN (Mycobacteriumtuberculosis) |
PF00291(PALP) | 5 | PHE B 285THR B 284GLY B 324GLY B 322GLY B 248 | NoneNoneNoneNoneLLP B 101 ( 3.3A) | 1.08A | 3tegA-5tchB:undetectable | 3tegA-5tchB:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u25 | DIHYDROLIPOAMIDEDEHYDROGENASE (E3COMPONENT OFPYRUVATE AND2-OXOGLUTARATEDEHYDROGENASECOMPLEXES) (Neisseriagonorrhoeae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ARG A 337GLY A 305GLY A 394ALA A 393GLY A 304 | None | 1.08A | 3tegA-5u25A:undetectable | 3tegA-5u25A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 5 | GLN A 81GLY A 70GLY A 50ALA A 226GLY A 224 | None | 1.06A | 3tegA-5uuwA:undetectable | 3tegA-5uuwA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 5 | GLN A 231GLN A 585GLY A 82GLY A 167GLY A 84 | None | 1.17A | 3tegA-5wugA:undetectable | 3tegA-5wugA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | GLU A 144GLY A 37GLY A 39ALA A 129GLY A 149 | None | 1.13A | 3tegA-5x7sA:undetectable | 3tegA-5x7sA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwm | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Oryctolaguscuniculus) |
no annotation | 5 | SER A 502GLN A 477PHE A 405GLY A 443ALA A 478 | None | 1.09A | 3tegA-6bwmA:undetectable | 3tegA-6bwmA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f9n | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTORSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ARG A1276THR A 372GLY A 13GLY A 385GLY A 34 | None | 1.13A | 3tegA-6f9nA:undetectable | 3tegA-6f9nA:10.60 |