SIMILAR PATTERNS OF AMINO ACIDS FOR 3TEG_A_DAHA416

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 THR A 301
GLY A 290
GLY A 323
ALA A 318
GLY A 287
 None
 1.05A 3tegA-1a2oA:
undetectable		 3tegA-1a2oA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		5 PHE A 297
PHE A 307
THR A 300
GLY A 250
GLY A 302
 None
 1.09A 3tegA-1d2kA:
undetectable		 3tegA-1d2kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 PHE A 187
GLY A 109
GLY A 113
ALA A 148
GLY A 144
 None
 0.97A 3tegA-1drkA:
undetectable		 3tegA-1drkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 SER A 218
GLU A 243
PHE A 263
GLY A 188
GLY A 184
 None
 1.18A 3tegA-1dysA:
undetectable		 3tegA-1dysA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLN A 434
PHE A 446
GLY A 401
ALA A 405
GLY A 486
 None
TP7  A1554 (-4.2A)
None
None
None
 1.17A 3tegA-1e6vA:
4.1		 3tegA-1e6vA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE

(Agrobacterium
sp. KNK712) 		PF00795
(CN_hydrolase) 		5 GLN A  11
PHE A  91
PHE A  44
GLY A  94
ALA A  48
 None
 1.12A 3tegA-1erzA:
undetectable		 3tegA-1erzA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 5 SER Y 383
GLN Y 387
PHE Y 348
GLY Y 362
GLY Y 350
 None
 1.14A 3tegA-1gllY:
undetectable		 3tegA-1gllY:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 PHE A 244
GLY A 166
GLY A 170
ALA A 203
GLY A 199
 None
 1.11A 3tegA-1jftA:
undetectable		 3tegA-1jftA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 PHE A 244
GLY A 166
GLY A 170
ALA A 203
GLY A 199
 None
 1.08A 3tegA-1jhzA:
undetectable		 3tegA-1jhzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 THR A 205
GLY A  65
GLY A  93
ALA A  95
GLY A  67
 None
 0.96A 3tegA-1kfiA:
3.6		 3tegA-1kfiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLN A 122
GLY A  81
GLY A 109
ALA A  83
GLY A  86
 None
 1.16A 3tegA-1poxA:
undetectable		 3tegA-1poxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		5 SER A 257
PHE A  66
THR A  67
ALA A 252
GLY A 309
 None
 1.08A 3tegA-1ta9A:
undetectable		 3tegA-1ta9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 PHE A 219
THR A 223
GLY A 218
GLY A 220
GLY A 216
 None
 1.17A 3tegA-1wpqA:
undetectable		 3tegA-1wpqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 5 SER A 208
ARG A 301
GLY A 182
ALA A  51
GLY A 309
 MG  A 501 ( 4.1A)
MG  A 501 ( 4.7A)
None
None
None
 1.09A 3tegA-1y8aA:
undetectable		 3tegA-1y8aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 ARG A 204
GLN A 218
PHE A 258
GLY A 281
GLY A 316
 TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.0A)
None
TYR  A 888 (-3.6A)
 0.95A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		10 SER A 180
ARG A 204
GLN A 218
GLU A 220
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 TYR  A 888 (-2.7A)
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.5A)
TYR  A 888 (-3.0A)
TYR  A 888 (-4.5A)
TYR  A 888 ( 4.0A)
None
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.60A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		10 SER A 180
GLN A 183
ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 TYR  A 888 (-2.7A)
None
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.0A)
TYR  A 888 (-4.5A)
TYR  A 888 ( 4.0A)
None
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.54A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 GLN A 650
GLU A 367
GLY A 390
GLY A 346
GLY A 387
 None
 1.07A 3tegA-2c11A:
undetectable		 3tegA-2c11A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		5 GLN A 422
PHE A 401
THR A 405
GLY A 410
GLY A 414
 None
 1.18A 3tegA-2ckrA:
undetectable		 3tegA-2ckrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		6 SER A  24
GLU A  19
PHE A  27
GLY A  87
GLY A 115
GLY A  16
 None
None
None
None
None
EDO  A 602 (-3.4A)
 1.29A 3tegA-2czqA:
undetectable		 3tegA-2czqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 PHE A 247
GLY A 304
GLY A 233
ALA A 236
GLY A 303
 None
 1.02A 3tegA-2gh9A:
undetectable		 3tegA-2gh9A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		5 GLN A 119
GLN A 132
GLU A  89
GLY A  92
GLY A  98
 None
 0.79A 3tegA-2o61A:
undetectable		 3tegA-2o61A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 GLU A 579
THR A 466
GLY A 440
GLY A 221
GLY A 436
 None
 0.96A 3tegA-2qqmA:
undetectable		 3tegA-2qqmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		8 GLN A 214
PHE A 254
PHE A 256
THR A 257
GLY A 288
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-4.2A)
GAX  A 352 (-3.8A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
GAX  A 352 (-3.2A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.69A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		8 GLU A 216
PHE A 254
PHE A 256
THR A 257
GLY A 288
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-3.7A)
GAX  A 352 (-3.8A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
GAX  A 352 (-3.2A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.62A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		7 SER A 174
GLN A 214
PHE A 256
THR A 257
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-2.8A)
GAX  A 352 (-4.2A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.81A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		7 SER A 174
GLU A 216
PHE A 256
THR A 257
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-2.8A)
GAX  A 352 (-3.7A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.99A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 PHE B 313
THR B 312
GLY B 113
ALA B 116
GLY B 306
 None
 1.11A 3tegA-2w2kB:
undetectable		 3tegA-2w2kB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		5 GLU A 112
GLY A  98
GLY A  93
ALA A  91
GLY A 100
 None
GOL  A 955 (-3.6A)
None
None
None
 1.06A 3tegA-2z9vA:
2.4		 3tegA-2z9vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A  54
GLU A  88
THR A 160
GLY A  85
GLY A  87
 MTA  A 315 (-2.4A)
None
MTA  A 315 (-3.6A)
MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
 1.12A 3tegA-3anxA:
undetectable		 3tegA-3anxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 SER A 215
GLN A 170
GLU A 216
GLY A 160
ALA A 162
 None
 1.11A 3tegA-3bg2A:
undetectable		 3tegA-3bg2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLN A 414
GLU A 410
GLY A 128
GLY A 108
ALA A 131
 None
 1.15A 3tegA-3cmgA:
undetectable		 3tegA-3cmgA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS

(Trichormus
variabilis) 		PF01965
(DJ-1_PfpI)
PF09537
(DUF2383) 		5 GLU A  24
PHE A 168
GLY A 113
GLY A 130
GLY A  80
 CSX  A 111 ( 3.0A)
None
CSX  A 111 ( 4.5A)
CSX  A 111 ( 3.5A)
CSX  A 111 ( 3.6A)
 1.08A 3tegA-3fseA:
undetectable		 3tegA-3fseA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A 322
PHE A 456
THR A 451
GLY A 284
ALA A 446
 None
 1.00A 3tegA-3gg4A:
undetectable		 3tegA-3gg4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gut TRANSCRIPTION FACTOR
P65

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		5 GLN A 119
GLN A 132
GLU A  89
GLY A  92
GLY A  98
 None
 0.95A 3tegA-3gutA:
undetectable		 3tegA-3gutA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		5 GLU A 269
GLY A 290
GLY A 284
ALA A 280
GLY A 288
 None
 0.81A 3tegA-3hl0A:
undetectable		 3tegA-3hl0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLN A 396
THR B 166
GLY B  16
GLY B  19
GLY B  14
 None
 0.97A 3tegA-3hrdA:
undetectable		 3tegA-3hrdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d) 		7 ARG A 358
GLN A 372
GLU A 374
THR A 413
GLY A 436
ALA A 456
GLY A 458
 None
PHE  A 509 (-3.4A)
PHE  A 509 (-3.6A)
PHE  A 509 (-3.7A)
PHE  A 509 (-4.0A)
PHE  A 509 ( 4.1A)
PHE  A 509 (-3.6A)
 0.93A 3tegA-3l4gA:
20.8		 3tegA-3l4gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 ARG B 591
GLN B 590
GLY B 694
ALA B 679
GLY B 670
 EDO  B 917 (-3.9A)
None
None
None
None
 1.08A 3tegA-3l91B:
undetectable		 3tegA-3l91B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		7 GLU A 261
PHE A 149
PHE A 120
THR A  91
GLY A  87
GLY A  89
ALA A  16
 ZN  A 501 (-2.7A)
UNL  A 504 ( 4.6A)
UNL  A 504 ( 4.8A)
UNL  A 504 ( 4.7A)
UNL  A 502 ( 3.2A)
None
UNL  A 504 ( 3.6A)
 1.30A 3tegA-3lotA:
undetectable		 3tegA-3lotA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 ARG A 790
GLY A 561
GLY A 553
ALA A 555
GLY A 559
 None
 1.17A 3tegA-3ob8A:
undetectable		 3tegA-3ob8A:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		11 SER A 171
ARG A 195
GLN A 208
GLU A 210
PHE A 248
PHE A 250
THR A 251
GLY A 271
GLY A 273
ALA A 294
GLY A 296
 PHE  A 980 (-3.5A)
AMP  A 992 (-4.0A)
PHE  A 980 ( 3.6A)
PHE  A 980 (-3.0A)
PHE  A 980 (-3.6A)
PHE  A 980 (-4.5A)
PHE  A 980 ( 4.1A)
PHE  A 980 (-4.0A)
None
PHE  A 980 ( 4.0A)
PHE  A 980 (-3.6A)
 0.61A 3tegA-3pcoA:
25.1		 3tegA-3pcoA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		11 SER A 171
GLN A 174
ARG A 195
GLN A 208
PHE A 248
PHE A 250
THR A 251
GLY A 271
GLY A 273
ALA A 294
GLY A 296
 PHE  A 980 (-3.5A)
PHE  A 980 ( 4.5A)
AMP  A 992 (-4.0A)
PHE  A 980 ( 3.6A)
PHE  A 980 (-3.6A)
PHE  A 980 (-4.5A)
PHE  A 980 ( 4.1A)
PHE  A 980 (-4.0A)
None
PHE  A 980 ( 4.0A)
PHE  A 980 (-3.6A)
 0.65A 3tegA-3pcoA:
25.1		 3tegA-3pcoA:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwx PUTATIVE FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Vibrio
parahaemolyticus) 		PF00669
(Flagellin_N) 		5 ARG A 236
GLN A  76
GLY A 138
GLY A 157
ALA A 145
 None
 1.18A 3tegA-3pwxA:
undetectable		 3tegA-3pwxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLU A  43
THR A 104
GLY A 100
ALA A   9
GLY A  11
 None
 1.05A 3tegA-3s2uA:
undetectable		 3tegA-3s2uA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 ARG A 204
GLN A 218
PHE A 258
GLY A 281
GLY A 316
 DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 ( 3.8A)
None
DAH  A 351 (-2.9A)
 0.93A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		6 ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 264
 DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 ( 3.8A)
DAH  A 351 (-4.8A)
DAH  A 351 (-4.0A)
None
 1.38A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		10 SER A 180
ARG A 204
GLN A 218
GLU A 220
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 DAH  A 351 (-2.9A)
DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 (-3.3A)
DAH  A 351 ( 3.8A)
DAH  A 351 (-4.8A)
DAH  A 351 (-4.0A)
DAH  A 351 (-4.6A)
DAH  A 351 (-3.0A)
DAH  A 351 (-2.9A)
 0.50A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		10 SER A 180
GLN A 183
ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 DAH  A 351 (-2.9A)
DAH  A 351 ( 4.3A)
DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 ( 3.8A)
DAH  A 351 (-4.8A)
DAH  A 351 (-4.0A)
DAH  A 351 (-4.6A)
DAH  A 351 (-3.0A)
DAH  A 351 (-2.9A)
 0.46A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 GLN A  81
GLY A  70
GLY A  50
ALA A 226
GLY A 224
 None
 1.18A 3tegA-3tsdA:
undetectable		 3tegA-3tsdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 SER A 163
THR A  90
GLY A 189
GLY A  86
GLY A 191
 None
 1.16A 3tegA-3v4cA:
undetectable		 3tegA-3v4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A  64
GLY A  29
GLY A  11
ALA A  27
GLY A  38
 None
 1.05A 3tegA-3w15A:
undetectable		 3tegA-3w15A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		5 PHE A 170
PHE A 160
GLY A 127
GLY A 151
GLY A 154
 None
None
None
NAG  A 602 (-4.0A)
None
 1.18A 3tegA-3wmtA:
undetectable		 3tegA-3wmtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 ARG A 241
GLN A 226
PHE A 316
GLY A 321
GLY A 227
 None
 1.17A 3tegA-3wzfA:
2.4		 3tegA-3wzfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 SER A  54
GLY A 312
GLY A  18
ALA A  20
GLY A 314
 None
 1.17A 3tegA-4eipA:
undetectable		 3tegA-4eipA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		5 GLU A  16
PHE A 167
GLY A 113
GLY A 129
GLY A  78
 None
 1.12A 3tegA-4ge0A:
undetectable		 3tegA-4ge0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 GLU A 181
PHE A 123
GLY A  28
GLY A 197
GLY A  26
 None
 1.12A 3tegA-4hpvA:
2.4		 3tegA-4hpvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS) 		5 GLN S 143
THR S 124
GLY S 133
ALA S 135
GLY S 139
 None
 0.97A 3tegA-4hzuS:
undetectable		 3tegA-4hzuS:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 GLN A  43
THR A 118
GLY A  81
GLY A 115
GLY A 112
 None
 1.13A 3tegA-4j0kA:
undetectable		 3tegA-4j0kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		5 GLN A 127
GLU A 129
GLY A 107
ALA A  61
GLY A 105
 None
CL  A 301 ( 4.2A)
None
CL  A 301 (-3.8A)
CL  A 301 (-3.6A)
 0.98A 3tegA-4jylA:
undetectable		 3tegA-4jylA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		5 GLN A 186
GLU A 154
PHE A  19
GLY A 236
GLY A 212
 None
 1.10A 3tegA-4mptA:
undetectable		 3tegA-4mptA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		9 ARG C 116
GLN C 129
PHE C 169
PHE C 171
THR C 172
GLY C 203
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.64A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		8 GLU C 131
PHE C 169
PHE C 171
THR C 172
GLY C 203
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 (-3.4A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.73A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		9 SER C  92
ARG C 116
GLN C 129
PHE C 169
PHE C 171
THR C 172
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 (-3.6A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.70A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		6 SER C  92
GLN C  95
ARG C 116
GLN C 129
ALA C 226
GLY C 228
 2U9  C 301 (-3.6A)
2U9  C 301 (-3.9A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 1.37A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		8 SER C  92
GLU C 131
PHE C 169
PHE C 171
THR C 172
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 (-3.6A)
2U9  C 301 (-3.4A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.96A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		5 THR A  23
GLY A 131
GLY A 165
ALA A 168
GLY A 128
 None
 0.88A 3tegA-4p79A:
undetectable		 3tegA-4p79A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 PHE A 158
THR A 157
GLY A 108
GLY A 227
GLY A 202
 None
 0.87A 3tegA-4r72A:
undetectable		 3tegA-4r72A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 SER A 422
GLY A 413
GLY A 558
ALA A 560
GLY A 562
 B12  A 803 (-3.4A)
None
None
None
B12  A 803 (-3.5A)
 1.05A 3tegA-4rasA:
undetectable		 3tegA-4rasA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 SER A 274
GLY A 143
GLY A 203
ALA A 202
GLY A  74
 None
 1.13A 3tegA-4rf7A:
2.1		 3tegA-4rf7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		5 PHE A 248
GLY A 172
GLY A 176
ALA A 209
GLY A 205
 None
 1.15A 3tegA-4rk1A:
undetectable		 3tegA-4rk1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 SER A 271
GLY A  19
GLY A 299
ALA A 300
GLY A  20
 None
CL  A 401 (-3.5A)
ANP  A 399 (-3.7A)
ANP  A 399 (-4.0A)
None
 1.17A 3tegA-4utgA:
2.1		 3tegA-4utgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		5 SER A 186
PHE A 273
GLY A 271
GLY A 319
GLY A 240
 None
 1.03A 3tegA-4uzjA:
undetectable		 3tegA-4uzjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLN A 187
PHE A 107
GLY A 215
GLY A 258
ALA A 370
 None
 1.15A 3tegA-4wkyA:
undetectable		 3tegA-4wkyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 SER A 381
THR A 367
GLY A 283
ALA A 464
GLY A 481
 None
 1.14A 3tegA-4zi6A:
undetectable		 3tegA-4zi6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 PHE A 210
GLY A 132
GLY A 136
ALA A 171
GLY A 167
 None
 1.00A 3tegA-4zjpA:
undetectable		 3tegA-4zjpA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLN A 433
PHE A 445
GLY A 400
ALA A 404
GLY A 485
 DYA  A 452 ( 3.9A)
GL3  A 447 (-3.9A)
MGN  A 402 ( 4.2A)
None
None
 1.17A 3tegA-5a8rA:
3.9		 3tegA-5a8rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 PHE A 312
GLY A 440
GLY A 534
ALA A 436
GLY A 438
 None
 1.13A 3tegA-5aa6A:
undetectable		 3tegA-5aa6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		5 SER A 428
PHE A 465
GLY A 270
GLY A 472
GLY A 271
 None
None
TXE  A 501 (-3.7A)
None
None
 1.16A 3tegA-5abmA:
undetectable		 3tegA-5abmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 SER E 147
ARG E 263
GLY E  48
ALA E  63
GLY E  46
 None
 0.99A 3tegA-5b04E:
undetectable		 3tegA-5b04E:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bov PUTATIVE EPOXIDE
HYDROLASE PROTEIN

(Klebsiella
pneumoniae) 		PF00561
(Abhydrolase_1) 		5 SER A 168
GLU A 285
GLY A 317
GLY A 290
GLY A 286
 None
 0.96A 3tegA-5bovA:
undetectable		 3tegA-5bovA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 ARG A 389
THR A 260
GLY A 321
GLY A 257
GLY A 319
 None
 1.09A 3tegA-5e4vA:
undetectable		 3tegA-5e4vA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuc VHH6

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLN E 117
GLU E   6
PHE E  37
GLY E  35
GLY E 116
 None
 1.15A 3tegA-5fucE:
undetectable		 3tegA-5fucE:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 GLN A 262
PHE A 436
GLY A 470
GLY A 474
GLY A 440
 None
 1.14A 3tegA-5glgA:
undetectable		 3tegA-5glgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A  10
GLN A   6
PHE A 250
GLY A  33
ALA A  35
 None
 1.14A 3tegA-5i51A:
undetectable		 3tegA-5i51A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		5 GLN A  68
THR A 188
GLY A  61
GLY A 164
GLY A  32
 None
PO4  A 403 ( 4.6A)
None
None
None
 1.16A 3tegA-5i84A:
undetectable		 3tegA-5i84A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF) 		5 SER A 205
GLY A  83
GLY A 259
ALA A 262
GLY A  85
 None
 1.14A 3tegA-5iaaA:
undetectable		 3tegA-5iaaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		5 GLN A 164
GLU A 181
THR A  20
GLY A 185
GLY A 182
 None
ADP  A 501 ( 4.8A)
ADP  A 501 (-3.1A)
None
None
 1.16A 3tegA-5ly3A:
undetectable		 3tegA-5ly3A:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		12 SER A 121
GLN A 124
ARG A 143
GLN A 157
GLU A 159
PHE A 232
PHE A 234
THR A 235
GLY A 254
GLY A 256
ALA A 275
GLY A 277
 None
 0.23A 3tegA-5mgvA:
62.1		 3tegA-5mgvA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLN A 433
PHE A 445
GLY A 400
ALA A 404
GLY A 485
 TRX  A 429 ( 4.3A)
GL3  A 447 (-4.1A)
MGN  A 402 ( 4.4A)
None
TRX  A 429 ( 4.5A)
 1.14A 3tegA-5n28A:
4.0		 3tegA-5n28A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 5 GLU A 532
GLY A 497
GLY A 495
ALA A 503
GLY A 530
 None
 1.12A 3tegA-5n4cA:
undetectable		 3tegA-5n4cA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 GLN A 310
GLY A 270
GLY A 272
ALA A 266
GLY A 269
 None
 1.10A 3tegA-5nofA:
undetectable		 3tegA-5nofA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 SER A 127
PHE A 123
GLY A 416
GLY A 420
GLY A 415
 None
 1.14A 3tegA-5nvaA:
undetectable		 3tegA-5nvaA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 PHE B 285
THR B 284
GLY B 324
GLY B 322
GLY B 248
 None
None
None
None
LLP  B 101 ( 3.3A)
 1.08A 3tegA-5tchB:
undetectable		 3tegA-5tchB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ARG A 337
GLY A 305
GLY A 394
ALA A 393
GLY A 304
 None
 1.08A 3tegA-5u25A:
undetectable		 3tegA-5u25A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 GLN A  81
GLY A  70
GLY A  50
ALA A 226
GLY A 224
 None
 1.06A 3tegA-5uuwA:
undetectable		 3tegA-5uuwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 GLN A 231
GLN A 585
GLY A  82
GLY A 167
GLY A  84
 None
 1.17A 3tegA-5wugA:
undetectable		 3tegA-5wugA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 GLU A 144
GLY A  37
GLY A  39
ALA A 129
GLY A 149
 None
 1.13A 3tegA-5x7sA:
undetectable		 3tegA-5x7sA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 5 SER A 502
GLN A 477
PHE A 405
GLY A 443
ALA A 478
 None
 1.09A 3tegA-6bwmA:
undetectable		 3tegA-6bwmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ARG A1276
THR A 372
GLY A  13
GLY A 385
GLY A  34
 None
 1.13A 3tegA-6f9nA:
undetectable		 3tegA-6f9nA:
10.60