SIMILAR PATTERNS OF AMINO ACIDS FOR 3TBG_D_RTZD2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		5 LEU A  55
VAL A  57
LEU A  67
THR A  63
ILE A  62
 None
 1.18A 3tbgD-1agxA:
0.0		 3tbgD-1agxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		5 LEU A  15
VAL A  77
LEU A  43
THR A  73
ILE A  75
 None
 1.18A 3tbgD-1bf6A:
0.0		 3tbgD-1bf6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 PHE A 377
LEU A  60
LEU A 321
ILE A 142
PHE A 324
 None
 0.99A 3tbgD-1c4oA:
0.0		 3tbgD-1c4oA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 PHE A 195
LEU A 248
VAL A 323
THR A 296
ILE A 332
 None
 1.17A 3tbgD-1dkdA:
undetectable		 3tbgD-1dkdA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5q EPIDERMIN MODIFYING
ENZYME EPID

(Staphylococcus
epidermidis) 		PF02441
(Flavoprotein) 		5 LEU A  25
VAL A  32
LEU A  80
ILE A   7
PHE A 113
 None
 1.15A 3tbgD-1g5qA:
0.0		 3tbgD-1g5qA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhe LEXA REPRESSOR

(Escherichia
coli) 		PF00717
(Peptidase_S24) 		5 PHE A 186
LEU A 158
VAL A 145
THR A 136
ILE A 188
 None
 0.99A 3tbgD-1jheA:
0.0		 3tbgD-1jheA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		5 PHE A  60
LEU A 219
THR A  19
LEU A  35
ILE A 189
 None
 1.20A 3tbgD-1jikA:
0.0		 3tbgD-1jikA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 PHE A 195
LEU A 248
VAL A 323
THR A 296
ILE A 332
 None
 1.13A 3tbgD-1la1A:
0.0		 3tbgD-1la1A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5z AMPA RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 PHE A  38
LEU A  71
THR A  79
VAL A  87
ILE A  91
 None
 1.03A 3tbgD-1m5zA:
0.0		 3tbgD-1m5zA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzv ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leishmania
tarentolae) 		PF00156
(Pribosyltran) 		5 PHE A 200
LEU A 159
GLU A 163
THR A 190
ILE A 187
 None
 1.14A 3tbgD-1mzvA:
undetectable		 3tbgD-1mzvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		5 PHE A 506
LEU A 556
VAL A 579
LEU A 575
ILE A 577
 None
 0.88A 3tbgD-1o70A:
undetectable		 3tbgD-1o70A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk1 SEX COMB ON MIDLEG
CG9495-PA

(Drosophila
melanogaster) 		PF00536
(SAM_1) 		5 PHE B  40
LEU B  53
VAL B  76
LEU B  64
ILE B  72
 None
 1.17A 3tbgD-1pk1B:
undetectable		 3tbgD-1pk1B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leishmania
donovani) 		PF00156
(Pribosyltran) 		5 PHE A 200
LEU A 159
GLU A 163
THR A 190
ILE A 187
 None
 0.99A 3tbgD-1qcdA:
undetectable		 3tbgD-1qcdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 PHE A 243
LEU A 451
THR A 262
ILE A 258
PHE A 318
 None
 1.09A 3tbgD-1r5nA:
undetectable		 3tbgD-1r5nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A 129
THR A 130
VAL A 133
LEU A  54
ILE A 192
 None
 1.16A 3tbgD-1rtrA:
undetectable		 3tbgD-1rtrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s79 LUPUS LA PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 PHE A 118
LEU A 131
VAL A 156
LEU A 180
ILE A 115
 None
 1.12A 3tbgD-1s79A:
undetectable		 3tbgD-1s79A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))

(Thermus
thermophilus) 		PF00118
(Cpn60_TCP1) 		5 PHE A 195
LEU A 248
VAL A 323
THR A 296
ILE A 332
 None
 1.15A 3tbgD-1srvA:
undetectable		 3tbgD-1srvA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 PHE A 206
LEU A 182
THR A 178
LEU A  55
ILE A  89
 None
 1.10A 3tbgD-1x9sA:
undetectable		 3tbgD-1x9sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 LEU A  18
VAL A   7
LEU A  55
ILE A  35
PHE A  92
 None
 1.15A 3tbgD-1xg2A:
undetectable		 3tbgD-1xg2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 PHE A 341
LEU A 433
VAL A 362
LEU A 409
ILE A 382
 None
 1.19A 3tbgD-1yvlA:
undetectable		 3tbgD-1yvlA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7o FILAMIN-C

(Homo sapiens) 		PF00630
(Filamin) 		5 PHE A  32
LEU A  46
VAL A  82
THR A  36
ILE A  34
 None
 1.13A 3tbgD-2d7oA:
undetectable		 3tbgD-2d7oA:
14.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A  58
VAL A  78
LEU A 372
THR A 375
ILE A 396
 None
 0.45A 3tbgD-2f9qA:
55.7		 3tbgD-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmq HYPOTHETICAL PROTEIN
EF0006

(Enterococcus
faecalis) 		PF09627
(PrgU) 		5 LEU A  64
THR A  63
LEU A  34
ILE A  99
PHE A 108
 None
 1.01A 3tbgD-2gmqA:
undetectable		 3tbgD-2gmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmq HYPOTHETICAL PROTEIN
EF0006

(Enterococcus
faecalis) 		PF09627
(PrgU) 		5 LEU A  64
THR A  63
VAL A  77
LEU A  34
ILE A  99
 None
 1.04A 3tbgD-2gmqA:
undetectable		 3tbgD-2gmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3j HYPOTHETICAL PROTEIN
PA4359

(Pseudomonas
aeruginosa) 		PF04023
(FeoA) 		5 LEU A  38
THR A  54
VAL A  52
LEU A  66
ILE A  50
 None
 1.12A 3tbgD-2h3jA:
undetectable		 3tbgD-2h3jA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6c CHLOROPHENOL
REDUCTION GENE K

(Desulfitobacterium
dehalogenans) 		PF13545
(HTH_Crp_2) 		5 PHE A 157
LEU A 198
VAL A 194
LEU A 178
ILE A 183
 None
 1.11A 3tbgD-2h6cA:
undetectable		 3tbgD-2h6cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 326
VAL A 343
LEU A 334
THR A 331
ILE A 330
 None
 1.20A 3tbgD-2i6tA:
undetectable		 3tbgD-2i6tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn4 ARGININE/SERINE-RIC
H 2
IMMUNOGLOBULIN
G-BINDING PROTEIN G,
SPLICING FACTOR

(Homo sapiens;
Streptococcus
sp. 'group G') 		PF00076
(RRM_1)
PF01378
(IgG_binding_B) 		5 LEU A  78
THR A  79
THR A  86
ILE A 102
PHE A  91
 None
 1.15A 3tbgD-2kn4A:
undetectable		 3tbgD-2kn4A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		5 LEU A 108
THR A 107
VAL A  33
LEU A 304
ILE A  37
 None
 1.21A 3tbgD-2o8rA:
undetectable		 3tbgD-2o8rA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF11531
(CARM1) 		5 LEU A 125
VAL A  85
LEU A  59
ILE A  70
PHE A  33
 None
 1.15A 3tbgD-2oqbA:
undetectable		 3tbgD-2oqbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 247
THR A 246
LEU A 344
THR A 340
ILE A 339
 None
None
735  A 469 ( 4.2A)
None
735  A 469 ( 4.1A)
 1.01A 3tbgD-2p54A:
undetectable		 3tbgD-2p54A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 PHE A  23
LEU A 229
THR A 225
LEU A   6
ILE A  37
 None
 1.17A 3tbgD-2pfzA:
undetectable		 3tbgD-2pfzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 LEU A 331
VAL A 338
LEU A 317
ILE A 356
PHE A 301
 None
 1.16A 3tbgD-2vmxA:
undetectable		 3tbgD-2vmxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vod LUPUS LA PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF05383
(La) 		5 PHE A 118
LEU A 131
VAL A 156
LEU A 180
ILE A 115
 None
 0.81A 3tbgD-2vodA:
undetectable		 3tbgD-2vodA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wiz ARCHAEAL HJC

(Archaeoglobus
fulgidus) 		PF01870
(Hjc) 		5 PHE A  94
LEU A  12
VAL A  52
LEU A  48
ILE A  50
 None
 0.94A 3tbgD-2wizA:
undetectable		 3tbgD-2wizA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wli POTASSIUM CHANNEL

(Magnetospirillum
magnetotacticum) 		PF01007
(IRK) 		5 PHE A 239
LEU A 232
THR A 231
LEU A 159
ILE A 224
 None
 0.96A 3tbgD-2wliA:
undetectable		 3tbgD-2wliA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		6 PHE A 575
LEU A 353
THR A 352
VAL A 372
LEU A 577
ILE A 373
 None
 1.48A 3tbgD-2wpgA:
undetectable		 3tbgD-2wpgA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		5 PHE A 235
LEU A 309
VAL A 312
LEU A 226
ILE A 287
 None
 1.20A 3tbgD-2x4lA:
undetectable		 3tbgD-2x4lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		5 LEU A 709
VAL A 772
LEU A 696
ILE A 697
PHE A 615
 None
 0.97A 3tbgD-2ya1A:
undetectable		 3tbgD-2ya1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 254
VAL A 317
LEU A 241
ILE A 242
PHE A 160
 None
 0.97A 3tbgD-2ya2A:
undetectable		 3tbgD-2ya2A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		5 LEU A 799
THR A 800
VAL A 804
GLU A 836
ILE A 807
 None
 1.03A 3tbgD-2ypfA:
undetectable		 3tbgD-2ypfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A 318
VAL A 234
LEU A 273
ILE A 359
PHE A 281
 None
 1.11A 3tbgD-3aupA:
undetectable		 3tbgD-3aupA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 PHE A 345
THR A 440
VAL A 366
LEU A 413
ILE A 386
 None
 1.18A 3tbgD-3cwgA:
undetectable		 3tbgD-3cwgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		5 PHE A 243
THR A  95
VAL A  93
LEU A 260
ILE A 247
 None
 1.19A 3tbgD-3dmeA:
undetectable		 3tbgD-3dmeA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 PHE A 155
LEU A 195
VAL A 191
LEU A 175
ILE A 180
 None
 1.12A 3tbgD-3e97A:
undetectable		 3tbgD-3e97A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ha9 UNCHARACTERIZED
THIOREDOXIN-LIKE
PROTEIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA) 		5 LEU A  47
THR A  48
VAL A 141
ILE A  99
PHE A 151
 None
 1.05A 3tbgD-3ha9A:
undetectable		 3tbgD-3ha9A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		5 LEU k 286
THR k 288
VAL k 291
ILE k 264
PHE k 269
 None
 1.10A 3tbgD-3jd5k:
undetectable		 3tbgD-3jd5k:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 PHE A 386
LEU A 271
THR A 274
GLU A 270
ILE A 312
 None
 1.12A 3tbgD-3l7gA:
undetectable		 3tbgD-3l7gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A 157
LEU A 141
VAL A 136
LEU A 228
ILE A 220
 None
 1.09A 3tbgD-3lx2A:
undetectable		 3tbgD-3lx2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 PHE A 193
LEU A 246
VAL A 321
LEU A 290
ILE A 330
 None
 0.87A 3tbgD-3m6cA:
undetectable		 3tbgD-3m6cA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjg EPIDERMIN
BIOSYNTHESIS PROTEIN
EPID

(Staphylococcus
aureus) 		PF02441
(Flavoprotein) 		5 LEU A  25
VAL A  32
LEU A  80
ILE A   7
PHE A 113
 None
 1.09A 3tbgD-3qjgA:
undetectable		 3tbgD-3qjgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwu DNA LIGASE

(Aquifex
aeolicus) 		PF09414
(RNA_ligase) 		5 PHE A 215
LEU A 202
GLU A 266
LEU A  64
ILE A 198
 None
 0.98A 3tbgD-3qwuA:
undetectable		 3tbgD-3qwuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		5 PHE A 264
LEU A 252
THR A 253
LEU A 285
ILE A 248
 None
 1.19A 3tbgD-3sy8A:
undetectable		 3tbgD-3sy8A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1u PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Azotobacter
vinelandii) 		PF00160
(Pro_isomerase) 		5 PHE A  27
LEU A   4
THR A  10
LEU A  15
ILE A   2
 None
 1.19A 3tbgD-3t1uA:
undetectable		 3tbgD-3t1uA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		5 LEU B 104
VAL B  36
LEU B  74
THR B  96
ILE B  76
 None
 1.14A 3tbgD-3wxmB:
undetectable		 3tbgD-3wxmB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 PHE A 299
LEU A 275
VAL A 287
LEU A 229
ILE A 195
 None
 1.14A 3tbgD-3zpcA:
undetectable		 3tbgD-3zpcA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7)
PF16453
(IQ_SEC7_PH) 		5 PHE A 731
LEU A 705
THR A 706
LEU A 637
ILE A 703
 None
 1.16A 3tbgD-4c0aA:
undetectable		 3tbgD-4c0aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 PHE D 129
LEU D 201
THR D 200
LEU D 277
ILE D 281
 None
 1.06A 3tbgD-4em6D:
undetectable		 3tbgD-4em6D:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev1 ANABENA TIC22

(Anabaena sp.) 		PF04278
(Tic22) 		5 PHE A 136
LEU A 122
THR A 125
LEU A 115
ILE A 118
 NHE  A 303 (-4.4A)
None
None
None
None
 1.18A 3tbgD-4ev1A:
undetectable		 3tbgD-4ev1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fno PEPTIDYL-TRNA
HYDROLASE

(Pseudomonas
aeruginosa) 		PF01195
(Pept_tRNA_hydro) 		5 PHE A  53
LEU A 178
VAL A   4
LEU A  32
ILE A   7
 None
 1.15A 3tbgD-4fnoA:
undetectable		 3tbgD-4fnoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoj REGF PROTEIN

(Neisseria
gonorrhoeae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 161
VAL A 166
LEU A 101
ILE A 125
PHE A 102
 None
None
ACT  A 303 ( 4.9A)
None
None
 1.07A 3tbgD-4hojA:
undetectable		 3tbgD-4hojA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 197
VAL A 236
LEU A 192
THR A 245
ILE A 244
 None
 1.20A 3tbgD-4i5jA:
undetectable		 3tbgD-4i5jA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE B 234
VAL B 273
LEU B 229
THR B 282
ILE B 281
 None
 1.19A 3tbgD-4i5nB:
undetectable		 3tbgD-4i5nB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jh8 METALLOTHIOL
TRANSFERASE FOSB

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 PHE A  69
LEU A   8
VAL A  45
LEU A  26
ILE A  42
 None
 1.08A 3tbgD-4jh8A:
undetectable		 3tbgD-4jh8A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lba CONJUGATIVE
TRANSPOSON
LIPOPROTEIN

(Bacteroides
eggerthii) 		PF12988
(DUF3872) 		5 PHE A 112
LEU A 140
VAL A  48
LEU A  67
PHE A  44
 None
EDO  A 204 ( 4.5A)
None
None
None
 1.06A 3tbgD-4lbaA:
undetectable		 3tbgD-4lbaA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 PHE A  92
LEU A  42
VAL A  13
LEU A  74
ILE A   9
 None
 1.18A 3tbgD-4lnfA:
undetectable		 3tbgD-4lnfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 234
VAL A 273
LEU A 229
THR A 282
ILE A 281
 None
 1.21A 3tbgD-4mewA:
undetectable		 3tbgD-4mewA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B 241
THR B 239
VAL B 144
ILE B 152
PHE B 198
 None
 1.04A 3tbgD-4nikB:
undetectable		 3tbgD-4nikB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npk EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 489
LEU A 503
VAL A 479
LEU A 472
ILE A 474
 None
 1.04A 3tbgD-4npkA:
undetectable		 3tbgD-4npkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		5 LEU A  86
THR A  89
VAL A  91
LEU A  48
ILE A  42
 None
 1.20A 3tbgD-4ns1A:
undetectable		 3tbgD-4ns1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		5 LEU A 198
THR A 191
VAL A 193
GLU A 200
LEU A  60
 None
 1.17A 3tbgD-4or8A:
undetectable		 3tbgD-4or8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2)
PF17047
(SMP_LBD) 		5 PHE A 461
LEU A 475
VAL A 451
LEU A 444
ILE A 446
 None
 1.11A 3tbgD-4p42A:
undetectable		 3tbgD-4p42A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		5 PHE A 168
LEU A 145
THR A 146
LEU A 185
ILE A 172
 None
 1.18A 3tbgD-4pfsA:
undetectable		 3tbgD-4pfsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pic ARGININE PHOSPHATASE
YWLE

(Geobacillus
stearothermophilus) 		PF01451
(LMWPc) 		5 LEU A 143
VAL A  30
GLU A 146
THR A  76
ILE A   4
 None
 1.03A 3tbgD-4picA:
undetectable		 3tbgD-4picA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pph CONGLUTIN GAMMA

(Lupinus
angustifolius) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A 333
VAL A 242
LEU A 287
ILE A 373
PHE A 295
 None
 1.13A 3tbgD-4pphA:
undetectable		 3tbgD-4pphA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 PHE A 105
LEU A 182
LEU A 124
THR A 119
ILE A 120
 None
 1.09A 3tbgD-4repA:
undetectable		 3tbgD-4repA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 LEU A 247
THR A 246
VAL A 224
ILE A 239
PHE A 123
 None
 1.20A 3tbgD-4ufcA:
undetectable		 3tbgD-4ufcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11

(Homo sapiens) 		PF07686
(V-set) 		5 LEU L 104
THR L 102
VAL L  11
ILE L  19
PHE L  62
 None
 1.06A 3tbgD-4ut7L:
undetectable		 3tbgD-4ut7L:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B 104
THR B 102
VAL B  11
ILE B  19
PHE B  62
 None
 1.12A 3tbgD-4uu9B:
undetectable		 3tbgD-4uu9B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PHE A 150
LEU A 135
VAL A 140
LEU A 124
ILE A 119
 None
 1.03A 3tbgD-4v2eA:
undetectable		 3tbgD-4v2eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		5 PHE A 264
LEU A 171
VAL A 253
LEU A 230
ILE A 257
 None
AF3  A 601 (-4.0A)
None
None
None
 1.04A 3tbgD-4xpzA:
undetectable		 3tbgD-4xpzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 PHE B 150
LEU B 135
VAL B 140
LEU B 124
ILE B 119
 None
 0.98A 3tbgD-4yebB:
undetectable		 3tbgD-4yebB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvd PLEIOTROPIC
REGULATOR 1

(Homo sapiens) 		PF00400
(WD40) 		5 PHE A 387
LEU A 356
THR A 364
THR A 353
ILE A 354
 None
 1.06A 3tbgD-4yvdA:
undetectable		 3tbgD-4yvdA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 PHE A 292
LEU A 307
VAL A 279
LEU A 266
ILE A 269
 None
 1.07A 3tbgD-4zpjA:
undetectable		 3tbgD-4zpjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI

(Saccharomyces
cerevisiae) 		PF03161
(LAGLIDADG_2) 		5 PHE A 508
LEU A 462
THR A 464
LEU A 485
ILE A 500
 None
 1.20A 3tbgD-5a0mA:
undetectable		 3tbgD-5a0mA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any E1

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		5 LEU A  29
THR A  17
VAL A  19
ILE A 282
PHE A 161
 None
 1.12A 3tbgD-5anyA:
undetectable		 3tbgD-5anyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 LEU X 198
THR X 195
VAL X 193
THR X 227
ILE X 238
 None
 1.14A 3tbgD-5evyX:
undetectable		 3tbgD-5evyX:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk0 TYROSINE RECOMBINASE
XERH

(Helicobacter
pylori) 		PF00589
(Phage_integrase) 		5 PHE A 136
LEU A  15
LEU A 109
ILE A 104
PHE A 112
 None
 1.01A 3tbgD-5jk0A:
undetectable		 3tbgD-5jk0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk0 TYROSINE RECOMBINASE
XERH

(Helicobacter
pylori) 		PF00589
(Phage_integrase) 		5 PHE A 136
LEU A  15
THR A  12
LEU A 109
ILE A 104
 None
 1.02A 3tbgD-5jk0A:
undetectable		 3tbgD-5jk0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PHE A 259
LEU A 249
THR A 248
VAL A 273
LEU A 256
 None
 1.19A 3tbgD-5lfnA:
undetectable		 3tbgD-5lfnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5miy E3 UBIQUITIN LIGASE
RAVN

(Legionella
pneumophila) 		no annotation 5 PHE A  91
THR A  19
VAL A  21
LEU A  71
ILE A  33
 None
 0.96A 3tbgD-5miyA:
undetectable		 3tbgD-5miyA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo sapiens) 		PF08210
(APOBEC_N) 		5 LEU A  35
THR A  33
VAL A  92
LEU A 116
ILE A 118
 None
 1.10A 3tbgD-5tkmA:
undetectable		 3tbgD-5tkmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0r DH270.UCA1 LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU L 107
THR L 105
VAL L  10
ILE L  18
PHE L  64
 None
 1.03A 3tbgD-5u0rL:
undetectable		 3tbgD-5u0rL:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2l HEAT SHOCK PROTEIN
104

(Candida
albicans) 		PF02861
(Clp_N) 		5 PHE A 128
LEU A  49
THR A  51
LEU A 119
ILE A 138
 None
 1.19A 3tbgD-5u2lA:
undetectable		 3tbgD-5u2lA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		5 LEU A 951
VAL A 513
GLU A 488
LEU A 969
ILE A 509
 None
 1.19A 3tbgD-5u70A:
undetectable		 3tbgD-5u70A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6v RAS-RELATED
GTP-BINDING PROTEIN
C

(Mus musculus) 		no annotation 5 PHE G 366
LEU G 334
VAL G 330
LEU G 242
ILE G 362
 None
 1.06A 3tbgD-5x6vG:
undetectable		 3tbgD-5x6vG:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 PHE A 108
THR A  68
VAL A  70
LEU A  57
ILE A   7
 None
 1.20A 3tbgD-5z03A:
undetectable		 3tbgD-5z03A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 PHE A  81
LEU A  55
LEU A 127
ILE A  77
PHE A  68
 None
 1.11A 3tbgD-6cgmA:
undetectable		 3tbgD-6cgmA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehr RAS-RELATED
GTP-BINDING PROTEIN
C

(Homo sapiens) 		PF04670
(Gtr1_RagA) 		5 PHE G 367
LEU G 335
VAL G 331
LEU G 243
ILE G 363
 None
 1.10A 3tbgD-6ehrG:
undetectable		 3tbgD-6ehrG:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g42 MINOR CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 5 PHE A 299
LEU A 207
VAL A 209
LEU A  39
ILE A 261
 None
 1.09A 3tbgD-6g42A:
undetectable		 3tbgD-6g42A:
9.47