SIMILAR PATTERNS OF AMINO ACIDS FOR 3TBG_D_RTZD1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		5 LEU A  68
GLY A 308
GLU A  40
GLN A 312
ALA A  81
 None
 1.06A 3tbgD-1a5cA:
undetectable		 3tbgD-1a5cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
GLC  A 672 (-2.7A)
None
 0.88A 3tbgD-1hsjA:
0.0		 3tbgD-1hsjA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 PHE A 369
LEU A 368
GLY A 378
LEU A 377
ALA A 374
 None
 1.02A 3tbgD-1jioA:
31.9		 3tbgD-1jioA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 456 (-2.6A)
None
 0.87A 3tbgD-1mg1A:
0.0		 3tbgD-1mg1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 5 PHE P 155
GLY P 299
LEU P 298
GLU P 110
ALA P 230
 None
None
None
MAL  P 727 (-2.8A)
None
 0.85A 3tbgD-1r6zP:
0.0		 3tbgD-1r6zP:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 5 GLY D 114
LEU D 163
PHE D 236
ALA D  66
ASP D  67
 None
 1.11A 3tbgD-1upfD:
0.0		 3tbgD-1upfD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Thermus
thermophilus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A  22
GLY A  99
LEU A 101
PHE A  65
ALA A 107
 None
 1.02A 3tbgD-1x1oA:
0.0		 3tbgD-1x1oA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 GLY A  53
GLU A  42
ALA A  19
ASP A  20
SER A  23
 None
K  A 413 (-2.9A)
None
None
None
 1.03A 3tbgD-1xrcA:
0.0		 3tbgD-1xrcA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
GLC  A 371 (-2.9A)
None
 0.81A 3tbgD-1y4cA:
1.4		 3tbgD-1y4cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 713
PHE A 592
LEU A 569
GLY A 573
LEU A 580
 None
 1.05A 3tbgD-1yr2A:
undetectable		 3tbgD-1yr2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		5 LEU A 289
PHE A 261
LEU A 284
GLY A 238
ASP A 282
 None
 1.14A 3tbgD-1zelA:
undetectable		 3tbgD-1zelA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a61 TRANSCRIPTIONAL
REGULATOR TM0710

(Thermotoga
maritima) 		PF01047
(MarR) 		5 GLY A  52
LEU A  54
GLU A  53
ALA A  89
ASP A  83
 None
 1.04A 3tbgD-2a61A:
undetectable		 3tbgD-2a61A:
15.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		8 LEU A 110
PHE A 112
PHE A 120
LEU A 121
GLY A 212
GLN A 244
ASP A 301
SER A 304
 None
None
HEM  A 600 (-4.6A)
None
None
None
None
None
 1.16A 3tbgD-2f9qA:
55.7		 3tbgD-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		9 LEU A 110
PHE A 112
PHE A 120
LEU A 121
GLY A 212
PHE A 247
ALA A 300
ASP A 301
SER A 304
 None
None
HEM  A 600 (-4.6A)
None
None
None
None
None
None
 0.73A 3tbgD-2f9qA:
55.7		 3tbgD-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 120
LEU A 121
GLY A 212
GLU A 216
GLN A 244
ASP A 301
 HEM  A 600 (-4.6A)
None
None
None
None
None
 1.12A 3tbgD-2f9qA:
55.7		 3tbgD-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 238
GLY A 340
LEU A 338
ALA A  78
SER A 235
 None
 1.15A 3tbgD-2rjtA:
undetectable		 3tbgD-2rjtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA

(Mycobacterium
tuberculosis) 		PF16708
(LppA) 		5 GLY A 127
PHE A 126
ALA A  78
ASP A  79
SER A  82
 GOL  A1208 (-3.3A)
None
None
None
None
 0.81A 3tbgD-2v7sA:
undetectable		 3tbgD-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 MTT  A1463 (-4.9A)
None
None
MTT  A1463 (-2.9A)
None
 0.84A 3tbgD-2vgqA:
undetectable		 3tbgD-2vgqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 PHE A 182
GLY A 326
LEU A 325
GLU A 137
ALA A 257
 None
None
None
MAL  A1488 (-2.9A)
None
 0.85A 3tbgD-2xz3A:
undetectable		 3tbgD-2xz3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 466 (-3.1A)
None
 0.88A 3tbgD-3a3cA:
undetectable		 3tbgD-3a3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
GLC  A 672 (-2.8A)
None
 0.80A 3tbgD-3dm0A:
undetectable		 3tbgD-3dm0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PHE A-193
GLY A -49
LEU A -50
GLU A-238
ALA A-118
 None
None
None
MAL  A 126 (-2.6A)
None
 0.82A 3tbgD-3ehsA:
undetectable		 3tbgD-3ehsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
GLC  A 672 (-2.7A)
None
 0.84A 3tbgD-3f5fA:
undetectable		 3tbgD-3f5fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 PHE C  27
GLY C 272
LEU C 275
PHE C 273
SER C 277
 None
 1.06A 3tbgD-3gi8C:
undetectable		 3tbgD-3gi8C:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.12A 3tbgD-3hiqA:
undetectable		 3tbgD-3hiqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.11A 3tbgD-3hiwA:
undetectable		 3tbgD-3hiwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU D  29
PHE D  33
PHE D  54
ALA D  69
SER D  72
 None
 1.02A 3tbgD-3hrdD:
undetectable		 3tbgD-3hrdD:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PHE A-188
GLY A -44
LEU A -45
GLU A-233
ALA A-113
 MAL  A 194 (-4.4A)
None
None
MAL  A 194 (-2.9A)
None
 0.84A 3tbgD-3l2jA:
undetectable		 3tbgD-3l2jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 PHE A 894
GLY A1038
LEU A1037
GLU A 849
ALA A 969
 MAL  A 600 (-4.8A)
None
None
MAL  A 600 (-2.9A)
None
 0.89A 3tbgD-3mp6A:
undetectable		 3tbgD-3mp6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PHE A-214
GLY A -70
LEU A -71
GLU A-259
ALA A-139
 None
None
None
MAL  A 111 (-3.4A)
None
 0.84A 3tbgD-3n93A:
undetectable		 3tbgD-3n93A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PHE A-192
GLY A -48
LEU A -49
GLU A-237
ALA A-117
 MAL  A5044 ( 4.9A)
None
None
MAL  A5044 (-2.9A)
None
 0.79A 3tbgD-3n94A:
undetectable		 3tbgD-3n94A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 PHE N 156
GLY N 300
LEU N 299
GLU N 111
ALA N 231
 None
None
None
MLR  N2001 (-2.9A)
None
 0.83A 3tbgD-3o3uN:
undetectable		 3tbgD-3o3uN:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1122 (-2.9A)
None
 0.82A 3tbgD-3oaiA:
undetectable		 3tbgD-3oaiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A 400 (-2.7A)
None
 0.85A 3tbgD-3ob4A:
undetectable		 3tbgD-3ob4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 548
LEU A 547
GLU A 111
ALA A 479
 MAL  A 700 ( 4.9A)
None
None
MAL  A 700 (-2.9A)
None
 0.84A 3tbgD-3osqA:
undetectable		 3tbgD-3osqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 MAL  A 700 (-4.9A)
None
None
MAL  A 700 (-3.0A)
None
 0.84A 3tbgD-3osrA:
undetectable		 3tbgD-3osrA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MLR  A 701 (-3.0A)
None
 0.83A 3tbgD-3py7A:
undetectable		 3tbgD-3py7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A 200
LEU A 205
GLY A  61
PHE A  66
ALA A 114
 None
 1.13A 3tbgD-3qreA:
undetectable		 3tbgD-3qreA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 MTT  A1205 (-4.9A)
None
None
MTT  A1205 (-2.9A)
None
 0.82A 3tbgD-3vd8A:
undetectable		 3tbgD-3vd8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 LEU A 203
GLY A 173
LEU A 172
GLU A 133
ASP A 102
 SAM  A 501 (-4.6A)
None
None
SAM  A 501 (-2.3A)
SAM  A 501 ( 4.9A)
 1.02A 3tbgD-3vywA:
undetectable		 3tbgD-3vywA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		5 LEU A 545
PHE A 123
GLY A 558
LEU A 560
GLU A 456
 None
 1.07A 3tbgD-3w5fA:
undetectable		 3tbgD-3w5fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A 478
LEU A 482
ALA A 471
ASP A 470
SER A 469
 None
None
None
K  A1524 (-3.6A)
None
 0.91A 3tbgD-4a1oA:
undetectable		 3tbgD-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 LEU A 133
GLY A 373
GLU A 105
GLN A 377
ALA A 146
 None
SO4  A1418 (-3.4A)
None
None
None
 1.05A 3tbgD-4d2jA:
undetectable		 3tbgD-4d2jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		5 PHE A 746
LEU A 709
PHE A 720
ALA A 764
SER A 705
 None
 1.13A 3tbgD-4dloA:
undetectable		 3tbgD-4dloA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MLR  A 500 (-4.0A)
None
None
MLR  A 500 (-2.2A)
None
 0.85A 3tbgD-4edqA:
undetectable		 3tbgD-4edqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-2.9A)
None
 0.83A 3tbgD-4egcA:
undetectable		 3tbgD-4egcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		5 PHE A  10
GLY A  26
LEU A  30
PHE A  23
ALA A  55
 None
 1.12A 3tbgD-4eqfA:
undetectable		 3tbgD-4eqfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MTT  A 501 (-2.8A)
None
 0.84A 3tbgD-4exkA:
undetectable		 3tbgD-4exkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Plasmodium
falciparum) 		PF00574
(CLP_protease) 		5 GLY A 144
LEU A 143
PHE A 170
ALA A 228
SER A 164
 None
 1.10A 3tbgD-4gm2A:
undetectable		 3tbgD-4gm2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 PHE A-214
GLY A -70
LEU A -71
GLU A-259
ALA A-139
 None
None
None
MTT  A 701 (-3.0A)
None
 0.83A 3tbgD-4h1gA:
undetectable		 3tbgD-4h1gA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-3.0A)
None
 0.80A 3tbgD-4ifpA:
undetectable		 3tbgD-4ifpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
TYI  A 308 ( 4.9A)
MAL  A 501 (-2.9A)
TYI  A 211 ( 3.8A)
 0.82A 3tbgD-4ikmA:
undetectable		 3tbgD-4ikmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MTT  A 501 (-2.9A)
None
 0.82A 3tbgD-4irlA:
undetectable		 3tbgD-4irlA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-3.0A)
None
 0.81A 3tbgD-4kv3A:
undetectable		 3tbgD-4kv3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN

(Salmonella
enterica) 		PF13347
(MFS_2) 		5 GLY A 409
LEU A 407
PHE A 412
ALA A 317
ASP A 320
 None
 1.05A 3tbgD-4m64A:
undetectable		 3tbgD-4m64A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		5 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 None
None
None
MAL  A1201 (-3.1A)
None
 0.82A 3tbgD-4my2A:
undetectable		 3tbgD-4my2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLY A 598
LEU A 597
ALA A 377
ASP A 322
SER A 672
 None
 1.13A 3tbgD-4o9xA:
undetectable		 3tbgD-4o9xA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A 453
PHE A 320
GLY A 335
ALA A 350
SER A 510
 None
 1.02A 3tbgD-4oe5A:
undetectable		 3tbgD-4oe5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-3.1A)
None
 0.83A 3tbgD-4pe2A:
undetectable		 3tbgD-4pe2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		5 PHE A-215
GLY A -71
LEU A -72
GLU A-260
ALA A-140
 GLC  A 901 (-4.8A)
None
None
GLC  A 901 (-3.1A)
None
 0.95A 3tbgD-4qszA:
undetectable		 3tbgD-4qszA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 601 (-2.8A)
None
 0.83A 3tbgD-4qvhA:
undetectable		 3tbgD-4qvhA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 None
None
None
MAL  A2201 (-3.0A)
None
 0.84A 3tbgD-4rwfA:
undetectable		 3tbgD-4rwfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 MTT  A1209 (-4.9A)
None
None
MTT  A1209 (-2.9A)
None
 0.83A 3tbgD-4tsmA:
undetectable		 3tbgD-4tsmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A 325
LEU A 194
PHE A 130
ALA A 150
SER A 216
 FAD  A 402 (-3.3A)
None
None
None
None
 1.14A 3tbgD-4wqmA:
undetectable		 3tbgD-4wqmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 PHE A 180
GLY A 324
LEU A 323
GLU A 135
ALA A 255
 None
None
None
MAL  A 801 (-2.8A)
None
 0.79A 3tbgD-4wrnA:
undetectable		 3tbgD-4wrnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 PHE A 162
GLY A 306
LEU A 305
GLU A 117
ALA A 237
 None
None
None
MAL  A 601 (-2.9A)
None
 0.84A 3tbgD-4wviA:
undetectable		 3tbgD-4wviA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A1201 (-3.1A)
None
 0.82A 3tbgD-4xa2A:
undetectable		 3tbgD-4xa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 None
None
None
MAL  A1900 (-2.8A)
None
 0.82A 3tbgD-4xajA:
undetectable		 3tbgD-4xajA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
vulgaris) 		PF03480
(DctP) 		5 PHE A 122
LEU A 132
GLY A 104
LEU A 106
ALA A 115
 None
 1.11A 3tbgD-4xeqA:
undetectable		 3tbgD-4xeqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 901 (-3.1A)
None
 0.86A 3tbgD-5azaA:
undetectable		 3tbgD-5azaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A 501 (-2.9A)
None
 0.86A 3tbgD-5c7rA:
undetectable		 3tbgD-5c7rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Acinetobacter
nosocomialis;
Escherichia
coli) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1201 (-3.0A)
None
 0.83A 3tbgD-5cfvA:
undetectable		 3tbgD-5cfvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-3.0A)
None
 0.82A 3tbgD-5dfmA:
undetectable		 3tbgD-5dfmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		6 PHE D 156
GLY D 300
LEU D 299
GLU D 111
ALA D 231
ASP D  14
 None
 1.29A 3tbgD-5disD:
undetectable		 3tbgD-5disD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 PHE A-216
GLY A -72
LEU A -73
GLU A-261
ALA A-141
 MTT  A1431 ( 4.3A)
None
None
MTT  A1431 (-2.5A)
None
 0.87A 3tbgD-5fsgA:
undetectable		 3tbgD-5fsgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 0.91A 3tbgD-5g6rA:
undetectable		 3tbgD-5g6rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-3.3A)
None
 0.98A 3tbgD-5gppA:
undetectable		 3tbgD-5gppA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-2.9A)
None
 0.83A 3tbgD-5gpqA:
undetectable		 3tbgD-5gpqA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MTT  A 501 (-2.9A)
None
 0.81A 3tbgD-5h7nA:
undetectable		 3tbgD-5h7nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MLR  A 501 ( 4.2A)
NA  A 507 (-3.5A)
None
MLR  A 501 (-2.4A)
None
 0.83A 3tbgD-5hz7A:
undetectable		 3tbgD-5hz7A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 PHE A 523
GLY A 667
LEU A 666
GLU A 478
ALA A 598
 None
None
None
MAL  A1001 (-3.1A)
None
 0.80A 3tbgD-5hzvA:
undetectable		 3tbgD-5hzvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 PHE A 211
GLY A 355
LEU A 354
GLU A 166
ALA A 286
 MAL  A 803 ( 4.5A)
None
None
MAL  A 803 (-2.7A)
None
 0.80A 3tbgD-5hzwA:
undetectable		 3tbgD-5hzwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 PHE A3823
GLY A3967
LEU A3966
GLU A3778
ALA A3898
 MAL  A4201 ( 4.2A)
None
None
MAL  A4201 (-3.0A)
None
 0.82A 3tbgD-5ii5A:
undetectable		 3tbgD-5ii5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 PHE A4125
GLY A4269
LEU A4268
GLU A4080
ALA A4200
 MAL  A4501 ( 4.7A)
None
None
MAL  A4501 (-2.7A)
None
 0.79A 3tbgD-5iicA:
undetectable		 3tbgD-5iicA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 PHE C 156
GLY C 300
LEU C 299
GLU C 111
ALA C 231
 None
None
None
MTT  C1203 (-3.0A)
None
 0.78A 3tbgD-5jj4C:
undetectable		 3tbgD-5jj4C:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		5 PHE A-213
GLY A -69
LEU A -70
GLU A-258
ALA A-138
 MAL  A 701 ( 4.9A)
None
None
MAL  A 701 (-2.9A)
None
 0.84A 3tbgD-5jonA:
undetectable		 3tbgD-5jonA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 146
GLY A 166
LEU A 167
PHE A 170
ALA A 179
 None
 1.08A 3tbgD-5o8xA:
undetectable		 3tbgD-5o8xA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 5 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 1.00A 3tbgD-5ojlA:
undetectable		 3tbgD-5ojlA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MAL  A 501 ( 4.4A)
None
None
MAL  A 501 (-2.9A)
None
 0.85A 3tbgD-5osqA:
undetectable		 3tbgD-5osqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
GLC  A1412 (-3.0A)
None
 0.82A 3tbgD-5t03A:
undetectable		 3tbgD-5t03A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1501 (-3.0A)
None
 0.81A 3tbgD-5tj2A:
undetectable		 3tbgD-5tj2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 PHE A 162
GLY A 306
LEU A 305
GLU A 117
ALA A 237
 None
None
None
MLR  A 501 (-2.8A)
None
 0.84A 3tbgD-5ttdA:
undetectable		 3tbgD-5ttdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 5 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 MAL  A2201 (-4.8A)
None
None
MAL  A2201 (-3.2A)
None
 0.80A 3tbgD-5v6yA:
undetectable		 3tbgD-5v6yA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 5 LEU A 131
LEU A 169
GLY A 175
LEU A 174
ALA A 105
 None
 0.82A 3tbgD-5w16A:
undetectable		 3tbgD-5w16A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1k CR1-10 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 LEU D  65
GLY D  46
GLU D  48
ALA D  90
ASP D  91
 None
 1.09A 3tbgD-5w1kD:
undetectable		 3tbgD-5w1kD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-2.9A)
None
 0.83A 3tbgD-5wq6A:
undetectable		 3tbgD-5wq6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 789
PHE A 706
GLY A 750
LEU A 747
SER A 755
 None
 1.07A 3tbgD-5xqoA:
undetectable		 3tbgD-5xqoA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 5 PHE A 236
GLY A 380
LEU A 379
GLU A 191
ALA A 311
 MTT  A 501 (-4.8A)
None
None
MTT  A 501 (-2.7A)
None
 0.80A 3tbgD-6anvA:
undetectable		 3tbgD-6anvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 5 PHE A -59
GLY A  85
LEU A  84
GLU A-104
ALA A  16
 None
None
None
MAL  A 402 (-3.0A)
None
 0.82A 3tbgD-6dm8A:
undetectable		 3tbgD-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 5 PHE B 293
LEU B 173
GLY B 179
LEU B 180
ALA B 285
 None
None
CLA  B1210 ( 4.7A)
CLA  B1210 (-3.6A)
None
 1.13A 3tbgD-6fosB:
undetectable		 3tbgD-6fosB:
12.98