SIMILAR PATTERNS OF AMINO ACIDS FOR 3TBG_C_RTZC2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 THR A  78
LEU A 142
VAL A  99
LEU A  61
PHE A  80
 None
 1.23A 3tbgC-1czfA:
0.0		 3tbgC-1czfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Escherichia
coli) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		5 LEU A  75
THR A  78
VAL A  81
LEU A 113
VAL A 111
 None
 1.18A 3tbgC-1d8lA:
0.0		 3tbgC-1d8lA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 THR A 400
THR A 179
VAL A 177
VAL A 347
PHE A 393
 None
 1.15A 3tbgC-1i8qA:
0.0		 3tbgC-1i8qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 THR A 380
LEU A 373
VAL A 396
LEU A 391
PHE A 382
 None
 1.34A 3tbgC-1lgfA:
10.4		 3tbgC-1lgfA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 LEU A 360
THR A 363
VAL A   5
GLU A 359
LEU A 613
 None
 1.35A 3tbgC-1m1cA:
0.0		 3tbgC-1m1cA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		5 LEU A 151
VAL A 123
LEU A  85
VAL A  83
THR A  80
 None
 1.42A 3tbgC-1oroA:
0.0		 3tbgC-1oroA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A1291
VAL A1265
VAL A1208
PHE A1321
PHE A1175
 None
 1.41A 3tbgC-1p0cA:
undetectable		 3tbgC-1p0cA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 588
THR A 587
VAL A 591
LEU A 552
THR A 550
 None
 1.21A 3tbgC-1qgrA:
0.0		 3tbgC-1qgrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 LEU A 160
THR A  43
VAL A  45
THR A 301
PHE A 369
 None
 1.25A 3tbgC-1t1eA:
0.0		 3tbgC-1t1eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 THR A  47
LEU A  25
THR A  27
VAL A  32
VAL A   9
 None
 1.20A 3tbgC-1yq9A:
undetectable		 3tbgC-1yq9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 THR A  56
LEU A  31
VAL A   4
VAL A  80
PHE A 484
 None
 1.37A 3tbgC-2bvmA:
undetectable		 3tbgC-2bvmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 306
VAL A  80
LEU A 218
VAL A 220
PHE A 181
 None
 1.36A 3tbgC-2c9kA:
1.9		 3tbgC-2c9kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  90
THR A  91
VAL A 116
THR A 117
PHE A 127
 None
 1.38A 3tbgC-2ctzA:
undetectable		 3tbgC-2ctzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		5 LEU A  62
VAL A  99
GLU A  66
LEU A  21
THR A 157
 None
 1.35A 3tbgC-2ezvA:
undetectable		 3tbgC-2ezvA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 THR A  54
VAL A  78
LEU A 372
THR A 375
PHE A 481
 None
 0.73A 3tbgC-2f9qA:
54.4		 3tbgC-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0v RAC-LIKE GTP-BINDING
PROTEIN ARAC7

(Arabidopsis
thaliana) 		PF00071
(Ras) 		5 THR A  27
VAL A 167
LEU A  58
VAL A  10
THR A  11
 None
 1.41A 3tbgC-2j0vA:
undetectable		 3tbgC-2j0vA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		5 THR A 715
VAL A 578
GLU A 747
LEU A 775
VAL A 770
 None
 1.23A 3tbgC-2jfdA:
undetectable		 3tbgC-2jfdA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olg PRO-PHENOLOXIDASE
ACTIVATING ENZYME-I

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 LEU A 320
THR A 255
VAL A 257
VAL A 117
THR A 116
 None
 1.17A 3tbgC-2olgA:
undetectable		 3tbgC-2olgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		5 THR B 399
VAL B 397
LEU B 343
VAL B 341
PHE B 388
 None
 1.42A 3tbgC-2wfxB:
undetectable		 3tbgC-2wfxB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 THR A 164
THR A 191
VAL A 187
LEU A  84
VAL A  71
 None
 1.29A 3tbgC-2ww9A:
1.4		 3tbgC-2ww9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 THR A 222
VAL A 321
VAL A 134
PHE A 165
PHE A 161
 None
 1.33A 3tbgC-2yikA:
undetectable		 3tbgC-2yikA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 LEU A 560
THR A 558
VAL A 574
THR A 575
PHE A 639
 None
 1.19A 3tbgC-2zwsA:
undetectable		 3tbgC-2zwsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 LEU A 282
THR A 285
VAL A 494
THR A 208
PHE A 146
 None
 1.45A 3tbgC-3a24A:
undetectable		 3tbgC-3a24A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		5 LEU A 178
THR A 180
VAL A 207
LEU A 199
PHE A 259
 None
 1.40A 3tbgC-3cswA:
undetectable		 3tbgC-3cswA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B

(Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 THR A 262
THR A 378
LEU A 319
VAL A 321
PHE A 263
 None
ADP  A 500 (-3.7A)
None
None
None
 1.49A 3tbgC-3d36A:
undetectable		 3tbgC-3d36A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9x ADHESIN A

(Bartonella
henselae) 		PF05662
(YadA_stalk) 		5 LEU A 389
THR A 397
VAL A 399
LEU A 407
PHE A 427
 None
 1.38A 3tbgC-3d9xA:
undetectable		 3tbgC-3d9xA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		5 THR A  74
LEU A1459
LEU A1476
VAL A1490
PHE A  49
 None
 1.45A 3tbgC-3eujA:
undetectable		 3tbgC-3eujA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmf DETHIOBIOTIN
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 THR A   7
LEU A 156
VAL A 161
LEU A 124
VAL A 122
 None
 1.14A 3tbgC-3fmfA:
undetectable		 3tbgC-3fmfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl3 PUTATIVE
THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Chlorobaculum
tepidum) 		PF08534
(Redoxin) 		5 THR A 123
LEU A  59
VAL A  91
LEU A  40
VAL A  46
 None
 1.18A 3tbgC-3gl3A:
undetectable		 3tbgC-3gl3A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 LEU A 214
VAL A 184
LEU A 150
VAL A 154
THR A 155
 None
 1.05A 3tbgC-3hxkA:
undetectable		 3tbgC-3hxkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		5 THR A 154
LEU A 270
THR A 267
LEU A 252
THR A 231
 None
 1.37A 3tbgC-3i09A:
undetectable		 3tbgC-3i09A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 THR A  89
VAL A  93
GLU A 462
LEU A 383
VAL A 381
 None
 0.94A 3tbgC-3izkA:
1.2		 3tbgC-3izkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		5 THR A  89
LEU A   6
GLU A   7
LEU A  19
VAL A  34
 None
 1.36A 3tbgC-3kr9A:
undetectable		 3tbgC-3kr9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE

(Corynebacterium
glutamicum) 		PF00578
(AhpC-TSA) 		5 THR A 159
LEU A 126
VAL A  86
LEU A 163
PHE A 157
 None
 1.50A 3tbgC-3lwaA:
undetectable		 3tbgC-3lwaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1037
LEU A 977
THR A 996
LEU A 961
THR A 990
 None
 1.36A 3tbgC-3va7A:
undetectable		 3tbgC-3va7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE

(Archaeoglobus
fulgidus) 		no annotation 5 THR A 518
LEU A 576
VAL A 577
VAL A 513
PHE A 495
 None
 1.49A 3tbgC-3vgpA:
undetectable		 3tbgC-3vgpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		5 THR A  75
VAL A  77
LEU A 257
VAL A   3
PHE A 230
 None
 1.35A 3tbgC-3w2xA:
undetectable		 3tbgC-3w2xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 LEU A  21
THR A  22
LEU A  98
VAL A 132
PHE A 123
 None
 1.38A 3tbgC-3zbmA:
undetectable		 3tbgC-3zbmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		5 LEU A 212
THR A 214
VAL A 189
VAL A 153
THR A 154
 None
 1.42A 3tbgC-4ao7A:
undetectable		 3tbgC-4ao7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		5 THR A 351
VAL A 349
LEU A  43
VAL A  40
PHE B 138
 None
 1.38A 3tbgC-4ci0A:
undetectable		 3tbgC-4ci0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		5 VAL A 349
LEU A  43
VAL A  40
THR A 385
PHE B 138
 None
 1.39A 3tbgC-4ci0A:
undetectable		 3tbgC-4ci0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 THR A 250
LEU A 297
GLU A 312
LEU A  94
PHE A 251
 None
None
2PE  A 504 (-4.1A)
None
None
 1.46A 3tbgC-4df9A:
undetectable		 3tbgC-4df9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 THR A 239
THR A 447
VAL A 411
LEU A 386
VAL A 384
 None
 1.43A 3tbgC-4gr5A:
undetectable		 3tbgC-4gr5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		5 THR A 124
VAL A 128
LEU A   9
VAL A  57
PHE A 207
 None
 1.19A 3tbgC-4jj6A:
undetectable		 3tbgC-4jj6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 LEU E 214
THR E 193
VAL E 216
VAL E 201
PHE E 184
 None
None
None
FAD  E 505 ( 4.2A)
None
 1.42A 3tbgC-4kprE:
2.2		 3tbgC-4kprE:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 THR A 471
VAL A 201
GLU A 167
VAL A 879
THR A 883
 None
 1.28A 3tbgC-4kxbA:
2.3		 3tbgC-4kxbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l35 CRUXRHODOPSIN-3

(Haloarcula
vallismortis) 		PF01036
(Bac_rhodopsin) 		5 LEU A 160
VAL A 164
VAL A 233
THR A 171
PHE A 223
 None
 1.48A 3tbgC-4l35A:
1.5		 3tbgC-4l35A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj3 HALOALKANE
DEHALOGENASE

(Mycolicibacterium
rhodesiae) 		PF00561
(Abhydrolase_1) 		5 THR A 148
LEU A 119
VAL A 133
LEU A 260
PHE A 246
 None
 1.19A 3tbgC-4mj3A:
undetectable		 3tbgC-4mj3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		5 LEU A 198
THR A 191
VAL A 193
GLU A 200
LEU A  60
 None
 1.26A 3tbgC-4or8A:
undetectable		 3tbgC-4or8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		5 LEU A 191
THR A 190
VAL A 342
LEU A 312
PHE A  41
 None
 1.09A 3tbgC-4roaA:
undetectable		 3tbgC-4roaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 LEU A 110
THR A 108
VAL A 101
LEU A  61
VAL A   5
 None
 1.37A 3tbgC-4tn5A:
undetectable		 3tbgC-4tn5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 THR A   7
LEU A 156
VAL A 161
LEU A 124
VAL A 122
 None
 1.21A 3tbgC-4wopA:
undetectable		 3tbgC-4wopA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 THR A 347
LEU A 373
THR A 418
VAL A 416
LEU A 386
 None
 1.20A 3tbgC-4xgjA:
undetectable		 3tbgC-4xgjA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		5 LEU A 158
THR A 157
VAL A 162
LEU A 186
PHE A 252
 None
 1.23A 3tbgC-4xuvA:
undetectable		 3tbgC-4xuvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 LEU A 328
THR A 324
LEU A 349
THR A 352
PHE A 364
 None
 1.29A 3tbgC-4xzcA:
2.5		 3tbgC-4xzcA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 353
VAL A  86
VAL A 205
THR A 204
PHE A 282
 None
 1.43A 3tbgC-5a7mA:
undetectable		 3tbgC-5a7mA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		5 LEU A  80
LEU A 141
VAL A 101
THR A  93
PHE A 145
 None
 1.47A 3tbgC-5ewtA:
undetectable		 3tbgC-5ewtA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A 464
VAL A 431
LEU A 530
PHE A 486
PHE A 488
 None
 1.18A 3tbgC-5f56A:
undetectable		 3tbgC-5f56A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A1037
LEU A 977
THR A 996
LEU A 961
THR A 990
 None
 1.37A 3tbgC-5i8iA:
3.2		 3tbgC-5i8iA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 THR A 507
GLU A 437
VAL A 123
THR A 124
PHE A  28
 None
 1.35A 3tbgC-5nsqA:
undetectable		 3tbgC-5nsqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L5

(Mycolicibacterium
smegmatis) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 LEU F  64
THR F  68
VAL F  96
VAL F 163
PHE F 137
 None
None
C  B  43 ( 3.7A)
None
None
 1.41A 3tbgC-5o60F:
undetectable		 3tbgC-5o60F:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN
SMALL ENVELOPE
PROTEIN M

(Tick-borne
encephalitis
virus) 		no annotation 5 THR D  53
VAL D  49
LEU A 460
VAL A 462
PHE A 449
 None
 1.41A 3tbgC-5o6vD:
undetectable		 3tbgC-5o6vD:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 LEU A 265
VAL A 257
LEU A 343
VAL A 324
PHE A 242
 None
 1.07A 3tbgC-5ucdA:
1.4		 3tbgC-5ucdA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umw GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE

(Streptomyces
sp. CB03234) 		no annotation 5 LEU A 130
THR A 131
VAL A  88
LEU A  26
PHE A  21
 None
 1.41A 3tbgC-5umwA:
undetectable		 3tbgC-5umwA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8w INTEGRATOR COMPLEX
SUBUNIT 9

(Homo sapiens) 		no annotation 5 THR A 624
LEU A 598
THR A 597
LEU A 643
VAL A 645
 None
 1.30A 3tbgC-5v8wA:
undetectable		 3tbgC-5v8wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 5 LEU B2625
VAL B2662
LEU B2653
PHE B2606
PHE B2650
 None
 1.43A 3tbgC-5wfcB:
undetectable		 3tbgC-5wfcB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 5 LEU B3674
THR B3087
VAL B3683
PHE B3914
PHE B3910
 None
 1.40A 3tbgC-6a70B:
undetectable		 3tbgC-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 5 THR C 232
THR C 307
VAL C 268
LEU C 236
PHE F 328
 None
 1.47A 3tbgC-6btmC:
undetectable		 3tbgC-6btmC:
9.81